感染甲型流感病毒后单核细胞和巨噬细胞的移动

IF 5.7 2区 医学 Q1 VIROLOGY
Cecilia Ruscitti , Coraline Radermecker , Thomas Marichal
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引用次数: 0

摘要

甲型流感病毒(IAV)感染是一项全球性的健康挑战,需要全面了解宿主的免疫反应,以制定有效的治疗干预措施。由于单核细胞和巨噬细胞在宿主防御、炎症和修复中发挥着至关重要的作用,本综述探讨了这些细胞在 IAV 感染期间和感染后的复杂历程。首先,我们强调了感染 IAV 后肺部驻留巨噬细胞群的动态和功能。其次,我们回顾了目前关于招募的单核细胞和单核细胞衍生细胞的知识,强调了它们在病毒清除、炎症、免疫调节和组织修复中的作用。第三,我们阐明了 IAV 诱导的巨噬细胞改变对长期肺免疫的影响。最后,我们强调了目前的知识空白,以及未来研究在揭示巨噬细胞对呼吸道病毒感染反应的复杂性方面令人兴奋的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Journey of monocytes and macrophages upon influenza A virus infection

Influenza A virus (IAV) infections pose a global health challenge that necessitates a comprehensive understanding of the host immune response to devise effective therapeutic interventions. As monocytes and macrophages play crucial roles in host defence, inflammation, and repair, this review explores the intricate journey of these cells during and after IAV infection. First, we highlight the dynamics and functions of lung-resident macrophage populations post-IAV. Second, we review the current knowledge of recruited monocytes and monocyte-derived cells, emphasising their roles in viral clearance, inflammation, immunomodulation, and tissue repair. Third, we shed light on the consequences of IAV-induced macrophage alterations on long-term lung immunity. We conclude by underscoring current knowledge gaps and exciting prospects for future research in unravelling the complexities of macrophage responses to respiratory viral infections.

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来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
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