Dermatology Reports最新文献

{"title":"The efficacy and safety of micro-needling combined with tacrolimus <i>versus</i> tacrolimus monotherapy for vitiligo treatment: a systematic review and meta-analysis.","authors":"Hadeel A Maaddawi, Abdulaziz A Aljuaid, Awadh M Alamri, Dhaifallah H Alghowairi, Abdullah S Bawazeer","doi":"10.4081/dr.2025.10166","DOIUrl":"https://doi.org/10.4081/dr.2025.10166","url":null,"abstract":"<p><p>Tacrolimus is a topical immunomodulator that has been used successfully in treating vitiligo; however, recent studies suggested that combining tacrolimus with micro-needling can increase its efficacy. This systematic review aimed to assess the efficacy and safety of micro-needling combined with tacrolimus to treat localized and stable nonsegmental vitiligo. We searched Medline, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL). The risk ratio (RR) was used to represent dichotomous outcomes, whereas the odds ratio (OR) was used for adverse events. Three randomized control trials (RCTs) (n=148 participants) were deemed eligible. The pooled effect estimate showed a statistically significant higher re-pigmentation rate in all assessed body areas in favor of treatment with micro-needling combined with tacrolimus (RR=2.02, 95% CI: 1.51-2.70). Nonetheless, no significant difference was found between micro-needling combined with tacrolimus and tacrolimus monotherapy in terms of 5-grade re-pigmentation scale (RR=0.93, 95% CI: 0.53-1.62), histopathological assessment (RR=0.90, 95% CI 0.47-1.75), and adverse events (OR: 1.72, 95% CI: 0.10-29.36). The number of included studies is low, with a relatively low sample size. Micro-needling combined with tacrolimus showed a clinically and statistically substantial improvement in the re-pigmentation of vitiligo sites with acceptable tolerability and safety profile.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adalimumab-induced facial erysipelas and its successful resolution with azithromycin in a 19-year-old female.","authors":"Caterina Mariarosaria Giorgio, Anna Balato, Gaetano Licata, Giuseppe Argenziano, Vittorio Tancredi, Eugenia Veronica Di Brizzi","doi":"10.4081/dr.2025.10278","DOIUrl":"https://doi.org/10.4081/dr.2025.10278","url":null,"abstract":"<p><p>A 19-year-old female with severe hidradenitis suppurativa (HS), treated with adalimumab for 10 months, developed facial erysipelas following an episode of pharyngitis. The infection presented with fever, severe cough, and a rapidly progressing erythematous plaque with edema on the left cheek, forehead, and periocular region. Laboratory tests confirmed a streptococcal infection. Due to allergies and intolerance to first-line antibiotics, azithromycin was administered, leading to complete resolution. This case highlights the increased risk of severe infections in immunosuppressed patients and underscores the importance of careful antibiotic selection and close monitoring for infections in patients receiving TNF-α inhibitors.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin infection by larva migrans and scabies mites: case reports on unusual skin localizations.","authors":"Alessandro Martella","doi":"10.4081/dr.2025.10098","DOIUrl":"https://doi.org/10.4081/dr.2025.10098","url":null,"abstract":"<p><p>Unusual skin infection localization represents a challenge to physicians regarding presentation and mode of acquisition, all of which might influence the diagnosis. At the same time, the administration of incorrect drugs due to a misdiagnosis might have a negative impact on the disease course. This article presents two case reports detailing the unusual presentation of larva migrans and scabies mites infection in two Italian patients, highlighting the importance of clinical vigilance and comprehensive evaluation of patients. These cases suggest how an accurate diagnosis requires a high index of suspicion and appropriate diagnostic tools, such as dermoscopy, for the prompt recognition of skin infections and the consequent optimal patient outcome.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world experience with vismodegib and sonidegib in advanced basal cell carcinoma: a multicenter Italian study.","authors":"Mario Valenti, Sara Di Giulio, Andrea Carugno, Pasquale Frascione, Angelo Valerio Marzano, Santo Raffaele Mercuri, Gianluca Nazzaro, Giulia Spallone, Giovanni Paolino, Marco Ardigò","doi":"10.4081/dr.2025.10196","DOIUrl":"https://doi.org/10.4081/dr.2025.10196","url":null,"abstract":"<p><p>Vismodegib and sonidegib are smoothened (SMO) inhibitors approved for the treatment of advanced basal cell carcinoma (aBCC). This study investigates the real-world experiences and outcomes associated with these therapies across multiple Italian centers. A retrospective, observational, multicenter study was conducted. Medical records of patients with local advanced basal cell carcinoma (laBCC) treated with SMO inhibitors outside of clinical trials from July 2019 to April 2024 were analyzed. A total of 57 patients were included in the study, with 19 (33.3%) receiving vismodegib and 38 (66.7%) receiving sonidegib. Vismodegib demonstrated a complete response (CR) in 31.6% of cases and a partial response (PR) in 26.3%. Sonidegib achieved a CR of 47.4% and a PR of 36.8%. The median treatment duration was 8 months for vismodegib and 12 months for sonidegib. Adverse events were more frequently reported with vismodegib. Treatment interruption due to adverse events occurred in 47.4% of vismodegib recipients and in 13.2% of those receiving sonidegib. The progression of the disease under treatment occurred in 7.9% of cases of patients under sonidegib and in 26.3% of cases under vismodegib. *************************************************************** *Appendix Authors list Valentina Benzecry Mancin,1 Veronica Benzi,2 Matteo Bianco,2,3 Alessandra Bulotta,4 Antonio Costanzo,2,3 Giuseppe Damiano,5 Nerina Denaro,6 Laura Eibenschutz,7 Barbara Merelli,8 Giulia Murgia,1 Alessandra Narcisi,3 Emanuela Passoni,1 Francesco Piscazzi,2,3 Vincenzo Russo5 1Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan; 2Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan; 3Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan; 4Department of Oncology, IRCCS San Raffaele, Milan; 5Unit of Immuno-Biotherapy of Melanoma and Solid Tumors, IRCCS Ospedale San Raffaele, Milan; 6Oncology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan; 7Oncologic and Preventive Dermatology Unit, IFO-San Gallicano Dermatological Institute IRCCS, Rome; 8Oncology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lucio phenomenon: a case report on an overlooked reaction in lepromatous leprosy.","authors":"Natsuda Sajjachareonpong, Poonnawis Sudtikoonaseth, Kowit Kampirapap, Monton Tanabodee, Sutsarun Prunglumpoo, Chanisa Kiatsurayanon","doi":"10.4081/dr.2025.10173","DOIUrl":"https://doi.org/10.4081/dr.2025.10173","url":null,"abstract":"<p><p>Our patient presented with a 5-year history of chronic, asymptomatic papulonodular lesions on the extremities. The lesions spread to the face and earlobes, with new ulcerative lesions on both legs for the past 8 months. Skin biopsy was compatible with lepromatous leprosy with Lucio phenomenon. Lucio phenomenon is a rare type of leprosy reaction found mostly in neglected lepromatous leprosy cases. Unfortunately, the patient developed pulmonary embolism and passed away. This case report focuses on the clinicopathological characteristics and management of Lucio phenomenon, which is an unusual form of leprosy reaction that often carries a poorer prognosis. Importantly, physicians should be able to differentiate Lucio phenomenon from other types of leprosy reactions for prompt management.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The tongue: a bridge between physiology and disorder.","authors":"Sabrine Nsir, Ghada Bouslama, Fadwa Ghanmi, Hanen Boukhris, Lamia Oualha, Souha Ben Youssef","doi":"10.4081/dr.2025.10262","DOIUrl":"https://doi.org/10.4081/dr.2025.10262","url":null,"abstract":"<p><p>The tongue, as a multifunctional organ, exhibits a variety of physiological characteristics as well as pathological alterations. Identifying and understanding these variations is crucial for ensuring an accurate diagnosis and appropriate management. This article explores the main common physiological variations, such as geographic tongue, fissured tongue, etc., as well as pathological conditions, including elementary lesions such as vesicles, bullae, erosions, ulcers, plaques, as well as surface changes (atrophy), color changes (coatings, pigmentation), or even shape alterations (infiltrations). It discusses current diagnostic tools and therapeutic approaches while emphasizing the importance of regular monitoring to prevent complications and maintain optimal oral health.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstruction of hand surgical wounds after pseudo-syndactyly correction or squamous cell carcinoma resection in patients affected from epidermolysis bullosa: a monocentric experience with a collagen-elastin dermal matrix substitute.","authors":"Giulia Bernante, Alessandro Portoghese, Mario Lando, Barbara Ferrari, Camilla Reggiani, Raimondo Feminò, Chiara Fiorentini, Cristina Magnoni","doi":"10.4081/dr.2024.10016","DOIUrl":"10.4081/dr.2024.10016","url":null,"abstract":"<p><p>In patients with epidermolysis bullosa (EB), surgery may be required to remove squamous cell carcinoma (SCC) of the hands or to correct pseudo-syndactyly. Dermal substitutes may represent a suitable tool to promote the healing of surgical wounds in EB. We review our experience with a collagen-elastin dermal matrix to promote surgical wound healing due to hand surgery to correct pseudo-syndactyly or SCC resection in