{"title":"Pembrolizumab-related hand and foot skin reaction.","authors":"Francesca Ambrogio, Carmelo Laface, Cosimo Castronovi, Riccardo Bortone, Edoardo Mortato, Fortunato Cassalia, Gerardo Cazzato, Caterina Foti","doi":"10.4081/dr.2026.10184","DOIUrl":"https://doi.org/10.4081/dr.2026.10184","url":null,"abstract":"<p><p>Hand and foot skin reaction (HFSR), usually associated with tyrosine kinase inhibitors, is characterized by painful erythema and hyperkeratosis at palmoplantar pressure points. HFSR differs from the more widely recognized chemotherapy-induced hand-foot syndrome (HFS) in terms of both clinical and histopathological features. Here we present the case of a 79-year-old man with advanced lung adenocarcinoma who developed grade 3 HFSR after receiving pembrolizumab, a PD-1 inhibitor. The patient initially presented with erythema, desquamation, and hyperkeratotic plaques on the palms and soles, followed by the development of vesiculobullous lesions. Histopathological findings supported the clinical diagnosis. Treatment included discontinuation of pembrolizumab, along with systemic and topical corticosteroids and salicylic acid, with marked improvement and resolution after about 2 months. Given the impact on quality of life and treatment continuity, clinicians should monitor for HFSR in patients receiving immune checkpoint inhibitors (ICIs) to allow for timely intervention.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Simona Kordeva, Konstantin Georgiev Tchernev, Georgi Tchernev
{"title":"Dermatosurgical rounds: extendable plastic surgery with careful perilesional undermining for high-risk periocular basal cell carcinoma.","authors":"Simona Kordeva, Konstantin Georgiev Tchernev, Georgi Tchernev","doi":"10.4081/dr.2026.11004","DOIUrl":"https://doi.org/10.4081/dr.2026.11004","url":null,"abstract":"<p><p>A 58-year-old male presented to the dermatology department with a primary complaint of an achromatic exophytic lesion measuring 0.5×2 cm, with irregular borders, located in the right periocular region at the junction of the preseptal lower eyelid and eyelid-cheek aesthetic subunits. The lesion protruded above the surrounding skin and was covered with central ulceration and a hemorrhagic crust. Based on the clinical presentation, basal cell carcinoma was suspected and surgical excision under local anesthesia was recommended. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thi Xuan Tam Huynh, Nguyen Anh Thu Tran, Van Ba Huynh
{"title":"Beyond<i> Staphylococcus aureus</i>: emerging Gram-negative isolates in pediatric impetigo in Southern Vietnam.","authors":"Thi Xuan Tam Huynh, Nguyen Anh Thu Tran, Van Ba Huynh","doi":"10.4081/dr.2026.10931","DOIUrl":"https://doi.org/10.4081/dr.2026.10931","url":null,"abstract":"<p><p>Impetigo is common in tropical regions, yet local data on bacterial spectra beyond Staphylococcus aureus remain limited. This study aimed to characterize clinical features, bacterial isolates, and resistance-related factors among patients with impetigo in the Mekong Delta, Vietnam. We conducted a prospective cross-sectional study of 74 patients with clinically diagnosed impetigo at Can Tho City Hospital of Dermato-Venereology from May 2020 to July 2022. Demographic and clinical data were collected using a standardized form. Lesion swabs were cultured, isolates were identified by conventional microbiological methods, and antimicrobial susceptibility was assessed by disk diffusion according to Clinical and Laboratory Standards Institute procedures. Disease severity was evaluated using the Skin Infection Rating Scale (SIRS). The mean age was 4.4±3.5 years; 58.1% of patients were aged 2-6 years. Non-bullous impetigo was the predominant subtype (71.6%), and most patients presented with moderate or severe disease. Cultures were positive in 43 patients (58.0%). S. aureus was the leading pathogen (79.1%), followed by Escherichia coli (11.7%), Staphylococcus species (4.6%), Pseudomonas aeruginosa (2.3%), and Proteus spp. (2.3%). No Streptococcus pyogenes was isolated. E. coli was detected in ecthyma and showed high resistance to antibiotic classes, including universal resistance to levofloxacin and piperacillin/tazobactam. No statistically significant association was found between S. aureus resistance and clinical subtype, baseline severity, prior antibiotic exposure, or disease duration. Impetigo in this setting was predominantly pediatric and S. aureus-associated; however, Gram-negative organisms, especially E. coli, may contribute to severe or ulcerative disease. Culture and susceptibility testing should be considered in complicated cases.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Filomena Barbato, Gaetano Licata, Giovanni Calandriello, Maria Elena Errico, Paolino Franzese, Caterina Mariarosaria Giorgio
