Documenta Ophthalmologica最新文献_第5页

Optic nerve involvement in patients with Lyme neuroborreliosis: an electrophysiological study 莱姆神经源性疾病患者的视神经受累：一项电生理学研究

IF 1.4 4区医学

Documenta Ophthalmologica Pub Date : 2024-04-15 DOI: 10.1007/s10633-024-09975-w

Jana Szanyi, Jan Kremlacek, Zuzana Kubova, Miroslav Kuba, Frantisek Vit, Jana Langrova, Pavel Gebousky, Juraj Szanyi

{"title":"Optic nerve involvement in patients with Lyme neuroborreliosis: an electrophysiological study","authors":"Jana Szanyi, Jan Kremlacek, Zuzana Kubova, Miroslav Kuba, Frantisek Vit, Jana Langrova, Pavel Gebousky, Juraj Szanyi","doi":"10.1007/s10633-024-09975-w","DOIUrl":"https://doi.org/10.1007/s10633-024-09975-w","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3>The aim of this neurophysiological study was to retrospectively analyze visual evoked potentials (VEPs) acquired during an examination for diagnosing optic nerve involvement in patients with Lyme neuroborreliosis (LNB). Attention was focused on LNB patients with peripheral facial palsy (PFP) and optic nerve involvement.<h3 data-test=\"abstract-sub-heading\">Methods</h3>A total of 241 Czech patients were classified as having probable/definite LNB (193/48); of these, 57 were younger than 40 years, with a median age of 26.3 years, and 184 were older than 40 years, with a median age of 58.8 years. All patients underwent pattern-reversal (PVEP) and motion-onset (MVEP) VEP examinations.<h3 data-test=\"abstract-sub-heading\">Results</h3>Abnormal VEP results were observed in 150/241 patients and were noted more often in patients over 40 years (p = 0.008). Muscle/joint problems and paresthesia were observed to be significantly more common in patients older than 40 years (p = 0.002, p = 0.030), in contrast to headache and decreased visual acuity, which were seen more often in patients younger than 40 years (p = 0.001, p = 0.033). Peripheral facial palsy was diagnosed in 26/241 LNB patients. Among patients with PFP, VEP peak times above the laboratory limit was observed in 22 (84.6%) individuals. Monitoring of patients with PFP and pathological VEP showed that the adjustment of visual system function occurred in half of the patients in one to more years, in contrast to faster recovery from peripheral facial palsy within months in most patients.<h3 data-test=\"abstract-sub-heading\">Conclusion</h3>In LNB patients, VEP helps to increase sensitivity of an early diagnostic process.","PeriodicalId":11207,"journal":{"name":"Documenta Ophthalmologica","volume":"49 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140616169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Slope between positive and negative ERG components in patients with open-angle glaucoma 开角型青光眼患者ERG正负分量之间的斜率

IF 1.4 4区医学

Documenta Ophthalmologica Pub Date : 2024-04-12 DOI: 10.1007/s10633-024-09972-z

Maja Sustar Habjan, Barbara Cvenkel

{"title":"Slope between positive and negative ERG components in patients with open-angle glaucoma","authors":"Maja Sustar Habjan, Barbara Cvenkel","doi":"10.1007/s10633-024-09972-z","DOIUrl":"https://doi.org/10.1007/s10633-024-09972-z","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3>To evaluate ERG morphology, in particular the slope between P50 and N95 components of the PERG, as well as between the b-wave and the photopic negative response (PhNR) of the light-adapted (LA) ERG in patients with retinal ganglion cell (RGC) dysfunction due to open-angle glaucoma.<h3 data-test=\"abstract-sub-heading\">Methods</h3>The PERG and LA-ERG traces of 16 glaucoma patients and 21 age-similar controls were retrospectively analysed. The ERG signal between the peak of the positive component (P50 and b-wave) towards the negative component (N95 and PhNR) was described by a linear regression y = a + bx, where the parameter b indicated the steepness of the P50-N95 and b-PhNR slope.<h3 data-test=\"abstract-sub-heading\">Results</h3>The P50-N95 slope was less steep in glaucoma patients (−0.079 ± 0.034 vs. −0.166 ± 0.050 in controls, p < 0.001), while the b-PhNR slope was not affected (−4.2 ± 2.1 vs. −4.4 ± 1.2, p = NS). The P50-N95 slope showed strong correlation with PhNR and N95 amplitude (r = −0.68 and −0.92, respectively; p < 0.001), while the b-PhNR slope correlated only with b-wave amplitude (r = −0.66, p < 0.001).<h3 data-test=\"abstract-sub-heading\">Conclusions</h3>The P50-N95 slope is a sensitive indicator of RGC dysfunction in patients with open-angle glaucoma. A similar component of LA-ERG, the b-PhNR slope, is less affected by glaucomatous RGC dysfunction and probably originates from similar retinal mechanisms as the b-wave.","PeriodicalId":11207,"journal":{"name":"Documenta Ophthalmologica","volume":"10 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140569972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accelerated hydroxychloroquine toxic retinopathy (response to letter) 加速羟氯喹中毒性视网膜病变（回信）

