{"title":"Normative data on a reliable and sensitive test of gustatory function.","authors":"Laura Marie Aalkjær, Alexander Wieck Fjældstad","doi":"10.61409/A09240590","DOIUrl":"https://doi.org/10.61409/A09240590","url":null,"abstract":"<p><strong>Introduction: </strong>Our sense of taste plays a key role in eating and drinking, guiding behaviour through warning and pleasure signalling. Taste dysfunction has severe consequences for patients. Reliable gustatory testing is relevant for researchers and clinicians, emphasising the need for reproducible measuring methods. This study aimed to provide normative data on the Taste-Drop-Test (TDT), which is already used in clinical and research settings.</p><p><strong>Methods: </strong>The TDT was administered to 424 healthy participants and 134 patients with gustatory dysfunction. The test consisted of liquid concentrations of four basic tastes: acidic, sweet, salty and bitter. After application, a test score was calculated for each individual.</p><p><strong>Results: </strong>In the healthy participants, a significant correlation was found between TDT score and olfactory function. Furthermore, a significant positive correlation was found for superior taste function for younger age and female sex. The cut-off value based on the tenth percentile in the healthy participants was 6.25.</p><p><strong>Conclusions: </strong>The TDT can distinguish between normo- and hypogeusia. We recommend using the TDT to researchers and clinicians when an accurate measurement of gustatory function is warranted.</p><p><strong>Funding: </strong>This project received no specific funding. Alexander Wieck Fjældstad is partially funded by the VELUX Foundation for other projects.</p><p><strong>Trial registration: </strong>The Central Denmark Region Ethics Committee approved the study (42832), which was conducted in consistency with the Declaration of Helsinki Ethical Principles of Medical Research.</p>","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 5","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rikke Brink Petersen, Christina Damgaard Buch, Christian Faergemann, Tine Nymark
{"title":"Bone deformities with hereditary multiple osteochondromas.","authors":"Rikke Brink Petersen, Christina Damgaard Buch, Christian Faergemann, Tine Nymark","doi":"10.61409/A11230696","DOIUrl":"https://doi.org/10.61409/A11230696","url":null,"abstract":"<p><strong>Introduction: </strong>Hereditary multiple osteochondromas (HMO) is a genetic skeletal disorder caused by defects in exostosin glycosyltransferase 1 (EXT1) or 2 (EXT2) genes. It develops mainly in the growth period and causes multiple osteochondromas (OC) in the physis of the long bones, leading to discomfort and deformities. This study aimed to investigate the anatomical distribution of OC, the frequency of deformities of the lower limbs, scoliosis and surgeries performed in a cohort of patients with HMO at the time of their enrolment in a regional surveillance programme.</p><p><strong>Methods: </strong>The study population included HMO patients from the Centre of Heritable and Complex Diseases (CAKS) in the Region of Southern Denmark. Information on surgical procedures and age at the time of diagnosis was obtained from medical records, while deformities were evaluated on early-onset scoliosis (EOS) scans from time of enrolment in the CAKS.</p><p><strong>Results: </strong>A total of 54 patients were included and 44 patients (82%) had an EOS scan. All except one (98%) HMO patient had OC in the knees at the time of their EOS scan. A total of 12 patients (27%) had leg length discrepancy, 30 (68%) had genu varum or valgum and 13 (30%) had scoliosis. The HMO patients had undergone a median of 2.0 (0-14) surgeries, where a median of four (1-23) OC were removed, mostly in the lower limb (68%).</p><p><strong>Conclusions: </strong>The majority of HMO patients in this cohort suffered from major anatomical burdens, leading to multiple surgeries and deformities. We suggest that a programme, such as the CAKS surveillance programme, may be beneficial to screening and follow-up of OC and deformities in patients with HMO.</p><p><strong>Funding: </strong>None.</p><p><strong>Trial registration: </strong>Not relevant.</p>","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 5","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christian H Steenkjær, Mia B Heintzelmann, Izabella Obál, Grethe Andersen, Jakob U Blicher
