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Transmission of severe acute respiratory syndrome coronavirus 2 from humans to animals: is there a risk of novel reservoirs? 严重急性呼吸系统综合征冠状病毒2从人类传播给动物：是否存在新的宿主风险？
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2023-10-02 DOI: 10.1016/j.coviro.2023.101365
Leira Fernández-Bastit , Júlia Vergara-Alert , Joaquim Segalés
{"title":"Transmission of severe acute respiratory syndrome coronavirus 2 from humans to animals: is there a risk of novel reservoirs?","authors":"Leira Fernández-Bastit ,&nbsp;Júlia Vergara-Alert ,&nbsp;Joaquim Segalés","doi":"10.1016/j.coviro.2023.101365","DOIUrl":"10.1016/j.coviro.2023.101365","url":null,"abstract":"<div><p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a zoonotic virus able to infect humans and multiple nonhuman animal species. Most natural infections in companion, captive zoo, livestock, and wildlife species have been related to a reverse transmission, raising concern about potential generation of animal reservoirs due to human–animal interactions. To date, American mink and white-tailed deer are the only species that led to extensive intraspecies transmission of SARS-CoV-2 after reverse zoonosis, leading to an efficient spread of the virus and subsequent animal-to-human transmission. Viral host adaptations increase the probability of new SARS-CoV-2 variants’ emergence that could cause a major global health impact. Therefore, applying the One Health approach is crucial to prevent and overcome future threats for human, animal, and environmental fields.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41129614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improvement of mucosal immunity by a live-attenuated SARS-CoV-2 nasal vaccine SARS-CoV-2减毒鼻用疫苗对黏膜免疫的改善作用
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2023-10-01 DOI: 10.1016/j.coviro.2023.101347
Jason Yeung , Tian Wang , Pei-Yong Shi
{"title":"Improvement of mucosal immunity by a live-attenuated SARS-CoV-2 nasal vaccine","authors":"Jason Yeung ,&nbsp;Tian Wang ,&nbsp;Pei-Yong Shi","doi":"10.1016/j.coviro.2023.101347","DOIUrl":"10.1016/j.coviro.2023.101347","url":null,"abstract":"<div><p>The effectiveness of early COVID-19 vaccines in reducing the severity of the disease has led to a focus on developing next-generation vaccines that can prevent infection and transmission of the virus. One promising approach involves the induction of mucosal immunity through nasal administration and a variety of mucosal vaccine candidates using different platforms are currently in development. Live-attenuated viruses, less pathogenic versions of SARS-CoV-2, have promising features as a mucosal vaccine platform and have the potential to induce hybrid immunity in individuals who have already received mRNA vaccines. This review discusses the potential benefits and considerations for the use of live-attenuated SARS-CoV-2 intranasal vaccines and highlights the authors' work in developing such a vaccine platform.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10281987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: Viruses and Cancer 编辑概述:病毒和癌症
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2023-10-01 DOI: 10.1016/j.coviro.2023.101364
Ethel Cesarman, Jennifer Totonchy
{"title":"Editorial overview: Viruses and Cancer","authors":"Ethel Cesarman,&nbsp;Jennifer Totonchy","doi":"10.1016/j.coviro.2023.101364","DOIUrl":"10.1016/j.coviro.2023.101364","url":null,"abstract":"","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10336372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic and pharmacological perturbation of hepatitis-C virus entry 丙型肝炎病毒进入的遗传和药理学扰动
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2023-10-01 DOI: 10.1016/j.coviro.2023.101362
Belén Carriquí-Madroñal , Lisa Lasswitz , Thomas von Hahn , Gisa Gerold
{"title":"Genetic and pharmacological perturbation of hepatitis-C virus entry","authors":"Belén Carriquí-Madroñal ,&nbsp;Lisa Lasswitz ,&nbsp;Thomas von Hahn ,&nbsp;Gisa Gerold","doi":"10.1016/j.coviro.2023.101362","DOIUrl":"10.1016/j.coviro.2023.101362","url":null,"abstract":"<div><p>Hepatitis-C virus (HCV) chronically infects 58 million individuals worldwide with variable disease outcome. While a subfraction of individuals exposed to the virus clear the infection, the majority develop chronic infection if untreated. Another subfraction of chronically ill proceeds to severe liver disease. The underlying causes of this interindividual variability include genetic polymorphisms in interferon genes. Here, we review available data on the influence of genetic or pharmacological perturbation of HCV host dependency factors on the clinically observed interindividual differences in disease outcome. We focus on host factors mediating virus entry into human liver cells. We assess available data on genetic variants of the major entry factors scavenger receptor class-B type I, CD81, claudin-1, and occludin as well as pharmacological perturbation of these entry factors. We review cell culture experimental and clinical cohort study data and conclude that entry factor perturbation may contribute to disease outcome of hepatitis C.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10282979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The more the merrier? Gene duplications in the coevolution of primate lentiviruses with their hosts 人越多越好?灵长类慢病毒与其宿主共同进化中的基因复制
