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Indonesian pineapple allergen extract for skin prick test as an alternative diagnostic tool in atopic dermatitis. 印尼菠萝过敏原提取物皮肤点刺试验作为特应性皮炎的替代诊断工具。
IF 1.3
Dermatology Reports Pub Date : 2025-10-10 DOI: 10.4081/dr.2025.10004
Cita Rosita Sigit Prakoeswa, Damayanti Damayanti, Sylvia Anggraeni, Menul Ayu Umborowati, Mochammad Ayyub Arachman, Trisniartami Setyaningrum
{"title":"Indonesian pineapple allergen extract for skin prick test as an alternative diagnostic tool in atopic dermatitis.","authors":"Cita Rosita Sigit Prakoeswa, Damayanti Damayanti, Sylvia Anggraeni, Menul Ayu Umborowati, Mochammad Ayyub Arachman, Trisniartami Setyaningrum","doi":"10.4081/dr.2025.10004","DOIUrl":"https://doi.org/10.4081/dr.2025.10004","url":null,"abstract":"<p><p>Several fruits have been identified as allergens and potential triggers for exacerbations of atopic dermatitis (AD). This study evaluated pineapple allergy and sensitization among adult patients with AD and examined the diagnostic accuracy of a locally produced pineapple allergen extract in skin prick tests (SPTs). A total of 30 adult patients with AD, with a mean age of 36.07±10.81 years, were enrolled in the study. Firstly, SPT was performed using a standard pineapple allergen extract manufactured by Astromed® (Astromed Inc., West Warwick, Rhode Island, USA). Subsequently, a second SPT was carried out with the pineapple allergen extract produced by Teaching Industry Allergen Dr. Soetomo General Academic Hospital, Universitas Airlangga (Surabaya, Indonesia). Data were analyzed for diagnostic test accuracy and agreement. The local pineapple SPT had a sensitivity of 33.33% and a specificity of 100%. The test exhibited a positive predictive value (PPV) of 100%, whereas the negative predictive value (NPV) was 93.10%. The agreement between the standard SPT and the local SPT was statistically significant, exhibiting moderate concordance (p=0.002). The Indonesian pineapple allergen extract for SPT can serve as an alternative diagnostic tool to assess pineapple allergy and sensitization in AD patients.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rare case of keloid combined with bullous pemphigoid. 瘢痕疙瘩合并大疱性类天疱疮一例。
IF 1.3
Dermatology Reports Pub Date : 2025-10-09 DOI: 10.4081/dr.2025.10484
Ying Zhang, Yiyi Gong, Xiangguang Shi, Huyan Chen, Yining Wei, Wenyu Wu, Mengguo Liu
{"title":"A rare case of keloid combined with bullous pemphigoid.","authors":"Ying Zhang, Yiyi Gong, Xiangguang Shi, Huyan Chen, Yining Wei, Wenyu Wu, Mengguo Liu","doi":"10.4081/dr.2025.10484","DOIUrl":"https://doi.org/10.4081/dr.2025.10484","url":null,"abstract":"<p><p>Keloids and bullous pemphigoid (BP) are two clinically and pathophysiologically distinct dermatologic disorders - the former involves abnormal scar formation due to excess collagen deposition, while the latter is an autoimmune blistering disease. We report a case of a 67-year-old man with a 19-year history of abdominal keloids and the subsequent appearance of vesicular skin lesions. Histopathologic examination revealed both keloidal fibrosis and subepidermal blister formation. Serum testing demonstrated elevated anti-BP180 antibody levels. Initial treatment with topical and systemic agents, including neomycin, glycyrrhizin, spironolactone, and minocycline, resulted in limited improvement. Subsequently, dupilumab - a monoclonal antibody against the interleukin (IL)-4 receptor α - was introduced. After two months of dupilumab therapy, the vesicular lesions resolved, keloids stabilized, serum anti-BP180 antibody levels normalized, and the Dermatology Life Quality Index (DLQI) score decreased from 11 to 2.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurothekeoma: a pediatric case report and literature review. 神经瘤：一个儿科病例报告和文献复习。
IF 1.3
Dermatology Reports Pub Date : 2025-09-25 DOI: 10.4081/dr.2025.10444
Enrico Melis, Francesco Bellinato, Paolo Gisondi, Sokol Sina
{"title":"Neurothekeoma: a pediatric case report and literature review.","authors":"Enrico Melis, Francesco Bellinato, Paolo Gisondi, Sokol Sina","doi":"10.4081/dr.2025.10444","DOIUrl":"https://doi.org/10.4081/dr.2025.10444","url":null,"abstract":"<p><p>Dear Editor, Neurothekeoma is a rare, benign, soft tissue tumor that primarily affects the dermis. Initially described as a variant of nerve sheath myxoma, it was later recognized as a distinct entity because of its histopathological and immunohistochemical differences, as it is thought to be derived from fibroblast. It is most commonly observed in children and young adults, is more frequent in females, and typically arises in the head, neck, and upper extremities. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilobed flap for reconstruction of wide-sized temporal forehead defect. 双叶皮瓣重建大面积颞额缺损。
IF 1.3
Dermatology Reports Pub Date : 2025-09-25 DOI: 10.4081/dr.2025.10103
Angelo Massimiliano D'Erme, Giovanni Bagnoni, Andrea Paradisi