{"title":"An adapted Danish translation of the Center for Neurologic Study Lability scale.","authors":"Christian H Steenkjær, Mia B Heintzelmann, Izabella Obál, Grethe Andersen, Jakob U Blicher","doi":"10.61409/A07240497","DOIUrl":"https://doi.org/10.61409/A07240497","url":null,"abstract":"<p><strong>Introduction: </strong>Pathological crying and/or laughing (pseudobulbar affect (PBA)) are socially debilitating symptoms seen in many neurological diseases, such as stroke, multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). One method for measuring the degree of PBA is the Center for Neurologic Study-Lability Scale (CNS-LS), a seven-item questionnaire validated for quantifying symptoms and supporting PBA diagnoses in ALS and MS. The aim of this study was to provide a Danish translation of the CNS-LS inspired by international guidelines on cross-cultural translation and adaptation of self-report measurements.</p><p><strong>Methods: </strong>Through a six-step process, the CNS-LS was translated and back-translated by four certified translators, followed by an expert committee examination. The translation was then field-tested by interviewing patients with ALS and MS after they had completed the CNS-LS. If at least 20% of participants found an item \"unclear\", it would be reevaluated.</p><p><strong>Results: </strong>Twelve patients with ALS patients and 30 patients with MS were tested and interviewed. None of the questionnaire items exceeded the 20% threshold for lack of clarity.</p><p><strong>Conclusion: </strong>We present a Danish translation of the CNS-LS to facilitate better diagnosis and quantification of PBA symptoms in Danish patients with ALS or MS.</p><p><strong>Funding: </strong>This study received funding from the PhD fellowship grant of Neuroscience Academy Denmark.</p><p><strong>Trial registration: </strong>Not relevant.</p>","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 5","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Short-term effect of inpatient treatment of psychogenic non-epileptic seizures.","authors":"Sigge Weisdorf, Mads Henrik Ravnborg","doi":"10.61409/A06240385","DOIUrl":"https://doi.org/10.61409/A06240385","url":null,"abstract":"<p><strong>Introduction: </strong>Psychogenic non-epileptic seizures (PNES) is a dissociative disorder with attacks resembling epileptic seizures. Previous studies have shown that patients with PNES have distinct demographical and health-related features. No studies, however, exist that describe Danish patients with PNES. In this study, we present the clinical characteristics of patients who received inpatient cognitive behavioural psychotherapy for PNES. We also present data on the short-term effect of PNES treatment for patients with and without comorbid epilepsy.</p><p><strong>Methods: </strong>In this retrospective study, we reviewed medical records for patients admitted for treatment of PNES at the Danish Epilepsy Centre from 2018 to 2023. We compared psychometric scores before and after admission as outcome measures.</p><p><strong>Results: </strong>Our cohort consisted of 86.6% women with a mean age of 34.1 years at admission. 29.1% lived alone, and only 39.6% were employed or under education. The patients had a long history of PNES (mean 68.6 months), and a large proportion had comorbid epilepsy (34.1%) or psychiatric comorbidity (67.2%). We found significant improvement in all psychometric scores after admission. Comorbid epilepsy had no significant impact on this effect.</p><p><strong>Conclusions: </strong>Danish patients receiving inpatient treatment for PNES are very similar to other published cohorts. Four weeks of psychotherapy significantly improved all psychometric scores for patients both with and without epilepsy.</p><p><strong>Funding: </strong>This study was funded entirely by the Danish Epilepsy Centre.</p><p><strong>Trial registration: </strong>Not relevant.</p>","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 5","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Josefine M Bruun, Pernille Andreassen, Louise E Fløe, Jesper G Eriksen, Poul Videbech, Søren P Johnsen, Trine Brogaard, Kelly E Irwin, Mette A Neergaard
