Paolo Iacovelli, Alessia Pacifico, Maria Mariano, Diego Orsini, Andrea D'Arino, Flavia Pigliacelli
{"title":"Phototherapy and mycosis fungoides: what’s new?","authors":"Paolo Iacovelli, Alessia Pacifico, Maria Mariano, Diego Orsini, Andrea D'Arino, Flavia Pigliacelli","doi":"10.4081/dr.2023.9830","DOIUrl":"https://doi.org/10.4081/dr.2023.9830","url":null,"abstract":"Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma, clinically characterized by erythematous-scaly patches and erythematous-violaceous nodules. Phototherapy plays an important role in MF, currently used as first line treatment in the early stages. The aim of this study is to analyze and review the different options of phototherapy on cutaneous lymphoma.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135995023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michela Curzio, Vittorio Macchini, Giovanni Di Lella, Antonio Massaro, Giulio Sonego
{"title":"Reconstruction of retroauricolar surgical defect using the \"Jigsaw puzzle\" advancement flap","authors":"Michela Curzio, Vittorio Macchini, Giovanni Di Lella, Antonio Massaro, Giulio Sonego","doi":"10.4081/dr.2023.9724","DOIUrl":"https://doi.org/10.4081/dr.2023.9724","url":null,"abstract":"We present the case of a 55 years old male patient who came to our attention because of a basal cell carcinoma of the right retroauricolar area, near the mastoid-auricle border. The tumour had a size of about 1,5 cm. Repairing retroauricolar surgical defects may be actually very challenging, firstly because an incorrect reconstruction may result in severe deformities which are extremely hard to conceal; so we decided to employ the \"jigsaw puzzle\" advancement flap, a versatile flap, firstly successfully used in the reconstruction of a nasal ala defect.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135996078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alice Verdelli, Daniela Massi, Vincenza Maio, Gabriele Cavazza, Alberto Corrà, Elena Biancamaria Mariotti, Lavinia Quintarelli, Valentina Ruffo Di Calabria, Cristina Aimo, Emiliano Antiga, Marzia Caproni
{"title":"Hydroxychloroquine-induced generalized myopathy in a patient with lupus tumidus: a case report","authors":"Alice Verdelli, Daniela Massi, Vincenza Maio, Gabriele Cavazza, Alberto Corrà, Elena Biancamaria Mariotti, Lavinia Quintarelli, Valentina Ruffo Di Calabria, Cristina Aimo, Emiliano Antiga, Marzia Caproni","doi":"10.4081/dr.2023.9771","DOIUrl":"https://doi.org/10.4081/dr.2023.9771","url":null,"abstract":"Lupus erythematosus tumidus (LET) is a subset of cutaneous lupus erythematosus that generally presents with urticaria-like papules and plaques located on sun-exposed areas. Systemic treatment with antimalarials, especially hydroxychloroquine (HCQ), is the first-line systemic therapy for LET. Even if these drugs have a safe profile, side effects such as retinal toxicity, maculopapular rash, gastrointestinal upset, hemolytic anemia and blue-gray discoloration of the skin or the mucous membranes, have been rarely reported in the literature. Herein, we describe a rare case of a 46-year-old smoking woman with LET who developed a generalized myopathy after HCQ treatment.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"918 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135993245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Non-invasive techniques in the clinical diagnosis of cutaneous lymphomas","authors":"Marco Ardigò","doi":"10.4081/dr.2023.9814","DOIUrl":"https://doi.org/10.4081/dr.2023.9814","url":null,"abstract":"Cutaneous lymphomas can be difficult to be even suspected in the clinical practise as they are simulators of many other dermatological inflammatory ands neoplastic diseases. The support of non-invasive techniques for skin analysis as dermoscopy and reflectance confocal microscopy are still anecdotic. On the practical prospective, as non-invasive techniques showed the potential of identify macro and micro features supporting the clinical suspicious of lymphomas, as they can be useful for differential diagnosis, and can support the biopsy site selection, a deeper and more spread study including large number of cases focusing on their effective usefulness merits to be considered. In this manuscript we report a narrative concise overview on dermoscopy and reflectance confocal microscopy features of cutaneous lymphomas.