Brief report: harmonic analysis of the 30 Hz flicker ERG in early-stage diabetic retinopathy.

IF 2.6 4区医学 Q2 OPHTHALMOLOGY

Documenta Ophthalmologica Pub Date : 2025-05-31 DOI:10.1007/s10633-025-10030-5

J Jason McAnany, Jason C Park

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引用次数: 0

Abstract

Purpose: To determine if harmonic components of the 30 Hz flicker ERG are useful for detecting neural dysfunction in diabetics who have mild or no non-proliferative diabetic retinopathy (NPDR).

Methods: Previously reported light-adapted flicker ERG data recorded from 20 diabetics who had no clinically-apparent retinopathy (NDR), 20 who had mild NPDR (MDR), and 20 non-diabetic controls were reanalyzed. From this dataset, the amplitude and phase of the 31.25 Hz flicker ERG fundamental and second harmonic were extracted. The 62.5 Hz flicker ERG fundamental was also extracted. Similar responses were also acquired prospectively from 10 controls, 5 NDR, and 5 MDR subjects, comprising a second dataset.

Results: Analysis of variance indicated that both diabetic groups had normal amplitudes elicited by the 31.25 Hz stimulus (fundamental and second harmonic), whereas the 62.5 Hz amplitude was reduced significantly in both diabetic groups. This pattern was found in both the retrospective and prospective analyses.

Conclusions: The second harmonic of the 31.25 Hz flicker response (equivalent to 62.5 Hz) was normal in early-stage DR, whereas the response to 62.5 Hz flicker stimuli was abnormal. The second harmonic of the ISCEV standard 30 Hz flicker ERG does not appear to be a useful indicator of neural dysfunction in early DR.

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简要报告：早期糖尿病视网膜病变30hz闪烁ERG的谐波分析。

目的：确定30 Hz闪烁ERG的谐波成分是否有助于检测轻度或无非增殖性糖尿病视网膜病变（NPDR）的糖尿病患者的神经功能障碍。方法：对20例无临床明显视网膜病变（NDR）的糖尿病患者、20例轻度NPDR （MDR）的糖尿病患者和20例非糖尿病对照组的光适应闪烁ERG数据进行重新分析。从该数据集中提取了31.25 Hz闪烁ERG基频和二次谐波的幅值和相位。提取了62.5 Hz闪烁ERG基元。从10名对照组、5名NDR和5名MDR受试者中也获得了类似的前瞻性反应，这些受试者组成了第二个数据集。结果：方差分析表明，糖尿病组和糖尿病组在31.25 Hz（基频和次谐波）刺激下的振幅均正常，而62.5 Hz的振幅均明显降低。在回顾性和前瞻性分析中都发现了这种模式。结论：在早期DR中，31.25 Hz闪烁反应的二次谐波（相当于62.5 Hz）是正常的，而对62.5 Hz闪烁刺激的二次谐波则是异常的。ISCEV标准30hz闪烁ERG的二次谐波似乎不是早期DR神经功能障碍的有用指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Documenta Ophthalmologica 医学-眼科学

CiteScore

3.50

自引率

21.40%

发文量

审稿时长

>12 weeks

期刊介绍： Documenta Ophthalmologica is an official publication of the International Society for Clinical Electrophysiology of Vision. The purpose of the journal is to promote the understanding and application of clinical electrophysiology of vision. Documenta Ophthalmologica will publish reviews, research articles, technical notes, brief reports and case studies which inform the readers about basic and clinical sciences related to visual electrodiagnosis and means to improve diagnosis and clinical management of patients using visual electrophysiology. Studies may involve animals or humans. In either case appropriate care must be taken to follow the Declaration of Helsinki for human subject or appropriate humane standards of animal care (e.g., the ARVO standards on Animal Care and Use).