Luigi Cerbone, Alessia Garau, Tiziana Borra, Paola Barbieri, Rebecca Parisi, Claudia Leporati, Marco Ghiglione, Federica Grosso
{"title":"Spontaneous remission of Merkel cell carcinoma presenting with tertiary lymphoid structures in an immunocompetent patient.","authors":"Luigi Cerbone, Alessia Garau, Tiziana Borra, Paola Barbieri, Rebecca Parisi, Claudia Leporati, Marco Ghiglione, Federica Grosso","doi":"10.4081/dr.2026.10799","DOIUrl":"https://doi.org/10.4081/dr.2026.10799","url":null,"abstract":"<p><p>Dear Editor, Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer predominantly affecting elderly males, with a median age at diagnosis of 76 years. Its pathogenesis is linked to three main risk factors: UV exposure, Merkel cell polyomavirus (MCPyV) infection, and immunosuppression. Standard management of localized disease (stage I/II) consists of wide local excision with sentinel lymph node biopsy (SLNB), followed by adjuvant radiotherapy according to disease stage. Despite optimal multimodal treatment, prognosis remains poor, with more than 50% of patients progressing to metastatic disease and a median overall survival of approximately 20 months with first-line avelumab. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147947883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Khushhal Farooqi, Sandesh Kumar Sharma, Zarghoon Tareen, Mohammad Hashim Wafa, Ahmad Haroon Baray
{"title":"Clinical determinants of health-related quality of life in Vitiligo: a cross-sectional analysis from Kandahar, Afghanistan.","authors":"Khushhal Farooqi, Sandesh Kumar Sharma, Zarghoon Tareen, Mohammad Hashim Wafa, Ahmad Haroon Baray","doi":"10.4081/dr.2026.10828","DOIUrl":"https://doi.org/10.4081/dr.2026.10828","url":null,"abstract":"<p><p>Vitiligo substantially impairs health-related quality of life (HRQoL), yet the independent impact of clinical characteristics remains inconsistent across populations. Data from Afghanistan are limited despite potential sociocultural influences. This multicenter cross-sectional study evaluated independent associations of disease severity, activity, duration, and extent with HRQoL among 402 adults with clinically confirmed vitiligo in Kandahar. Disease severity was assessed using the Vitiligo Area Severity Index (VASI), along with anatomical extent and activity status. HRQoL was measured using the Dermatology Life Quality Index (DLQI). Multivariable linear regression analyses with robust standard errors were adjusted for age, sex, and psychological distress. The mean DLQI score was 5.1±3.0. VASI demonstrated a weak but statistically significant correlation with DLQI (r=0.135; p=0.007). Moreover, higher VASI scores independently predicted poorer HRQoL (β=0.071; p=0.008). Stable and repigmenting disease was associated with an approximately 1.18-point higher DLQI score compared with progressive disease (p<0.001). Disease duration and anatomical extent were not independent predictors. The model explained 18.4% of DLQI variance. Severity and activity were the principal correlates of HRQoL impairment.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147940632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment on effectiveness and safety of plasma radiofrequency ablation in facial and eye rejuvenation: a preliminary retrospective study.","authors":"Adone Baroni, Giuseppe Lodi","doi":"10.4081/dr.2026.10428","DOIUrl":"https://doi.org/10.4081/dr.2026.10428","url":null,"abstract":"<p><p>The eyes and facial skin play a crucial role in preserving a youthful appearance; they greatly impact the perception of freshness and vitality. Various non-invasive and invasive procedures now treat dermatochalasis and facial wrinkles, including a relatively new technique developed in the past 15 years. Plasma radiofrequency ablation, an advanced, minimally invasive technique, combines the use of plasma energy and radiofrequency to treat various skin conditions, including facial wrinkles and dermatochalasis. This treatment acts to stimulate collagen, tightening skin and improving texture, with minimal downtime and low risk of side effects. Fifteen patients with dermatochalasis and ten patients with facial wrinkles underwent plasma radiofrequency ablation treatments. It is a minimally invasive treatment for dermatochalasis and wrinkles that provides effective results with short recovery times, but it is not without risks - such as infection, post-inflammatory hyperpigmentation, or scarring - especially in patients who do not follow post-care instructions precisely. This preliminary retrospective study aims to discuss and share the authors' experiences with plasma radiofrequency ablation for the treatment of dermatochalasis and facial wrinkles.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147927507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cosimo Di Raimondo, Edoardo Mortato, Pier Paolo Di Domenico, Luca Bianchi, Marco Galluzzo
