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Association of interleukin-6 rs1800796 polymorphism with keloid susceptibility and severity in a Vietnamese population: a case-control study. 越南人群中白细胞介素-6 rs1800796多态性与瘢痕疙瘩易感性和严重程度的关系：一项病例对照研究
IF 1
Dermatology Reports Pub Date : 2026-09-10 DOI: 10.4081/dr.2026.10835
Nam Hao Chau, Hoai Thu Le, Phuong Anh Huynh, Nhu Nhat Quynh Nguyen, Trung The Van
{"title":"Association of interleukin-6 rs1800796 polymorphism with keloid susceptibility and severity in a Vietnamese population: a case-control study.","authors":"Nam Hao Chau, Hoai Thu Le, Phuong Anh Huynh, Nhu Nhat Quynh Nguyen, Trung The Van","doi":"10.4081/dr.2026.10835","DOIUrl":"https://doi.org/10.4081/dr.2026.10835","url":null,"abstract":"<p><p>Keloids are fibroproliferative skin tumors characterized by excessive collagen deposition and persistent inflammation. Interleukin (IL)-6 plays a key role in wound healing and fibrosis, and promoter polymorphisms of the IL-6 gene have been implicated in keloid susceptibility in several populations. However, data on Vietnamese patients remain limited. We conducted a case-control study including 47 patients with clinically diagnosed keloids and 43 age- and sex-matched healthy controls to investigate the association between the IL-6 rs1800796 (-572 C>G) polymorphism and both keloid susceptibility and scar severity. Genotyping was performed using allele-specific oligonucleotide - polymerase chain reaction (ASO-PCR). Scar severity was assessed using the Vancouver Scar Scale (VSS). The CG genotype and G allele were significantly more frequent in patients with keloid than in controls. Carriers of the G allele demonstrated an increased risk of keloid formation and exhibited progressively higher VSS scores compared with CC homozygotes. These findings suggest that the IL-6 rs1800796 G allele is associated with increased susceptibility to keloids and greater scar severity in Vietnamese patients.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"18 3","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The efficacy and safety of intravenous immunoglobulin in pemphigus vulgaris and bullous pemphigoid: a systematic review and meta-analysis. 静脉注射免疫球蛋白治疗寻常型天疱疮和大疱性类天疱疮的疗效和安全性：一项系统综述和荟萃分析。
IF 1
Dermatology Reports Pub Date : 2026-09-07 DOI: 10.4081/dr.2026.10560
Hatem Alwusaidi, Mohammed Alahmadi, Sara Alghamdi, Sarah Almulla, Zaker Khoj, Yousef Al Mashhrawi, Shahd Aleid, Jana Alwusaidi
{"title":"The efficacy and safety of intravenous immunoglobulin in pemphigus vulgaris and bullous pemphigoid: a systematic review and meta-analysis.","authors":"Hatem Alwusaidi, Mohammed Alahmadi, Sara Alghamdi, Sarah Almulla, Zaker Khoj, Yousef Al Mashhrawi, Shahd Aleid, Jana Alwusaidi","doi":"10.4081/dr.2026.10560","DOIUrl":"https://doi.org/10.4081/dr.2026.10560","url":null,"abstract":"<p><p>Autoimmune blistering diseases (AIBDs) encompass various skin conditions that involve the production of autoantibodies that attach to specific antigens found in the skin and mucous membranes. This systematic review examined the efficacy and safety of intravenous immunoglobulin (IVIG) therapy for AIBDs. The search included PubMed, Science Direct, Google Scholar, Wiley, and EBSCO using the following keyword combinations: (Pemphigus Vulgaris OR Bullous Pemphigoid OR Autoimmune Blistering Disease) AND (Intravenous Immunoglobulin OR IVIG) AND (Efficacy OR Long-term Outcomes) AND (Safety OR Adverse Effects OR Quality of Life). Of 617 papers, 12 articles were considered suitable for the systematic review and extracted through the database search. A meta-analysis demonstrated an efficacy of 85.0% (95% confidence interval [CI]: 75.5-92.3, p<0.001) for IVIG therapy in AIBDs. Subgroup analyses showed relapse rates of 18.2% (95% CI: 9.3-27.0, p<0.001) and adverse event rates of 48.0% (95% CI: 28.7-67.3, p<0.001). Rapid clinical responses occurred within 1-4 weeks, with sustained remission lasting up to 44 months. Corticosteroid use was reduced by 76-90%, and autoantibody titers declined significantly. While adverse events were common (26-88% of patients), most were mild, with severe complications (<5%). IVIG is effective for AIBDs, offering rapid control, durable remission, and significant steroid reduction. Standardized protocols for dosing and monitoring are needed, and future research should focus on large-scale trials to confirm long-term benefits.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concomitant oral and genital mucosal involvement in classical Sweet syndrome. 经典甜综合征并发口腔和生殖器粘膜受累。
