Dermatology Reports最新文献_第7页

Pregnancy and lactation during anifrolumab treatment in systemic lupus erythematosus. 全身性红斑狼疮治疗期间的妊娠和哺乳期。

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Dermatology Reports Pub Date : 2026-07-14 DOI: 10.4081/dr.2026.10921

Maria Bernardette Cilona, Giovanni Paolino, Luca Moroni, Giuseppe Alvise Ramirez, Federica Pasi, Eleonora Sabetta, Antonella Poloniato, Federica Barzaghi, Maria Teresa Castiglioni, Valentina Canti

引用次数: 0

Solitary hemorrhagic cutaneous mastocytoma of infancy with digital localization: a case report. 婴幼儿单发出血性皮肤肥大细胞瘤伴指位定位1例。

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Dermatology Reports Pub Date : 2026-07-08 DOI: 10.4081/dr.2026.10834

Filomena Barbato, Luca Damiani, Francesca Gaudiello, Melissa Iandolo, Giovanni Calandriello, Gaetano Licata, Caterina Mariarosaria Giorgio

{"title":"Solitary hemorrhagic cutaneous mastocytoma of infancy with digital localization: a case report.","authors":"Filomena Barbato, Luca Damiani, Francesca Gaudiello, Melissa Iandolo, Giovanni Calandriello, Gaetano Licata, Caterina Mariarosaria Giorgio","doi":"10.4081/dr.2026.10834","DOIUrl":"https://doi.org/10.4081/dr.2026.10834","url":null,"abstract":"Solitary cutaneous mastocytoma is the most common form of pediatric cutaneous mastocytosis and usually follows a benign, self-limited course. However, atypical clinical presentations such as hemorrhagic or bullous evolution and uncommon anatomical localization may raise diagnostic concerns and lead to unnecessary investigations. We report the case of a male infant presenting with a solitary hemorrhagic mastocytoma localized on a finger. The lesion showed episodic blistering and hemorrhage after minimal mechanical stimulation, without systemic symptoms. Dermoscopic examination revealed a structureless erythematous-violaceous background without melanocytic features. Histopathological analysis demonstrated a dense dermal mast cell infiltrate with strong CD117 and CD25 expression, confirming the diagnosis. Conservative management resulted in spontaneous regression without sequelae. This case highlights the importance of clinicopathological correlation in recognizing atypical presentations of solitary mastocytoma and avoiding misdiagnosis and overtreatment.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful treatment of disseminated post-burn pyogenic granuloma with systemic corticosteroid: a case report. 全身皮质类固醇成功治疗弥散性烧伤后化脓性肉芽肿1例。

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Dermatology Reports Pub Date : 2026-07-07 DOI: 10.4081/dr.2026.10346

Tara Barat, Nader Pazyar, Narges Eslami, Elmira Esmizadeh

引用次数: 0

Pilot study of topical management of folliculitis: clinical outcomes and safety in routine practice. 毛囊炎局部治疗的初步研究：临床结果和常规实践的安全性。

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Dermatology Reports Pub Date : 2026-07-06 DOI: 10.4081/dr.2026.10810

Meda-Elena Stefancu, Dionisio Franco Barattini, Ionel Botnaru, Carmen Vizman, Luca Stucchi, Luca Barattini

