Dermatology Reports最新文献_第9页

Intra-class switch among interleukin-17 inhibitors for the treatment of plaque psoriasis: a single-center experience. 白细胞介素-17抑制剂治疗斑块型银屑病的类内转换：单中心经验

IF 2.3

Dermatology Reports Pub Date : 2025-05-23 Epub Date: 2024-11-12 DOI: 10.4081/dr.2024.10080

Gioele Ghezzi, Luciano Ibba, Luigi Gargiulo, Alessandra Narcisi, Antonio Costanzo, Mario Valenti

{"title":"Intra-class switch among interleukin-17 inhibitors for the treatment of plaque psoriasis: a single-center experience.","authors":"Gioele Ghezzi, Luciano Ibba, Luigi Gargiulo, Alessandra Narcisi, Antonio Costanzo, Mario Valenti","doi":"10.4081/dr.2024.10080","DOIUrl":"10.4081/dr.2024.10080","url":null,"abstract":"Psoriasis is a chronic immune-mediated disease primarily affecting the skin. The most common subtype is plaque psoriasis, which can affect any body area, with a predilection for the knees, elbows, scalp, lumbosacral region, and genitalia. The European guidelines adopted in Italy recommend systemic therapies for moderate-to-severe psoriasis, defined by a Psoriasis Area and Severity Index (PASI) ≥10, Dermatology Life Quality Index (DLQI) ≥10, and/or Body Surface Area (BSA) ≥10. Over the past two decades, the development of biological agents has revolutionized psoriasis management, targeting specific cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-23, and IL-17. Among these, ixekizumab, secukinumab, brodalumab, and bimekizumab are approved for the treatment of moderate-to-severe plaque psoriasis. However, some patients require switching therapy because of primary/secondary ineffectiveness or side effects. We retrospectively analyzed 20 patients who had switched from one anti-IL-17 drug to another, assessing both safety and effectiveness. At baseline, the median PASI score was 10 (interquartile range [IQR] 4.5). After 16 weeks, it decreased to 2 (IQR 5.5), and after one year, it decreased further to 1 (IQR 2). Eight (40%) and six patients (30%) achieved PASI 90 and PASI 100 at 16 weeks, respectively. After one year, sustained effectiveness was observed, with PASI 90 (57.1%), PASI 100 (35.7%), and PASI≤2 (78.6%). No serious adverse events (AEs) or discontinuations due to AEs were observed during the study period. Our study confirms the safety and effectiveness of intra-class switching among IL-17 antagonists within the same class and highlights that switching between different classes of IL-17 inhibitors can be a valid option when patients fail to respond or lose effectiveness with a particular inhibitor. However, a deeper understanding requires further large-scale and long-term studies.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regenerative therapies in lichen sclerosus genitalis patients and possible efficacy in preventing squamous cell carcinoma development: a long-term follow-up pilot study. 生殖硬化地衣患者的再生治疗及其预防鳞状细胞癌发展的可能疗效：一项长期随访的初步研究。

IF 2.3

Dermatology Reports Pub Date : 2025-05-23 Epub Date: 2024-11-27 DOI: 10.4081/dr.2024.10079

Marinella Tedesco, Barbara Bellei, Lavinia Alei, Monia Di Prete, Carlo Cota, Tiziano Pallara, Antonio Bonadies, Alessandra Latini, Stefania De Fazio, Emilia Migliano

{"title":"Regenerative therapies in lichen sclerosus genitalis patients and possible efficacy in preventing squamous cell carcinoma development: a long-term follow-up pilot study.","authors":"Marinella Tedesco, Barbara Bellei, Lavinia Alei, Monia Di Prete, Carlo Cota, Tiziano Pallara, Antonio Bonadies, Alessandra Latini, Stefania De Fazio, Emilia Migliano","doi":"10.4081/dr.2024.10079","DOIUrl":"10.4081/dr.2024.10079","url":null,"abstract":"Lichen sclerosus (LS) is a chronic scleroatrophic dermatosis of unknown etiology that usually affects the anogenital area and occasionally the extragenital sites, with no definitive cure. LS patients are at higher risk of developing squamous cell carcinoma (SCC) in their lifetime compared to the general population. Through a retrospective study, we evaluated the impact of regenerative medicine-based therapies on SCC onset in the context of genital LS. Patients with LS treated at our institute from March 2013 to December 2022 were reviewed. A total of 319 patients, including 34 treated with adipose-derived stem cell (ADSCs) grafts, 31 treated with ADSCs grafts and platelet-rich plasma (PRP), and 254 treated with PRP, were identified. In parallel, data extracted from the histologic institutional database, searching for SCC in the anogenital area, were matched to surgical records. None of the 319 LS patients developed skin SCC in the anogenital area. Our data suggest that cellular and acellular therapies achieving therapeutic control prevent continuous tissue remodeling and its evolution and, therefore, neoplastic degeneration. Regenerative approaches are considered a valid strategy for treating symptomatic LS patients despite prolonged first-line medical treatment. Studying the genital carcinogenesis of LS cases, we reported for the first time a protective role of PRP, ADSCs, and combined therapies. Thus, in terms of cancer prevention, we propose that regenerative therapies ameliorating disease control in non-responders to conventional therapy represent an important innovative tool.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatitis artefacta: a challenging diagnosis. 人工皮炎：一个具有挑战性的诊断。

