Danish medical journal最新文献_第3页

Clinical experience of a systemic algorithm for diagnosis of cardiac amyloidosis. 一种系统算法诊断心脏淀粉样变的临床经验。

IF 1.2 4区医学

Danish medical journal Pub Date : 2025-08-07 DOI: 10.61409/A11240771

Julie Bjerre Tarp, Marie Bayer Elming, Lisbeth Marner, Christian Haarmark, Alex Hørby Christensen, Jens Jakob Thune

{"title":"Clinical experience of a systemic algorithm for diagnosis of cardiac amyloidosis.","authors":"Julie Bjerre Tarp, Marie Bayer Elming, Lisbeth Marner, Christian Haarmark, Alex Hørby Christensen, Jens Jakob Thune","doi":"10.61409/A11240771","DOIUrl":"https://doi.org/10.61409/A11240771","url":null,"abstract":"Introduction: Cardiac amyloidosis is an underdiagnosed disease, and its prevalence is probably higher than previously estimated. We aimed to investigate the effect of introducing a systemic diagnostic algorithm for cardiac amyloidosis in clinical practice.Methods: A systematic diagnostic algorithm was developed and clinically applied in two hospitals in Eastern Denmark. Elderly patients (males > 60 years, females > 70 years) with left ventricular hypertrophy (≥ 12 mm) and diastolic dysfunction leading to a suspicion of cardiac amyloidosis were referred for standardised workup, including biochemistry and bone scintigraphy.Results: A total of 224 patients (median age 76 years (70-83); 65% males) were included in the analysis. In total, 43 (19%) patients (84% males) were diagnosed with cardiac amyloidosis. Among the 43 diagnosed patients, 38 had transthyretin wild-type amyloidosis, one had the hereditary form and four had monoclonal-immunoglobulin-light-chain amyloidosis. Patients with cardiac amyloidosis were significantly older (81 versus 75 years old, p less-than 0.001) and more often male (84% versus 61%, p = 0.004) than the overall screened population.Conclusions: Systematic screening for cardiac amyloidosis in older patients with cardiac hypertrophy and echocardiographic signs of diastolic dysfunction is feasible and shows a diagnostic yield of 19% in the assessed population.Funding: None.Trial registration: Not relevant.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 9","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical consequences of smartwatch implementation in a cardiology outpatient clinic. 智能手表在心脏病门诊实施的临床效果。

IF 1.2 4区医学

Danish medical journal Pub Date : 2025-08-06 DOI: 10.61409/A12240906

Christopher Schürenberg Petersen, Jonas Bjerring Olesen, Sebastian Kinnberg Nielsen, Mads Hashiba Jensen, Ali Al-Alak, Signe Stelling Risom, Anders Holt, Diaco Hamawand, Rasmus Borup Hansen, Morten Lock Hansen, Morten Lamberts

{"title":"Clinical consequences of smartwatch implementation in a cardiology outpatient clinic.","authors":"Christopher Schürenberg Petersen, Jonas Bjerring Olesen, Sebastian Kinnberg Nielsen, Mads Hashiba Jensen, Ali Al-Alak, Signe Stelling Risom, Anders Holt, Diaco Hamawand, Rasmus Borup Hansen, Morten Lock Hansen, Morten Lamberts","doi":"10.61409/A12240906","DOIUrl":"https://doi.org/10.61409/A12240906","url":null,"abstract":"Introduction: Long-term cardiac monitoring has become more accessible with the advent of consumer-oriented wearable devices. Smartwatches (SWs) hold promise for extended rhythm monitoring owing to their availability and direct electronic health record (EHR) integration. We studied the clinical consequences of SW implementation in patients with palpitations.Methods: Patients referred for palpitations or with inconclusive diagnostics were issued a SW for up to three months. They were instructed to take an SW-electrocardiogram (ECG) during symptoms and transfer it to the EHR. A cardiologist interpreted the ECGs, diagnosed the patient and initiated relevant clinical actions.Results: We included 50 patients with a median age of 57 years (IQR: 45-64), 56% women. The following ECG diagnoses were made: 20 (40%) had sinus rhythm, six (12%) had extrasystoles and 24 (48%) had clinically relevant arrhythmias. Consequently, 25 (50%) completed their arrhythmia evaluation, whereas clinical actions were taken in 25 (50%). Notably, more than 20% underwent an electrophysiology study and ablation. Patients found the SW to be user-friendly with minimal impact on their daily life.Conclusions: SW use for symptom-based diagnosis had a high yield for both arrhythmia detection and completion of arrhythmia evaluation. Additional studies are needed to determine if SWs may replace traditional ECG monitoring.Funding: The project was funded by internal funds at the Department of Cardiology, Herlev and Gentofte University Hospital (HGH), Denmark.Trial registration: As a quality assurance project, no ethical board approval was needed under Danish law. The study was approved by the HGH directors.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 9","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Danish Amputation Database. 丹麦截肢数据库。

