Danish medical journal最新文献_第2页

Immediate prepectoral breast reconstruction using bovine pericardium matrix.

IF 1 4区医学

Danish medical journal Pub Date : 2025-01-21 DOI: 10.61409/A08240522

Thomas Takahashi Bentzon, Maja Abu-Khalil, Alessandro Venzo, Dina Reem Matzen, Tina Engberg Damsgaard

{"title":"Immediate prepectoral breast reconstruction using bovine pericardium matrix.","authors":"Thomas Takahashi Bentzon, Maja Abu-Khalil, Alessandro Venzo, Dina Reem Matzen, Tina Engberg Damsgaard","doi":"10.61409/A08240522","DOIUrl":"https://doi.org/10.61409/A08240522","url":null,"abstract":"Introduction: Immediate, implant-based breast reconstruction has become increasingly popular as a single-stage procedure with prepectoral placement of the implant following the introduction of biologic matrices. Only a few studies have described the use of bovine pericardium matrixTutomesh, a xenograft derived from bovine pericardium - and the use of laser-assisted indocyanine green angiography (ICG-A) to assess skin flap perfusion.Methods: All patients who underwent a mastectomy followed by immediate reconstruction using prepectoral direct-to-implant with bovine pericardium from July 2019 to June 2021 were included. Complications were registered using the Clavien-Dindo classification. Postsurgical complications were analysed with multivariate logistic regression and feature selection.Results: A total of 81 prepectoral breast reconstructions were performed in 56 patients. The overall complication rate was 38.2%, and 14.3% required reoperation. Implant loss occurred in 3.7%. Multivariate logistic regression analysis demonstrated a statistically significant association between the risk of skin necrosis and previous breast surgery (p = 0.020) along with an increasing risk of implant rotation with increasing age (p = 0.010). The median follow-up was 9.9 months, and 11.1% of the breast reconstructions required postsurgical aesthetic correction.Conclusions: Bovine pericardium may be used in prepectoral breast reconstruction with a good outcome. Careful patient selection is crucial, and ICG-A is helpful in reducing the risk of post-surgical complications.Funding: None.Trial registration: Not relevant.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter regarding "Complications following biopsy of an intra-abdominal or retroperitoneal mass compared with a renal mass".

IF 1 4区医学

Danish medical journal Pub Date : 2025-01-17

Abdul Basit, Abu Qais, Muhammad Idrees Khan, Sulaiman Shah, Faisal Saeed

引用次数: 0

Reply to letter regarding "Complications following biopsy of an intraabdominal or retroperitoneal mass compared with a renal mass".

IF 1 4区医学

Danish medical journal Pub Date : 2025-01-17

Katrine Schou-Jensen, Frederik Ferløv Thomsen

引用次数: 0

Blunt cerebrovascular injuries and association with cervical spine injury.

IF 1 4区医学

Danish medical journal Pub Date : 2024-12-19 DOI: 10.61409/A01240067

Hanna Sissel Foldager Jeppesen, Lasse Kristensen, Ole Brink, Kristian Høy

{"title":"Blunt cerebrovascular injuries and association with cervical spine injury.","authors":"Hanna Sissel Foldager Jeppesen, Lasse Kristensen, Ole Brink, Kristian Høy","doi":"10.61409/A01240067","DOIUrl":"https://doi.org/10.61409/A01240067","url":null,"abstract":"Introduction: Blunt cerebrovascular injuries (BCVI) associated with cervical spine injuries (CSI) carry a high risk of morbidity and mortality. This nationwide Danish study, covering the years 2017-2023, aimed to identify key BCVI predictors in patients with CSI to support improved early detection and management strategies.Methods: The study analysed data from four level-1 trauma centres using the Abbreviated Injury Scale to classify BCVI cases. Factors assessed included age, sex, type of cervical injury and the Injury Severity Score (ISS).Results: Age and sex were not significant predictors of BCVI (p = 0.12, p = 0.65). However, any form of CSI was a strong predictor (p less-than 0.001; odds ratios (OR) = 26.3; confidence intervals (95% CI): 16.84-41.12), as were cervical spine ligamentous injuries (p = 0.0007; OR = 5.4; 95% CI: 2.3-12.89). An increase in ISS score significantly correlated with BCVI risk (p = 0.001; OR = 1.03 per unit increase; 95% CI: 1.01-1.05). Specific cervical fractures were not independent predictors of BCVI.Conclusions: From a Danish cohort of patients admitted to a level 1 trauma centre, we found a BCVI incidence of three per thousand. In case of verified injury to the cervical region, the incidence rose to 6.25%. Our findings underscore the need for increased vigilance and a standardised nationwide algorithm to prevent disability, loss of health-related quality of life, and mortality in CSI patients at risk of BCVI.Funding: The study was funded by Offerfonden, Dagmar Marshall Fonden, and Torben and Alice Frimodt Fonden.Trial registration: The data collection was approved by the local ethical committee and the Central Denmark Region Office for Research: 1-45-70-19-23.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Components of eye health checks provided by optician retail stores in Denmark. 丹麦眼镜零售店提供的眼健康检查的组成部分。