{"title":"Patient and relative experiences with cancer and pre-existing mental disorders.","authors":"Josefine M Bruun, Pernille Andreassen, Louise E Fløe, Jesper G Eriksen, Poul Videbech, Søren P Johnsen, Trine Brogaard, Kelly E Irwin, Mette A Neergaard","doi":"10.61409/A06240374","DOIUrl":"https://doi.org/10.61409/A06240374","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with cancer and pre-existing severe mental disorders (SMD) have higher cancer mortality rates, but research on barriers to optimal treatment is limited, particularly from the perspectives of patients and relatives. This qualitative study aimed to highlight the experiences of patients and relatives regarding their cancer trajectories in Denmark to explore barriers to optimal cancer care for this patient population.</p><p><strong>Methods: </strong>A total of 11 semi-structured individual interviews were conducted with eight patients with cancer and pre-existing SMD and three relatives. An eclectic theoretical framework was applied to explore the participants' and relatives' experiences.</p><p><strong>Results: </strong>Identified barriers included mental health stigma and lack of direct communication about the patients' SMD with oncology staff. While most participants wished to undergo the recommended cancer treatment, some feared adverse psychiatric side effects and worsening of mental health symptoms. Additionally, participants reported barriers such as limited consultation time, lack of clinician continuity and social isolation, which impeded access to sufficient information and support during their cancer trajectory.</p><p><strong>Conclusions: </strong>The study identified barriers such as mental health stigma and insufficient communication about patients' mental disorders. A patient-centred approach to cancer care, which includes formal guidelines and training for healthcare professionals, is recommended.</p><p><strong>Funding: </strong>The work was supported by the Danish Cancer Society [grant number R283-A16499].</p><p><strong>Trial registration: </strong>Not relevant.</p>","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 5","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julie Leth-Petersen, Karin Sundberg, Charlotte Kvist Ekelund, Olav Bjørn Petersen, Lone Nikoline Nørgaard, Lisa Neerup Jensen, Lotte Harmsen, Martin G Tolsgaard
{"title":"Creation of stakeholder value at a tertiary foetal medicine centre.","authors":"Julie Leth-Petersen, Karin Sundberg, Charlotte Kvist Ekelund, Olav Bjørn Petersen, Lone Nikoline Nørgaard, Lisa Neerup Jensen, Lotte Harmsen, Martin G Tolsgaard","doi":"10.61409/A11240830","DOIUrl":"https://doi.org/10.61409/A11240830","url":null,"abstract":"<p><strong>Introduction: </strong>Little is known about how a tertiary foetal medicine unit creates value for its stakeholders. This study explored stakeholder perspectives to uncover nuances in value creation within a highly specialised unit.</p><p><strong>Methods: </strong>A cross-sectional exploratory survey was conducted at the Foetal Medicine Unit at Copenhagen University Hospital (Rigshospitalet), Denmark. Participants included patients, clinicians, referring hospitals, international partners and administrators. Questionnaires were designed by specialists, and data analysed using logistic regression and descriptive statistics.</p><p><strong>Results: </strong>The study surveyed patients (104, 64.2% response rate) and healthcare providers: internal (13/19, 63.2%), national (27/29, 93.1%), international (20/27, 74.1%) and administrators (5/11, 45.4%). Stakeholders emphasised the importance of specialised training. While patients accepted trainee involvement, most preferred certified specialists. Patients referred for pregnancy complications had significantly higher expectations of physician expertise than routine screenings (odds ratio = 2.58 (95% confidence interval: 1.13-5.88), p = 0.02). Key success metrics were patient outcomes, staff satisfaction and patient satisfaction.</p><p><strong>Conclusions: </strong>Discrepancies were found between patients' acceptance of trainee involvement and their preference for certified specialists. Patients referred for complications had even higher expectations of physician expertise. Patient outcomes, patient satisfaction and staff satisfaction were consistently identified as the most important success indicators.</p><p><strong>Funding: </strong>None.</p><p><strong>Trial registration: </strong>Not relevant.</p>","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 5","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luma Issa Mahmoud, Henrik Kehlet, Sten Madsbad, Martin Lindberg-Larsen, Claus Varnum, Thomas Jakobsen, Mikkel Rathsach Andersen, Manuel Josef Bieder, Søren Overgaard, Torben Bæk Hansen, Kirill Gromov, Christoffer Calov Jørgensen
