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Cutting-edge insights: LC-OCT and 5% cyclosporine for early lichen sclerosus treatment.
IF 2.3
Dermatology Reports Pub Date : 2025-03-18 DOI: 10.4081/dr.2025.10279
Caterina Mariarosaria Giorgio, Vittorio Tancredi, Gaetano Licata, Elvira Moscarella, Giuseppe Argenziano, Elisabetta Fulgione, Graziella Babino, Paolino Franzese, Eugenia Veronica Di Brizzi
{"title":"Cutting-edge insights: LC-OCT and 5% cyclosporine for early lichen sclerosus treatment.","authors":"Caterina Mariarosaria Giorgio, Vittorio Tancredi, Gaetano Licata, Elvira Moscarella, Giuseppe Argenziano, Elisabetta Fulgione, Graziella Babino, Paolino Franzese, Eugenia Veronica Di Brizzi","doi":"10.4081/dr.2025.10279","DOIUrl":"https://doi.org/10.4081/dr.2025.10279","url":null,"abstract":"<p><p>Dear Editor, Atrophic lichen sclerosus (ALS) is a chronic inflammatory dermatosis with significant morbidity, primarily affecting genital areas. The disease is often misdiagnosed or underdiagnosed, resulting in delayed treatment and progression to atrophic stages and permanent scars. While corticosteroids remain the first-line treatment, their long-term use may lead to adverse effects such as skin atrophy, prompting the need for alternative therapies. Cyclosporine, a calcineurin inhibitor, has shown efficacy in managing immune-mediated skin diseases and is delivered effectively through the Pentravan® vehicle. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe relapse of generalized psoriasis in a young patient with Löfgren syndrome history.
IF 2.3
Dermatology Reports Pub Date : 2025-03-13 DOI: 10.4081/dr.2025.10021
Ermira Ziçishti, Migena Vargu, Sabina Dedej, Eriselda Kurushi, Valbona Zenelaj, Ermira Vasili
{"title":"Severe relapse of generalized psoriasis in a young patient with Löfgren syndrome history.","authors":"Ermira Ziçishti, Migena Vargu, Sabina Dedej, Eriselda Kurushi, Valbona Zenelaj, Ermira Vasili","doi":"10.4081/dr.2025.10021","DOIUrl":"https://doi.org/10.4081/dr.2025.10021","url":null,"abstract":"<p><p>Psoriasis and sarcoidosis are two systemic inflammatory diseases characterized by elevated Th1 and Th17 lymphocyte activity and overlapping genetic components. Although psoriasis often accompanies known comorbidities, the simultaneous presence of acute sarcoidosis (Löfgren syndrome) is uncommon. A 23-year-old Caucasian male patient with a history of mild psoriasis without relapse since childhood presented with generalized psoriatic plaques. In May 2020, he experienced symptoms compatible with Löfgren syndrome (LöS), which followed complete resolution after three months of systemic corticosteroid therapy. After one year of treatment with adalimumab, the Psoriasis Area and Severity Index (PASI) decreased from 25.3 to 4.2, while sarcoidosis remained stable. The common pathogenic mechanisms between psoriasis and sarcoidosis warrant further investigation. This case emphasizes the importance of vigilance for respiratory symptoms in psoriasis patients and the potential for psoriasis reoccurrence post-sarcoidosis. Dermatologists need to be aware of these associations, promoting comprehensive management strategies for psoriatic patients with a history of sarcoidosis.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mendelian randomization analysis of the causal association between metabolite and skin cancer.