{"title":"Pilot study of topical management of folliculitis: clinical outcomes and safety in routine practice.","authors":"Meda-Elena Stefancu, Dionisio Franco Barattini, Ionel Botnaru, Carmen Vizman, Luca Stucchi, Luca Barattini","doi":"10.4081/dr.2026.10810","DOIUrl":"https://doi.org/10.4081/dr.2026.10810","url":null,"abstract":"Folliculitis is a common inflammatory skin condition for which non-antibiotic topical management options remain limited. This pilot study reports clinical performance, safety, and feasibility data from the use of a medical device gel containing hyaluronic acid (HA) and hydrogen peroxide used in dermatologic practice. Adults aged 18-45 years with a diagnosis of folliculitis applied the gel for 8 weeks according to the instructions for use. Clinical outcomes included lesion count, Total Severity Score (TSS), Investigator Global Assessment of Performance (IGAP), patient satisfaction, and Dermatology Life Quality Index (DLQI). Safety was assessed through adverse event (AE) reporting. Thirteen patients (mean age 30.1±7.7 years) were included. Enrollment rate and study conduct supported the feasibility of a future comparative trial. From baseline to week 8, mean lesion count showed a three-fold reduction, accompanied by a 66.6% improvement in TSS. Investigator- and patient-reported assessments indicated consistent clinical improvement with a positive impact on quality of life. Two mild and transient local effects were reported. Overall, these preliminary observations suggest favorable safety and performance of the gel in routine folliculitis management and support further controlled studies.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melanocytic nevi in the genital area: dermoscopic clues to diagnosis. 生殖区域黑素细胞痣：皮肤镜诊断线索。

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Dermatology Reports Pub Date : 2026-07-06 DOI: 10.4081/dr.2026.10927

Vincenzo De Giorgi, Giovanni Cecchi, Sara Simi, Elisabetta Magnaterra, Gabriella Perillo, Federica Fazzari, Daniela Massi, Biancamaria Zuccaro

{"title":"Melanocytic nevi in the genital area: dermoscopic clues to diagnosis.","authors":"Vincenzo De Giorgi, Giovanni Cecchi, Sara Simi, Elisabetta Magnaterra, Gabriella Perillo, Federica Fazzari, Daniela Massi, Biancamaria Zuccaro","doi":"10.4081/dr.2026.10927","DOIUrl":"https://doi.org/10.4081/dr.2026.10927","url":null,"abstract":"Benign melanocytic nevi on genital mucosal or semimucosal sites may show clinical and dermoscopic atypia, often leading to biopsy. We retrospectively reviewed histologically confirmed genital melanocytic nevi diagnosed at the University of Florence (Italy) between January 2005 and December 2022 in patients aged ≥14 years. Forty-three patients were included (14 males, 29 females; median age 34 years). Lesions were more common on vulvar than penile sites, especially the labia minora and glans. Two predominant global dermoscopic patterns were present in 40 lesions (93%): a comet pattern in 25 (58%), characterized by a darker, densely structured \"head\" (most commonly linear pigmentation and/or globules, sometimes with a blue hue) and a less pigmented \"tail\", and a globular pattern in 15 (35%), characterized by large, well-defined blue-to-black clods/globules with uniform pigmentation; 3 lesions (7%) had a nonspecific pattern. Recognition of these benign patterns, together with attention to melanoma-associated mucosal clues, may support more confident assessment and management of genital pigmented lesions.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Full-length 16S rRNA metabarcoding characterization of facial skin microbiota in acne patients: a case study in the Mekong Delta of Viet Nam. 痤疮患者面部皮肤微生物群的全长16S rRNA元条形码特征：以越南湄公河三角洲地区为例

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Dermatology Reports Pub Date : 2026-06-29 DOI: 10.4081/dr.2026.10643

Xuong Mau Tu, Pha Thi Nguyen, Thanh Ngoc Nguyen, Lieu Thuy Thi Nguyen, Dung Ngoc Tran, Phong Xuan Huynh