{"title":"Distinctive dermoscopic features of early juvenile xanthogranuloma within the benign cephalic histiocytosis spectrum.","authors":"Filomena Barbato, Gaetano Licata, Giovanni Calandriello, Maria Elena Errico, Paolino Franzese, Caterina Mariarosaria Giorgio","doi":"10.4081/dr.2026.10805","DOIUrl":"https://doi.org/10.4081/dr.2026.10805","url":null,"abstract":"<p><p>Dear Editor, A 10‑month‑old child presented with multiple asymptomatic papules involving the forehead, scalp, lateral cervical folds, axillary creases, and diaper area. The lesions appeared as dome‑shaped erythematous to flesh‑colored papules with superficial scaling. In the diaper region, the papules were sharply demarcated and showed a central yellowish core surrounded by a pale peripheral rim. No mucosal involvement, systemic symptoms, or laboratory abnormalities were detected. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sulaiman Khalid Alfouzan, Pillai Arun Gopinathan, Ikram Ul Haq, Faisal Alsharif, Saud Alsharif, Juwana Salah Salamah
{"title":"Trends in dermatological research publications in the Arab world from 2000 to 2023: a bibliometric analysis.","authors":"Sulaiman Khalid Alfouzan, Pillai Arun Gopinathan, Ikram Ul Haq, Faisal Alsharif, Saud Alsharif, Juwana Salah Salamah","doi":"10.4081/dr.2026.10622","DOIUrl":"https://doi.org/10.4081/dr.2026.10622","url":null,"abstract":"<p><p>This bibliometric analysis examines the publication trends in dermatology within the Arab world from 2000 to 2023. The study highlights the region's scientific contributions and evaluates the global visibility and impact of dermatological research. The Web of Science (WoS) database was employed to conduct a retrospective bibliometric analysis. The bibliometric indicators, like the global overview of dermatology research, categorization of research by country, citation metrics, annual growth rates, leading publishing journals, prominent countries, authorship patterns, authors, and analysis of the top key words, were analyzed. VOSviewer software was employed. The authors from Arab countries produced 2,390 dermatology records from 2000 to 2023, representing 2.22% of global dermatology research. Saudi Arabia (35%) and Egypt (26.73%) were the primary contributors. The Cureus journal was the preferred publication, while Hamida Turki was recognized as the most prolific author. The study illustrates consistent growth in dermatology research and collaboration, with prospects for future advancement.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luigi Naldi, Maria Rosa Valetto, Simone Cazzaniga, Sergio Cima, Silvia Emendi, Nicoletta Scarpa, Eugenio Santoro, Pietro Dri, Vincenzo Bettoli
{"title":"\"Acne in the Age of ChatGPT\": an artificial intelligence-generated and evidence-based continuing medical education distance course for Italian physicians.","authors":"Luigi Naldi, Maria Rosa Valetto, Simone Cazzaniga, Sergio Cima, Silvia Emendi, Nicoletta Scarpa, Eugenio Santoro, Pietro Dri, Vincenzo Bettoli","doi":"10.4081/dr.2026.10935","DOIUrl":"https://doi.org/10.4081/dr.2026.10935","url":null,"abstract":"<p><p>The AI-CHECK (Artificial Intelligence for CME Health E-learning Contents and Knowledge) study aimed to explore ChatGPT's potential in continuing medical education (CME). In particular, its third phase investigated artificial intelligence (AI)'s ability to develop a CME course on acne in Italian and assessed participants' satisfaction and attitudes toward AI-generated content. The e-learning course \"Acne in the Age of ChatGPT\" was hosted on the SAEPE platform and offered free to Italian physicians from May to September 2025. It included a handbook, two clinical vignettes, a knowledge questionnaire, and pre- and post-course surveys. ChatGPT-4 generated all educational materials following structured prompts. Content was reviewed by an expert dermatologist. A total of 556 physicians enrolled, with 95% completing the course. Most participants (74.4%) expressed support for AI use in medicine, while 79.8% recognized its value in developing CME materials. Overall satisfaction was excellent: over 95% rated the course as relevant, high-quality, and effective. This study demonstrates that ChatGPT can generate high-quality CME content with human supervision, ensuring accuracy and reliability. AI integration in CME shows promise for scalable, personalized, and innovative medical education.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149037008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Microbial burden of repackaged <i>versus</i> original-tube clobetasol propionate 0.05% after 7 days of in-use exposure: a pilot study with paired unopened controls.","authors":"Yi-En Wei, Mu-Le Ho, Wen-Tsao Ho","doi":"10.4081/dr.2026.10926","DOIUrl":"https://doi.org/10.4081/dr.2026.10926","url":null,"abstract":"<p><p>Dear Editor, In Taiwan, dermatology and primary care clinics commonly dispense clobetasol propionate 0.05% cream either in the manufacturer's original aluminum tube or, more often, by transferring cream from larger factory containers into small plastic boxes at the clinic counter. This long-standing practice reduces drug waste and dispensing costs, but it is performed in a routine consultation environment rather than under laboratory conditions, and the destination boxes are not pre-sterilized. Patients therefore periodically express concern that repackaged creams may be more easily contaminated than original tubes. Empirical data are scarce. We undertook a small comparative pilot study with paired unopened controls (one for each packaging type) to address this concern. