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Merkel cell carcinoma following photodynamic therapy in a high-risk patient. 高危患者光动力治疗后的默克尔细胞癌。
IF 1
Dermatology Reports Pub Date : 2026-06-18 DOI: 10.4081/dr.2026.10485
Francesca Polita, Massimiliano Mengarino, Valentina Carelli, Esther Hanspeter, Rosita Saraceno
{"title":"Merkel cell carcinoma following photodynamic therapy in a high-risk patient.","authors":"Francesca Polita, Massimiliano Mengarino, Valentina Carelli, Esther Hanspeter, Rosita Saraceno","doi":"10.4081/dr.2026.10485","DOIUrl":"https://doi.org/10.4081/dr.2026.10485","url":null,"abstract":"<p><p>Dear Editor, Merkel cell carcinoma (MCC) is defined as a rare but highly aggressive skin cancer originating from neuroendocrine cells. Clinically, it usually appears as a rapidly growing, solid, asymptomatic, redviolaceous nodule. Its development is primarily associated with the integration of the Merkel cell polyomavirus (MCPyV) and extended exposure to ultraviolet (UV) radiation. The disease predominantly affects older individuals with fair skin. There is an increased incidence of MCC among immunocompromised individuals, such as patients suffering from hematological malignancies. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dermatosurgical rounds: modified rhomboid transposition flap combining the Limberg and Dufourmentel techniques for reconstruction of primary defects following skin cancer excision in the zygomatic region. 皮肤外科：改良菱形转位皮瓣结合Limberg和Dufourmentel技术重建颧骨区皮肤癌切除后的原发性缺损。
IF 1
Dermatology Reports Pub Date : 2026-06-17 DOI: 10.4081/dr.2026.10953
Georgi Tchernev, Konstantin Georgiev Tchernev, Simona Kordeva
{"title":"Dermatosurgical rounds: modified rhomboid transposition flap combining the Limberg and Dufourmentel techniques for reconstruction of primary defects following skin cancer excision in the zygomatic region.","authors":"Georgi Tchernev, Konstantin Georgiev Tchernev, Simona Kordeva","doi":"10.4081/dr.2026.10953","DOIUrl":"https://doi.org/10.4081/dr.2026.10953","url":null,"abstract":"<p><p>An 82-year-old female presented to the dermatology department with a primary complaint of an achromatic tumorous lesion measuring 1.5×1.5 cm, protruding above the surrounding skin, covered with hemorrhagic crust, with irregular borders, located in the right zygomatic region. Based on the clinical presentation, squamous cell carcinoma was suspected and surgical excision under local anesthesia was recommended. Additionally, a solitary formation was observed in the right parotid region, suspected to represent a lymph node conglomerate. A lymph node biopsy has been scheduled in another department for further evaluation. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of topical sofpironium bromide in treating primary axillary hyperhidrosis: systematic review and meta-analysis of randomized controlled trials. 局部使用索匹溴铵治疗原发性腋下多汗症的疗效和安全性：随机对照试验的系统评价和荟萃分析。
IF 1.3
Dermatology Reports Pub Date : 2026-06-16 DOI: 10.4081/dr.2026.10853
Yuichiro Oshima, Takashi Hashimoto, Hiroshi Miyama, Tomoko Fujimoto
{"title":"Efficacy and safety of topical sofpironium bromide in treating primary axillary hyperhidrosis: systematic review and meta-analysis of randomized controlled trials.","authors":"Yuichiro Oshima, Takashi Hashimoto, Hiroshi Miyama, Tomoko Fujimoto","doi":"10.4081/dr.2026.10853","DOIUrl":"https://doi.org/10.4081/dr.2026.10853","url":null,"abstract":"<p><p>This systematic review and meta-analysis aimed to comprehensively evaluate the efficacy and safety of topical sofpironium bromide in patients with primary axillary hyperhidrosis (PAH) in various published randomized controlled trials (RCTs). The study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We systematically searched PubMed, Scopus, Web of Science, Embase, and Medline databases through April 30, 2025, using keywords related to sofpironium and PAH. The odds ratio (OR) or mean difference (MD) was calculated using a random effects model with 95% confidence interval (CI). Three RCTs of sofpironium were included in the meta-analysis, with 1,209 patients with PAH. Sofpironium, compared to the vehicle, showed statistically significant improvement in the Hyperhidrosis Disease Severity Measure-Axillary (HDSM-Ax) score (OR=2.35, 95% CI [1.82 to 3.04]), Hyperhidrosis Disease Severity Scale (HDSS) score (OR=2.02, [1.46 to 2.79]), Dermatology Life Quality Index (DLQI) score (MD=-2.75, [-3.58 to -1.92]), and gravimetric sweat production (MD=-26.39, [-44.65 to -8.12]). The incidences of anticholinergic adverse events (AEs) and application site AEs were statistically higher in patients treated with sofpironium. Sofpironium is an effective treatment for PAH associated with significant improvements in sweat reduction and QOL for patients, although the drug also has risks of anticholinergic or application-site AEs.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dermatosurgical pearls: the East-West advancement flap for reconstruction of primary defects following skin cancer excision in the nasal region. 皮肤外科珍珠：东西推进皮瓣重建鼻部皮肤癌切除后原发缺损。