IF 1.2 4区医学

Danish medical journal Pub Date : 2025-07-22 DOI: 10.61409/A02250084

Signe Hulsbæk, Morten Tange Kristensen, Ulla Riis Madsen, Veronica Leeberg, Poul Pedersen, Dea Krogh Larsen, Anne Mette Sørensen, Christen Ravn, Per Hviid Gundtoft, Rehne Lessmann Hansen

{"title":"The Danish Amputation Database.","authors":"Signe Hulsbæk, Morten Tange Kristensen, Ulla Riis Madsen, Veronica Leeberg, Poul Pedersen, Dea Krogh Larsen, Anne Mette Sørensen, Christen Ravn, Per Hviid Gundtoft, Rehne Lessmann Hansen","doi":"10.61409/A02250084","DOIUrl":"https://doi.org/10.61409/A02250084","url":null,"abstract":"Introduction: National data has the potential to advance future research and drive quality improvements for patients with major lower-extremity amputations (MLEA). This study aimed to evaluate the implementation of the Danish Amputation Database (DanAmp) by investigating data completeness and validity.Methods: Demographic, surgical and post-surgery data were collected during hospital admission. After implementation at three departments, completeness and validity were evaluated from 1 February to 1 June 2024. Completeness was evaluated by comparing the number of surgical procedures in the hospital's electronic system with registrations in DanAmp. Data validity was evaluated by an audit of up to 15 consecutive patient records per department. The percentage agreement was calculated (agreement (n)/total possible numbers (N)). Variables with an agreement exceeding 90% were considered satisfactory.Results: A total of 68 procedures were registered in DanAmp across the three departments, and 71 procedures were registered in the hospital's electronic system, corresponding to 96% completeness for all types of procedures. A total of 43 patient records were audited, revealing that 29 of 35 variables had a satisfactory validity exceeding 90% agreement.Conclusions: This study demonstrated a high completeness and satisfactory validity of data from three orthopaedic departments, underscoring DanAmp's potential in driving research and quality improvements for MLEA.Funding: The project is funded by the Region Zealand and Region of Southern Denmark Research Fund (2022) and the Independent Research Fund Denmark (DFF), grant ID: 10.46540/3165-00053B (2023).Trial registration: Not relevant.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 8","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrograde cricopharyngeal dysfunction management with botulinum toxin A. 肉毒毒素A治疗逆行环咽功能障碍。