{"title":"Bilobed flap for reconstruction of wide-sized temporal forehead defect.","authors":"Angelo Massimiliano D'Erme, Giovanni Bagnoni, Andrea Paradisi","doi":"10.4081/dr.2025.10103","DOIUrl":"https://doi.org/10.4081/dr.2025.10103","url":null,"abstract":"<p><p>We present the case of an 82-year-old woman with a basal cell carcinoma, whose excision resulted in a 6×4 cm defect, which was reconstructed using a bilobed flap. The aim of this flap was to maintain the aesthetic boundaries of the forehead, either keeping symmetry with the contralateral side with minimal distortion, or taking advantage of the best color match of adjacent tissue.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
True leukonychia: case reports and review of the literature. 真性白甲：病例报告及文献回顾。
IF 1.3
Dermatology Reports Pub Date : 2025-09-24 DOI: 10.4081/dr.2025.10405
Azhar Ahmed, Mohammed Alahmadi, Ascia Almowald, Hind Almohanna
{"title":"True leukonychia: case reports and review of the literature.","authors":"Azhar Ahmed, Mohammed Alahmadi, Ascia Almowald, Hind Almohanna","doi":"10.4081/dr.2025.10405","DOIUrl":"https://doi.org/10.4081/dr.2025.10405","url":null,"abstract":"<p><p>Leukonychia refers to the whitening of the nail plate. We identified 22 cases reported in the literature. This study presents two cases of idiopathic leukonychia from Saudi Arabia, which, to our knowledge, are the first reported cases in the region. The first case involves a 26-year-old male with a decade-long history of white discoloration affecting all fingernails. He exhibited low vitamin B12 and elevated thyroid-stimulating hormone (TSH) levels. The second case involves a 23-year-old female with asymptomatic white discoloration on five fingernails and a positive family history of leukonychia in her younger brother. This case series contributes to the limited knowledge of true leukonychia and emphasizes the importance of recognizing its benign nature and distinguishing it from other nail disorders.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-TIF-1γ-positive dermatomyositis associated with colorectal adenocarcinoma: a case report. 结直肠腺癌伴抗- tif -1γ阳性皮肌炎1例
IF 1.3
Dermatology Reports Pub Date : 2025-09-23 DOI: 10.4081/dr.2025.10489
Sofia Spagnolini, Arlind Kalaja, Stefano Macchi, Ignazio Stanganelli, Maria Beatrice De Felici Del Giudice
{"title":"Anti-TIF-1γ-positive dermatomyositis associated with colorectal adenocarcinoma: a case report.","authors":"Sofia Spagnolini, Arlind Kalaja, Stefano Macchi, Ignazio Stanganelli, Maria Beatrice De Felici Del Giudice","doi":"10.4081/dr.2025.10489","DOIUrl":"https://doi.org/10.4081/dr.2025.10489","url":null,"abstract":"<p><p>Dermatomyositis (DM) is a rare autoimmune disease characterized by inflammatory involvement of skin and muscles, often associated with malignancy, particularly in the presence of anti-transcription intermediary factor 1 gamma (TIF-1γ) antibodies. This case report describes a 57-year-old Senegalese man with anti-TIF-1γ-positive DM and colorectal adenocarcinoma with liver metastases, presenting with severe dermatological symptoms such as ulcerations, the \"red on white\" sign, and scalp pustulosis, as well as systemic features including dysphagia and muscle weakness. Diagnosis was confirmed through clinical evaluation, serological testing, and histopathology. Treatment with corticosteroids, intravenous immunoglobulin (IVIG), and surgical tumor resection led to significant improvement. This case underscores the importance of recognizing DM's dermatological signs, conducting thorough malignancy screening, and implementing a multidisciplinary approach for effective management and improved outcomes, given the rarity of the association with colorectal cancer.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unusual site presentation of dermatitis herpetiformis: line-field confocal optical coherence tomography for effective management. 疱疹样皮炎的异常部位表现：线场共聚焦光学相干断层扫描的有效治疗。
IF 1.3
Dermatology Reports Pub Date : 2025-09-17 DOI: 10.4081/dr.2025.10100
Luca Bettolini, Stefano Bighetti, Sara Rovaris, Iacopo Ghini, Vincenzo Maione
{"title":"Unusual site presentation of dermatitis herpetiformis: line-field confocal optical coherence tomography for effective management.","authors":"Luca Bettolini, Stefano Bighetti, Sara Rovaris, Iacopo Ghini, Vincenzo Maione","doi":"10.4081/dr.2025.10100","DOIUrl":"https://doi.org/10.4081/dr.2025.10100","url":null,"abstract":"<p><p>Dermatitis herpetiformis (DH) is an uncommon autoimmune blistering skin disorder linked to gluten sensitivity. This report describes the line-field confocal optical coherence tomography (LC-OCT) features in a DH case, correlating with histopathological findings. A 60-year-old man exhibited erythematous papules and vesicles on the trunk with itching and burning, alongside alternating bowel issues. LC-OCT revealed subepidermal hypo-reflective areas with hyper-reflective floating cells at the dermal papillae tips. Histopathology showed subepidermal vesiculation and neutrophilic microabscesses, confirmed by granular IgA deposits in the dermal papillae via direct immunofluorescence. The patient tested positive for anti-tissue transglutaminase antibodies, was referred to a gastroenterologist, and began dapsone treatment, resolving the skin lesions. LC-OCT findings were consistent with histopathology, supporting its utility in diagnosing DH. Despite clinical similarities between DH and other blistering disorders, LC-OCT offers a non-invasive diagnostic approach, aiding in identifying optimal biopsy sites and expediting treatment. Further studies are warranted to validate LC-OCT's potential.