IF 1 4区医学

Danish medical journal Pub Date : 2024-12-11 DOI: 10.61409/A05240301

Ida N Frederiksen, Danson V Muttuvelu, Yosif Subhi, Marie Lr Rasmussen

{"title":"Components of eye health checks provided by optician retail stores in Denmark.","authors":"Ida N Frederiksen, Danson V Muttuvelu, Yosif Subhi, Marie Lr Rasmussen","doi":"10.61409/A05240301","DOIUrl":"https://doi.org/10.61409/A05240301","url":null,"abstract":"Introduction: This study aimed to report the components of optometrist-facilitated eye health checks in optician chain stores in Denmark.Methods: In this survey-based cross-sectional study, we screened the 600 optician stores listed on the website of Fight for Sight Denmark and included optician store chains with more than 50 stores nationwide. The websites of each chain were reviewed to identify current trends in eye health checks, from which an interview guide was developed. Survey data were collected by conducting in-person interviews in three different optician stores from each chain.Results: Five optician store chains were eligible for inclusion in this study. All but one chain included at least non-contact air-puff tonometry and non-mydriatic colour fundus photography in their eye health check. In two of the chains, telemedical evaluation was mandatory for all abnormal results found by the in-store optometrists, whereas telemedical services were optional in the remaining optician chains.Conclusions: This study reported the contents and organisation of optometrist-facilitated eye health checks across the five largest optician store chains in Denmark. We found that the content of eye health checks differs between chains and that their results are evaluated differently. Standardisation of the area and development of guidelines may be necessary if optometrists are to play a role in eye health screening.Funding: None.Trial registration: Not relevant.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arterial pH and short-term mortality in adult non-traumatic acute patients.

IF 1 4区医学

Danish medical journal Pub Date : 2024-12-11 DOI: 10.61409/A06240407

Marius Moen Christiansen, Ameer Jamal Iversen, Annmarie Touborg Lassen, Isik Somuncu Johansen, Flemming Schønning Rosenvinge, Michael Dan Arvig

{"title":"Arterial pH and short-term mortality in adult non-traumatic acute patients.","authors":"Marius Moen Christiansen, Ameer Jamal Iversen, Annmarie Touborg Lassen, Isik Somuncu Johansen, Flemming Schønning Rosenvinge, Michael Dan Arvig","doi":"10.61409/A06240407","DOIUrl":"https://doi.org/10.61409/A06240407","url":null,"abstract":"Introduction: Acid-base disturbances are common in the emergency department, with acidosis and alkalosis being associated with an elevated risk of mortality and morbidity. Understanding the relationship between pH and mortality may serve to optimise patient outcomes. The primary objective was to describe the association between arterial blood pH and 0-2-day mortality in adult non-traumatic acute visits. The secondary objective was to describe this association for 3-7-day mortality.Methods: This population-based, multicentre cohort study included all adult non-traumatic acute visits in the Region of Southern Denmark between 2016 and 2018 who had an arterial blood gas (ABG) drawn within four hours of arrival. We described 0-2- and 3-7-day mortality stratified by pH level, controlled for confounding factors and reported as hazard ratio (HR) compared to normal pH.Results: A total of 64,725 acute visits in 31,650 individuals with an ABG were included. The overall mortality rate for index visits was 2.4% on days 0-2 and 2.1% on days 3-7. Patients with severe acidosis (pH less-than 7.20) had 20.8% and 8.9% mortality rates (HR = 9.6 and 5.2), whereas patients with acidosis (pH 7.20-7.34) had mortality rates of 7.4% and 5.2% (HR = 4.1 and 2.7) on day 0-2 and 3-7, respectively. Our secondary analysis found a 0-2-day mortality rate of nearly 60% in patients with a pH less-than 6.90.Conclusion: The short-term mortality rates increased with the severity of acidosis. The highest mortality rate was found in patients with a pH less-than 6.90.Funding: None.Trial registration: Not relevant.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ChatGPT versus physician-derived answers to drug-related questions. ChatGPT 与医生对药物相关问题的回答对比。