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"73 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136112685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A lower eyelid and cheek defect reconstruction","authors":"Vittoria Cioppa, Pietro Rubegni, Ernesto De Piano","doi":"10.4081/dr.2023.9859","DOIUrl":"https://doi.org/10.4081/dr.2023.9859","url":null,"abstract":"A 91 years old woman presented with a recurrent cutaneous squamous cell carcinoma (CSCC) involving the right lower eyelid and cheek. Recurrence occurred after one month from an incomplete surgical excision: histology reported a tumor infiltration of the subcutaneous tissue and deep margin. [...]","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136116343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nhi Thi Uyen Pham, Thuong Van Nguyen, Hao Trong Nguyen
{"title":"HLA-Cw6 increases the risk of psoriasis and early onset before twenty-seven years of age among the Vietnamese population","authors":"Nhi Thi Uyen Pham, Thuong Van Nguyen, Hao Trong Nguyen","doi":"10.4081/dr.2023.9854","DOIUrl":"https://doi.org/10.4081/dr.2023.9854","url":null,"abstract":"Psoriasis, a chronic inflammatory skin disorder affects people worldwide and is associated with the HLA-Cw6 allele which varies across ethnicities, and is higher in Caucasians than in Asians. We investigated the HLA-Cw6 prevalence in Vietnamese patients with psoriasis and its correlation with onset age and disease severity. We examined the association between HLA-Cw6 and the clinical features in 121 patients with psoriasis and 30 healthy controls and observed that HLA-Cw6 was significantly higher in patients with psoriasis (64.5%) than in the controls (26.7%) (p=0.0001) with an OR of 4.98 (2.04–12.15). The mean age of psoriasis onset was significantly lower in patients with positive HLA-Cw6 than those with negative HLA-Cw6. The AA genotype was more common in patients with mild psoriasis (100%), whereas the TA genotype was prevalent in patients with moderate and severe psoriasis (47.2% and 59.0%, respectively) and in those with high PASI scores (55.1% and 54.1%, respectively). Hence, HLA-Cw6 is a major genetic risk factor for psoriasis in Vietnamese patients, with higher prevalence in patients with early-onset disease. Furthermore, different HLA-Cw6 genotypes are associated with different disease severities.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136115938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Filipa David, Ana Catarina Trigo, José Ribeiro, Joana Cancela
{"title":"Heparin-induced thrombocytopenia: a rare presentation with skin necrosis","authors":"Filipa David, Ana Catarina Trigo, José Ribeiro, Joana Cancela","doi":"10.4081/dr.2023.9855","DOIUrl":"https://doi.org/10.4081/dr.2023.9855","url":null,"abstract":"Heparin-induced thrombocytopenia is the most clinically relevant non-haemorrhagic complication of heparin and is characterised by the presence of anti-PF4/heparin-IgG antibodies. The circulating PF4/heparin-IgG immune complex binds to platelets via their FcyIIa receptors, activating them and promoting their aggregation, with consequent platelet consumption, thrombocytopenia and thrombotic phenomena. Despite thrombocytopenia, this condition is not typically associated with bleeding complications. Instead, thrombosis is the most serious complication of Heparin-induced thrombocytopenia, contributing to increased morbidity and mortality. Thrombotic events can be venous and arterial, such as deep vein thrombosis, pulmonary embolism, myocardial infarction, and thrombotic stroke. Skin necrosis at the site of heparin injections is a rare but well-described manifestation of Heparin-induced thrombocytopenia. We report a case of Heparin-induced thrombocytopenia presented as skin necrosis, highlighting the importance of recognising this potentially fatal condition and the need for an immediate cessation of all sources of heparin and its replacement by other anticoagulants.