IF 2.3
Dermatology Reports Pub Date : 2025-03-12 DOI: 10.4081/dr.2025.10159
Duanyu Wang, Minghao Tan, Nora Iv, Rattanaricky Ung, Gechhorng Lim, Vahid Say, Sokheng Phal, Pengkhun Nov
{"title":"Mendelian randomization analysis of the causal association between metabolite and skin cancer.","authors":"Duanyu Wang, Minghao Tan, Nora Iv, Rattanaricky Ung, Gechhorng Lim, Vahid Say, Sokheng Phal, Pengkhun Nov","doi":"10.4081/dr.2025.10159","DOIUrl":"https://doi.org/10.4081/dr.2025.10159","url":null,"abstract":"<p><p>Skin cancer (SC) is a significant public health issue, with increasing incidence rates globally. Although environmental factors such as ultraviolet (UV) exposure are recognized risk factors, the impact of metabolites on SC development has not been thoroughly examined. This study seeks to explore the causal association between metabolites and SC risks using a Mendelian randomization (MR) approach. Our analysis revealed a total of 76 metabolites associated with SC risk. Of them, leucine to N-palmitoyl-sphingosine ratio, glycerol to palmitoylcarnitine ratio, oleoyl-linoleoyl-glycerol levels, and hypotaurine-to-taurine ratio were strongly associated with SC. Notably, leucine to N-palmitoyl-sphingosine ratio and glycerol to palmitoylcarnitine ratio were linked to increased risk factors for SC. However, oleoyl-linoleoyl-glycerol levels and hypotaurine-to-taurine ratio served as the protective indicators of SC. This study highlights the potential role of metabolites in skin cancer etiology, suggesting that metabolic factors may serve as important targets for prevention and risk assessment strategies.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psoriasiform rash possibly induced by oral propranolol in a 12-month-old girl with infantile hemangioma: a case report and literature review. 一名患有婴儿血管瘤的 12 个月大女孩可能因口服普萘洛尔而诱发牛皮癣样皮疹：病例报告和文献综述。
IF 2.3
Dermatology Reports Pub Date : 2025-03-05 DOI: 10.4081/dr.2025.10239
Sahar Alruhaimi, Fatimah Alowirdi, Waleed Al-Ajroush
{"title":"Psoriasiform rash possibly induced by oral propranolol in a 12-month-old girl with infantile hemangioma: a case report and literature review.","authors":"Sahar Alruhaimi, Fatimah Alowirdi, Waleed Al-Ajroush","doi":"10.4081/dr.2025.10239","DOIUrl":"https://doi.org/10.4081/dr.2025.10239","url":null,"abstract":"<p><p>Infantile hemangiomas are the most common soft-tissue tumors in children, with propranolol, a non-cardioselective β-blocker, considered the first-line treatment for complicated cases. β-blockers have been reported to be the most common causative agents for drug-induced psoriasis in adults. In the pediatric population, only one previous case exists. We report the case of a 12-month-old girl who developed a psoriasiform rash after starting oral propranolol for infantile hemangiomas on the scalp. The patient had no personal or family history of psoriasis, and the rash appeared one week post-initiation of propranolol, presenting as well-defined erythematous, scaly plaques over the body, including the scalp. Infectious causes were excluded, and the rash was diagnosed as a psoriasiform rash, possibly induced by oral propranolol. The patient was switched to atenolol, which resulted in improvement of the hemangioma and complete resolution of the skin lesions. This case highlights the rare but significant risk of psoriasiform eruptions associated with β-blocker therapy in infants, emphasizing the need for careful recognition and monitoring of this potential adverse effect in pediatric patients treated for infantile hemangiomas.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rosacea-like eruptions associated with upadacitinib in atopic dermatitis: two case reports and management strategies.