IF 1 4区医学

Danish medical journal Pub Date : 2024-12-11 DOI: 10.61409/A05240360

Ole Kl Helgestad, Astrid J Hjelholt, Søren V Vestergaard, Samuel Azuz, Eva A Sædder, Thure F Overvad

{"title":"ChatGPT versus physician-derived answers to drug-related questions.","authors":"Ole Kl Helgestad, Astrid J Hjelholt, Søren V Vestergaard, Samuel Azuz, Eva A Sædder, Thure F Overvad","doi":"10.61409/A05240360","DOIUrl":"https://doi.org/10.61409/A05240360","url":null,"abstract":"Introduction: Large language models have recently gained interest within the medical community. Their clinical impact is currently being investigated, with potential application in pharmaceutical counselling, which has yet to be assessed.Methods: We performed a retrospective investigation of ChatGPT 3.5 and 4.0 in response to 49 consecutive inquiries encountered in the joint pharmaceutical counselling service of the Central and North Denmark regions. Answers were rated by comparing them with the answers generated by physicians.Results: ChatGPT 3.5 and 4.0 provided answers rated better or equal in 39 (80%) and 48 (98%) cases, respectively, compared to the pharmaceutical counselling service. References did not accompany answers from ChatGPT, and ChatGPT did not elaborate on what would be considered most clinically relevant when providing multiple answers.Conclusions: In drug-related questions, ChatGPT (4.0) provided answers of a reasonably high quality. The lack of references and an occasionally limited clinical interpretation makes it less useful as a primary source of information.Funding: None.Trial registration: Not relevant.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of frenotomy in infants with ankyloglossia on maternal nipple pain - a systematic review.

IF 1 4区医学

Danish medical journal Pub Date : 2024-12-11 DOI: 10.61409/A06240378

Lærke Nørgaard Albertsen, Therese Ovesen

{"title":"The effect of frenotomy in infants with ankyloglossia on maternal nipple pain - a systematic review.","authors":"Lærke Nørgaard Albertsen, Therese Ovesen","doi":"10.61409/A06240378","DOIUrl":"https://doi.org/10.61409/A06240378","url":null,"abstract":"Introduction: Ankyloglossia in breastfeeding infants has been proposed to cause maternal nipple pain. Lingual frenotomy has been cited to reduce maternal nipple pain. The aim of this systematic review was to investigate if frenotomy in infants with ankyloglossia and breastfeeding problems reduces maternal nipple pain.Methods: We conducted a systematic literature search for RCTs comparing frenotomy to a sham procedure or usual care in mother-infant dyads with ankyloglossia and maternal nipple pain. Maternal nipple pain was registered as the main outcome. We conducted a meta-analysis and assessed the risk of bias using Rob 2.0 and the quality of evidence, adopting the GRADE approach.Results: Five RCTs were included in the review. Three RCTs were used for the meta-analysis. The meta-analysis showed a significant pre-post intervention reduction in maternal nipple pain in the frenotomy group compared with the comparison group: mean difference = -1.23; 95% confidence interval: -1.88 to -0.57. The overall bias was assessed to range from \"some concerns\" to \"high\". The quality of evidence for the assessed outcome, maternal nipple pain, was classified as \"low\" to \"very low\".Conclusions: We found that frenotomy reduced maternal nipple pain in the short term. Despite being statistically significant, the clinical relevance of a 1.2-point reduction on a ten-point VAS must be questioned. Due to a considerable risk of bias along with a low study quality, the definitive benefit of frenotomy on maternal nipple pain remains unproven. Hence, quality large-scale RCTs are warranted.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Counselling and prescription of contraception related to pregnancy termination. 与终止妊娠有关的避孕咨询和处方。

