Current Osteoporosis Reports最新文献_第9页

Bone-Muscle Crosstalk: Musculoskeletal Complications of Chemotherapy. 骨肌相声:化疗的肌肉骨骼并发症。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2022-12-01 DOI: 10.1007/s11914-022-00749-4

Brian A Hain, David L Waning

{"title":"Bone-Muscle Crosstalk: Musculoskeletal Complications of Chemotherapy.","authors":"Brian A Hain, David L Waning","doi":"10.1007/s11914-022-00749-4","DOIUrl":"https://doi.org/10.1007/s11914-022-00749-4","url":null,"abstract":"Purpose of review: Chemotherapy drugs combat tumor cells and reduce metastasis. However, a significant side effect of some chemotherapy strategies is loss of skeletal muscle and bone. In cancer patients, maintenance of lean tissue is a positive prognostic indicator of outcomes and helps to minimize the toxicity associated with chemotherapy. Bone-muscle crosstalk plays an important role in the function of the musculoskeletal system and this review will focus on recent findings in preclinical and clinical studies that shed light on chemotherapy-induced bone-muscle crosstalk.Recent findings: Chemotherapy-induced loss of bone and skeletal muscle are important clinical problems. Bone antiresorptive drugs prevent skeletal muscle weakness in preclinical models. Chemotherapy-induced loss of bone can cause muscle weakness through both changes in endocrine signaling and mechanical loading between muscle and bone. Chemotherapy-induced changes to bone-muscle crosstalk have implications for treatment strategies and patient quality of life. Recent findings have begun to determine the role of chemotherapy in bone-muscle crosstalk and this review summarizes the most relevant clinical and preclinical studies.","PeriodicalId":11080,"journal":{"name":"Current Osteoporosis Reports","volume":"20 6","pages":"433-441"},"PeriodicalIF":4.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10634411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Osteoclast Recycling and the Rebound Phenomenon Following Denosumab Discontinuation. 破骨细胞再循环与地诺单抗停药后的反弹现象

IF 4.2 2区医学

Current Osteoporosis Reports Pub Date : 2022-12-01 Epub Date: 2022-10-06 DOI: 10.1007/s11914-022-00756-5

Albert S Kim, Christian M Girgis, Michelle M McDonald

{"title":"Osteoclast Recycling and the Rebound Phenomenon Following Denosumab Discontinuation.","authors":"Albert S Kim, Christian M Girgis, Michelle M McDonald","doi":"10.1007/s11914-022-00756-5","DOIUrl":"10.1007/s11914-022-00756-5","url":null,"abstract":"Purpose of review: Inhibition of receptor activator of nuclear factor kappa-B ligand (RANKL) with denosumab is an effective treatment in a number of conditions including osteoporosis where suppression of bone resorption is desired. However, denosumab discontinuation is associated with rebound increase in bone resorption and subsequent loss in bone mass and a rapid return to baseline fracture risk. We review recent data on the rebound increase in bone resorption following denosumab discontinuation and the potential mechanisms behind this phenomenon.Recent findings: Osteoclasts have been considered to be highly specialised cells that undergo apoptosis after fulfilling their function of bone resorption. However, recent studies suggest that osteoclasts are longer lived cells which migrate through vasculature and are capable of undergoing fission into a novel cell type (the osteomorph) and re-fusion in a process termed osteoclast recycling. The life cycle of the osteoclast is more complex than previously appreciated. Osteoclast recycling provides a novel mechanistic framework to examine changes in osteoclast biology in response to treatment of bone diseases and provides an exciting new avenue towards personalised medicine.","PeriodicalId":11080,"journal":{"name":"Current Osteoporosis Reports","volume":"20 6","pages":"505-515"},"PeriodicalIF":4.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10634418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Gabapentin and Pregabalin on Calcium Homeostasis: Implications for Physical Rehabilitation of Musculoskeletal Tissues. 加巴喷丁和普瑞巴林对钙稳态的影响:对肌肉骨骼组织物理康复的影响。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2022-12-01 DOI: 10.1007/s11914-022-00750-x

Perla C Reyes Fernandez, Christian S Wright, Stuart J Warden, Julia Hum, Mary C Farach-Carson, William R Thompson

