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Tissue-resident memory T cells in protective immunity to influenza virus 流感病毒保护性免疫中的组织驻留记忆 T 细胞
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2024-03-08 DOI: 10.1016/j.coviro.2024.101397
Seungwoo Lee , Karen KM Yeung , Tania H Watts
{"title":"Tissue-resident memory T cells in protective immunity to influenza virus","authors":"Seungwoo Lee ,&nbsp;Karen KM Yeung ,&nbsp;Tania H Watts","doi":"10.1016/j.coviro.2024.101397","DOIUrl":"https://doi.org/10.1016/j.coviro.2024.101397","url":null,"abstract":"<div><p>Influenza virus is an important human pathogen with significant pandemic potential. Tissue-resident memory T cells (Trm) in the lung provide critical protection against influenza, but unlike Trm at other mucosal sites, Trm in the respiratory tract (RT) are subject to rapid attrition in mice, mirroring the decline in protective immunity to influenza virus over time. Conversely, dysfunctional Trm can drive fibrosis in aged mice. The requirement for local antigen to induce and maintain RT Trm must be considered in vaccine strategies designed to induce this protective immune subset. Here, we discuss recent studies that inform our understanding of influenza-specific respiratory Trm, and the factors that influence their development and persistence. We also discuss how these biological insights are being used to develop vaccines that induce Trm in the RT, despite the limitations to monitoring Trm in humans.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":"65 ","pages":"Article 101397"},"PeriodicalIF":5.9,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1879625724000117/pdfft?md5=f18cd080d8b6c2b16f27010dbe9f2ea5&pid=1-s2.0-S1879625724000117-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140062200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of trained innate immunity against mucosal cancer 训练有素的先天免疫对粘膜癌的作用
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2024-02-01 DOI: 10.1016/j.coviro.2024.101387
Tao Wang , Yanling Wang , Jinjing Zhang , Yushi Yao
{"title":"Role of trained innate immunity against mucosal cancer","authors":"Tao Wang ,&nbsp;Yanling Wang ,&nbsp;Jinjing Zhang ,&nbsp;Yushi Yao","doi":"10.1016/j.coviro.2024.101387","DOIUrl":"https://doi.org/10.1016/j.coviro.2024.101387","url":null,"abstract":"<div><p>Mucosal tissues are frequent targets of both primary and metastatic cancers. This has highlighted the significance of both innate and adaptive anti-cancer immunity at mucosal sites. Trained innate immunity (TII) is an emerging concept defined as enhanced reactivity of innate leukocytes long after a previous stimulation that induces prolonged epigenetic, transcriptional, and metabolic changes. Trained innate leukocytes can respond to heterologous targets due to their lacking of antigen-specificity in most cases. Emerging experimental and clinical data suggest that certain microbes or their products induce TII in mucosal-associated innate leukocytes which endows heterologous anti-tumor innate immunity, in both prophylactic and therapeutic scenarios. In this mini-review, we summarize updated findings on the significance of TII in mucosal cancers. We also attempt to raise a few key questions critical to our further understanding on the roles of TII in mucosal cancers, and to the potential application of TII as anti-cancer strategy.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":"64 ","pages":"Article 101387"},"PeriodicalIF":5.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139737921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatitis-B virus: replication cycle, targets, and antiviral approaches 乙型肝炎病毒:复制周期、靶点和抗病毒方法
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2023-12-01 DOI: 10.1016/j.coviro.2023.101360
Nour Nasser , Pierre Tonnerre , Abdellah Mansouri , Tarik Asselah
{"title":"Hepatitis-B virus: replication cycle, targets, and antiviral approaches","authors":"Nour Nasser ,&nbsp;Pierre Tonnerre ,&nbsp;Abdellah Mansouri ,&nbsp;Tarik Asselah","doi":"10.1016/j.coviro.2023.101360","DOIUrl":"10.1016/j.coviro.2023.101360","url":null,"abstract":"<div><p><span>An estimated 257 million people are chronic carriers of hepatitis-B virus (HBV) infection, which resulted in around 1 million deaths, mainly due to hepatocellular carcinoma (HCC). Long-term nucleotide analog treatment<span> of HBV infection is associated with favorable prognosis, no disease progression, and a reduction of HCC risk, but lifelong treatments are required. A better understanding of HBV replication cycle and the </span></span>host immune response<span> will likely improve the identification of new targets for drug development. Studies are ongoing to determine if it is possible to successfully combine direct-acting antivirals (DAA) with an immunomodulatory therapy to allow increased cure rates. This review will start with summarizing the HBV replication cycle, recall current treatments, and then discuss potential targets and antiviral approaches in development to optimistically reach the HBV cure.</span></p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":"63 ","pages":"Article 101360"},"PeriodicalIF":5.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10210636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The natural virome and pandemic potential: Disease X 自然病毒和大流行潜力:X病。
