Pathogenesis of severe acute respiratory syndrome coronavirus-2 in nonhuman primates

IF 5.7 2区 医学 Q1 VIROLOGY
Taylor Saturday, Neeltje van Doremalen
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引用次数: 0

Abstract

The continued pressure of COVID-19 on public health worldwide underlines the need for a better understanding of the mechanisms of disease caused by severe acute respiratory syndrome coronavirus-2. Though many animal models are readily available for use, the nonhuman primate (NHP) models are considered the gold standard in recapitulating disease progression in humans. In this review, we highlight the relevant research since the beginning of the pandemic to critically evaluate the importance of this model. We characterize the disease’s clinical manifestations, aspects of viral replication and shedding, induction of the host’s immune response, and pathological findings that broaden our understanding of the importance of NHPs in research to strengthen our public health approach to the pandemic.

严重急性呼吸系统综合征冠状病毒2型在非人灵长类动物中的发病机制。
新冠肺炎对全球公共卫生的持续压力突出表明,有必要更好地了解严重急性呼吸综合征冠状病毒2引起的疾病机制。尽管许多动物模型很容易使用,但非人类灵长类动物(NHP)模型被认为是概括人类疾病进展的黄金标准。在这篇综述中,我们强调了自疫情开始以来的相关研究,以批判性地评估该模型的重要性。我们描述了该疾病的临床表现、病毒复制和脱落的各个方面、宿主免疫反应的诱导以及病理学发现,这些发现拓宽了我们对NHP在研究中的重要性的理解,以加强我们应对疫情的公共卫生方法。
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来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
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