The Impacts of COVID-19 on Musculoskeletal Health.

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Current Osteoporosis Reports Pub Date : 2022-08-01 Epub Date: 2022-06-20 DOI:10.1007/s11914-022-00734-x

Olatundun D Awosanya, Ushashi C Dadwal, Erik A Imel, Qigui Yu, Melissa A Kacena

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Abstract

Purpose of review: Although COVID-19 was originally characterized as a respiratory disease, recent findings have shown lingering side effects in those who have recovered, and much is still unknown about the long-term consequences of the illness. Thus, the potential of unearthing multi-system dysfunction is high, with current data revealing significant impacts on musculoskeletal health.

Recent findings: Multiple animal models of COVID-19 infection have revealed significant post-infection bone loss at several different skeletal sites. While how this loss occurred is unknown, this current review discusses the primary bone loss studies, and examines the possible mechanisms of action including: direct infection of bone marrow macrophages or hematopoietic progenitors, a proinflammatory response as a result of the COVID-19 induced cytokine storm, and/or a result of hypoxia and oxidative stress. This review will further examine how therapeutics used to treat COVID-19 affect the skeletal system. Finally, this review will examine the possible consequence that delayed care and limited healthcare accessibility has on musculoskeletal-related patient outcomes. It is important to investigate the potential impact COVID-19 infection has on musculoskeletal health.

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COVID-19 对肌肉骨骼健康的影响。

审查目的：尽管 COVID-19 最初被定性为一种呼吸系统疾病，但最近的研究结果表明，该病对已康复者的副作用挥之不去，而且该病的长期后果仍有许多未知数。因此，发现多系统功能障碍的可能性很大，目前的数据显示，这种疾病对肌肉骨骼健康有重大影响：多种感染 COVID-19 的动物模型显示，感染后多个不同骨骼部位的骨质明显流失。虽然骨质流失是如何发生的尚不清楚，但本综述讨论了主要的骨质流失研究，并探讨了可能的作用机制，包括：骨髓巨噬细胞或造血祖细胞的直接感染、COVID-19 诱导的细胞因子风暴导致的促炎反应和/或缺氧及氧化应激的结果。本综述将进一步探讨用于治疗 COVID-19 的疗法如何影响骨骼系统。最后，本综述将探讨延迟治疗和有限的医疗可及性对肌肉骨骼相关患者预后可能造成的影响。研究 COVID-19 感染对肌肉骨骼健康的潜在影响非常重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

8.80

自引率

2.30%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.