IF 1 4区医学

Danish medical journal Pub Date : 2024-11-20 DOI: 10.61409/A04240264

Christina Franseth Lie, Louise Frøisland, Christian Backer Mogensen, Kamilla Gerhard Nielsen

{"title":"Counselling and prescription of contraception related to pregnancy termination.","authors":"Christina Franseth Lie, Louise Frøisland, Christian Backer Mogensen, Kamilla Gerhard Nielsen","doi":"10.61409/A04240264","DOIUrl":"https://doi.org/10.61409/A04240264","url":null,"abstract":"Introduction: Even though Denmark has the highest contraceptive use (42%) of the Nordic countries, 19% of all pregnancies in Denmark end in termination. Various contraceptive options are available, and unwanted pregnancies therefore ought to be avoidable. This study aimed to investigate if women received counselling and prescriptions for contraception during their termination and if this or other factors impacted their risk of repeat termination.Methods: This was an analytical, historical and retrospective cohort study. Data were collected manually from 310 medical records at the Hospital of Southern Jutland between 2016 and 2019.Results: A total of 82% of patients received contraceptive counselling during their termination, and 35% of these patients received a contraceptive prescription for future use. A total of 17% had a repeat termination within three years after receiving counselling; 23% of the women who did not receive contraceptive counselling experienced one or more repeat pregnancy terminations within the following three-year period. The risk of repeat termination during the follow-up period was significantly higher among the patients with a previous termination.Conclusions: The majority of the women received contraceptive counselling at the time of their termination. Women who previously had an abortion were twice as likely to undergo a repeat termination during the follow-up period. Further research is necessary to establish whether counselling and prescription of contraceptives have a significant impact on repeat terminations.Funding: None.Trial registration: Approval R. no. 20/22908.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"71 12","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compliance with endocrine therapy among breast cancer survivors. 乳腺癌幸存者对内分泌治疗的依从性

IF 1 4区医学

Danish medical journal Pub Date : 2024-11-20 DOI: 10.61409/A05240316

Emma Marie Torpe, Tobias Berg, Maj-Britt Jensen, Bent Ejlertsen

{"title":"Compliance with endocrine therapy among breast cancer survivors.","authors":"Emma Marie Torpe, Tobias Berg, Maj-Britt Jensen, Bent Ejlertsen","doi":"10.61409/A05240316","DOIUrl":"https://doi.org/10.61409/A05240316","url":null,"abstract":"Introduction: Most postmenopausal women with early-stage oestrogen receptor-positive breast cancer are allocated to five years of endocrine therapy. This treatment is not without adverse effects, which may lead to treatment discontinuation. This study aimed to assess compliance with endocrine therapy among postmenopausal women with early-stage oestrogen receptor-positive breast cancer and examine its association with disease-free survival.Methods: This study retrospectively identified a cohort of 360 postmenopausal women diagnosed in the period from 1 January 2015 to 31 December 2017 at Rigshospitalet, Copenhagen, Denmark, with early-stage oestrogen receptor-positive breast cancer in the clinical database of the Danish Breast Cancer Group. Kaplan-Meier was used to estimate compliance and disease-free survival.Results: A total of 346 patients receiving endocrine therapy were included, 240 were compliant, and 106 were non-compliant. The median follow-up was 6.5 years (95% confidence interval (CI): 6.4-6.7 years). The compliance at 4.5 years was 68.8% (95% CI: 64.1-74.0%). Disease-free survival was significantly higher for the compliant group (adjusted HR = 2.29; 95% CI: 1.34-3.91).Conclusions: We found a low compliance at 4.5 years and most discontinuations were due to adverse effects. The study provides evidence that low compliance with endocrine therapy had a negative impact on disease-free survival.Funding: The study was funded by the Danish Cancer Society.Trial registration: The study was approved by the research overview of the Capital of Denmark and the Center for Health.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"71 12","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0