IF 1.3
Dermatology Reports Pub Date : 2026-06-09 DOI: 10.4081/dr.2026.10938
Simona Kordeva, Konstantin Georgiev Tchernev, Georgi Tchernev
{"title":"Dermatosurgical pearls: the East-West advancement flap for reconstruction of primary defects following skin cancer excision in the nasal region.","authors":"Simona Kordeva, Konstantin Georgiev Tchernev, Georgi Tchernev","doi":"10.4081/dr.2026.10938","DOIUrl":"https://doi.org/10.4081/dr.2026.10938","url":null,"abstract":"<p><p>A 62-year-old male presented to the dermatology department with a primary complaint of an achromatic tumorous lesion protruding above the surrounding skin, with central atrophy, irregular borders, and visible telangiectasias, located on the nasal distal third, slightly toward the left nasal dorsum. Based on the clinical presentation, basal cell carcinoma was suspected and surgical excision under local anesthesia was recommended. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148203729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complete remission of keratosis lichenoides chronica with abrocitinib. 阿布替尼完全缓解慢性地衣样角化病。
IF 1.3
Dermatology Reports Pub Date : 2026-06-08 DOI: 10.4081/dr.2026.10666
Caterina Mariarosaria Giorgio, Anna Balato, Giuseppe Argenziano, Paolino Franzese, Elisabetta Fulgione, Mariateresa Cantelli, Maria Maddalena Nicoletti, Gaetano Licata
{"title":"Complete remission of keratosis lichenoides chronica with abrocitinib.","authors":"Caterina Mariarosaria Giorgio, Anna Balato, Giuseppe Argenziano, Paolino Franzese, Elisabetta Fulgione, Mariateresa Cantelli, Maria Maddalena Nicoletti, Gaetano Licata","doi":"10.4081/dr.2026.10666","DOIUrl":"https://doi.org/10.4081/dr.2026.10666","url":null,"abstract":"<p><p>Dear Editor, Keratosis lichenoides chronica (KLC), also known as Nekam's disease, is a rare and recalcitrant lichenoid dermatosis. It manifests with keratotic violaceous papules arranged in linear or reticulated patterns and typically follows a chronic and disabling course. Therapeutic guidelines are lacking, and conventional treatments - including corticosteroids, retinoids, immunosuppressants, and phototherapy - often fail to provide sustained benefit. Given its rarity, each therapeutic observation carries significant relevance. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atypical chronic leg ulcers revealing pancreatic panniculitis associated with pancreatic adenocarcinoma. 非典型慢性腿部溃疡显示胰腺胰膜炎与胰腺腺癌相关。
IF 1.3
Dermatology Reports Pub Date : 2026-06-08 DOI: 10.4081/dr.2026.10291
Sara Rovaris, Cecilia Catapano, Marina Vanturini, Paola Monari
{"title":"Atypical chronic leg ulcers revealing pancreatic panniculitis associated with pancreatic adenocarcinoma.","authors":"Sara Rovaris, Cecilia Catapano, Marina Vanturini, Paola Monari","doi":"10.4081/dr.2026.10291","DOIUrl":"https://doi.org/10.4081/dr.2026.10291","url":null,"abstract":"<p><p>Dear Editor, Pancreatic panniculitis (PP) is a rare form of lobular panniculitis associated with pancreatic disorders, including acute and chronic pancreatitis and pancreatic neoplasms. It develops in a small percentage of patients with pancreatic disease and may represent the first manifestation of an occult malignancy. Clinically, PP usually presents with painful erythematous-to-violaceous nodules on the lower extremities, which may ulcerate and discharge oily brown material secondary to liquefactive fat necrosis induced by circulating pancreatic enzymes. Because of its rarity and heterogeneous presentation, diagnosis is frequently delayed or initially misdirected toward more common inflammatory or vascular conditions. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful use of dupilumab in a patient with atopic dermatitis and autosomal dominant polycystic kidney disease: a case report. 杜匹单抗在特应性皮炎和常染色体显性多囊肾病患者中的成功应用：1例报告。
IF 1.3
Dermatology Reports Pub Date : 2026-06-04 DOI: 10.4081/dr.2026.10522
Arlind Kalaja, Barbara Cocuroccia, Donatella Sordi, Anna Dattolo, Sabatino Pallotta, Ignazio Stanganelli, Filomena Russo
{"title":"Successful use of dupilumab in a patient with atopic dermatitis and autosomal dominant polycystic kidney disease: a case report.","authors":"Arlind Kalaja, Barbara Cocuroccia, Donatella Sordi, Anna Dattolo, Sabatino Pallotta, Ignazio Stanganelli, Filomena Russo","doi":"10.4081/dr.2026.10522","DOIUrl":"https://doi.org/10.4081/dr.2026.10522","url":null,"abstract":"<p><p>This case report explores the management of a young female with both atopic dermatitis (AD) and autosomal dominant polycystic kidney disease (ADPKD), treated with dupilumab. Although these conditions are distinct, their coexistence poses clinical challenges. Dupilumab, a monoclonal antibody targeting interleukin (IL)-4 and IL-13, is effective for moderate-to-severe AD. This case highlights the safety and efficacy of dupilumab in ADPKD patients, with no adverse renal effects observed.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148155750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erythema nodosum-like panniculitis during BRAF inhibitor therapy for melanoma: never forget latent tuberculosis infection. BRAF抑制剂治疗黑素瘤期间结节样红斑炎：不要忘记潜伏性结核感染。