{"title":"Effects of Gabapentin and Pregabalin on Calcium Homeostasis: Implications for Physical Rehabilitation of Musculoskeletal Tissues.","authors":"Perla C Reyes Fernandez, Christian S Wright, Stuart J Warden, Julia Hum, Mary C Farach-Carson, William R Thompson","doi":"10.1007/s11914-022-00750-x","DOIUrl":"https://doi.org/10.1007/s11914-022-00750-x","url":null,"abstract":"Purpose of review: In this review, we discuss the mechanism of action of gabapentinoids and the potential consequences of long-term treatment with these drugs on the musculoskeletal system.Recent findings: Gabapentinoids, such as gabapentin (GBP) and pregabalin (PGB) were designed as antiepileptic reagents and are now commonly used as first-line treatment for neuropathic pain and increasingly prescribed off-label for other pain disorders such as migraines and back pain. GBP and PGB exert their analgesic actions by selectively binding the α2δ1 auxiliary subunit of voltage-sensitive calcium channels, thereby inhibiting channel function. Numerous tissues express the α2δ1 subunit where GBP and PGB can alter calcium-mediated signaling events. In tissues such as bone, muscle, and cartilage, α2δ1 has important roles in skeletal formation, mechanosensation, and normal tissue function/repair that may be affected by chronic use of gabapentinoids. Long-term use of gabapentinoids is associated with detrimental musculoskeletal outcomes, including increased fracture risk. Therefore, understanding potential complications is essential for clinicians to guide appropriate treatments.","PeriodicalId":11080,"journal":{"name":"Current Osteoporosis Reports","volume":"20 6","pages":"365-378"},"PeriodicalIF":4.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108402/pdf/nihms-1882513.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9312701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Does Aging Activate T-cells to Reduce Bone Mass and Quality? 衰老是否激活t细胞以减少骨量和骨质?

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2022-10-01 DOI: 10.1007/s11914-022-00745-8

Rajeev Aurora, Deborah Veis

{"title":"Does Aging Activate T-cells to Reduce Bone Mass and Quality?","authors":"Rajeev Aurora, Deborah Veis","doi":"10.1007/s11914-022-00745-8","DOIUrl":"https://doi.org/10.1007/s11914-022-00745-8","url":null,"abstract":"Purpose of review: Aging leads to decline in bone mass and quality starting at age 30 in humans. All mammals undergo a basal age-dependent decline in bone mass. Osteoporosis is characterized by low bone mass and changes in bone microarchitecture that increases the risk of fracture. About a third of men over the age of 50 years are osteoporotic because they have higher than basal bone loss. In women, there is an additional acute decrement in bone mass, atop the basal rate, associated with loss of ovarian function (menopause) causing osteoporosis in about half of the women. Both genetics and environmental factors such as smoking, chronic infections, diet, microbiome, and metabolic disease can modulate basal age-dependent bone loss and eventual osteoporosis. Here, we review recent studies on the etiology of age-dependent decline in bone mass and propose a mechanism that integrates both genetic and environmental factors.Recent findings: Recent findings support that aging and menopause dysregulate the immune system leading to sterile low-grade inflammation. Both animal models and human studies demonstrate that certain kinds of inflammation, in both men and women, mediate bone loss. Senolytics, meant to block a wide array of age-induced effects by preventing cellular senescence, have been shown to improve bone mass in aged mice. Based on a synthesis of the recent data, we propose that aging activates long-lived tissue resident memory T-cells to become senescent and proinflammatory, leading to bone loss. Targeting this population may represent a promising osteoporosis therapy. Emerging data indicates that there are several mechanisms that lead to sterile low-grade chronic inflammation, inflammaging, that cause age- and estrogen-loss dependent osteoporosis in men and women.","PeriodicalId":11080,"journal":{"name":"Current Osteoporosis Reports","volume":"20 5","pages":"326-333"},"PeriodicalIF":4.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016147/pdf/nihms-1879820.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9111176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Weight Loss Interventions and Skeletal Health in Persons with Diabetes. 糖尿病患者的减肥干预和骨骼健康。

IF 4.2 2区医学

Current Osteoporosis Reports Pub Date : 2022-10-01 Epub Date: 2022-08-30 DOI: 10.1007/s11914-022-00744-9