{"title":"Efficacy and safety of mogamulizumab in Sézary syndrome with concomitant Crohn's disease.","authors":"Cosimo Di Raimondo, Edoardo Mortato, Pier Paolo Di Domenico, Luca Bianchi, Marco Galluzzo","doi":"10.4081/dr.2026.10823","DOIUrl":"https://doi.org/10.4081/dr.2026.10823","url":null,"abstract":"<p><p>Dear Editor, Mogamulizumab is a humanized, defucosylated monoclonal antibody targeting CC chemokine receptor 4 (CCR4), expressed on malignant T cells in cutaneous T-cell lymphomas (CTCL), particularly mycosis fungoides and Sézary syndrome. By enhancing antibody-dependent cellular cytotoxicity, mogamulizumab selectively depletes CCR4-positive malignant lymphocytes and has demonstrated significant clinical activity in advanced CTCL, including in patients refractory to multiple prior therapies. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147927509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giovanni Paolino, Matteo Riccardo Di Nicola, Nathalie Rizzo, Santo Raffaele Mercuri
{"title":"Widespread dermoscopic alterations of multiple melanocytic nevi in a patient receiving vandetanib: implications for dermatological surveillance.","authors":"Giovanni Paolino, Matteo Riccardo Di Nicola, Nathalie Rizzo, Santo Raffaele Mercuri","doi":"10.4081/dr.2026.10851","DOIUrl":"https://doi.org/10.4081/dr.2026.10851","url":null,"abstract":"<p><p>Dear Editor, Regression-like dermoscopic and histopathological changes in pre-existing melanocytic nevi have increasingly been reported in patients undergoing modern oncologic therapies, particularly immune checkpoint inhibitors (such as ipilimumab, nivolumab, and pembrolizumab) and targeted agents including BRAF and MEK inhibitors. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147927485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dermatology ReportsPub Date : 2026-05-11Epub Date: 2025-07-11DOI: 10.4081/dr.2025.10363
Filomena Barbato, Maria Maddalena Nicoletti, Gaetano Licata, Eugenia Veronica Di Brizzi, Giuseppe Argenziano, Caterina Mariarosaria Giorgio
{"title":"Dermoscopy of kaposiform hemangioendothelioma: a case report.","authors":"Filomena Barbato, Maria Maddalena Nicoletti, Gaetano Licata, Eugenia Veronica Di Brizzi, Giuseppe Argenziano, Caterina Mariarosaria Giorgio","doi":"10.4081/dr.2025.10363","DOIUrl":"10.4081/dr.2025.10363","url":null,"abstract":"<p><p>Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor of infancy, characterized by an infiltrative, firm, and ill-defined plaque that may be associated with the Kasabach-Merritt phenomenon. While the diagnosis is primarily clinical and histopathological, dermoscopy may provide valuable insights into its microstructural features. We present the case of a newborn with congenital KHE involving the lumbar and right gluteal region, focusing on its dermoscopic characteristics. The lesion exhibited a homogeneous, grayish-blue background with no discernible vascular structures, a feature that may aid in differentiating KHE from other vascular tumors. The findings contribute to the understanding of dermoscopic patterns in KHE, highlighting its potential role in early diagnosis.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13188948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dermatology ReportsPub Date : 2026-05-11Epub Date: 2025-09-17DOI: 10.4081/dr.2025.10100
Luca Bettolini, Stefano Bighetti, Sara Rovaris, Iacopo Ghini, Vincenzo Maione
{"title":"Unusual site presentation of dermatitis herpetiformis: line-field confocal optical coherence tomography for effective management.","authors":"Luca Bettolini, Stefano Bighetti, Sara Rovaris, Iacopo Ghini, Vincenzo Maione","doi":"10.4081/dr.2025.10100","DOIUrl":"10.4081/dr.2025.10100","url":null,"abstract":"<p><p>Dermatitis herpetiformis (DH) is an uncommon autoimmune blistering skin disorder linked to gluten sensitivity. This report describes the line-field confocal optical coherence tomography (LC-OCT) features in a DH case, correlating with histopathological findings. A 60-year-old man exhibited erythematous papules and vesicles on the trunk with itching and burning, alongside alternating bowel issues. LC-OCT revealed subepidermal hypo-reflective areas with hyper-reflective floating cells at the dermal papillae