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2023-11-22 DOI: 10.1016/j.coviro.2023.101377
Philip Lawrence , Michelle Heung , Julia Nave , Christoph Henkel , Beatriz Escudero-Pérez
{"title":"The natural virome and pandemic potential: Disease X","authors":"Philip Lawrence ,&nbsp;Michelle Heung ,&nbsp;Julia Nave ,&nbsp;Christoph Henkel ,&nbsp;Beatriz Escudero-Pérez","doi":"10.1016/j.coviro.2023.101377","DOIUrl":"10.1016/j.coviro.2023.101377","url":null,"abstract":"<div><p>Over the last decade, the emergence of several zoonotic viruses has demonstrated that previously unknown or neglected pathogens have the potential to cause epidemics and therefore to pose a threat to global public health. Even more concerning are the estimated 1.7 million still-undiscovered viruses present in the natural environment or ‘global virome’, with many of these as-yet uncharacterized viruses predicted to be pathogenic for humans. Thus, in order to mitigate disease emergence and prevent future pandemics, it is crucial to identify the global extent of viral threats to which humans may become exposed. This requires cataloguing the viruses that exist in the environment within their various and diverse host species, and also understanding the viral, host, and environmental factors that dictate the circumstances that result in viral spillover into humans. We also address here which strategies can be implemented as countermeasure initiatives to reduce the risk of emergence of new diseases.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":"63 ","pages":"Article 101377"},"PeriodicalIF":5.9,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1879625723000779/pdfft?md5=4f6ecf08963be84a929494708f55f8b6&pid=1-s2.0-S1879625723000779-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138298634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathogenesis of severe acute respiratory syndrome coronavirus-2 in nonhuman primates 严重急性呼吸系统综合征冠状病毒2型在非人灵长类动物中的发病机制。
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2023-10-10 DOI: 10.1016/j.coviro.2023.101375
Taylor Saturday, Neeltje van Doremalen
{"title":"Pathogenesis of severe acute respiratory syndrome coronavirus-2 in nonhuman primates","authors":"Taylor Saturday,&nbsp;Neeltje van Doremalen","doi":"10.1016/j.coviro.2023.101375","DOIUrl":"10.1016/j.coviro.2023.101375","url":null,"abstract":"<div><p>The continued pressure of COVID-19 on public health worldwide underlines the need for a better understanding of the mechanisms of disease caused by severe acute respiratory syndrome coronavirus-2. Though many animal models are readily available for use, the nonhuman primate (NHP) models are considered the gold standard in recapitulating disease progression in humans. In this review, we highlight the relevant research since the beginning of the pandemic to critically evaluate the importance of this model. We characterize the disease’s clinical manifestations, aspects of viral replication and shedding, induction of the host’s immune response, and pathological findings that broaden our understanding of the importance of NHPs in research to strengthen our public health approach to the pandemic.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":"63 ","pages":"Article 101375"},"PeriodicalIF":5.9,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41194380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: The virome in health and disease (2022) 编辑综述：健康与疾病中的病毒组（2022）。
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2023-10-05 DOI: 10.1016/j.coviro.2023.101376
Jelle Matthijnssens, Evelien Adriaenssens
{"title":"Editorial overview: The virome in health and disease (2022)","authors":"Jelle Matthijnssens,&nbsp;Evelien Adriaenssens","doi":"10.1016/j.coviro.2023.101376","DOIUrl":"10.1016/j.coviro.2023.101376","url":null,"abstract":"","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":"63 ","pages":"Article 101376"},"PeriodicalIF":5.9,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41107541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transmission of severe acute respiratory syndrome coronavirus 2 from humans to animals: is there a risk of novel reservoirs? 严重急性呼吸系统综合征冠状病毒2从人类传播给动物：是否存在新的宿主风险？
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2023-10-02 DOI: 10.1016/j.coviro.2023.101365
Leira Fernández-Bastit , Júlia Vergara-Alert , Joaquim Segalés