{"title":"Perioperative GLP1-RA management and risk of aspiration in patients with diabetes undergoing fast-track hip and knee arthroplasty.","authors":"Luma Issa Mahmoud, Henrik Kehlet, Sten Madsbad, Martin Lindberg-Larsen, Claus Varnum, Thomas Jakobsen, Mikkel Rathsach Andersen, Manuel Josef Bieder, Søren Overgaard, Torben Bæk Hansen, Kirill Gromov, Christoffer Calov Jørgensen","doi":"10.61409/A09240629","DOIUrl":"https://doi.org/10.61409/A09240629","url":null,"abstract":"<p><strong>Introduction: </strong>Glucagon-like peptide-1 receptor agonists (GLP1-RAs) are increasingly used to manage type 2 diabetes (T2D) and obesity. Recently, concerns have been raised regarding perioperative GLP1-RA management due to delayed gastric emptying and the potential risk of pulmonary aspiration. However, since no prospective data are available on surgical patients, we aimed to investigate the risk of perioperative pulmonary aspiration in patients with T2D treated with a GLP1-RA undergoing fast-track hip and knee arthroplasty.</p><p><strong>Methods: </strong>This was a prospective observational study within a multicentre fast-track hip and knee replacement collaboration in patients with T2D with receiving GLP-1 RA. Detailed data were collected from 1 October 2022 to 1 April 2024, including perioperative GLP1-RA management, type of anaesthesia, complications and postoperative length of stay (LOS).</p><p><strong>Results: </strong>Among 426 patients with T2D, 19% had spinal anaesthesia without sedation, 53% had spinal anaesthesia with propofol sedation, and 26% had general anaesthesia. Data on perioperative management of GLP1-RAs were available in 93% of all patients, of whom 92% had continued their usual GLP1-RA regimen perioperatively, and the median LOS was one (IQR: 1-1) day. There were no cases with perioperative aspiration (0%; 95% confidence interval (CI): 0.0-0.9%) or LOS > 2 days (7%; 95% CI: 5-9%) potentially related to GLP1-RA-associated delayed gastric emptying.</p><p><strong>Conclusion: </strong>Our results support reconsidering the arguments for prolonged withholding of GLP1-RA treatment before surgery and suggest that it may be safe to continue GLP1-RA treatment up to the day of surgery in these patients.</p><p><strong>Funding: </strong>This study was supported financially by a grant from the NOVO NORDISK Foundation (grant number NNF21SA0073760).</p><p><strong>Trial registration: </strong></p><p><strong>Clinicaltrials: </strong>gov (NCT05613439).</p>","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 5","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Osman Heider Ahmed, Matilde Winther-Jensen, Ole Lander Svendsen
{"title":"Incidence of acute Charcot foot in patients with diabetes.","authors":"Osman Heider Ahmed, Matilde Winther-Jensen, Ole Lander Svendsen","doi":"10.61409/A08240556","DOIUrl":"https://doi.org/10.61409/A08240556","url":null,"abstract":"<p><strong>Introduction: </strong>Acute Charcot foot is a rare but serious complication of diabetes mellitus. With improved diabetes treatment, the annual incidence of acute Charcot foot may have decreased. This study aimed to investigate the annual incidence and incidence rate of acute Charcot foot in patients with an ICD diagnosis code of diabetes in Denmark from 2000 to 2021. Furthermore, the analyses included differences between the five Danish regions. Finally, the impact of the COVID-19 pandemic and the nurses' strike in the summer of 2021 in Denmark was also examined.</p><p><strong>Methods: </strong>This was a register-based study conducted in Denmark from 2000 to 2021. Nation-wide and regional, annual incidence and incidence rates of acute Charcot foot were calculated. Kendall's tau was used to test changes in incidence rates.</p><p><strong>Results: </strong>A significant increase was found in the annual incidence of acute Charcot foot with a correlation of 0.6 (p less-than 0.0005) together with a decline in the annual incidence rate of acute Charcot foot (correlation of -0.6 with p = 0.0005). No differences were observed between theDanish regions. No change in acute Charcot foot incidence rate among diabetes patients was found during 2018-2021 (correlation of 0.3; p = 0.5).</p><p><strong>Conclusion: </strong>The annual incidence increased, whereas the annual incidence rate of acute Charcot foot in patients with an ICD diagnosis code of diabetes in Denmark declined during 2000-2021, with no significant regional differences or change during the COVID-19 and nurses' strike.</p><p><strong>Funding: </strong>None.</p><p><strong>Trial registration: </strong>Not relevant.