Symptom profiles in long COVID compared to functional somatic disorder and the general population.

IF 1.2 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Danish medical journal Pub Date : 2025-09-09 DOI:10.61409/A09240627

Jane Agergaard, Lisbeth Frostholm, Per Fink, Thomas Meinertz Dantoft, Berit Schiøttz-Christensen, Marie Weinreich Petersen

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引用次数: 0

Abstract

Introduction: Long COVID, characterised by persistent symptoms following COVID-19, affects about 10% of individuals recovering from SARS-CoV-2. The overlap of symptoms described in long COVID and functional somatic disorder (FSD) raises questions about shared pathophysiology. This report compares the prevalence and profiles of physical symptoms among patients with long COVID, patients with FSD and the general population.

Methods: Data from a cohort of patients with long COVID referred for diagnostics, a cohort of patients seen in a regional clinic for FSD and individuals from the general population were used. Questionnaires, including the bodily distress syndrome checklist, were used to assess physical symptoms.

Results: A total of 436 patients with long COVID, 264 patients with FSD and 9,656 individuals from the general population were included. A lower prevalence of symptoms was observed in patients with long COVID than in patients with FSD. However, the prevalence of symptoms in patients with long COVID remained higher than in the general population. In patients with long COVID, dominant symptoms were from the general symptoms (GS) cluster (concentration difficulties, fatigue, headache, memory problems) and muscle pain. Additionally, 11% met the criteria for multi-organ FSD, exhibiting a similar symptom profile to patients with FSD.

Conclusions: A total of 11% of long COVID patients had a symptom profile similar to that of patients with multi-organ FSD. GS, including fatigue and muscle pain, were common. These findings highlight the need for prospective studies to identify patients with similar symptoms, pathogenesis and treatment options.

Funding: None.

Trial registration: Not relevant.

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与功能性躯体疾病和普通人群相比，长冠状病毒的症状概况。

长冠状病毒的特征是在COVID-19之后持续出现症状，约10%的SARS-CoV-2患者会受到影响。长冠状病毒病和功能性躯体疾病（FSD）中描述的症状重叠引发了对共同病理生理学的质疑。本报告比较了长冠状病毒感染者、FSD患者和一般人群中身体症状的患病率和概况。方法：数据来自转诊的长COVID患者队列、在FSD区域诊所就诊的患者队列和普通人群。问卷，包括身体痛苦综合征检查表，被用来评估身体症状。结果：共纳入长冠肺炎患者436例，FSD患者264例，普通人群9656例。长COVID患者的症状发生率低于FSD患者。然而，长期感染新冠肺炎的患者出现症状的比例仍高于普通人群。在长冠状病毒感染者中，主要症状为一般症状（GS）类（注意力集中困难、疲劳、头痛、记忆问题）和肌肉疼痛。此外，11%符合多器官FSD的标准，表现出与FSD患者相似的症状特征。结论：11%的长冠患者的症状特征与多器官FSD患者相似。包括疲劳和肌肉疼痛在内的GS很常见。这些发现强调了前瞻性研究的必要性，以确定具有相似症状、发病机制和治疗方案的患者。资金:没有。试验注册：不相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Danish medical journal MEDICINE, GENERAL & INTERNAL-

CiteScore

2.30

自引率

6.20%

发文量

审稿时长

3-8 weeks

期刊介绍： The Danish Medical Journal (DMJ) is a general medical journal. The journal publish original research in English – conducted in or in relation to the Danish health-care system. When writing for the Danish Medical Journal please remember target audience which is the general reader. This means that the research area should be relevant to many readers and the paper should be presented in a way that most readers will understand the content. DMJ will publish the following articles: • Original articles • Protocol articles from large randomized clinical trials • Systematic reviews and meta-analyses • PhD theses from Danish faculties of health sciences • DMSc theses from Danish faculties of health sciences.