Weight Loss Interventions and Skeletal Health in Persons with Diabetes.

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Current Osteoporosis Reports Pub Date : 2022-10-01 Epub Date: 2022-08-30 DOI:10.1007/s11914-022-00744-9

Qi Zhao, Sonal V Khedkar, Karen C Johnson

{"title":"Weight Loss Interventions and Skeletal Health in Persons with Diabetes.","authors":"Qi Zhao, Sonal V Khedkar, Karen C Johnson","doi":"10.1007/s11914-022-00744-9","DOIUrl":null,"url":null,"abstract":"Purpose of review: Weight loss is recommended for improving glycemic control and reducing cardiovascular risk factors in persons with diabetes. However, both diabetes and weight loss have been associated with detrimental skeletal health. This review aims to summarize recent study findings on the effects of lifestyle interventions for weight loss on skeletal health among persons with type 2 diabetes (T2D).Recent findings: A few large-scale observational studies have demonstrated an increased fragility fracture risk associated with weight loss among persons with T2D. Randomized control trials in persons with T2D also have shown that intentional lifestyle interventions for weight loss are associated with a greater decrease in bone mineral density (BMD) and an increase in the risk of fracture. The biological mechanisms underlying the compromised bone health during lifestyle interventions for weight loss are complex and not yet conclusive. However, there is evidence to suggest that bone loss and increased fracture risk during intentional weight loss may be mitigated by some intervention approaches, such as high protein intake, calcium supplementation, and resistance and balance training. There is still a lack of studies investigating the effects of different interventions for weight loss on skeletal health among persons with T2D. However, certain types of diet and physical activity intervention combined with bone monitoring and fracture risk prediction may help achieve weight loss goals and maintain skeletal health among persons with T2D during intentional weight loss.","PeriodicalId":11080,"journal":{"name":"Current Osteoporosis Reports","volume":"20 5","pages":"240-248"},"PeriodicalIF":4.2000,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522834/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Osteoporosis Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11914-022-00744-9","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/8/30 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose of review: Weight loss is recommended for improving glycemic control and reducing cardiovascular risk factors in persons with diabetes. However, both diabetes and weight loss have been associated with detrimental skeletal health. This review aims to summarize recent study findings on the effects of lifestyle interventions for weight loss on skeletal health among persons with type 2 diabetes (T2D).

Recent findings: A few large-scale observational studies have demonstrated an increased fragility fracture risk associated with weight loss among persons with T2D. Randomized control trials in persons with T2D also have shown that intentional lifestyle interventions for weight loss are associated with a greater decrease in bone mineral density (BMD) and an increase in the risk of fracture. The biological mechanisms underlying the compromised bone health during lifestyle interventions for weight loss are complex and not yet conclusive. However, there is evidence to suggest that bone loss and increased fracture risk during intentional weight loss may be mitigated by some intervention approaches, such as high protein intake, calcium supplementation, and resistance and balance training. There is still a lack of studies investigating the effects of different interventions for weight loss on skeletal health among persons with T2D. However, certain types of diet and physical activity intervention combined with bone monitoring and fracture risk prediction may help achieve weight loss goals and maintain skeletal health among persons with T2D during intentional weight loss.

Abstract Image

查看原文本刊更多论文

糖尿病患者的减肥干预和骨骼健康。

回顾的目的：建议糖尿病患者减轻体重，以改善血糖控制和减少心血管风险因素。然而，糖尿病和减肥都与有害骨骼健康有关。本综述旨在总结近期关于减肥生活方式干预对 2 型糖尿病（T2D）患者骨骼健康影响的研究结果：一些大规模的观察性研究表明，体重减轻会增加 2 型糖尿病患者发生脆性骨折的风险。对 2 型糖尿病患者进行的随机对照试验也表明，为减轻体重而有意采取的生活方式干预措施与骨矿物质密度（BMD）的大幅下降和骨折风险的增加有关。减肥生活方式干预期间骨健康受损的生物机制十分复杂，目前尚无定论。不过，有证据表明，一些干预方法，如高蛋白摄入、钙补充、阻力和平衡训练等，可减轻有意减肥期间的骨质流失和骨折风险增加。目前仍缺乏有关不同减肥干预措施对 T2D 患者骨骼健康影响的研究。不过，某些类型的饮食和体育锻炼干预措施与骨监测和骨折风险预测相结合，可能有助于实现减肥目标，并在有意减肥期间保持 T2D 患者的骨骼健康。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

8.80

自引率

2.30%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.