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2023-10-01 DOI: 10.1016/j.coviro.2023.101350
Martin Müller, Daniel Sauter
{"title":"The more the merrier? Gene duplications in the coevolution of primate lentiviruses with their hosts","authors":"Martin Müller,&nbsp;Daniel Sauter","doi":"10.1016/j.coviro.2023.101350","DOIUrl":"10.1016/j.coviro.2023.101350","url":null,"abstract":"<div><p>Gene duplications are a major source of genetic diversity and evolutionary innovation. Newly formed, duplicated genes can provide a selection advantage in constantly changing environments. One such example is the arms race of HIV and related lentiviruses with innate immune responses of their hosts. In recent years, it has become clear that both sides have benefited from multiple gene duplications. For example, amplifications of antiretroviral factors such as apolipoprotein-B mRNA-editing enzyme catalytic polypeptide-3 (APOBEC3), interferon-induced transmembrane protein (IFITM), and tripartite motif-containing (TRIM) proteins have expanded the repertoire of cell-intrinsic defense mechanisms and increased the barriers to retroviral replication and cross-species transmission. Conversely, recent studies have also shed light on how duplications of accessory lentiviral genes and Long terminal repeat (LTR) elements can provide a selection advantage in the coevolution with antiviral host proteins.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10282484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antigenic evolution of SARS coronavirus 2 SARS冠状病毒的抗原进化
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2023-10-01 DOI: 10.1016/j.coviro.2023.101349
Anna Z Mykytyn, Ron AM Fouchier, Bart L Haagmans
{"title":"Antigenic evolution of SARS coronavirus 2","authors":"Anna Z Mykytyn,&nbsp;Ron AM Fouchier,&nbsp;Bart L Haagmans","doi":"10.1016/j.coviro.2023.101349","DOIUrl":"10.1016/j.coviro.2023.101349","url":null,"abstract":"<div><p>SARS coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, emerged in China in December 2019. Vaccines developed were very effective initially, however, the virus has shown remarkable evolution with multiple variants spreading globally over the last three years. Nowadays, newly emerging Omicron lineages are gaining substitutions at a fast rate, resulting in escape from neutralization by antibodies that target the Spike protein. Tools to map the impact of substitutions on the further antigenic evolution of SARS-CoV-2, such as antigenic cartography, may be helpful to update SARS-CoV-2 vaccines. In this review, we focus on the antigenic evolution of SARS-CoV-2, highlighting the impact of Spike protein substitutions individually and in combination on immune escape.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10275788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The role of nuclear pores and importins for herpes simplex virus infection 核孔和输入蛋白在单纯疱疹病毒感染中的作用
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2023-10-01 DOI: 10.1016/j.coviro.2023.101361
Katinka Döhner , Manutea C Serrero , Beate Sodeik
{"title":"The role of nuclear pores and importins for herpes simplex virus infection","authors":"Katinka Döhner ,&nbsp;Manutea C Serrero ,&nbsp;Beate Sodeik","doi":"10.1016/j.coviro.2023.101361","DOIUrl":"10.1016/j.coviro.2023.101361","url":null,"abstract":"<div><p>Microtubule transport and nuclear import are functionally connected, and the nuclear pore complex (NPC) can interact with microtubule motors. For several alphaherpesvirus proteins, nuclear localization signals (NLSs) and their interactions with specific importin-α proteins have been characterized. Here, we review recent insights on the roles of microtubule motors, capsid-associated NLSs, and importin-α proteins for capsid transport, capsid docking to NPCs, and genome release into the nucleoplasm, as well as the role of importins for nuclear viral transcription, replication, capsid assembly, genome packaging, and nuclear capsid egress. Moreover, importin-α proteins exert antiviral effects by promoting the nuclear import of transcription factors inducing the expression of interferons (IFN), cytokines, and IFN-stimulated genes, and the IFN-inducible MxB restricts capsid docking to NPCs.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10336373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Advantages and challenges of Newcastle disease virus as a vector for respiratory mucosal vaccines 新城疫病毒作为呼吸道黏膜疫苗载体的优势和挑战。
