Anders Valentin A Nielsen, Casper Kierulf Lassen, Dilek Cakar, Jacob Christensen, Mads Lind Ingeman, Andreas Halgreen Eiset, Eva Aggerholm Sædder
{"title":"年轻成人急诊入院曲马多诱发癫痫的患病率和特点。","authors":"Anders Valentin A Nielsen, Casper Kierulf Lassen, Dilek Cakar, Jacob Christensen, Mads Lind Ingeman, Andreas Halgreen Eiset, Eva Aggerholm Sædder","doi":"10.61409/A02250108","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Tramadol is an opioid analgesic used to treat moderately severe pain. Overuse and recreational use of tramadol may cause seizures, but the extent of this problem remains unclear. This study evaluates admissions with tramadol-induced seizures (TIS) among young adults admitted to the emergency department (ED).</p><p><strong>Methods: </strong>A cross-sectional study was conducted on all patients aged 15-30 years with a seizure diagnosis admitted to the ED at Aarhus University Hospital from 1 January 2021 to 31 December 2022. Data were retrieved from a retrospective medical records review.</p><p><strong>Results: </strong>We identified 232 unique patients with 352 seizure admissions; 41 patients (17.7%) (38 male (92%)) with 62 admissions secondary to TIS. The mean (± standard deviation) age of persons with TIS was 20.34 years (± 3.19) compared to 21.88 years (± 4.45) for those with other seizure aetiologies (p = 0.00947). The median tramadol dose was 200 mg (range: 50-1,200 mg, IQR: 50-300 mg). A subgroup of 12 patients accounted for 33/62 (53%) of total TIS admissions. Concomitant cannabis use was common and was reported in 40% of TIS admissions. Among the 62 TIS admissions, only two patients had a prescription for tramadol. The mean time spent in the ED was 5.74 hours (± 5.12). A CT of the brain was performed in 33/62 (53%) of TIS admissions. A total of 31 ambulatory follow-up neurological evaluations were conducted.</p><p><strong>Conclusions: </strong>Tramadol is a frequent cause of seizures among young adults admitted to the ED. Targeted interventions to reduce recreational use among young adults are urgently needed.</p><p><strong>Funding: </strong>None.</p><p><strong>Trial registration: </strong>Not relevant.</p>","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 8","pages":""},"PeriodicalIF":1.2000,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prevalence and characteristics of tramadol-induced seizures in young adult emergency admissions.\",\"authors\":\"Anders Valentin A Nielsen, Casper Kierulf Lassen, Dilek Cakar, Jacob Christensen, Mads Lind Ingeman, Andreas Halgreen Eiset, Eva Aggerholm Sædder\",\"doi\":\"10.61409/A02250108\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Tramadol is an opioid analgesic used to treat moderately severe pain. Overuse and recreational use of tramadol may cause seizures, but the extent of this problem remains unclear. This study evaluates admissions with tramadol-induced seizures (TIS) among young adults admitted to the emergency department (ED).</p><p><strong>Methods: </strong>A cross-sectional study was conducted on all patients aged 15-30 years with a seizure diagnosis admitted to the ED at Aarhus University Hospital from 1 January 2021 to 31 December 2022. Data were retrieved from a retrospective medical records review.</p><p><strong>Results: </strong>We identified 232 unique patients with 352 seizure admissions; 41 patients (17.7%) (38 male (92%)) with 62 admissions secondary to TIS. The mean (± standard deviation) age of persons with TIS was 20.34 years (± 3.19) compared to 21.88 years (± 4.45) for those with other seizure aetiologies (p = 0.00947). The median tramadol dose was 200 mg (range: 50-1,200 mg, IQR: 50-300 mg). A subgroup of 12 patients accounted for 33/62 (53%) of total TIS admissions. Concomitant cannabis use was common and was reported in 40% of TIS admissions. Among the 62 TIS admissions, only two patients had a prescription for tramadol. The mean time spent in the ED was 5.74 hours (± 5.12). A CT of the brain was performed in 33/62 (53%) of TIS admissions. A total of 31 ambulatory follow-up neurological evaluations were conducted.</p><p><strong>Conclusions: </strong>Tramadol is a frequent cause of seizures among young adults admitted to the ED. Targeted interventions to reduce recreational use among young adults are urgently needed.</p><p><strong>Funding: </strong>None.</p><p><strong>Trial registration: </strong>Not relevant.</p>\",\"PeriodicalId\":11119,\"journal\":{\"name\":\"Danish medical journal\",\"volume\":\"72 8\",\"pages\":\"\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2025-07-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Danish medical journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.61409/A02250108\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Danish medical journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.61409/A02250108","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Prevalence and characteristics of tramadol-induced seizures in young adult emergency admissions.
Introduction: Tramadol is an opioid analgesic used to treat moderately severe pain. Overuse and recreational use of tramadol may cause seizures, but the extent of this problem remains unclear. This study evaluates admissions with tramadol-induced seizures (TIS) among young adults admitted to the emergency department (ED).
Methods: A cross-sectional study was conducted on all patients aged 15-30 years with a seizure diagnosis admitted to the ED at Aarhus University Hospital from 1 January 2021 to 31 December 2022. Data were retrieved from a retrospective medical records review.
Results: We identified 232 unique patients with 352 seizure admissions; 41 patients (17.7%) (38 male (92%)) with 62 admissions secondary to TIS. The mean (± standard deviation) age of persons with TIS was 20.34 years (± 3.19) compared to 21.88 years (± 4.45) for those with other seizure aetiologies (p = 0.00947). The median tramadol dose was 200 mg (range: 50-1,200 mg, IQR: 50-300 mg). A subgroup of 12 patients accounted for 33/62 (53%) of total TIS admissions. Concomitant cannabis use was common and was reported in 40% of TIS admissions. Among the 62 TIS admissions, only two patients had a prescription for tramadol. The mean time spent in the ED was 5.74 hours (± 5.12). A CT of the brain was performed in 33/62 (53%) of TIS admissions. A total of 31 ambulatory follow-up neurological evaluations were conducted.
Conclusions: Tramadol is a frequent cause of seizures among young adults admitted to the ED. Targeted interventions to reduce recreational use among young adults are urgently needed.
期刊介绍：
The Danish Medical Journal (DMJ) is a general medical journal. The journal publish original research in English – conducted in or in relation to the Danish health-care system. When writing for the Danish Medical Journal please remember target audience which is the general reader. This means that the research area should be relevant to many readers and the paper should be presented in a way that most readers will understand the content.
DMJ will publish the following articles:
• Original articles
• Protocol articles from large randomized clinical trials
• Systematic reviews and meta-analyses
• PhD theses from Danish faculties of health sciences
• DMSc theses from Danish faculties of health sciences.
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