重新思考非综合征性牙齿缺失的遗传病因学。

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Current Osteoporosis Reports Pub Date : 2022-12-01 Epub Date: 2022-11-15 DOI:10.1007/s11914-022-00761-8
Ariadne Letra
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引用次数: 1

摘要

综述的目的:通过对人类和动物模型的遗传研究,我们进一步了解了许多基因在非综合征性牙齿缺失(TA)病因中的作用。本综述旨在讨论最近发现的可能导致牙齿缺失症的基因:尽管研究取得了进展,但考虑到遗传异质性、可变表达性以及经常观察到的与非综合征性牙齿缺失相关的假定致病变体的不完全渗透性,了解非综合征性牙齿缺失的遗传因素仍具有挑战性。下一代测序技术为新基因和变异体的发现提供了平台,并为TA病因学的范式转换概念提供了依据。本综述总结了与非综合征TA相关的基因和通路的现有知识,重点是最近发现的基因/变异体。文中还介绍了提示TA可能存在多基因变异的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Rethinking the Genetic Etiology of Nonsyndromic Tooth Agenesis.

Purpose of review: Genetic studies in humans and animal models have improved our understanding of the role of numerous genes in the etiology of nonsyndromic tooth agenesis (TA). The purpose of this review is to discuss recently identified genes potentially contributing to TA.

Recent findings: Despite research progress, understanding the genetic factors underlying nonsyndromic TA has been challenging given the genetic heterogeneity, variable expressivity, and incomplete penetrance of putatively pathogenic variants often observed associated with the condition. Next-generation sequencing technologies have provided a platform for novel gene and variant discoveries and informed paradigm-shifting concepts in the etiology of TA. This review summarizes the current knowledge on genes and pathways related to nonsyndromic TA with a focus on recently identified genes/variants. Evidence suggesting possible multi-locus variation in TA is also presented.

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来源期刊
Current Osteoporosis Reports
Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
8.80
自引率
2.30%
发文量
44
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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