IF 2.3

Dermatology Reports Pub Date : 2025-05-23 Epub Date: 2024-11-29 DOI: 10.4081/dr.2024.10014

Giulia Ciccarese, Giorgia Salvia, Cristian Fidanzi, Mario Mastrolonardo, Francesco Drago

引用次数: 0

Emergency consultations in pediatric dermatology at a children's hospital in Saudi Arabia. 沙特阿拉伯一家儿童医院的儿科皮肤科急诊会诊。

IF 2.3

Dermatology Reports Pub Date : 2025-05-23 Epub Date: 2024-10-28 DOI: 10.4081/dr.2024.10030

Rawan AlDosari, Latifah Albrahim, Abeer Alkhodier, Rayan Alkhodair, Mohammed AlJasser

引用次数: 0

Application of ChatGPT as a content generation tool in continuing medical education: acne as a test topic. ChatGPT作为内容生成工具在继续医学教育中的应用：痤疮作为测试主题。

IF 2.3

Dermatology Reports Pub Date : 2025-05-23 Epub Date: 2024-11-28 DOI: 10.4081/dr.2024.10138

Luigi Naldi, Vincenzo Bettoli, Eugenio Santoro, Maria Rosa Valetto, Anna Bolzon, Fortunato Cassalia, Simone Cazzaniga, Sergio Cima, Andrea Danese, Silvia Emendi, Monica Ponzano, Nicoletta Scarpa, Pietro Dri

{"title":"Application of ChatGPT as a content generation tool in continuing medical education: acne as a test topic.","authors":"Luigi Naldi, Vincenzo Bettoli, Eugenio Santoro, Maria Rosa Valetto, Anna Bolzon, Fortunato Cassalia, Simone Cazzaniga, Sergio Cima, Andrea Danese, Silvia Emendi, Monica Ponzano, Nicoletta Scarpa, Pietro Dri","doi":"10.4081/dr.2024.10138","DOIUrl":"10.4081/dr.2024.10138","url":null,"abstract":"The large language model (LLM) ChatGPT can answer open-ended and complex questions, but its accuracy in providing reliable medical information requires a careful assessment. As part of the AI-CHECK (Artificial Intelligence for CME Health E-learning Contents and Knowledge) study, aimed at evaluating the potential of ChatGPT in continuous medical education (CME), we compared ChatGPT-generated educational content to the recommendations of the National Institute for Health and Care Excellence (NICE) guidelines on acne vulgaris. ChatGPT version 4 was exposed to a 23-item questionnaire developed by an experienced dermatologist. A panel of five dermatologists rated the answers positively in terms of \"quality\" (87.8%), \"readability\" (94.8%), \"accuracy\" (75.7%), \"thoroughness\" (85.2%), and \"consistency\" with guidelines (76.8%). The references provided by ChatGPT obtained positive ratings for \"pertinence\" (94.6%), \"relevance\" (91.2%), and \"update\" (62.3%). The internal reproducibility was adequate both for answers (93.5%) and references (67.4%). Answers related to issues of uncertainty and/or controversy in the scientific community scored the lowest. This study underscores the need to develop rigorous evaluation criteria for AI-generated medical content and for expert oversight to ensure accuracy and guideline adherence.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and dermoscopic assessment of angiosarcoma: a diagnostic classification for early detection. 血管肉瘤的临床和皮肤镜评估：早期发现的诊断分类。

IF 2.3

Dermatology Reports Pub Date : 2025-05-23 DOI: 10.4081/dr.2025.10132

Vincenzo De Giorgi, Biancamaria Zuccaro, Giovanni Cecchi, Gabriella Perillo, Ignazio Stanganelli, Piero Covarelli