IF 2.3
Dermatology Reports Pub Date : 2025-03-04 DOI: 10.4081/dr.2025.10193
Claudia Paganini, Edoardo Mortato, Lorenzo Tofani, Alfredo Belcastro, Marina Talamonti, Cosimo Di Raimondo, Luca Bianchi, Marco Galluzzo
{"title":"Rosacea-like eruptions associated with upadacitinib in atopic dermatitis: two case reports and management strategies.","authors":"Claudia Paganini, Edoardo Mortato, Lorenzo Tofani, Alfredo Belcastro, Marina Talamonti, Cosimo Di Raimondo, Luca Bianchi, Marco Galluzzo","doi":"10.4081/dr.2025.10193","DOIUrl":"https://doi.org/10.4081/dr.2025.10193","url":null,"abstract":"<p><p>Atopic dermatitis (AD) is a chronic inflammatory skin disease often requiring systemic therapies for moderate-to-severe cases. Janus kinase (JAK) inhibitors, including upadacitinib, have emerged as effective options, targeting pro-inflammatory cytokines involved in AD pathogenesis. However, adverse dermatologic reactions, such as rosacea-like eruptions, have been observed, potentially linked to immune pathway modulation. This report describes two patients with severe AD who achieved complete disease clearance with upadacitinib but developed rosacea-like eruptions. Both cases required discontinuation of the drug and treatment with antibiotics, which resolved the symptoms. However, withdrawal led to AD flares in one patient, necessitating the reintroduction of upadacitinib at a reduced dose combined with prophylactic antibiotics. These cases underscore the efficacy of JAK inhibitors while highlighting the challenge of managing adverse effects. Individualized treatment approaches, including dose adjustments and adjunctive therapies, are essential for balancing AD control with tolerability. Further research is needed to optimize the management of these reactions.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paradoxical reaction under dupilumab triggered by occasional ketoprofen intake.
IF 2.3
Dermatology Reports Pub Date : 2025-02-28 DOI: 10.4081/dr.2025.10214
Filippo Chersi, Sanja Javor, Rosella Gallo, Elia Sala, Cesare Massone
{"title":"Paradoxical reaction under dupilumab triggered by occasional ketoprofen intake.","authors":"Filippo Chersi, Sanja Javor, Rosella Gallo, Elia Sala, Cesare Massone","doi":"10.4081/dr.2025.10214","DOIUrl":"https://doi.org/10.4081/dr.2025.10214","url":null,"abstract":"<p><p>Dupilumab, a monoclonal antibody targeting the IL-4/13 signaling pathway, effectively treats moderate-to-severe atopic dermatitis (AD). Common side effects include injection site reactions, conjunctivitis, and respiratory infections. We report the case of a 28-year-old woman with severe AD involving the periocular and chin regions, genital areas, arms, and legs (Eczema Area and Severity Index [EASI]: 24, itch Visual Analog Scale [VAS]: 8) who showed significant improvement after initiating dupilumab therapy. However, following ketoprofen intake for headache relief, she developed a lupus-like erythematous maculopapular rash on the periocular and malar regions. Immunological tests (ANA, ENA) and photopatch testing ruled out autoimmune or allergic causes. Dupilumab was stopped, and treatment with oral prednisone and cetirizine led to complete resolution. This case highlights a potential drug interaction between dupilumab and ketoprofen, emphasizing the need for awareness of paradoxical facial erythema reactions in patients undergoing dupilumab therapy.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel therapeutic approach for loxoscelism: efficacy of cefixime and netilmicin sulfate combination therapy.
IF 2.3
Dermatology Reports Pub Date : 2025-02-28 DOI: 10.4081/dr.2025.10215
Caterina Mariarosaria Giorgio, Gaetano Licata, Vittorio Tancredi, Paolino Franzese, Nicola Maria Giorgio, Giuseppe Argenziano, Eugenia Veronica Di Brizzi
{"title":"Novel therapeutic approach for loxoscelism: efficacy of cefixime and netilmicin sulfate combination therapy.","authors":"Caterina Mariarosaria Giorgio, Gaetano Licata, Vittorio Tancredi, Paolino Franzese, Nicola Maria Giorgio, Giuseppe Argenziano, Eugenia Veronica Di Brizzi","doi":"10.4081/dr.2025.10215","DOIUrl":"https://doi.org/10.4081/dr.2025.10215","url":null,"abstract":"<p><p>Dear Editor, Loxoscelism, caused by bites from Loxosceles spiders, notably Loxosceles reclusa, presents with necrotic skin lesions and, in severe cases, systemic symptoms such as hemolysis, acute renal failure, and disseminated intravascular coagulation (DIC). The venom's sphingomyelinase D (SMD) enzyme induces direct tissue damage and an inflammatory response, leading to cell death, dermal necrosis, and increased vascular permeability, which can result in hemolysis and thrombosis. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Yellow urticaria as a rare dermatological manifestation of biliary obstruction: a case report.
