Role of trained innate immunity against mucosal cancer

IF 5.7 2区 医学 Q1 VIROLOGY
Tao Wang , Yanling Wang , Jinjing Zhang , Yushi Yao
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引用次数: 0

Abstract

Mucosal tissues are frequent targets of both primary and metastatic cancers. This has highlighted the significance of both innate and adaptive anti-cancer immunity at mucosal sites. Trained innate immunity (TII) is an emerging concept defined as enhanced reactivity of innate leukocytes long after a previous stimulation that induces prolonged epigenetic, transcriptional, and metabolic changes. Trained innate leukocytes can respond to heterologous targets due to their lacking of antigen-specificity in most cases. Emerging experimental and clinical data suggest that certain microbes or their products induce TII in mucosal-associated innate leukocytes which endows heterologous anti-tumor innate immunity, in both prophylactic and therapeutic scenarios. In this mini-review, we summarize updated findings on the significance of TII in mucosal cancers. We also attempt to raise a few key questions critical to our further understanding on the roles of TII in mucosal cancers, and to the potential application of TII as anti-cancer strategy.

训练有素的先天免疫对粘膜癌的作用
粘膜组织是原发性和转移性癌症的常发目标。这凸显了粘膜部位先天性和适应性抗癌免疫的重要性。训练有素的先天性免疫(TII)是一个新兴概念,其定义是先天性白细胞在受到先前刺激后很长时间内反应性增强,从而诱发长时间的表观遗传、转录和代谢变化。训练有素的先天性白细胞由于缺乏抗原特异性,在大多数情况下可对异源靶点做出反应。新出现的实验和临床数据表明,某些微生物或其产物可诱导粘膜相关先天性白细胞产生TII,从而在预防和治疗中产生异源抗肿瘤先天性免疫。在这篇小型综述中,我们总结了有关 TII 在粘膜癌症中重要性的最新研究成果。我们还试图提出几个关键问题,这些问题对于我们进一步了解 TII 在粘膜癌中的作用以及 TII 作为抗癌策略的潜在应用至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
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