Surgical treatment of breast fibroadenomas.

IF 1.2 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Danish medical journal Pub Date : 2025-09-09 DOI:10.61409/A03250179

Cecilie Jansen, Nethe Eichen, Niels Kroman, Tove Tvedskov

{"title":"Surgical treatment of breast fibroadenomas.","authors":"Cecilie Jansen, Nethe Eichen, Niels Kroman, Tove Tvedskov","doi":"10.61409/A03250179","DOIUrl":null,"url":null,"abstract":"Introduction: Fibroadenoma is a benign tumour with a prevalence of 9-22% and the third most common palpable breast tumour. Management is primarily conservative, but treatment varies due to a lack of national guidelines. We aimed to estimate the proportion of women diagnosed with fibroadenoma who underwent surgical excision in Denmark between 2011 and 2014, including regional differences in age, tumour size and year of surgery.Methods: In this nationwide registry-based cohort study, we identified all patients who underwent surgical excision of a fibroadenoma from 1 January 2011 to 31 December 2014, using the Danish National Register of Pathology. This registry provided information on age and region. Operation rates were calculated using population data from Statistics Denmark.Results: We identified 1,843 patients. The mean size of surgically removed fibroadenomas was 25.5 mm, and the mean age at surgery was 37 years. Patients > 50 years had a significantly higher proportion of small fibroadenomas (less-than 20 mm) removed than younger patients (p less-than 0.01). The overall operation rate was 20.6 per 100,000 women per year, highest in the 18-25-year age group (56.8 per 100,000 per year). Significant regional variation was found (p less-than 0.01), with the North Denmark Region having the highest operation rate (43.6 per 100,000 per year).Conclusions: Despite conservative management being recommended in Denmark during the study period, many fibroadenomas were surgically removed, and considerable regional variations were recorded. National guidelines are needed to ensure uniform, evidence-based treatment and reduce overtreatment.Funding: None.Trial registration: nr. SABN 3-3013-1306/1.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"72 10","pages":""},"PeriodicalIF":1.2000,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Danish medical journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.61409/A03250179","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Fibroadenoma is a benign tumour with a prevalence of 9-22% and the third most common palpable breast tumour. Management is primarily conservative, but treatment varies due to a lack of national guidelines. We aimed to estimate the proportion of women diagnosed with fibroadenoma who underwent surgical excision in Denmark between 2011 and 2014, including regional differences in age, tumour size and year of surgery.

Methods: In this nationwide registry-based cohort study, we identified all patients who underwent surgical excision of a fibroadenoma from 1 January 2011 to 31 December 2014, using the Danish National Register of Pathology. This registry provided information on age and region. Operation rates were calculated using population data from Statistics Denmark.

Results: We identified 1,843 patients. The mean size of surgically removed fibroadenomas was 25.5 mm, and the mean age at surgery was 37 years. Patients > 50 years had a significantly higher proportion of small fibroadenomas (less-than 20 mm) removed than younger patients (p less-than 0.01). The overall operation rate was 20.6 per 100,000 women per year, highest in the 18-25-year age group (56.8 per 100,000 per year). Significant regional variation was found (p less-than 0.01), with the North Denmark Region having the highest operation rate (43.6 per 100,000 per year).

Conclusions: Despite conservative management being recommended in Denmark during the study period, many fibroadenomas were surgically removed, and considerable regional variations were recorded. National guidelines are needed to ensure uniform, evidence-based treatment and reduce overtreatment.

Funding: None.

Trial registration: nr. SABN 3-3013-1306/1.

查看原文本刊更多论文

乳腺纤维腺瘤的外科治疗。

纤维腺瘤是一种良性肿瘤，发病率为9-22%，是第三常见的乳腺可触及肿瘤。治疗主要是保守的，但由于缺乏国家指导方针，治疗方法各不相同。我们的目的是估计2011年至2014年间丹麦诊断为纤维腺瘤的女性接受手术切除的比例，包括年龄、肿瘤大小和手术年份的地区差异。方法：在这项全国范围内基于登记的队列研究中，我们使用丹麦国家病理登记册，确定了2011年1月1日至2014年12月31日期间接受纤维腺瘤手术切除的所有患者。该登记处提供了有关年龄和地区的信息。使用丹麦统计局的人口数据计算手术率。结果：我们确定了1843例患者。手术切除纤维腺瘤的平均大小为25.5 mm，平均手术年龄为37岁。50岁以下患者的小纤维腺瘤（小于20 mm）切除比例明显高于年轻患者（p < 0.01）。总手术率为每年每10万名妇女20.6例，在18-25岁年龄组中最高（每年每10万名妇女56.8例）。发现显著的地区差异（p < 0.01），北丹麦地区的手术率最高（每年每10万人中有43.6例）。结论：尽管在研究期间丹麦推荐保守治疗，但许多纤维腺瘤是手术切除的，并且记录了相当大的区域差异。需要制定国家指南，以确保统一的循证治疗并减少过度治疗。资金:没有。试验注册：编号：SABN 3-3013-1306/1。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Danish medical journal MEDICINE, GENERAL & INTERNAL-

CiteScore

2.30

自引率

6.20%

发文量

审稿时长

3-8 weeks

期刊介绍： The Danish Medical Journal (DMJ) is a general medical journal. The journal publish original research in English – conducted in or in relation to the Danish health-care system. When writing for the Danish Medical Journal please remember target audience which is the general reader. This means that the research area should be relevant to many readers and the paper should be presented in a way that most readers will understand the content. DMJ will publish the following articles: • Original articles • Protocol articles from large randomized clinical trials • Systematic reviews and meta-analyses • PhD theses from Danish faculties of health sciences • DMSc theses from Danish faculties of health sciences.