Dermatology Reports最新文献

{"title":"Real-world experience with vismodegib and sonidegib in advanced basal cell carcinoma: a multicenter Italian study.","authors":"Mario Valenti, Sara Di Giulio, Andrea Carugno, Pasquale Frascione, Angelo Valerio Marzano, Santo Raffaele Mercuri, Gianluca Nazzaro, Giulia Spallone, Giovanni Paolino, Marco Ardigò","doi":"10.4081/dr.2025.10196","DOIUrl":"https://doi.org/10.4081/dr.2025.10196","url":null,"abstract":"<p><p>Vismodegib and sonidegib are smoothened (SMO) inhibitors approved for the treatment of advanced basal cell carcinoma (aBCC). This study investigates the real-world experiences and outcomes associated with these therapies across multiple Italian centers. A retrospective, observational, multicenter study was conducted. Medical records of patients with local advanced basal cell carcinoma (laBCC) treated with SMO inhibitors outside of clinical trials from July 2019 to April 2024 were analyzed. A total of 57 patients were included in the study, with 19 (33.3%) receiving vismodegib and 38 (66.7%) receiving sonidegib. Vismodegib demonstrated a complete response (CR) in 31.6% of cases and a partial response (PR) in 26.3%. Sonidegib achieved a CR of 47.4% and a PR of 36.8%. The median treatment duration was 8 months for vismodegib and 12 months for sonidegib. Adverse events were more frequently reported with vismodegib. Treatment interruption due to adverse events occurred in 47.4% of vismodegib recipients and in 13.2% of those receiving sonidegib. The progression of the disease under treatment occurred in 7.9% of cases of patients under sonidegib and in 26.3% of cases under vismodegib. *************************************************************** *Appendix Authors list Valentina Benzecry Mancin,1 Veronica Benzi,2 Matteo Bianco,2,3 Alessandra Bulotta,4 Antonio Costanzo,2,3 Giuseppe Damiano,5 Nerina Denaro,6 Laura Eibenschutz,7 Barbara Merelli,8 Giulia Murgia,1 Alessandra Narcisi,3 Emanuela Passoni,1 Francesco Piscazzi,2,3 Vincenzo Russo5 1Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan; 2Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan; 3Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan; 4Department of Oncology, IRCCS San Raffaele, Milan; 5Unit of Immuno-Biotherapy of Melanoma and Solid Tumors, IRCCS Ospedale San Raffaele, Milan; 6Oncology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan; 7Oncologic and Preventive Dermatology Unit, IFO-San Gallicano Dermatological Institute IRCCS, Rome; 8Oncology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lucio phenomenon: a case report on an overlooked reaction in lepromatous leprosy.","authors":"Natsuda Sajjachareonpong, Poonnawis Sudtikoonaseth, Kowit Kampirapap, Monton Tanabodee, Sutsarun Prunglumpoo, Chanisa Kiatsurayanon","doi":"10.4081/dr.2025.10173","DOIUrl":"https://doi.org/10.4081/dr.2025.10173","url":null,"abstract":"<p><p>Our patient presented with a 5-year history of chronic, asymptomatic papulonodular lesions on the extremities. The lesions spread to the face and earlobes, with new ulcerative lesions on both legs for the past 8 months. Skin biopsy was compatible with lepromatous leprosy with Lucio phenomenon. Lucio phenomenon is a rare type of leprosy reaction found mostly in neglected lepromatous leprosy cases. Unfortunately, the patient developed pulmonary embolism and passed away. This case report focuses on the clinicopathological characteristics and management of Lucio phenomenon, which is an unusual form of leprosy reaction that often carries a poorer prognosis. Importantly, physicians should be able to differentiate Lucio phenomenon from other types of leprosy reactions for prompt management.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The tongue: a bridge between physiology and disorder.","authors":"Sabrine Nsir, Ghada Bouslama, Fadwa Ghanmi, Hanen Boukhris, Lamia Oualha, Souha Ben Youssef","doi":"10.4081/dr.2025.10262","DOIUrl":"https://doi.org/10.4081/dr.2025.10262","url":null,"abstract":"<p><p>The tongue, as a multifunctional organ, exhibits a variety of physiological characteristics as well as pathological alterations. Identifying and understanding these variations is crucial for ensuring an accurate diagnosis and appropriate management. This article explores the main common physiological variations, such as geographic tongue, fissured tongue, etc., as well as pathological conditions, including elementary lesions such as vesicles, bullae, erosions, ulcers, plaques, as well as surface changes (atrophy), color changes (coatings, pigmentation), or even shape alterations (infiltrations). It discusses current diagnostic tools and therapeutic approaches while emphasizing the importance of regular monitoring to prevent complications and maintain optimal oral health.