IF 1.4 4区医学

Documenta Ophthalmologica Pub Date : 2024-04-05 DOI: 10.1007/s10633-024-09974-x

Ayushi Mohapatra, Prasad Gupta, Dhanashree Ratra

引用次数: 0

Unusual OCT findings in a patient with CABP4-associated cone-rod synaptic disorder. 一名 CABP4 相关锥-杆突触障碍患者的异常 OCT 发现。

IF 1.4 4区医学

Documenta Ophthalmologica Pub Date : 2024-04-01 Epub Date: 2024-01-11 DOI: 10.1007/s10633-023-09961-8

Jit Kai Tan, Gavin Arno, Dragana Josifova, Moin D Mohamed, Omar A Mahroo

{"title":"Unusual OCT findings in a patient with CABP4-associated cone-rod synaptic disorder.","authors":"Jit Kai Tan, Gavin Arno, Dragana Josifova, Moin D Mohamed, Omar A Mahroo","doi":"10.1007/s10633-023-09961-8","DOIUrl":"10.1007/s10633-023-09961-8","url":null,"abstract":"Purpose: Bi-allelic variants in CABP4 are associated with congenital cone-rod synaptic disorder, which has also been classified, electrophysiologically, as incomplete congenital stationary night blindness (iCSNB). We describe clinical findings in a patient who demonstrated an unusual macular optical coherence tomography (OCT) phenotype, not previously reported in this condition.Methods: Our patient underwent multimodal retinal imaging, international standard full-field ERG testing and whole genome sequencing.Results: The patient was a 60-year-old woman with non-progressive visual impairment since birth, nystagmus and preference for dim lighting. Clinical fundus examination was unremarkable. OCT imaging revealed a hypo-reflective zone under an elevated fovea in both eyes. ERGs showed an electronegative DA10 response, with severely abnormal light-adapted responses. Whole genome sequencing revealed homozygosity for a known pathogenic variant in CABP4. No variants were found in other genes that could explain the patient's phenotype.Conclusions: OCT findings of foveal elevation and an underlying hypo-reflective zone are novel in this condition. Whilst the clinical history was similar to achromatopsia and other cone dysfunction syndromes, ERG findings suggested disease associated with CACNA1F or CABP4. As CACNA1F is X-linked, CABP4 was more likely, and confirmed on genetic testing. The patient saw better in dim light, confirming that night blindness is not a feature of CABP4-associated disease. Our case highlights the value of ERGs in discriminating between causes of cone dysfunction, and extends the range of retinal imaging phenotypes reported in this disorder.","PeriodicalId":11207,"journal":{"name":"Documenta Ophthalmologica","volume":" ","pages":"115-120"},"PeriodicalIF":1.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10954985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139416649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Videoocular assessment of eye movement activity in an ataxia-telangiectasia: a case study. 共济失调-特朗日综合症患者眼球运动活动的视频评估：一项个案研究。

IF 1.4 4区医学

Documenta Ophthalmologica Pub Date : 2024-04-01 Epub Date: 2024-02-14 DOI: 10.1007/s10633-024-09964-z

Sofia A Mironets, Marina A Shurupova, Alexander F Karelin

引用次数: 0

Sensitivity and specificity of the uniform field electroretinogram in glaucoma detection in comparison to the pattern electroretinogram. 均匀视野视网膜电图与模式视网膜电图在青光眼检测中的灵敏度和特异性比较。

IF 1.4 4区医学

Documenta Ophthalmologica Pub Date : 2024-04-01 Epub Date: 2024-01-20 DOI: 10.1007/s10633-023-09960-9

Asma Hermas, Catherine Tsilfidis, Rustum Karanjia, Garfield Miller, Ange-Lynca Kantungane, Amanda El-Salibi, Irfan N Kherani, Shveta Bali, Stuart Coupland