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2023-10-01 DOI: 10.1016/j.coviro.2023.101348
Rik L de Swart , George A Belov
{"title":"Advantages and challenges of Newcastle disease virus as a vector for respiratory mucosal vaccines","authors":"Rik L de Swart ,&nbsp;George A Belov","doi":"10.1016/j.coviro.2023.101348","DOIUrl":"10.1016/j.coviro.2023.101348","url":null,"abstract":"<div><p>Newcastle disease virus (NDV) is an avian pathogen with an unsegmented negative-strand RNA genome. Properties such as the ease of genome modification, respiratory tract tropism, and self-limiting replication in mammals make NDV an attractive vector for vaccine development. Experimental NDV-based vaccines against multiple human and animal pathogens elicited both systemic and mucosal immune responses and were protective in preclinical animal studies, but their real-life efficacy remains to be demonstrated. Only recently, the first results of clinical trials of NDV-based vaccines against SARS-CoV-2 became available, highlighting the challenges that need to be overcome to fully realize the potential of NDV as a platform for the rapid development of economically affordable and effective mucosal vaccines.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10282381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of the viral polymerase during adaptation of influenza A viruses to new hosts 病毒聚合酶在甲型流感病毒适应新宿主过程中的作用
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2023-10-01 DOI: 10.1016/j.coviro.2023.101363
Brad Gilbertson , Melanie Duncan , Kanta Subbarao
{"title":"Role of the viral polymerase during adaptation of influenza A viruses to new hosts","authors":"Brad Gilbertson ,&nbsp;Melanie Duncan ,&nbsp;Kanta Subbarao","doi":"10.1016/j.coviro.2023.101363","DOIUrl":"10.1016/j.coviro.2023.101363","url":null,"abstract":"<div><p>As a group, influenza-A viruses (IAV) infect a wide range of animal hosts, however, they are constrained to infecting selected host species by species-specific interactions between the host and virus, that are required for efficient replication of the viral RNA genome. When IAV cross the species barrier, they acquire mutations in the viral genome to enable interactions with the new host factors, or to compensate for their loss. The viral polymerase genes polymerase basic 1, polymerase basic 2, and polymerase-acidic are important sites of host adaptation. In this review, we discuss why the viral polymerase is so vital to the process of host adaptation, look at some of the known viral mutations, and host factors involved in adaptation, particularly of avian IAV to mammalian hosts.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10336371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A review of broadly protective monoclonal antibodies to treat Ebola virus disease 广泛保护性单克隆抗体治疗埃博拉病毒病的研究进展
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2023-08-01 DOI: 10.1016/j.coviro.2023.101339
Pramila Rijal , Francesca R. Donnellan
{"title":"A review of broadly protective monoclonal antibodies to treat Ebola virus disease","authors":"Pramila Rijal ,&nbsp;Francesca R. Donnellan","doi":"10.1016/j.coviro.2023.101339","DOIUrl":"10.1016/j.coviro.2023.101339","url":null,"abstract":"<div><p>The filovirus vaccine and the therapeutic monoclonal antibody (mAb) research have made substantial progress. However, existing vaccines and mAbs approved for use in humans are specific to <em>Zaire ebolavirus</em> (EBOV). Since other Ebolavirus species are a continuing threat to public health, the search for broadly protective mAbs has drawn attention. Here, we review viral glycoprotein-targeting mAbs that have proved their broader protective efficacy in animal models. MBP134<sup>AF</sup>, the most advanced of these new-generation mAb therapies, has recently been deployed in Uganda during the <em>Sudan ebolavirus</em> outbreak. Furthermore, we discuss the measures associated with enhancing antibody therapies and the risks associated with them, including the rise of escape mutations following the mAb treatment and naturally occurring EBOV variants.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10322442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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