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136115008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Translation and validation of patient-oriented eczema measure in the Greek language","authors":"Garyfallia Stefanou, Stamatis Gregoriou, Mihalis Bakakis, Styliani Mastraftsi, Alexandros Stratigos, Stathis Kontodimas, Konstantinos Sfaelos, Georgia Kourlaba","doi":"10.4081/dr.2023.9689","DOIUrl":"https://doi.org/10.4081/dr.2023.9689","url":null,"abstract":"Our purpose was to translate and validate the Patient Oriented Eczema Measure (POEM) in Greek. POEM translation was carried out with parallel back-translation procedure. To examine reliability and validity, 59 AD adult patients were recruited. A questionnaire including demographics, POEM, and Dermatology Life Quality Index (DLQI) was completed through physicians’ interview with patients. A second POEM completion took place 3-7 days after the initial visit. POEM items showed good internal consistency among study participants [Cronbach’s alpha = 0.88] and no overall floor and ceiling effects were detected. The POEM and DLQI scores were significantly correlated (Spearman rho = 0.71; p<0.001). The average ICC (95% CI) of POEM score between interviews was 0.89 (0.80, 0.94) indicating good to excellent test-retest reliability. As the use of patient reported outcome measures in Greece is increasing, it is important to have access in Greek translated - validated tools that are commonly used in literature.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136098503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis of pediatric outpatient visits uncovers disparities in molluscum contagiosum treatment across medical specialties in the United States","authors":"Karan Rajalingam, Wei-Shen Chen, Ann Lin","doi":"10.4081/dr.2023.9851","DOIUrl":"https://doi.org/10.4081/dr.2023.9851","url":null,"abstract":"Molluscum contagiosum (MC) is a common viral infection that affects the skin of children. This study compared demographic data and treatment patterns for MC patients across US medical specialties. Using the National Ambulatory Medical Care Survey database from 2000 to 2016, we found an average of 471,383 pediatric MC visits yearly. Most visits were made by Caucasians (91.0%) or non-Hispanics (82.9%). Pediatricians handled most cases (46.5%), followed by dermatologists (36.8%) and family medicine physicians (10.6%). Dermatologists saw more Caucasian patients (95% vs. 84%) and more patients with private insurance (83% vs. 73%) than pediatricians. Patients living in non-metropolitan areas were more likely to visit family medicine physicians (55.0%) than pediatricians (26.4%) or dermatologists (16.3%). Pediatricians favored spontaneous resolution (70%) over dermatologists (38%). Pediatricians mainly used terpenoids (12%), steroids (4%), and imiquimod (4%), while dermatologists preferred terpenoids (20%), imiquimod (12%), and curettage (10%). Pediatricians oversee most MC cases, but treatment strategies significantly differ from the best-practice guidelines.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136098187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara Rovaris, Giuseppe La Rosa, Sara Mezzana, Francesco Tonon, Luigi Mori, Eugenio Monti, Giuseppe Mazzeo, Piergiacomo Calzavara-Pinton, Mariachiara Arisi
{"title":"When the diagnosis is written in the DNA: a case of erythropoietic protoporphyria in a patient with a chromosome 18 deletion","authors":"Sara Rovaris, Giuseppe La Rosa, Sara Mezzana, Francesco Tonon, Luigi Mori, Eugenio Monti, Giuseppe Mazzeo, Piergiacomo Calzavara-Pinton, Mariachiara Arisi","doi":"10.4081/dr.2023.9784","DOIUrl":"https://doi.org/10.4081/dr.2023.9784","url":null,"abstract":"We present a case of erythropoietic protoporphyria (EPP) in a 21-year-old man who sought medical attention in April 2022 due to diffuse edema and erythema of the hands, which he had been experiencing since childhood and occurring shortly after sun exposure. The patient's medical history revealed a partial deletion of the long arm of chromosome 18. Based on the patient's medical background and clinical symptoms, we conducted various tests, including measuring total erythrocyte protoporphyrin levels and evaluating the fluorometric emission peak of plasma porphyrins using a spectrofluorometer. Additionally, a genetic analysis revealed a complete deletion of the FECH gene on one allele and the presence of an intronic variant on the other allele, identified as c.315–48T>C (IVS3–48T>C) and classified as a susceptibility polymorphism. In June 2022, the patient underwent an Afamelanotide implant, which resulted in an improvement in his clinical condition.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135786171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}