{"title":"Sensitivity and specificity of the uniform field electroretinogram in glaucoma detection in comparison to the pattern electroretinogram.","authors":"Asma Hermas, Catherine Tsilfidis, Rustum Karanjia, Garfield Miller, Ange-Lynca Kantungane, Amanda El-Salibi, Irfan N Kherani, Shveta Bali, Stuart Coupland","doi":"10.1007/s10633-023-09960-9","DOIUrl":"10.1007/s10633-023-09960-9","url":null,"abstract":"Purpose: To determine the ability of the photopic negative response (PhNR) of the uniform field electroretinogram (UF-ERG) to identify early glaucomatous changes in comparison to the checkerboard and bar stimuli of the pattern electroretinogram (PERG).Methods: Forty-nine glaucoma patients were classified into two groups: glaucoma-suspect (23 eyes) and early to moderate glaucoma (30 eyes), based on their clinical examination and the results of standard automated perimetry. Thirty patients (30 eyes) with intraocular pressures (IOP) of 21 mmHg or less, with no history of reported high IOP, were included as controls. PERG and UF-ERG recordings were obtained on a Diagnosys D-341 Attaché-Envoy System. Visual field testing was done only for glaucoma-suspect and glaucoma patients.Results: All three tests (PERG bar stimulus, PERG checkerboard stimulus and PhNR) displayed significantly prolonged peak times for glaucoma and glaucoma-suspect patients, with delays ranging from 7.8 to 14.8%, depending on the test. The PERG bar stimulus also showed a significantly lower N95 amplitude for both glaucoma groups (with reductions of 26.0% and 33.0% for glaucoma-suspect and glaucoma groups, respectively). The PERG checkerboard N95 amplitude component had high sensitivity for detecting glaucoma patients but a low specificity (97% and 37%, respectively; AUC = 0.61). Overall, the PhNR peak time showed the highest sensitivity and specificity (77% and 90%, respectively; AUC = 0.87).Conclusions: PERG bar stimuli and the PhNR of the UF-ERG can be used in the clinical setting to detect glaucoma-related changes in glaucoma-suspect and glaucoma patients. However, our data confirm that the PhNR peak time has the best combined sensitivity and specificity.","PeriodicalId":11207,"journal":{"name":"Documenta Ophthalmologica","volume":" ","pages":"97-106"},"PeriodicalIF":1.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139502374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of eccentric fixation on the steady-state pattern electroretinogram. 偏心固定对稳态模式视网膜电图的影响

IF 1.4 4区医学

Documenta Ophthalmologica Pub Date : 2024-04-01 Epub Date: 2024-02-28 DOI: 10.1007/s10633-024-09967-w

Evelyn B N Friedel, Julia Haldina, Kathrin Nickel, Michael Bach, Ludger Tebartz van Elst, Sven P Heinrich

{"title":"Effect of eccentric fixation on the steady-state pattern electroretinogram.","authors":"Evelyn B N Friedel, Julia Haldina, Kathrin Nickel, Michael Bach, Ludger Tebartz van Elst, Sven P Heinrich","doi":"10.1007/s10633-024-09967-w","DOIUrl":"10.1007/s10633-024-09967-w","url":null,"abstract":"Purpose: The steady-state pattern electroretinogram (ssPERG) is used to assess retinal ganglion cell function in a variety of research contexts and diagnostic applications. In certain groups of patients or study participants, stable central fixation of the stimulus is not guaranteed. The present study aimed at assessing the effects of misfixation on the ssPERG response to checkerboard reversal stimuli.Methods: Using two check sizes (0.8° and 15°), we compared ssPERG responses for several amounts of fixation deviation, ranging from 0° to 19° horizontally and from 0° to 14° diagonally. The stimulus area extended to 15° eccentricity, stimulus reversal rate was 15/s.Results: Up to around 7° eccentricity, there was no sizable effect of fixation deviation under most conditions. Effects were somewhat larger for nasal than for temporal deviation, in particular for small checks. Diagonal deviation was associated with a response to luminance onset/offset at 7.5 Hz (subharmonic of the reversal rate), most prominently when the interior of a large check was fixated.Conclusion: Generally, moderate inaccuracies of fixation do not have a sizable effect on ssPERG amplitude. However, with large checks, the luminance response has to be considered.","PeriodicalId":11207,"journal":{"name":"Documenta Ophthalmologica","volume":" ","pages":"87-95"},"PeriodicalIF":1.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10954955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139982553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ISCEV standard for clinical pattern electroretinography (2024 update). ISCEV 临床模式视网膜电图标准（2024 年更新）。

IF 1.4 4区医学

Documenta Ophthalmologica Pub Date : 2024-04-01 Epub Date: 2024-03-15 DOI: 10.1007/s10633-024-09970-1