{"title":"Clinical and dermoscopic assessment of angiosarcoma: a diagnostic classification for early detection.","authors":"Vincenzo De Giorgi, Biancamaria Zuccaro, Giovanni Cecchi, Gabriella Perillo, Ignazio Stanganelli, Piero Covarelli","doi":"10.4081/dr.2025.10132","DOIUrl":"https://doi.org/10.4081/dr.2025.10132","url":null,"abstract":"Cutaneous and mucosal angiosarcoma (CMA) is a rare and aggressive tumor of vascular endothelial cells that can occur in any body site, including the skin and mucosa. A history of radiation and chronic lymphedema are well-established risk factors, but the causes of sporadic CMA are less clear. Dermoscopy has emerged as a useful noninvasive tool that can aid in diagnosing cutaneous tumors, including CMA, by providing magnified images of the skin surface and subsurface structures. However, to date, little is known about the dermoscopic patterns of CMA. This study aimed to evaluate the clinical and dermatoscopic features of CMA in order to create a classification that can be useful in the early diagnosis of this rare but fearful tumor. A descriptive, retrospective analysis was conducted on the clinical and dermoscopic characteristics of histopathologically confirmed cases of CMA. The study population consisted of ten patients with a histologically confirmed diagnosis of CMA, including six males (60%) and four females (40%). By analyzing our cases clinically and dermoscopically, we classify them into three configurations to facilitate an early and more accurate diagnosis: melanoma-like pattern, benign vascular-like pattern (both cutaneous and mucosal), and inflammatory-like pattern. The identification of CMA poses a diagnostic dilemma for clinicians, as its clinical presentation often overlaps with other benign and malignant dermatological conditions. Dermoscopy, although it does not provide specific or pathognomonic parameters, may improve the diagnostic accuracy of these lesions in conjunction with clinical and histological features. For the first time in the literature, we have attempted to classify the extreme clinical and dermoscopic polymorphism of angiosarcoma by describing three patterns that can be extremely useful for achieving an early and accurate diagnosis of this fearsome and aggressive tumor.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nightmares caused by isotretinoin in treating hidradenitis suppurativa: a case report and clinical insights. 异维甲酸治疗化脓性汗腺炎致恶梦1例报告及临床观察。

IF 2.3

Dermatology Reports Pub Date : 2025-05-23 Epub Date: 2024-12-06 DOI: 10.4081/dr.2024.10171

Fawaz Aljehani, Shumukh Alqahtani, Sara Alharbi, Seham Alsulami

引用次数: 0

A delayed Tenzel flap. 一个延迟的腾泽尔扇动。

IF 2.3

Dermatology Reports Pub Date : 2025-05-23 Epub Date: 2024-11-18 DOI: 10.4081/dr.2024.10151

Francesca Falcinelli, Giovanni Rubegni, Ernesto De Piano

引用次数: 0

Pediatric genital warts successfully treated with photodynamic therapy. 小儿生殖器疣成功治疗光动力疗法。

IF 2.3

Dermatology Reports Pub Date : 2025-05-23 Epub Date: 2024-11-04 DOI: 10.4081/dr.2024.9979

Federica Li Pomi, Andrea D'Aloja, Antonio Di Tano, Mario Vaccaro, Francesco Borgia

引用次数: 0

Increased serum interleukin-31 levels correlate with pruritus in psoriatic patients: a cross-sectional study in Vietnam. 血清白细胞介素-31水平升高与银屑病患者瘙痒相关：越南横断面研究

IF 2.3

Dermatology Reports Pub Date : 2025-05-23 Epub Date: 2024-11-27 DOI: 10.4081/dr.2024.10090

Chuyen Thi Hong Nguyen, Liem Viet Quoc Tran

{"title":"Increased serum interleukin-31 levels correlate with pruritus in psoriatic patients: a cross-sectional study in Vietnam.","authors":"Chuyen Thi Hong Nguyen, Liem Viet Quoc Tran","doi":"10.4081/dr.2024.10090","DOIUrl":"10.4081/dr.2024.10090","url":null,"abstract":"Psoriasis is recognized not only as a skin disease but also as a systemic disorder. Interleukin-31 (IL-31) may be associated with psoriasis and systemic inflammation. We aimed to quantify serum IL-31 levels in patients with psoriasis and explore their associations with specific clinical manifestations. Thirty patients with psoriasis and 30 healthy controls were included in this study. Demographic information and clinical characteristics were obtained through physical examination and medical history review. Serum IL-31 levels were measured using an enzyme-linked immunosorbent assay. IL-31 concentration was significantly higher in patients with psoriasis than those in the control group (p<0.001). Patients with psoriasis vulgaris, psoriasis erythroderma, and pustular psoriasis had significantly higher serum IL-31 levels than healthy controls. Additionally, serum IL-31 levels were associated with itch numerical rating scale (NRS) scores and body mass index (BMI) but not with disease severity as measured by the Psoriasis Area and Severity Index (PASI). In patients with psoriasis, increased serum IL-31 levels correlated with itch severity but not with PASI. This suggests that IL-31 may play a critical role in the pathogenesis of psoriasis and could be a valuable target for further studies and therapeutic interventions.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0