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting JAK/STAT signaling: ruxolitinib cream in the management of concurrent vitiligo and discoid lupus erythematosus. 靶向JAK/STAT信号：鲁索利替尼乳膏治疗并发白癜风和盘状红斑狼疮。
IF 1.3
Dermatology Reports Pub Date : 2025-09-11 DOI: 10.4081/dr.2025.10458
Andrea Bassi, Vincenzo Piccolo, Grazia Gallippi, Giuseppe Argenziano, Michela Magnano, Carlo Mazzatenta
{"title":"Targeting JAK/STAT signaling: ruxolitinib cream in the management of concurrent vitiligo and discoid lupus erythematosus.","authors":"Andrea Bassi, Vincenzo Piccolo, Grazia Gallippi, Giuseppe Argenziano, Michela Magnano, Carlo Mazzatenta","doi":"10.4081/dr.2025.10458","DOIUrl":"https://doi.org/10.4081/dr.2025.10458","url":null,"abstract":"<p><p>Dear Editor, A 50-year-old Caucasian male presented with a 30-year history of facial vitiligo, primarily affecting the chin and the perioral and periorbital regions. He had undergone multiple treatments over the years, including targeted phototherapy, topical corticosteroids, and calcineurin inhibitors, with limited success. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The landscape of dermatology: the critical role of diversity, equity, and inclusion. 皮肤科的景观：多样性，公平和包容的关键作用。
IF 1.3
Dermatology Reports Pub Date : 2025-09-08 DOI: 10.4081/dr.2025.10389
Emilie A Foltz, Harkirat K Minhas, Joel Bervell
{"title":"The landscape of dermatology: the critical role of diversity, equity, and inclusion.","authors":"Emilie A Foltz, Harkirat K Minhas, Joel Bervell","doi":"10.4081/dr.2025.10389","DOIUrl":"https://doi.org/10.4081/dr.2025.10389","url":null,"abstract":"<p><p>The landscape of dermatology is undergoing a significant transformation as the field grapples with the implications of diversity, equity, and inclusion (DEI) initiatives. These efforts are pivotal in addressing and reducing disparities in patient outcomes, particularly for people of color (POC). This summary examines the disparities in dermatology, the importance of DEI initiatives, the impact of a recent Supreme Court decision, and the ongoing debates within the American Academy of Dermatology (AAD) regarding DEI policies. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psoriasis treatments in Europe during the 19th century. 19世纪欧洲牛皮癣的治疗。
IF 1.3
Dermatology Reports Pub Date : 2025-09-05 DOI: 10.4081/dr.2025.1028
Flavio Stocco, Carlo Cota, Maria Concetta Fargnoli, Viviana Lora
{"title":"Psoriasis treatments in Europe during the 19<sup>th</sup> century.","authors":"Flavio Stocco, Carlo Cota, Maria Concetta Fargnoli, Viviana Lora","doi":"10.4081/dr.2025.1028","DOIUrl":"https://doi.org/10.4081/dr.2025.1028","url":null,"abstract":"<p><p>Psoriasis is a dermatological disorder whose clinical manifestations have attracted the interest of physicians since ancient times. Hippocrates of Cos in the 5th century B.C. and later Galen in the 1st century A.D. were the first to refer to skin lesions characterized by scales and itching. In the 19th century, dermatology progressed, gaining scientific autonomy and leading to improvements both in the clinical study of psoriasis and in the search for new treatment methodologies. The dermatological schools established in this century, located in London, Paris, and Vienna, dedicated themselves to studying skin diseases, adopting unique methodological approaches and creating dermatological nomenclature. The English school focused on the objective description of lesions, while the French school was the first to approach the study of evolutionary processes, formulating theories not always based on experimental methods. Finally, the Austrian school based its research entirely on the study of diseases through the use of instruments and laboratory tests. Representatives of all three schools played a crucial role in the scientific progress of dermatology, leading to the subsequent evolution and improvement of therapies, which gradually replaced the use of ancient remedies and archaic administration methods. The treatments promoted by the different 19th-century European dermatologists reflected both their scientific thinking and the medical beliefs of the time. For this reason, the following historical-medical reconstruction of the evolution of psoriasis therapies in the 19th century can contribute to enriching the studies of dermatology.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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