</p>","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 4","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Suicidal behaviour among youngsters in a suicide low-incidence population.","authors":"Símun Johannesen, Pál M Weihe, August G Wang","doi":"10.61409/A02240126","DOIUrl":"https://doi.org/10.61409/A02240126","url":null,"abstract":"<p><strong>Introduction: </strong>The Faroe Islands are a country in the North Atlantic with a population of approximately 53,000 inhabitants. The suicide incidence rate is very low, at some 5/100,000 annual suicides. The Faroese school system participates in the European School Survey Project (ESPAD) every four years, organised by the Department of Occupational Medicine and Public Health. This study aimed to describe the frequency of suicide attempts and ideation among ninth-grades in the Faroes and to elucidate suicide risk factors.</p><p><strong>Methods: </strong>Data from the ESPAD surveys were obtained from the partners. We used data on suicide attempts and thoughts of self-harm and included the risk factors of gender, smoking and alcohol consumption. Binary logistic regression was used to calculate associations.</p><p><strong>Results: </strong>The participants were 16-year-old ninth graders. The prevalence of young people with suicide attempts was similar to those of other European countries, as was the prevalence of thoughts of self-harm. The prevalence of suicide attempts and thoughts of self-harm was higher among girls and associated with daily smoking and alcohol. The prevalence of thoughts of self-harm was higher among girls and daily smokers but not associated with alcohol consumption.</p><p><strong>Conclusions: </strong>This study found that the number of suicide attempts was in line with those of other European countries, as was the prevalence of students with thoughts of self-harm. We discuss reasons why this is the case in an otherwise suicide low-incidence population. The association between suicide attempts and thoughts of self-harm on the one hand, and the risk factors of female gender, daily smoking and alcohol consumption (only for attempted suicide) on the other was expected.</p><p><strong>Funding: </strong>None.</p><p><strong>Trial registration: </strong>Not relevant.</p>","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 4","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kasper Steen, Morten Bendixen, Thomas Decker Christensen
{"title":"The experience of video-assisted thoracoscopic lobectomies.","authors":"Kasper Steen, Morten Bendixen, Thomas Decker Christensen","doi":"10.61409/A09240649","DOIUrl":"https://doi.org/10.61409/A09240649","url":null,"abstract":"<p><strong>Introduction: </strong>Video-assisted thoracoscopic surgery (VATS) lobectomy is increasingly replacing open thoracotomy as the standard surgical treatment for early-stage non-small cell lung cancer owing to its greater efficacy, as demonstrated in RCTs. This study aimed to examine the effectiveness and evolution of lung cancer treatment by VATS lobectomy in a single centre.</p><p><strong>Methods: </strong>This retrospective single-centre cohort study at the Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Denmark, examined operative reports for all VATS lobectomies performed in-house from 3 March 2008 to 6 July 2023, as well as medical records at one-year follow-up for 10% of the patients.</p><p><strong>Results: </strong>VATS lobectomies were identified (N = 1,705). A steady annual increase in performed procedures and the number of performing surgeons was observed, and more frail patients underwent the procedure. Operation time, mean chest tube drainage time, length of hospitalisation and rate of annual conversions declined along with the amount and severity of post-operative complications, cancer recurrence and mortality at the one-year follow-up.</p><p><strong>Conclusions: </strong>Treatment effectiveness, measured by peri- and post-operative outcomes, aligned with the efficiency presented in RCTs, with significant benefits of VATS compared to traditional anterolateral thoracotomy. Furthermore, treatment effectiveness evolved during the study period, and the introduction and training of new surgeons improved, enhancing the quality and availability of VATS throughout the period.</p><p><strong>Funding: </strong>None.</p><p><strong>Trial registration: </strong>Not relevant.</p>","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 4","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}