{"title":"Transmission of severe acute respiratory syndrome coronavirus 2 from humans to animals: is there a risk of novel reservoirs?","authors":"Leira Fernández-Bastit ,&nbsp;Júlia Vergara-Alert ,&nbsp;Joaquim Segalés","doi":"10.1016/j.coviro.2023.101365","DOIUrl":"10.1016/j.coviro.2023.101365","url":null,"abstract":"<div><p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a zoonotic virus able to infect humans and multiple nonhuman animal species. Most natural infections in companion, captive zoo, livestock, and wildlife species have been related to a reverse transmission, raising concern about potential generation of animal reservoirs due to human–animal interactions. To date, American mink and white-tailed deer are the only species that led to extensive intraspecies transmission of SARS-CoV-2 after reverse zoonosis, leading to an efficient spread of the virus and subsequent animal-to-human transmission. Viral host adaptations increase the probability of new SARS-CoV-2 variants’ emergence that could cause a major global health impact. Therefore, applying the One Health approach is crucial to prevent and overcome future threats for human, animal, and environmental fields.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":"63 ","pages":"Article 101365"},"PeriodicalIF":5.9,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41129614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improvement of mucosal immunity by a live-attenuated SARS-CoV-2 nasal vaccine SARS-CoV-2减毒鼻用疫苗对黏膜免疫的改善作用
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2023-10-01 DOI: 10.1016/j.coviro.2023.101347
Jason Yeung , Tian Wang , Pei-Yong Shi
{"title":"Improvement of mucosal immunity by a live-attenuated SARS-CoV-2 nasal vaccine","authors":"Jason Yeung ,&nbsp;Tian Wang ,&nbsp;Pei-Yong Shi","doi":"10.1016/j.coviro.2023.101347","DOIUrl":"10.1016/j.coviro.2023.101347","url":null,"abstract":"<div><p>The effectiveness of early COVID-19 vaccines in reducing the severity of the disease has led to a focus on developing next-generation vaccines that can prevent infection and transmission of the virus. One promising approach involves the induction of mucosal immunity through nasal administration and a variety of mucosal vaccine candidates using different platforms are currently in development. Live-attenuated viruses, less pathogenic versions of SARS-CoV-2, have promising features as a mucosal vaccine platform and have the potential to induce hybrid immunity in individuals who have already received mRNA vaccines. This review discusses the potential benefits and considerations for the use of live-attenuated SARS-CoV-2 intranasal vaccines and highlights the authors' work in developing such a vaccine platform.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":"62 ","pages":"Article 101347"},"PeriodicalIF":5.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10281987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: Viruses and Cancer 编辑概述:病毒和癌症
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2023-10-01 DOI: 10.1016/j.coviro.2023.101364
Ethel Cesarman, Jennifer Totonchy
{"title":"Editorial overview: Viruses and Cancer","authors":"Ethel Cesarman,&nbsp;Jennifer Totonchy","doi":"10.1016/j.coviro.2023.101364","DOIUrl":"10.1016/j.coviro.2023.101364","url":null,"abstract":"","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":"62 ","pages":"Article 101364"},"PeriodicalIF":5.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10336372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic and pharmacological perturbation of hepatitis-C virus entry 丙型肝炎病毒进入的遗传和药理学扰动
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2023-10-01 DOI: 10.1016/j.coviro.2023.101362
Belén Carriquí-Madroñal , Lisa Lasswitz , Thomas von Hahn , Gisa Gerold
{"title":"Genetic and pharmacological perturbation of hepatitis-C virus entry","authors":"Belén Carriquí-Madroñal ,&nbsp;Lisa Lasswitz ,&nbsp;Thomas von Hahn ,&nbsp;Gisa Gerold","doi":"10.1016/j.coviro.2023.101362","DOIUrl":"10.1016/j.coviro.2023.101362","url":null,"abstract":"<div><p>Hepatitis-C virus (HCV) chronically infects 58 million individuals worldwide with variable disease outcome. While a subfraction of individuals exposed to the virus clear the infection, the majority develop chronic infection if untreated. Another subfraction of chronically ill proceeds to severe liver disease. The underlying causes of this interindividual variability include genetic polymorphisms in interferon genes. Here, we review available data on the influence of genetic or pharmacological perturbation of HCV host dependency factors on the clinically observed interindividual differences in disease outcome. We focus on host factors mediating virus entry into human liver cells. We assess available data on genetic variants of the major entry factors scavenger receptor class-B type I, CD81, claudin-1, and occludin as well as pharmacological perturbation of these entry factors. We review cell culture experimental and clinical cohort study data and conclude that entry factor perturbation may contribute to disease outcome of hepatitis C.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":"62 ","pages":"Article 101362"},"PeriodicalIF":5.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10282979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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