{"title":"Full-length 16S rRNA metabarcoding characterization of facial skin microbiota in acne patients: a case study in the Mekong Delta of Viet Nam.","authors":"Xuong Mau Tu, Pha Thi Nguyen, Thanh Ngoc Nguyen, Lieu Thuy Thi Nguyen, Dung Ngoc Tran, Phong Xuan Huynh","doi":"10.4081/dr.2026.10643","DOIUrl":"https://doi.org/10.4081/dr.2026.10643","url":null,"abstract":"Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit in which skin microbiome dysbiosis plays a key pathogenic role. This study, based on full-length 16S rRNA gene amplicon sequencing (V1-V9), characterized facial microbial diversity in 45 participants classified as healthy (n=15), mild acne (n=15), and moderate-severe acne (n=15), using pooled samples for downstream microbiome analyses. Samples from the skin surface and sebaceous follicles were analyzed by 16S rRNA (V1-V9) sequencing using Illumina MiniSeq and processed via QIIME2. Alpha diversity (observed taxa, Shannon index), beta diversity (Bray-Curtis dissimilarity, permutational multivariate analysis of variance [PERMANOVA]), and biomarker taxa (linear discriminant analysis effect size [LEfSe]) were assessed. Bacillota, mainly Staphylococcus spp., predominated on the skin surface, with relative abundance increasing with acne severity, whereas follicles were dominated by Cutibacterium acnes (Actinomycetota). Follicular samples showed lower richness and Shannon diversity than surface samples, though intergroup differences were not significant. Principal coordinates analysis (PCoA) explained >65% of variation, revealing greater dispersion among surface communities but no clear clustering by severity (PERMANOVA p>0.3). LEfSe identified distinct bacterial biomarkers across clinical groups. Overall, site-specific microbial shifts - particularly C. acnes and Staphylococcus dysbiosis - appear central to acne development, suggesting microbiome-targeted interventions as potential therapeutic strategies.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperbaric oxygen therapy in the reconstruction of giant rhinophyma: a case series. 高压氧治疗在巨大鼻肿重建中的应用：一个病例系列。

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Dermatology Reports Pub Date : 2026-06-29 DOI: 10.4081/dr.2026.10365

Mendy Hatibie Oley, Maximillian Christian Oley, Vania Sukarno, Stevy Chrisye Suoth, Muhammad Faruk

{"title":"Hyperbaric oxygen therapy in the reconstruction of giant rhinophyma: a case series.","authors":"Mendy Hatibie Oley, Maximillian Christian Oley, Vania Sukarno, Stevy Chrisye Suoth, Muhammad Faruk","doi":"10.4081/dr.2026.10365","DOIUrl":"https://doi.org/10.4081/dr.2026.10365","url":null,"abstract":"Rhinophyma is a progressive, disfiguring form of rosacea that affects the nasal soft tissues and leads to functional and cosmetic challenges. Surgical excision is the primary treatment, but healing can be complicated by scarring, infection, and graft failure, especially in extensive lesions. Hyperbaric oxygen therapy (HBOT) has been suggested as an adjunctive treatment to enhance healing, reduce inflammation, and improve skin-graft survival. This case series presents three patients with giant rhinophyma who underwent surgical excision, with one requiring a split-thickness skin graft (STSG). Postoperatively, HBOT sessions (90 minutes at 2.4 atmospheres absolute [ATA]) were administered for 5-10 days, depending on the lesion severity. All patients demonstrated excellent healing with complete epithelialization and no evidence of hypertrophic scarring or short-term recurrence. HBOT contributed to faster recovery, improved skin-graft survival, and enhanced cosmetic outcomes. These findings suggest that HBOT is a promising adjunct in the surgical management of rhinophyma, although larger studies are required to validate its efficacy.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Line-field confocal optical coherence tomography for biopsy-site selection and treatment monitoring in plaque morphea. 线场共聚焦光学相干断层扫描在斑块斑块活检部位选择和治疗监测中的应用。

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Dermatology Reports Pub Date : 2026-06-25 DOI: 10.4081/dr.2026.10923

Giuseppe P A Gemma, Carolina Dall'Ara, Mirella Scattone, Marco Virone, Roberta De Carolis, Luca Gargano, Luca Fania, Andrea Ascione, Giovanni Pellacani, Camilla Chello

引用次数: 0

Comparison of the effectiveness of 30% Aloe vera cream and 20% urea cream as topical treatment for xerosis cutis in chronic kidney disease: a randomized clinical trial. 30%芦荟乳膏和20%尿素乳膏局部治疗慢性肾病皮肤干燥症的疗效比较：一项随机临床试验。