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teledermatology: Canadian dermatologists' practice patterns, perceived challenges and future recommendations.","authors":"Sidra Sarfaraz, Tarek Turk, Samuel A J Lowe, Luvneet Verma, Marlene Dytoc","doi":"10.4081/dr.2025.10197","DOIUrl":"https://doi.org/10.4081/dr.2025.10197","url":null,"abstract":"<p><p>The use of teledermatology has increased significantly in recent years. The objective of this study was to determine Canadian dermatologists' and dermatology residents' perspectives on teledermatology. An online survey was created to determine participants' teledermatology practice patterns and their perception of the challenges, education, training, and research in teledermatology. The survey was distributed through the Canadian Dermatology Association and by administrative staff at Canadian Dermatology departments. There were 33 respondents: 66.7% of respondents started using teledermatology during the COVID-19 pandemic, and 93.8% reported that teledermatology accounted for 0-25% of their practice. Convenience, access, and safety were identified as the primary advantages of teledermatology. Teledermatology was mainly utilized for medication monitoring or refills and to assess, manage, or follow up on dermatitis, other chronic inflammatory conditions, and pre-diagnosed dermatologic conditions. Poor photo quality (32.3%) and the inability to conduct physical examinations or accurately diagnose conditions (74.2%) were reported as significant challenges. Respondents recommended education on the medicolegal considerations of teledermatology and research on how teledermatology compares to in-person consultations. Overall, teledermatology offers convenience, access, and improved safety for patients and healthcare professionals. However, addressing challenges related to physical examinations, accurate diagnoses, and photo quality is essential for optimal care delivery.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synchronous melanomas: one on tattoo and one on healthy skin.","authors":"Francesco Ricci, Gianluca Pistore, Giovanni Di Lella, Luca Fania, Siavash Rahimi, Cristina Fortes, Annarita Panebianco, Damiano Abeni","doi":"10.4081/dr.2025.10234","DOIUrl":"https://doi.org/10.4081/dr.2025.10234","url":null,"abstract":"<p><p>Tattooing is a widespread practice among the population, particularly among young people. With the increased popularity of tattoos, there have also been several reports of acute and chronic adverse events after tattooing. Malignant melanoma cases arising from tattoos have been increasingly described; however, there is no clear relationship between this practice and tumorigenesis. We present a case of two synchronous melanomas (one located on a decorative tattoo) and update the literature.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autochtonous <i>Emergomyces pasteurianus</i> subcutaneous infection in an Italian immunocompromised patient: a case report and review.","authors":"Claudio Farina, Marco Cavallini, Daniele Gambini, Michele Parietti, Alessandra Tebaldi, Davide Guarneri, Paolo Sena","doi":"10.4081/dr.2025.10251","DOIUrl":"https://doi.org/10.4081/dr.2025.10251","url":null,"abstract":"<p><p>We describe the second case of infection by Emergomyces pasteurianus that occurred in Italy. The patient presented ulcerated nodular lesions primarily in the forehead, beneath the orbital and nasal areas, but also in the neck and fingers in the early stages. Treatment involved amphotericin B, followed by long-term itraconazole, which resulted in complete clinical resolution. A review of the literature is also included.