tips. Histopathology showed subepidermal vesiculation and neutrophilic microabscesses, confirmed by granular IgA deposits in the dermal papillae via direct immunofluorescence (DIF). The patient tested positive for anti-tissue transglutaminase antibodies, was referred to a gastroenterologist, and began dapsone treatment, resolving the skin lesions. LC-OCT findings were consistent with histopathology, supporting its utility in diagnosing DH. Despite clinical similarities between DH and other blistering disorders, LCOCT offers a non-invasive diagnostic approach, aiding in identifying optimal biopsy sites and expediting treatment. Further studies are warranted to validate LC-OCT's potential.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dermatology ReportsPub Date : 2026-05-11Epub Date: 2025-08-18DOI: 10.4081/dr.2025.10435
Jinhao Zhang, Xiangze Meng, Yun Wang, Wei Liu
{"title":"A bibliometric study of the top 100 most-cited articles on melanoma: insights into research trends and characteristics.","authors":"Jinhao Zhang, Xiangze Meng, Yun Wang, Wei Liu","doi":"10.4081/dr.2025.10435","DOIUrl":"10.4081/dr.2025.10435","url":null,"abstract":"<p><p>Improving insights into current research and literature on melanoma enables healthcare providers to offer patients better care by applying the latest advancements. This bibliometric study analyzed the characteristics and trends in melanoma research through the top-cited articles. The top 100 most-cited articles on melanoma were published between 1969 and 2020, and the average number of citations was 36.8-893.9 (mean 176.8). Notably, the frequencies of the main key words, including antineoplastic agents, genetics, randomized controlled trials, metastatic melanoma, BRAF, and monoclonal antibodies, during 2010-2020 were significantly higher than during 1969-2009. Specifically, the main study topics after 2010 were drug research aspects, such as drug safety, drug efficacy, drug resistance, drug withdrawal, cytotoxic T lymphocyte-associated protein 4 (CTLA-4), programmed cell death 1/programmed death-ligand 1 (PD-1/PD-L1), ipilimumab, nivolumab, trametinib, dabrafenib, vemurafenib, and various drug adverse effects. The emergence of immunotherapy caused a burst of citations and substantially changed the distribution of top-cited articles.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13281541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dermatology ReportsPub Date : 2026-05-11Epub Date: 2025-07-29DOI: 10.4081/dr.2025.10477
Vincenzo Piccolo, Teresa Russo, Carlo Mazzatenta, Giuseppe Argenziano, Julia Nowowiejska, Mario Cutrone, Markus Danielsson Darlington, Aimilios Lallas, Ramon Grimalt, Andrea Bassi
{"title":"Self-induced discoloration of the face with red exogenous pigment detected by dermoscopy: a novel type of dermatitis artefacta in the COVID-19 era.","authors":"Vincenzo Piccolo, Teresa Russo, Carlo Mazzatenta, Giuseppe Argenziano, Julia Nowowiejska, Mario Cutrone, Markus Danielsson Darlington, Aimilios Lallas, Ramon Grimalt, Andrea Bassi","doi":"10.4081/dr.2025.10477","DOIUrl":"10.4081/dr.2025.10477","url":null,"abstract":"<p><p>Dear Editor, Dermatitis artefacta (DA) is a condition on the border of psychiatry and dermatology, characterized by patients intentionally causing skin lesions to pretend that they are ill. DA is a very challenging entity to diagnose, as it can mimic many other disorders and is usually recognized only after exclusion of all other diseases. Herein, we report 3 cases of a novel cutaneous condition that could fall into the spectrum of DA. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dermatology ReportsPub Date : 2026-05-11Epub Date: 2025-09-11DOI: 10.4081/dr.2025.10458
Andrea Bassi, Vincenzo Piccolo, Grazia Gallippi, Giuseppe Argenziano, Michela Magnano, Carlo Mazzatenta
{"title":"Targeting JAK/STAT signaling: ruxolitinib cream in the management of concurrent vitiligo and discoid lupus erythematosus.","authors":"Andrea Bassi, Vincenzo Piccolo, Grazia Gallippi, Giuseppe Argenziano, Michela Magnano, Carlo Mazzatenta","doi":"10.4081/dr.2025.10458","DOIUrl":"10.4081/dr.2025.10458","url":null,"abstract":"<p><p>Dear Editor, A 50-year-old Caucasian male presented with a 30-year history of facial vitiligo, primarily affecting the chin and the perioral and periorbital regions. He had undergone multiple treatments over the years, including targeted phototherapy, topical corticosteroids, and calcineurin inhibitors, with limited success. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13339905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}