IF 1.3
Dermatology Reports Pub Date : 2026-06-04 DOI: 10.4081/dr.2026.10380
Alba Guglielmo, Lorenzo D'Alì, Maria Ludovica Deotto, Alessia Cimadamore, Gaetano Pascoletti, Elena Poletto, Alessandro Minisini
{"title":"Erythema nodosum-like panniculitis during BRAF inhibitor therapy for melanoma: never forget latent tuberculosis infection.","authors":"Alba Guglielmo, Lorenzo D'Alì, Maria Ludovica Deotto, Alessia Cimadamore, Gaetano Pascoletti, Elena Poletto, Alessandro Minisini","doi":"10.4081/dr.2026.10380","DOIUrl":"https://doi.org/10.4081/dr.2026.10380","url":null,"abstract":"<p><p>Dear Editor, Targeted therapies for melanoma play a pivotal role in the management of patients with advanced BRAF-mutated disease. Despite their efficacy, these treatments are associated with a spectrum of adverse events, particularly cutaneous toxicities, including photo-aggravated eruptions, increased risk of non-melanoma skin cancers, and other less frequent manifestations. Herein, we describe a clinical case and briefly review a rare and likely under-recognized adverse event: erythema nodosum (EN)-like panniculitis during BRAF inhibitor therapy. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148155771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Soft tissue chondroma of the thumb mimicking a glomus tumor. 拇指软组织软骨瘤类似于血管球瘤。
IF 1.3
Dermatology Reports Pub Date : 2026-05-29 DOI: 10.4081/dr.2026.10740
Yu Yusa, Takeshi Sawamura, Hiroyoshi Suzuki
{"title":"Soft tissue chondroma of the thumb mimicking a glomus tumor.","authors":"Yu Yusa, Takeshi Sawamura, Hiroyoshi Suzuki","doi":"10.4081/dr.2026.10740","DOIUrl":"https://doi.org/10.4081/dr.2026.10740","url":null,"abstract":"<p><p>A 28-year-old man presented with a 12-year history of a right thumbnail deformity and a two-year history of pain. Clinical examination revealed an 8×8 mm pale, reddish, tender mass beneath the posterior nail fold. The overlying nail plate was flattened. Magnetic resonance imaging (MRI) showed a well-defined lesion with homogeneous low signal intensity on T1-weighted images and high signal intensity on T2-weighted images, with marginal enhancement. Based on Carroll's classic triad - pain, localized tenderness, and cold sensitivity - and the subungual location, a glomus tumor was clinically suspected. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148053214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness and safety of topical L-ascorbic acid 15% serum compared to retinol 0.1% serum for skin aging: a double-blind randomized controlled trial study. 外用15% l -抗坏血酸血清与0.1%视黄醇血清治疗皮肤衰老的有效性和安全性：一项双盲随机对照试验研究。
IF 1.3
Dermatology Reports Pub Date : 2026-05-28 DOI: 10.4081/dr.2026.10293
Keiko Yolanda Gunardi, Endi Novianto, Triana Agustin, Dewi Friska, Githa Rahmayunitha
{"title":"Effectiveness and safety of topical L-ascorbic acid 15% serum compared to retinol 0.1% serum for skin aging: a double-blind randomized controlled trial study.","authors":"Keiko Yolanda Gunardi, Endi Novianto, Triana Agustin, Dewi Friska, Githa Rahmayunitha","doi":"10.4081/dr.2026.10293","DOIUrl":"https://doi.org/10.4081/dr.2026.10293","url":null,"abstract":"<p><p>Aging is characterized by a progressive decline in physiological functions, including skin integrity and regeneration, with visible signs of skin aging typically emerging from the fourth decade of life onward. Extrinsic factors can accelerate this process. Retinoic acid has long been used as a standard anti-aging treatment, although it is associated with various side effects. L-ascorbic acid (LAA) 15% serum has emerged as a potential alternative with minimal side effects, yet its efficacy and safety in comparison to retinol 0.1% serum remain insufficiently studied. This double-blind, split-face, randomized clinical trial aimed to evaluate the effectiveness and safety of LAA relative to retinol in treating skin aging. Using the modified Dermoscopy Photo Aging Scale (DPAS) and JANUS-III, assessments were conducted on participants' cheeks. Results indicated significant improvements in both the LAA and retinol groups at weeks 2 and 4. However, no statistically significant differences were observed between the two interventions at these time points. Both treatments demonstrated similar safety profiles, suggesting that LAA is as effective and safe as retinol for anti-aging therapy.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148041482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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