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications in nail surgery and prevention strategies: a comprehensive review.","authors":"Anna Bolzon, Bertrand Richert, Giuseppe Emilio Cannata, Andrea Sechi","doi":"10.4081/dr.2025.10216","DOIUrl":"https://doi.org/10.4081/dr.2025.10216","url":null,"abstract":"<p><p>Nail surgery, commonly performed to manage a wide range of nail disorders, is associated with potential complications that can affect patient's recovery and outcomes. This review provides a detailed overview of these possible complications and strategies for their prevention. Surgical complications in nail procedures can be classified into specific and non-specific. Specific complications are associated with damage to particular structures of the nail unit, such as the matrix, nail bed, or hyponychium. Non-specific complications, such as hematoma, infection, and necrosis, may be a consequence of any surgical procedure and are not directly related to the anatomical structures involved in the operation. Recognizing factors that can contribute to these complications, such as the choice of surgical techniques, patient comorbidity management, and the implementation of postoperative care practices, is essential to reduce their incidence. This work reports the current evidence and best practices in order to reduce surgical risks and improve patient outcomes. Examining each complication and its prevention strategies in detail, this review is a practical resource for clinicians who manage nail surgery cases.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatological insight as the key to diagnosing intestinal Behçet's disease misdiagnosed as Crohn's: a case report.","authors":"Caterina Mariarosaria Giorgio, Eugenia Veronica Di Brizzi, Gaetano Licata, Carmine Fiorentino, Giuseppe Argenziano, Luca Damiani","doi":"10.4081/dr.2025.10232","DOIUrl":"https://doi.org/10.4081/dr.2025.10232","url":null,"abstract":"<p><p>This report presents the case of a 22-year-old male with recurrent genital ulcers, oral aphthae, and gastrointestinal ulcerations initially diagnosed as Crohn's disease by gastroenterologists. Despite overlapping clinical and histological features between Crohn's disease and intestinal Behçet's disease, a dermatological consultation raised suspicion for Behçet's, leading to a revised diagnosis. This case highlights the helpful role of dermatologists in avoiding misdiagnosis and ensuring appropriate treatments for complex inflammatory conditions.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare vascular manifestation in chronic myeloid leukemia: a case report and literature review of Bier's spot development during nilotinib treatment.","authors":"Ahmed Alsaati, Turki Hakami, Sultan Bajawi, Gamil Mohammed, Nouf Bajawi, Nadya Al-Faraidy","doi":"10.4081/dr.2025.10160","DOIUrl":"https://doi.org/10.4081/dr.2025.10160","url":null,"abstract":"<p><p>Bier's spots are rare angiospastic macules often associated with physiologic vasoconstriction. This case report describes a 35-year-old man with chronic myeloid leukemia treated with nilotinib who developed Bier's spots, a previously unreported adverse effect of the drug. The patient presented with asymptomatic hypopigmented macules on the hands and legs that appeared during venous stasis and resolved with elevation. This case emphasizes the need to recognize potential vascular side effects of tyrosine kinase inhibitors and highlights Bier's spots as a benign but remarkable manifestation in patients undergoing nilotinib therapy.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth hormone deficiency and secondary adrenal insufficiency in petrified ears syndrome: a case report and literature review.","authors":"Sebastiano Recalcati, Alberto Vassallo, Marta Villanova, Roberto Lanzi, Marco Losa, Maria Grazia Patricelli, Paola Carrera, Fabrizio Fantini","doi":"10.4081/dr.2025.10263","DOIUrl":"https://doi.org/10.4081/dr.2025.10263","url":null,"abstract":"<p><p>Petrified ear is a rare clinical entity characterized by the progressive hardening of normal flexible auricular cartilage, leading to partial or complete auricular stiffness. In many cases, it provides a valuable clinical clue that allows the clinician to detect endocrinopathies (particularly Addison's disease) in a patient who has not received a diagnosis. We present the first documented case of petrified ears, which resulted in the diagnosis of both secondary hypoadrenalism and growth hormone deficiency (GHD). Additionally, we review the relevant literature. Petrified ears syndrome is probably an underreported clinical manifestation of other systemic disorders. It may, at times, serve as a useful and simple clinical clue to suspect underlying endocrinopathies even in the absence of typical features.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}