IF 1.2 4区医学

Danish medical journal Pub Date : 2025-07-22 DOI: 10.61409/A03250166

Dalia Gustaityte Larsen, Mathilde Aalling, Nichlas Udholm, Padraig O'Leary

{"title":"Retrograde cricopharyngeal dysfunction management with botulinum toxin A.","authors":"Dalia Gustaityte Larsen, Mathilde Aalling, Nichlas Udholm, Padraig O'Leary","doi":"10.61409/A03250166","DOIUrl":"https://doi.org/10.61409/A03250166","url":null,"abstract":"Introduction: Retrograde cricopharyngeal dysfunction (R-CPD) is the inability to belch due to impaired upper oesophageal sphincter relaxation. Botulinum toxin A injection shows promise, but standardised protocols are lacking.Objective: To evaluate the effect of botulinum toxin A for R-CPD in a Danish population.Methods: A retrospective case series study at Aarhus University Hospital included R-CPD patients treated from January 2021 to December 2024. The diagnosis was clinical, supported by otorhinolaryngological examination, modified barium swallow and oesophagoscopy. Under general anaesthesia, all patients received 50 IU of botulinum toxin A into the cricopharyngeal muscle. Symptom relief and adverse effects were assessed at follow-ups performed at two weeks and three months. Statistical analysis with Fisher's exact test compared treatment responses in patients aged 18-25 years versus those over 25 years.Results: Among 40 patients (22 males, 18 females, mean age 27.5 years), 35 experienced symptom relief within two weeks. Long-term follow-up (31 patients) showed that 18 continued to belch after three months. Thirteen patients required additional treatments with botulinum toxin A doses increased to 75-100 IU, 24 achieved satisfactory results, while nine await further procedures.Conclusions: Botulinum toxin A is a safe, effective R-CPD treatment with minor side effects (transient dysphagia, mild sore throat, sour eructation) and no vocal fold or respiratory complications. Over half of the patients improved after 50 IU treatment, whereas one-third required dose escalation, suggesting that 100 IU may enhance outcomes.Funding: None.Trial registration: Not relevant.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 8","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidental findings of coronary computed tomography angiography. 冠状动脉计算机断层造影的偶然发现。

IF 1.2 4区医学

Danish medical journal Pub Date : 2025-07-22 DOI: 10.61409/A10240756

Maria Ellingsøe Vistisen, Andreea Iuliana Danaila, Henrik Vadmann

{"title":"Incidental findings of coronary computed tomography angiography.","authors":"Maria Ellingsøe Vistisen, Andreea Iuliana Danaila, Henrik Vadmann","doi":"10.61409/A10240756","DOIUrl":"https://doi.org/10.61409/A10240756","url":null,"abstract":"Introduction: The use of coronary CT angiography (CCTA) is increasing in Denmark, which leads to more incidental extracardiac findings (ECF), especially lung nodules. While ECF often need further investigation, only a small percentage is ultimately confirmed to be cancer. This study investigates ECF found on CCTA and presents information about patients ultimately diagnosed with cancer.Methods: This registry-based retrospective study included data from 1 January 2018 to 31 December 2022 from the Department of Cardiology and Endocrinology at the North Denmark Regional Hospital. The patients' personal identification numbers (CPR numbers) were used to obtain data in the electronic patient journal systems. The ECF and characteristics of the patients with cancer are presented in tables using descriptive statistics.Results: In the study period, 2,635 patients underwent CCTA. ECF were identified in 643 patients and were predominantly lung nodules (40.9%). A total of 406 patients (63.1%) were referred for an acute lung cancer conference and/or to a control programme. Among patients who underwent CCTA (2,635), 17 (0.65%) were diagnosed with cancer.Conclusions: ECF are common incidental findings in CCTA. However, in our study, only 0.65% of the ECF were subsequently identified as cancer.Funding: None TRIAL REGISTRATION. The use of the data in this quality assurance study was approved by the participating hospitals and by the Data Responsible Unit of the North Denmark Region (approval No. K2023-066).","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 8","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and characteristics of tramadol-induced seizures in young adult emergency admissions. 年轻成人急诊入院曲马多诱发癫痫的患病率和特点。

IF 1.2 4区医学

Danish medical journal Pub Date : 2025-07-22 DOI: 10.61409/A02250108

Anders Valentin A Nielsen, Casper Kierulf Lassen, Dilek Cakar, Jacob Christensen, Mads Lind Ingeman, Andreas Halgreen Eiset, Eva Aggerholm Sædder