Qi Zhao, Sonal V Khedkar, Karen C Johnson

{"title":"Weight Loss Interventions and Skeletal Health in Persons with Diabetes.","authors":"Qi Zhao, Sonal V Khedkar, Karen C Johnson","doi":"10.1007/s11914-022-00744-9","DOIUrl":"10.1007/s11914-022-00744-9","url":null,"abstract":"Purpose of review: Weight loss is recommended for improving glycemic control and reducing cardiovascular risk factors in persons with diabetes. However, both diabetes and weight loss have been associated with detrimental skeletal health. This review aims to summarize recent study findings on the effects of lifestyle interventions for weight loss on skeletal health among persons with type 2 diabetes (T2D).Recent findings: A few large-scale observational studies have demonstrated an increased fragility fracture risk associated with weight loss among persons with T2D. Randomized control trials in persons with T2D also have shown that intentional lifestyle interventions for weight loss are associated with a greater decrease in bone mineral density (BMD) and an increase in the risk of fracture. The biological mechanisms underlying the compromised bone health during lifestyle interventions for weight loss are complex and not yet conclusive. However, there is evidence to suggest that bone loss and increased fracture risk during intentional weight loss may be mitigated by some intervention approaches, such as high protein intake, calcium supplementation, and resistance and balance training. There is still a lack of studies investigating the effects of different interventions for weight loss on skeletal health among persons with T2D. However, certain types of diet and physical activity intervention combined with bone monitoring and fracture risk prediction may help achieve weight loss goals and maintain skeletal health among persons with T2D during intentional weight loss.","PeriodicalId":11080,"journal":{"name":"Current Osteoporosis Reports","volume":"20 5","pages":"240-248"},"PeriodicalIF":4.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9251252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Muscle and Bone Defects in Metastatic Disease. 转移性疾病中的肌肉和骨缺损。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2022-10-01 Epub Date: 2022-08-22 DOI: 10.1007/s11914-022-00741-y

Martina Pauk, Hiroaki Saito, Eric Hesse, Hanna Taipaleenmäki

{"title":"Muscle and Bone Defects in Metastatic Disease.","authors":"Martina Pauk, Hiroaki Saito, Eric Hesse, Hanna Taipaleenmäki","doi":"10.1007/s11914-022-00741-y","DOIUrl":"10.1007/s11914-022-00741-y","url":null,"abstract":"Purpose of review: The present review addresses most recently identified mechanisms implicated in metastasis-induced bone resorption and muscle-wasting syndrome, known as cachexia.Recent findings: Metastatic disease in bone and soft tissues is often associated with skeletal muscle defects. Recent studies have identified a number of secreted molecules and extracellular vesicles that contribute to cancer cell growth and metastasis leading to bone destruction and muscle atrophy. In addition, alterations in muscle microenvironment including dysfunctions in hepatic and mitochondrial metabolism have been implicated in cancer-induced regeneration defect and muscle loss. Moreover, we review novel in vitro and animal models including promising new drug candidates for bone metastases and cancer cachexia. Preservation of bone health could be highly beneficial for maintaining muscle mass and function. Therefore, a better understanding of molecular pathways implicated in bone and muscle crosstalk in metastatic disease may provide new insights and identify new strategies to improve current anticancer therapeutics.","PeriodicalId":11080,"journal":{"name":"Current Osteoporosis Reports","volume":"20 5","pages":"273-289"},"PeriodicalIF":4.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9547709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impacts of COVID-19 on Musculoskeletal Health. COVID-19 对肌肉骨骼健康的影响。

IF 4.2 2区医学

Current Osteoporosis Reports Pub Date : 2022-08-01 Epub Date: 2022-06-20 DOI: 10.1007/s11914-022-00734-x