D A Thompson, M Bach, J J McAnany, M Šuštar Habjan, S Viswanathan, A G Robson

{"title":"ISCEV standard for clinical pattern electroretinography (2024 update).","authors":"D A Thompson, M Bach, J J McAnany, M Šuštar Habjan, S Viswanathan, A G Robson","doi":"10.1007/s10633-024-09970-1","DOIUrl":"10.1007/s10633-024-09970-1","url":null,"abstract":"The pattern electroretinogram (PERG) is a localized retinal response evoked by a contrast-reversing pattern, usually a black and white checkerboard, which provides information about macular and retinal ganglion cell function. This document, from the International Society for Clinical Electrophysiology of Vision (ISCEV; www.iscev.org ) presents an updated and revised Standard for clinical PERG testing. This replaces the 2013 and all earlier versions. Minimum protocols for basic PERG stimuli, recording methods and reporting are specified, to promote consistency of methods for diagnosis and monitoring purposes, while responding to evolving clinical practices and technology. The main changes in the updated ISCEV Standard for clinical PERG include expanded guidance about large stimulus fields, stimulus parameters for simultaneous PERG and pattern visual evoked potential recording, baseline drift correction, and use of consistent ambient room lighting. These changes aim to provide a clinically relevant document about current practice which will facilitate good quality recordings and inter-laboratory comparisons.","PeriodicalId":11207,"journal":{"name":"Documenta Ophthalmologica","volume":" ","pages":"75-85"},"PeriodicalIF":1.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10954931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140136605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case of persistent corneal epithelial damage after cataract surgery leading to diagnosis of vitamin A deficiency. 白内障手术后持续性角膜上皮损伤导致维生素 A 缺乏症的诊断病例。

IF 1.4 4区医学

Documenta Ophthalmologica Pub Date : 2024-04-01 Epub Date: 2024-01-24 DOI: 10.1007/s10633-023-09963-6

Fuyuki Yamada, Kumiko Kato, Ryunosuke Nagashima, Yuka Yonekawa, Yuzen Kashima, Mineo Kondo

{"title":"Case of persistent corneal epithelial damage after cataract surgery leading to diagnosis of vitamin A deficiency.","authors":"Fuyuki Yamada, Kumiko Kato, Ryunosuke Nagashima, Yuka Yonekawa, Yuzen Kashima, Mineo Kondo","doi":"10.1007/s10633-023-09963-6","DOIUrl":"10.1007/s10633-023-09963-6","url":null,"abstract":"Purpose: To report our findings of reduced full-field electroretinograms (ff-ERGs) and abnormal optical coherence tomographic (OCT) images in a patient with poor visual acuity after cataract surgery who was eventually diagnosed with vitamin A deficiency (VAD).Methods: This was a clinical study of a patient who complained of blurred vision after cataract surgery. To determine the cause of the reduced vision, we recorded full-field electroretinograms (ff-ERGs) to determine the scotopic and photopic status of the retina. We also performed optical coherence tomography to assess the changes in the retinal structure. Serological tests were performed.Results: A 74-year-old man presented with persistent corneal epithelial damages and reduced vision that developed after conventional cataract surgery. OCT showed an interrupted ellipsoid zone, and fundus autofluorescence (FAF) showed a severe hypofluorescence in the retina of the left eye. The scotopic ff-ERGs were severely reduced, and the photopic ff-ERGs were mildly reduced. Serological examinations revealed a vitamin A concentration < 7 IU/dL (normal, 97-316 IU/dL). Based on these findings, we diagnosed the patient with VAD and started treatment with oral vitamin A supplements. After three months, his visual acuity, ff-ERGs, and OCT findings recovered to normal levels. The amplitudes and implicit times of the RETeval flicker ERGs increased to be within the normal range, and the hypofluorescence of the left eye disappeared. The length of the photoreceptor outer segments increased after the vitamin A supplementation.Conclusion: Our findings indicate that the ERGs are helpful for diagnosing patients with VAD associated with persistent corneal epithelial damages.","PeriodicalId":11207,"journal":{"name":"Documenta Ophthalmologica","volume":" ","pages":"121-128"},"PeriodicalIF":1.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139541185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The IPS and ISCEV joint guidelines for full-field stimulus testing. IPS 和 ISCEV 全场刺激测试联合指南。

IF 1.4 4区医学

Documenta Ophthalmologica Pub Date : 2024-02-01 DOI: 10.1007/s10633-024-09966-x

J K Jolly, C Matsumoto, R Hamilton

引用次数: 0