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149037024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Domain-specific Skindex-29 response under biologics, conventional systemics, and phototherapy: a four-time-point real-world brief report.","authors":"Ardea Milidrag, Milena Zlatanović, Vesna Miličić, Gordana Ristić, Kristina Andrić, Ana Ravić-Nikolić","doi":"10.4081/dr.2026.10651","DOIUrl":"https://doi.org/10.4081/dr.2026.10651","url":null,"abstract":"<p><p>Skindex-29 provides a domain-specific assessment of quality-of-life (QoL) burden in psoriasis, but real-world comparisons across treatment modalities and clinically relevant time points remain limited. We prospectively followed 183 adults with psoriasis (Psoriasis Area Severity Index [PASI]>10) treated with phototherapy, conventional systemic agents, or biologics in a tertiary center. Skindex-29 total and domain scores were assessed at weeks 0, 4, 12, and 16. Total scores decreased significantly within all modalities (all p<0.001), with earlier and larger observed reductions among patients receiving biologics. After Benjamini-Hochberg adjustment, between-group differences remained significant for total scores at weeks 0, 4, and 16; for Emotions and Functioning at weeks 0, 4, and 16; and for Symptoms at week 4. PASI was strongly correlated with all domains (r=0.692-0.795; all p<0.001). Skindex-29 may complement PASI in domain-aware monitoring, although the non-randomized design precludes causal interpretation.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149037006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<i>IFNG</i> rs2430561 polymorphism and its association with disease onset, cutaneous severity, and activity in Vietnamese patients with lupus erythematosus.","authors":"Thi Xuan Tam Huynh, Thanh Luan Phan","doi":"10.4081/dr.2026.10886","DOIUrl":"https://doi.org/10.4081/dr.2026.10886","url":null,"abstract":"<p><p>Interferon (IFN)-γ plays a central role in lupus pathogenesis, and the IFNG rs2430561 (+874 T/A) polymorphism has been linked to systemic lupus erythematosus (SLE) in several populations. This study investigated the association of rs2430561 with disease onset, cutaneous severity, and global activity in Vietnamese patients with lupus erythematosus (LE). A case-control study was conducted on 34 LE patients and 34 age- and sex-matched healthy controls. Clinical characteristics, Cutaneous Lupus Disease Area and Severity Index (CLASI), and Systemic Lupus Erythematosus Disease Activity Index-2K (SLEDAI-2K) were collected. Genotyping was performed using allele-specific polymerase chain reaction (PCR). Genotype distribution differed significantly between patients and controls (p=0.048). Carriers of the A allele had a younger disease onset than TT patients (33.6±7.7 vs. 47.1±13.6 years) and showed a higher likelihood of onset ≤40 years (odds ratio [OR]=2.4; p=0.026). The rs2430561 genotype was associated with cutaneous severity: mean CLASI scores were AA 14.7, TA 11.8, and TT 5.8 (p=0.003). A-allele carriers had a 5.8-fold higher prevalence of severe CLASI (≥21; p=0.010). Systemic disease activity also differed: mean SLEDAI-2K scores were AA 12.0, TA 11.8, and TT 6.3 (p=0.010). The A allele was associated with a 4.7-fold higher prevalence of severe activity (>12; p=0.001). The IFNG rs2430561 A allele is associated with earlier onset and more severe cutaneous and systemic disease in Vietnamese LE patients, highlighting the potential contribution of IFN-γ pathway variation to disease expression.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149037039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chiara Del Re, Vincenzo Filastro, Gaia Fasano, Giancarlo Valenti, Domenico D'Amico
{"title":"When anti-tumor necrosis factor-α backfires: paradoxical psoriasis and psoriatic arthritis in a patient with hidradenitis suppurativa.","authors":"Chiara Del Re, Vincenzo Filastro, Gaia Fasano, Giancarlo Valenti, Domenico D'Amico","doi":"10.4081/dr.2026.10808","DOIUrl":"https://doi.org/10.4081/dr.2026.10808","url":null,"abstract":"<p><p>Dear Editor, Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the folliculoapocrine units. Biological therapies, historically led by the anti-tumor necrosis factor (TNF)-α antibody adalimumab, have transformed severe HS management. Recently, interleukin (IL)-17 inhibitors (secukinumab, bimekizumab) were also approved in Europe for moderate-to-severe HS. However, TNF-α blockade can paradoxically induce or exacerbate inflammatory skin and joint conditions, including psoriasis (incidence 1-5%) and psoriatic arthritis. We report a case of paradoxical inverse psoriasis and suspected early psoriatic arthritis induced by adalimumab in an HS patient, successfully managed by switching to secukinumab. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}