{"title":"Prevalence and characteristics of tramadol-induced seizures in young adult emergency admissions.","authors":"Anders Valentin A Nielsen, Casper Kierulf Lassen, Dilek Cakar, Jacob Christensen, Mads Lind Ingeman, Andreas Halgreen Eiset, Eva Aggerholm Sædder","doi":"10.61409/A02250108","DOIUrl":"https://doi.org/10.61409/A02250108","url":null,"abstract":"Introduction: Tramadol is an opioid analgesic used to treat moderately severe pain. Overuse and recreational use of tramadol may cause seizures, but the extent of this problem remains unclear. This study evaluates admissions with tramadol-induced seizures (TIS) among young adults admitted to the emergency department (ED).Methods: A cross-sectional study was conducted on all patients aged 15-30 years with a seizure diagnosis admitted to the ED at Aarhus University Hospital from 1 January 2021 to 31 December 2022. Data were retrieved from a retrospective medical records review.Results: We identified 232 unique patients with 352 seizure admissions; 41 patients (17.7%) (38 male (92%)) with 62 admissions secondary to TIS. The mean (± standard deviation) age of persons with TIS was 20.34 years (± 3.19) compared to 21.88 years (± 4.45) for those with other seizure aetiologies (p = 0.00947). The median tramadol dose was 200 mg (range: 50-1,200 mg, IQR: 50-300 mg). A subgroup of 12 patients accounted for 33/62 (53%) of total TIS admissions. Concomitant cannabis use was common and was reported in 40% of TIS admissions. Among the 62 TIS admissions, only two patients had a prescription for tramadol. The mean time spent in the ED was 5.74 hours (± 5.12). A CT of the brain was performed in 33/62 (53%) of TIS admissions. A total of 31 ambulatory follow-up neurological evaluations were conducted.Conclusions: Tramadol is a frequent cause of seizures among young adults admitted to the ED. Targeted interventions to reduce recreational use among young adults are urgently needed.Funding: None.Trial registration: Not relevant.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 8","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immediate versus postponed blastocyst transfer in stimulated or programmed frozen embryo transfer cycles - a protocol for a non-blinded randomised clinical trial. 在刺激或程序化冷冻胚胎移植周期中立即与推迟囊胚移植——一项非盲随机临床试验方案

IF 1.2 4区医学

Danish medical journal Pub Date : 2025-07-22 DOI: 10.61409/A03250214

Clara Colombo, Amalie Somuncu Johansen, Marte Saupstad, Sara Johanna Bergenheim, Tine Vrist Dam, Nathalie Friis Wang, Birgitte Oxlund-Mariegaard, Ellen Løkkegaard, Merete Husth, Mette Petri Lauritsen, Julie Lyng Forman, Nina La Cour Freiesleben, Bugge Nøhr, Kristine Løssl, Anja Pinborg