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Dermatology Reports Pub Date : 2026-06-24 DOI: 10.4081/dr.2026.10496

Nur Hikmah Fajriani, Khairuddin Djawad, Farida Tabri, Andi Alfian Zainuddin, Haerani Rasyid, Widya Widita

{"title":"Comparison of the effectiveness of 30% Aloe vera cream and 20% urea cream as topical treatment for xerosis cutis in chronic kidney disease: a randomized clinical trial.","authors":"Nur Hikmah Fajriani, Khairuddin Djawad, Farida Tabri, Andi Alfian Zainuddin, Haerani Rasyid, Widya Widita","doi":"10.4081/dr.2026.10496","DOIUrl":"https://doi.org/10.4081/dr.2026.10496","url":null,"abstract":"Xerosis is a prevalent skin disorder among patients with chronic kidney disease (CKD) undergoing hemodialysis (HD). While both Aloe vera cream 30% and urea cream 20% have been shown to improve skin hydration in cases of xerosis cutis, direct comparisons between the two are limited. This study aims to compare the effectiveness of both creams in treating xerosis cutis in patients with chronic kidney disease on hemodialysis (CKD-HD). A randomized controlled trial was conducted involving 35 eligible CKD-HD patients. Each patient received either urea cream 20% or A. vera cream 30%, which was applied to both their left and right arms. Skin moisture was assessed weekly using corneometer readings and overall dry skin (ODS) scores over 4 weeks. The present study reveals that both treatments significantly increased corneometer readings and decreased ODS scores compared to baseline (p<0.05), but no significant difference was found between the two creams (p>0.05). In conclusion, A. vera cream 30% and urea cream 20% demonstrate similar effectiveness in improving skin moisture for patients with xerosis cutis associated with CKD-HD.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148307469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cohort study of obese patients with moderate-to-severe psoriasis using biological medicines in Catalonia, Spain. 一项在西班牙加泰罗尼亚使用生物药物治疗中重度牛皮癣的肥胖患者的队列研究。

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Dermatology Reports Pub Date : 2026-06-23 DOI: 10.4081/dr.2026.10247

Judit Riera-Arnau, Daniel Wang, Jordi Mollet, Lucía Bellas, Ricardo Boy, Carlos González-Cruz, Mònica Sabaté, Elena Ballarín, Vicenç García-Patos, Glòria Aparicio

{"title":"A cohort study of obese patients with moderate-to-severe psoriasis using biological medicines in Catalonia, Spain.","authors":"Judit Riera-Arnau, Daniel Wang, Jordi Mollet, Lucía Bellas, Ricardo Boy, Carlos González-Cruz, Mònica Sabaté, Elena Ballarín, Vicenç García-Patos, Glòria Aparicio","doi":"10.4081/dr.2026.10247","DOIUrl":"10.4081/dr.2026.10247","url":null,"abstract":"Obesity impacts both the clinical management and therapeutic strategies for psoriasis. This study aims to describe the use of biological medicines in treating obese patients with moderate-to-severe psoriasis. We conducted a retrospective cohort study (2007-2022) of obese patients who initiated biological treatments for moderate-severe psoriasis. The primary outcome was the number of biological treatment lines required to achieve an optimal or adequate Psoriasis Area and Severity Index (PASI) score reduction. Secondary outcomes included the duration of biological use and reasons for discontinuation. We included 58 patients (mean age 50 years, body mass index [BMI] 35.9 kg/m2, psoriasis duration 16.5 years). Biological treatments enabled 77.6% (45) of patients to achieve an optimal response, and 87.9% (51) achieved an adequate response. The median time-to-response was 2-7 months, with the greatest improvements seen with adalimumab, etanercept, and ustekinumab. The primary reason for discontinuation was lack of effectiveness (50% of first-line treatments). This study suggests that systemic biologics are effective for obese psoriasis patients and emphasizes the need for close monitoring of reasons that lead to discontinuation. As biologics evolve, refining guidelines will be essential for optimizing psoriasis management in obese patients.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0