Musculoskeletal Deficits and Cognitive Impairment: Epidemiological Evidence and Biological Mechanisms.

IF 5.3 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Current Osteoporosis Reports Pub Date : 2022-10-01 Epub Date: 2022-06-29 DOI:10.1007/s11914-022-00736-9

Sophia X Sui, Julián Balanta-Melo, Julie A Pasco, Lilian I Plotkin

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引用次数: 4

Abstract

Purpose of review: Cognitive impairment is associated with obesity, sarcopenia, and osteoporosis. However, no critical appraisal of the literature on the relationship between musculoskeletal deficits and cognitive impairment, focusing on the epidemiological evidence and biological mechanisms, has been published to date. Herein, we critically evaluate the literature published over the past 3 years, emphasizing interesting and important new findings, and provide an outline of future directions that will improve our understanding of the connections between the brain and the musculoskeletal system.

Recent findings: Recent literature suggests that musculoskeletal deficits and cognitive impairment share pathophysiological pathways and risk factors. Cytokines and hormones affect both the brain and the musculoskeletal system; yet, lack of unified definitions and standards makes it difficult to compare studies. Interventions designed to improve musculoskeletal health are plausible means of preventing or slowing cognitive impairment. We highlight several musculoskeletal health interventions that show potential in this regard.

Abstract Image

查看原文本刊更多论文

肌肉骨骼缺陷和认知障碍:流行病学证据和生物学机制。

综述目的:认知障碍与肥胖、肌肉减少症和骨质疏松症有关。然而，迄今为止，还没有对肌肉骨骼缺陷和认知障碍之间关系的文献进行批判性评估，重点关注流行病学证据和生物学机制。在此，我们批判性地评估过去3年发表的文献，强调有趣和重要的新发现，并提供未来方向的概述，这将提高我们对大脑和肌肉骨骼系统之间联系的理解。最近的发现:最近的文献表明，肌肉骨骼缺陷和认知障碍具有共同的病理生理途径和危险因素。细胞因子和激素影响大脑和肌肉骨骼系统;然而，由于缺乏统一的定义和标准，使得比较研究变得困难。旨在改善肌肉骨骼健康的干预措施是预防或减缓认知障碍的合理手段。我们强调了在这方面显示潜力的几种肌肉骨骼健康干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

8.80

自引率

2.30%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.