{"title":"Immediate versus postponed blastocyst transfer in stimulated or programmed frozen embryo transfer cycles - a protocol for a non-blinded randomised clinical trial.","authors":"Clara Colombo, Amalie Somuncu Johansen, Marte Saupstad, Sara Johanna Bergenheim, Tine Vrist Dam, Nathalie Friis Wang, Birgitte Oxlund-Mariegaard, Ellen Løkkegaard, Merete Husth, Mette Petri Lauritsen, Julie Lyng Forman, Nina La Cour Freiesleben, Bugge Nøhr, Kristine Løssl, Anja Pinborg","doi":"10.61409/A03250214","DOIUrl":"10.61409/A03250214","url":null,"abstract":"Introduction: It is standard clinical practice to postpone frozen embryo transfer (FET) for at least one menstrual cycle after a failed fresh embryo transfer or a freeze-all cycle. Delaying FET has been hypothesised to minimise the negative effect of controlled ovarian stimulation. However, this practice may be associated with increased psychological distress and delayed time to pregnancy. In this clinical study, we aim to investigate whether immediate SC- or PC-FET is non-inferior to postponed SC- and PC-FET in terms of live birth rate (LBR).Methods: The study is designed as a multicentre, randomised controlled, non-blinded, non-inferiority trial. A total of 484 women aged 18-45 years who are set to undergo SC- or PC-FET will be included in the trial. Participants will be randomised 1:1 to FET in the first cycle after a failed fresh transfer or freeze all (FET immediate) or to FET in a subsequent cycle (FET postponed). The main outcome will be LBR.Conclusions: If immediate FET proves to be as efficient and safe as postponed FET, immediate FET offers various advantages, such as a shorter time to pregnancy for couples who did not conceive in the fresh cycle and lower expenses due to a shorter freezing time.Funding: This work was supported by a research grant from Merck Denmark. Merck Denmark was in no way involved in the design of the study and will not be involved in the analysis or interpretation of results.Trial registration: Clinicaltrials: gov (NCT06304792).","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 8","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of the Copenhagen Ankle Range of Motion Scale. 哥本哈根踝关节活动度量表的开发和验证。

IF 1.2 4区医学

Danish medical journal Pub Date : 2025-07-22 DOI: 10.61409/A06240381

Saber M Saber, Ida Tryggedsson, Maj Britt Køhler Astow, Anne Marie Halmø Elholm, Kenneth Chukwuemeka Obionu, Michael Ringdom Krogsgaard

{"title":"Development and validation of the Copenhagen Ankle Range of Motion Scale.","authors":"Saber M Saber, Ida Tryggedsson, Maj Britt Køhler Astow, Anne Marie Halmø Elholm, Kenneth Chukwuemeka Obionu, Michael Ringdom Krogsgaard","doi":"10.61409/A06240381","DOIUrl":"https://doi.org/10.61409/A06240381","url":null,"abstract":"Introduction: It would be advantageous if patients could self-report ankle range of motion (ROM). This study aimed to develop the Copenhagen Ankle Range of Motion Scale (CARS).Methods: After input from healthcare professionals and patients, a pictorial questionnaire was developed to report ankle dorsiflexion with a straight knee and a flexed knee and ankle plantiflexion. CARS outcomes were compared to goniometer measurements made by a nurse and a doctor. Reliability, interclass correlation coefficients (ICC), agreements and correlations were calculated.Results: A total of 102 patients were enrolled. ICCs for goniometer measurements by a nurse and a doctor were 0.66-0.77. There was good agreement between the pictorial choices made by doctors and nurses, with a weighted kappa between 0.63 and 0.71. Agreement between CARS measures and the mean of goniometer measures by the two observers showed a weighted kappa of 0.32-0.5, and Pearson correlation coefficients between patient selections and the mean goniometer measurement were 0.53-0.56.Conclusions: CARS can be used to obtain an indication of ankle ROM without the patient's physical attendance and can standardise estimates of ankle ROM in clinical practice. It was not possible to calculate the tool's sensitivity, specificity and positive/negative predictive values. Further development with patient involvement may improve the validity of CARS version 2.0.Funding: None.Trial registration: Not relevant.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 8","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Opioid and benzodiazepine use among adolescents and young adults in Denmark. 丹麦青少年和青年中阿片类药物和苯二氮卓类药物的使用情况。

IF 1.2 4区医学

Danish medical journal Pub Date : 2025-07-08 DOI: 10.61409/A08240534

Anne-Sofie Hartvig Klærke, Kasper Iversen, Michael Lodberg Olsen, Sidsel Lauge West, Natascha Nydal, Lars Gadegaard Hansen, Tina Leth, Caroline Adolphsen, Marianne Abildgaard, Carl Martin Söderström, Mads Bang-Nielsen, Anders Bang-Nielsen, Jakob Hartvig Thomsen

