Relationship of Aging, Inflammation, and Skeletal Stem Cells and Their Effects on Fracture Repair.

IF 5.3 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Current Osteoporosis Reports Pub Date : 2022-10-01 Epub Date: 2022-09-21 DOI:10.1007/s11914-022-00742-x

L Henry Goodnough, Stuart B Goodman

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引用次数: 7

Abstract

Purpose of review: This review summarizes recent investigations into the cellular and molecular effects of skeletal aging on the inflammatory response and stem cell function after fracture.

Recent findings: Proper regulation of the inflammatory phase of fracture healing is essential. Aging is associated with chronic inflammation, which inhibits bone formation and promotes bone resorption. Osteogenic differentiation and anti-senescence pathways in skeletal stem cells are impaired in geriatric fractures. As the population ages, fragility fractures will continue to represent a significant clinical problem, which will require innovative clinical solutions. Skeletal stem cells in geriatric individuals demonstrate defects in anti-senescence pathways that lead to impaired osteogenic differentiation in vitro in humans. Small molecule-based therapies can partially reverse the aging phenotype. In the future, molecular- or cell-based therapies modulating either inflammatory cells or skeletal stem cells represent potential therapeutic targets to augment contemporary fracture healing interventions in osteoporotic or aging individuals.

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衰老、炎症和骨骼干细胞的关系及其对骨折修复的影响。

综述目的:本文综述了近年来骨骼老化对骨折后炎症反应和干细胞功能的细胞和分子影响的研究进展。最近的研究发现:适当调节骨折愈合的炎症期是必不可少的。衰老与慢性炎症有关，慢性炎症会抑制骨形成并促进骨吸收。骨干细胞的成骨分化和抗衰老途径在老年骨折中受损。随着人口老龄化，脆性骨折将继续是一个重要的临床问题，这将需要创新的临床解决方案。老年个体的骨骼干细胞在抗衰老途径中表现出缺陷，导致体外人类成骨分化受损。基于小分子的治疗可以部分逆转衰老表型。在未来，调节炎症细胞或骨骼干细胞的分子或细胞疗法代表了潜在的治疗靶点，以增加当代骨质疏松症或衰老个体的骨折愈合干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

8.80

自引率

2.30%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.