IF 2.3
Dermatology Reports Pub Date : 2025-02-28 DOI: 10.4081/dr.2025.10248
Mohammad Almutairi, Khalid Nabil Nagshabandi, Reem Alsergani, Sultan Alsalem
{"title":"Yellow urticaria as a rare dermatological manifestation of biliary obstruction: a case report.","authors":"Mohammad Almutairi, Khalid Nabil Nagshabandi, Reem Alsergani, Sultan Alsalem","doi":"10.4081/dr.2025.10248","DOIUrl":"https://doi.org/10.4081/dr.2025.10248","url":null,"abstract":"<p><p>Urticaria is a prevalent inflammatory dermatological condition with a global estimated lifetime prevalence of up to 20%. Yellow urticaria is not a distinct medical condition; rather, it refers to the manifestation of yellow-colored wheals that appear in certain individuals with elevated serum bilirubin levels. This excess bilirubin accumulates in various tissues, including the conjunctiva and skin. The occurrence of yellow urticaria is notably rare and uncommon. In this report, we present a case of yellow-colored urticaria in a patient diagnosed with obstructive biliary stones, complemented by a concise review of previously documented cases in the literature.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-life effectiveness of narrowband UVB phototherapy for pityriasis lichenoides: a retrospective study.
IF 2.3
Dermatology Reports Pub Date : 2025-02-27 DOI: 10.4081/dr.2025.10272
Rachele Bardelli, Francesco Bellinato, Andrea Carugno, Nicola Zerbinati, Paolo Gisondi, Giampiero Girolomoni
{"title":"Real-life effectiveness of narrowband UVB phototherapy for pityriasis lichenoides: a retrospective study.","authors":"Rachele Bardelli, Francesco Bellinato, Andrea Carugno, Nicola Zerbinati, Paolo Gisondi, Giampiero Girolomoni","doi":"10.4081/dr.2025.10272","DOIUrl":"https://doi.org/10.4081/dr.2025.10272","url":null,"abstract":"<p><p>Dear Editor, Pityriasis lichenoides (PL) is an inflammatory skin disease of unknown etiology. The clinical spectrum of pityriasis lichenoides encompasses febrile ulcer-necrotic Mucha-Habermann disease (FUMHD), pityriasis lichenoides et varioliformis acuta (PLEVA), and pityriasis lichenoides chronica (PLC). Phototherapy is an effective and well-tolerated modality that is often successful for persistent PL or resistant to topical treatments. A retrospective observational study was conducted involving patients from the dermatology section of the University of Verona with a confirmed histological diagnosis of PLEVA and PLC accessed between January 2003 and June 2024. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generalized bullous drug eruption triggered by ceftriaxone: a case report and literature overview.
IF 2.3
Dermatology Reports Pub Date : 2025-02-25 DOI: 10.4081/dr.2025.10208
Khuzama Alfalah, Khalid Nabil Nagshabandi, Hala Abdullah Almusa
{"title":"Generalized bullous drug eruption triggered by ceftriaxone: a case report and literature overview.","authors":"Khuzama Alfalah, Khalid Nabil Nagshabandi, Hala Abdullah Almusa","doi":"10.4081/dr.2025.10208","DOIUrl":"https://doi.org/10.4081/dr.2025.10208","url":null,"abstract":"<p><p>Ceftriaxone is a widely used third-generation cephalosporin antibiotic known for its efficacy and safety. However, hypersensitivity reactions, including rare cases of generalized bullous fixed drug eruption (GBFDE), have been reported. We present the case of a 68-year-old female with a history of multiple comorbidities who developed a generalized bullous drug eruption two days after initiating intravenous ceftriaxone for a suspected respiratory infection. Clinical evaluation revealed extensive bullae and erythematous patches sparing mucous membranes, with histopathology confirming drug-induced epidermal changes. Direct immunofluorescence ruled out autoimmune bullous disorders. Prompt discontinuation of ceftriaxone, systemic corticosteroids, and supportive topical treatments led to marked clinical improvement. This case underscores the importance of recognizing rare but severe cutaneous reactions to ceftriaxone. Early diagnosis and intervention are crucial to minimizing complications and ensuring favorable outcomes.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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