{"title":"Opioid and benzodiazepine use among adolescents and young adults in Denmark.","authors":"Anne-Sofie Hartvig Klærke, Kasper Iversen, Michael Lodberg Olsen, Sidsel Lauge West, Natascha Nydal, Lars Gadegaard Hansen, Tina Leth, Caroline Adolphsen, Marianne Abildgaard, Carl Martin Söderström, Mads Bang-Nielsen, Anders Bang-Nielsen, Jakob Hartvig Thomsen","doi":"10.61409/A08240534","DOIUrl":"https://doi.org/10.61409/A08240534","url":null,"abstract":"Introduction: We aimed to investigate the prevalence of opioid and benzodiazepine use among Danish youths aged 13-26 years, and to document their knowledge of opioids, benzodiazepines and overdose prevention.Methods: An anonymous questionnaire was distributed via email and posters at youth educational institutions, and via social media. From September 2023 to April 2024, a total of 1,222 responses were collected.Results: In the present study, most adolescents and young adults knew of opioids and benzodiazepines (90.7% and 71.8%, respectively). Approximately one out of four had used one or the other at least once (opioids: 24.4%, benzodiazepines: 24.6%). One third of respondents with prior opioid use had their debut age using opioids between 16-18 (32.9%), and one third at an even younger age (32.6%). Only 7.1% reported gaining access to opioids through a doctor. Nearly one in four of the respondents had witnessed someone overdose (24.9%). However, less than half (41.2%) knew of the antidote that prevents opioid overdoses.Conclusions: Although our results may be restricted to certain Danish youth groups, knowledge and use of highly addictive substances appear widespread. Among our respondents, nearly one out of four reported prior use of opioids and benzodiazepines. The majority had their debut age using opioids at a young age, between 16 and 18 years or younger. Less than half knew of the antidote that can reverse an opioid overdose.Funding: Antidote Danmark.Trial registration: This study was a voluntary survey and, in accordance with Danish legislation, did not require ethical approval.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 8","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outpatient versus inpatient surgery for ankle fractures - a protocol for a randomised controlled trial. 踝关节骨折的门诊手术与住院手术——一项随机对照试验的方案。

IF 1.2 4区医学

Danish medical journal Pub Date : 2025-06-26 DOI: 10.61409/A10240746

Christian Gr Rasmussen, Peter Larsen, Christian Pedersen, Rasmus Elsoe

{"title":"Outpatient versus inpatient surgery for ankle fractures - a protocol for a randomised controlled trial.","authors":"Christian Gr Rasmussen, Peter Larsen, Christian Pedersen, Rasmus Elsoe","doi":"10.61409/A10240746","DOIUrl":"10.61409/A10240746","url":null,"abstract":"Introduction: In recent years, outpatient surgical treatment for ankle fractures has been introduced for selected fracture types and patients with a low degree of comorbidity. Limited evidence is available to guide the choice between inpatient and outpatient care for ankle fractures. This randomised controlled trial aims to investigate the effect of inpatient versus outpatient surgery of ankle fractures on patient-reported outcomes at 12 weeks.Methods: This study is a single-centre non-inferiority randomised controlled trial investigating outpatient care for surgically treated ankle fractures. A total of 86 patients will be included in the study and randomised 1:1 to either outpatient or inpatient care. The primary outcome is the Foot and Ankle Outcome Score at three months after surgery. Secondary outcomes will include patient satisfaction, pain, physical function and adverse events.Conclusions: Conducting a randomised controlled trial investigating inpatient versus outpatient surgery for ankle fractures on both patient-reported outcomes, patient satisfaction, adverse events, pain, function and bone healing will provide evidence to guide future recommendations in the planning of surgical treatment for ankle fractures.Funding: The study is partially funded by Helsefonden and the North Denmark Region.Trial registration: The study was pre-registered on Clinicaltrials.gov ID: NCT05389436, 20 May 2022.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 7","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0