Olatundun D Awosanya, Ushashi C Dadwal, Erik A Imel, Qigui Yu, Melissa A Kacena

{"title":"The Impacts of COVID-19 on Musculoskeletal Health.","authors":"Olatundun D Awosanya, Ushashi C Dadwal, Erik A Imel, Qigui Yu, Melissa A Kacena","doi":"10.1007/s11914-022-00734-x","DOIUrl":"10.1007/s11914-022-00734-x","url":null,"abstract":"Purpose of review: Although COVID-19 was originally characterized as a respiratory disease, recent findings have shown lingering side effects in those who have recovered, and much is still unknown about the long-term consequences of the illness. Thus, the potential of unearthing multi-system dysfunction is high, with current data revealing significant impacts on musculoskeletal health.Recent findings: Multiple animal models of COVID-19 infection have revealed significant post-infection bone loss at several different skeletal sites. While how this loss occurred is unknown, this current review discusses the primary bone loss studies, and examines the possible mechanisms of action including: direct infection of bone marrow macrophages or hematopoietic progenitors, a proinflammatory response as a result of the COVID-19 induced cytokine storm, and/or a result of hypoxia and oxidative stress. This review will further examine how therapeutics used to treat COVID-19 affect the skeletal system. Finally, this review will examine the possible consequence that delayed care and limited healthcare accessibility has on musculoskeletal-related patient outcomes. It is important to investigate the potential impact COVID-19 infection has on musculoskeletal health.","PeriodicalId":11080,"journal":{"name":"Current Osteoporosis Reports","volume":"20 4","pages":"213-225"},"PeriodicalIF":4.2,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40071606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MicroRNA and Diabetic Bone Disease MicroRNA与糖尿病骨病

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2022-06-01 DOI: 10.1007/s11914-022-00731-0

S. Daamouch, Lejla Emini, M. Rauner, L. Hofbauer

引用次数: 1

Sleep Disruption and Bone Health. 睡眠中断和骨骼健康。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2022-06-01 DOI: 10.1007/s11914-022-00733-y

Christine Swanson

{"title":"Sleep Disruption and Bone Health.","authors":"Christine Swanson","doi":"10.1007/s11914-022-00733-y","DOIUrl":"https://doi.org/10.1007/s11914-022-00733-y","url":null,"abstract":"Purpose of review: Review recent literature investigating the relationship between bone health and sleep/circadian disruptions (e.g., abnormal sleep duration, night shift work).Recent findings: Short and long sleep are associated with low bone mineral density (BMD). Recent data from observational studies identified an increased risk of fracture in women with short sleep. Studies suggest that age, sex, weight change, and concurrent circadian misalignment may modify the effects of sleep restriction on bone metabolism. Interventional studies demonstrate alterations in bone metabolism and structure in response to circadian disruption that could underlie the increased fracture risk seen with night shift work. The effects of sleep and circadian disruption during adolescence may have lifelong skeletal consequences if they adversely impact bone modeling. Data suggest that short sleep and night shift work negatively impact bone metabolism and health. Rigorous studies of prevalent sleep and circadian disruptions are needed to determine mechanisms and develop prevention strategies to optimize lifelong skeletal health.","PeriodicalId":11080,"journal":{"name":"Current Osteoporosis Reports","volume":"20 3","pages":"202-212"},"PeriodicalIF":4.3,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108658/pdf/nihms-1884694.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9554873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Vitamin D Regulation of Immune Function. 维生素D对免疫功能的调节

IF 4.2 2区医学

Current Osteoporosis Reports Pub Date : 2022-06-01 Epub Date: 2022-05-04 DOI: 10.1007/s11914-022-00732-z

Daniel D Bikle

{"title":"Vitamin D Regulation of Immune Function.","authors":"Daniel D Bikle","doi":"10.1007/s11914-022-00732-z","DOIUrl":"10.1007/s11914-022-00732-z","url":null,"abstract":"Purpose of review: To review the mechanisms by which vitamin D and its metabolites regulate the immune system to facilitate the ability of the body to prevent and/or treat SARS-CoV2 and other respiratory infections and encourage further research into the role that vitamin D supplementation plays in preventing/treating such infections.Recent findings: Vitamin D deficiency is associated with an increased risk of SARS-CoV2 and other respiratory infections. Clinical trials in general demonstrate that correction of vitamin D deficiency reduces the risk of hospitalization, ICU admission, and death from SARS-CoV2 infection. The airway epithelium and alveolar macrophages express the enzyme, CYP27B1, that produces the active metabolite of vitamin D, 1,25(OH)2D, and the vitamin D receptor, VDR. Vitamin D and its metabolites promote the innate immune response, which provides the first line of defense against viral and bacterial infections while restricting the adaptive immune response, which if unchecked promotes the inflammatory response leading to the acute respiratory distress syndrome and death. The rationale for treating vitamin D deficiency to reduce the risk of SARS-CoV2 infection and supplementing patients with vitamin D early in the course of SARS-CoV2 infection rests primarily on the ability of vitamin D metabolites to promote an effective immune response to the infection.","PeriodicalId":11080,"journal":{"name":"Current Osteoporosis Reports","volume":"20 1","pages":"186-193"},"PeriodicalIF":4.2,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44745228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0