patients affected by EB. Overall, 12 patients (mean age, 29±11 years, range 13-51; four females) with EB were considered, with a total of 25 different interventions (16 SCC removals; 3 amputations for recurrent infiltrating SCC; 6 pseudo-syndactyly corrections). All patients received a collagen-elastin dermal matrix sheet. Neodermis was achieved in all patients, and no adverse events potentially associated with the graft occurred. No SCC recurrence was reported at sites operated for either SCC resection or amputation. The opening of the first or second commissure appears to be maintained for over 1 year after the procedure, preserving digital function. We believe that the application of a dermal substitute, together with a close dressing protocol, may represent a suitable strategy for obtaining physiological tissue regeneration and maintaining proper hand function in patients with EB.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"17 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scabies clinically diagnosed with eosine 2% magnification dermoscopy.","authors":"Giulio Cortonesi, Emanuele Trovato, Corinne Orsini, Elisa Cinotti, Eugenio Capalbo, Vittoria Cioppa","doi":"10.4081/dr.2024.10099","DOIUrl":"10.4081/dr.2024.10099","url":null,"abstract":"<p><p>Dear Editor, The diagnosis of scabies is primarily clinical; however, the variability in presentation can complicate it. Besides dermoscopy, different non-invasive imaging techniques have been used to assist in scabies diagnosis: 400x magnification, line-field confocal optical coherence tomography (LC-OCT), reflectance confocal microscopy (RCM), and high-frequency ultrasound (HFUS) could be useful for the diagnosis of various diseases such as benign tumors, malignant tumors, and infectious diseases of all types (viral, bacterial, and parasitic). On the other hand, all these techniques are strictly operator- and device-dependent. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"17 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of unilateral nevoid telangiectasia in a Saudi pediatric patient.","authors":"Almuntsrbellah Almudimeegh, Khalid Nabil Nagshabandi, Maee Barakeh, Turky Alsehli","doi":"10.4081/dr.2024.10091","DOIUrl":"10.4081/dr.2024.10091","url":null,"abstract":"<p><p>Unilateral nevoid telangiectasia (UNT) is a rare congenital or acquired benign cutaneous vascular anomaly first identified by Blaschko in 1899. It is characterized by superficial telangiectasias with a reticular or linear pattern on one side of the body, often following a dermatomal distribution. We present the first case of UNT documented in Saudi Arabia in a 12-year-old girl.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"17 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological and clinical profiles of cutaneous leishmaniasis cases in Amhara National Regional State, Northwest Ethiopia: a multicenter retrospective study.","authors":"Bizuayehu Gashaw, Endalew Yizengaw, Endalkachew Nibret, Addisu Workineh, Adisu Abebe","doi":"10.4081/dr.2024.10089","DOIUrl":"10.4081/dr.2024.10089","url":null,"abstract":"<p><p>Cutaneous leishmaniasis (CL) is caused by Leishmania parasites. Ethiopia is one of the top ten countries with a high CL load, and Amhara National Regional State (ANRS) is one of the CL hotspot areas in the country. This study examined cutaneous leishmaniasis's epidemiology and clinical profiles in the ANRS region. It was conducted from April to October 2023 across eight Leishmaniasis Treatment Centres (LTCs). A data review was done from patients presenting to these centers between June 2018 and July 2023. Chi-square test and logistic regression were performed using SPSS-23. A total of 1729 patients with CL were recorded, resulting in an overall burden of 8.6 cases per 10,000 outpatients. Patients were from 112 districts, and most of them (71.1%) presented with localized cutaneous leishmaniasis (LCL). Approximately 12% of patients lived with the disease for over a year without treatment, while 13.2% of patients were multiple-time comers. Cutaneous leishmaniasis continues to be a significant public health issue in the ANRS region. Approximately onethird of CL patients exhibit the mucocutaneous leishmaniasis (MCL) clinical form. There has been a notable delay among CL patients in seeking diagnosis and treatment. It is essential to conduct large-scale community-based studies and studies focused on both traditional and modern treatment centers to accurately estimate the prevalence of CL in the region. Follow-up and molecular studies are crucial for enhancing our understanding of the clinical features of the disease. Furthermore, raising community awareness about CL prevention and control can help patients obtain early diagnosis and treatment.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"17 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}