IF 1
Dermatology Reports Pub Date : 2026-09-02 DOI: 10.4081/dr.2026.10915
Simone Ragonesi, Andrea Corio, Alessandro Di Salvatore, Nicola Di Meo, Stefano Di Bella, Iris Zalaudek
{"title":"Concomitant oral and genital mucosal involvement in classical Sweet syndrome.","authors":"Simone Ragonesi, Andrea Corio, Alessandro Di Salvatore, Nicola Di Meo, Stefano Di Bella, Iris Zalaudek","doi":"10.4081/dr.2026.10915","DOIUrl":"https://doi.org/10.4081/dr.2026.10915","url":null,"abstract":"<p><p>Dear Editor, Sweet syndrome (SS) is a rare inflammatory dermatosis characterized by the abrupt onset of painful erythematous plaques, papules and nodules associated with a neutrophilic dermal infiltrate, fever, and peripheral neutrophilia. It is classified into three major subtypes: the classical form, frequently associated with infections, pregnancy, inflammatory bowel disease and other autoimmune disorders; the malignancy-associated form, linked to both solid-organ and hematologic malignancies, particularly acute myeloid leukemia and myelodysplastic syndromes; and the drug-induced form. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148879280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Membranous aplasia cutis congenita. 先天性胆囊膜。
IF 1
Dermatology Reports Pub Date : 2026-09-01 Epub Date: 2025-11-17 DOI: 10.4081/dr.2025.10544
Gabriele Poddine, Sara Salvagno, Francesco Bellinato, Paolo Gisondi, Giampiero Girolomoni
{"title":"Membranous aplasia cutis congenita.","authors":"Gabriele Poddine, Sara Salvagno, Francesco Bellinato, Paolo Gisondi, Giampiero Girolomoni","doi":"10.4081/dr.2025.10544","DOIUrl":"10.4081/dr.2025.10544","url":null,"abstract":"<p><p>Dear Editor, Aplasia cutis congenita (ACC) is a rare congenital malformation characterized by the focal absence of skin visible at birth, most frequently involving the scalp, although any part of the body may be affected. The estimated incidence is approximately 1 to 3 per 10,000 live births. The pathogenesis is heterogeneous and yet not fully understood. Proposed etiologies include genetic factors, teratogenic insult exposure, vascular disruptions, and mechanical trauma in utero. Clinically, ACC presents with variable morphology. The most frequent presentation is a well-demarcated area of ulceration or atrophic scarring on the scalp. ACC can rarely manifest as a bullous or membranous lesion with a cystic, translucent appearance, occasionally associated with deeper tissue involvement. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145539562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unusual dermoscopic features of multiple pilomatricomas, including a rare bullous variant. 不同寻常的皮肤镜特征的多发性毛瘤，包括一个罕见的大泡变体。
IF 1
Dermatology Reports Pub Date : 2026-09-01 Epub Date: 2025-11-04 DOI: 10.4081/dr.2025.10317
Caterina Mariarosaria Giorgio, Mario Diplomatico, Gaetano Licata, Luca Damiani, Francesco Esposito, Eugenia Veronica Di Brizzi, Filomena Barbato
{"title":"Unusual dermoscopic features of multiple pilomatricomas, including a rare bullous variant.","authors":"Caterina Mariarosaria Giorgio, Mario Diplomatico, Gaetano Licata, Luca Damiani, Francesco Esposito, Eugenia Veronica Di Brizzi, Filomena Barbato","doi":"10.4081/dr.2025.10317","DOIUrl":"10.4081/dr.2025.10317","url":null,"abstract":"<p><p>Dear Editor, Pilomatricoma, or Malherbe's calcifying epithelioma, is a benign neoplasm derived from hair follicle matrix cells. It usually presents as a solitary, firm, slow-growing subcutaneous nodule. Multiple pilomatricomas occur in about 2% of cases and may be associated with syndromes like Gardner's syndrome, Turner syndrome, and myotonic dystrophy. The bullous variant is an exceptionally rare form that presents with an overlying blister due to lymphatic dilation. Fewer than 30 cases of bullous pilomatricoma have been reported, and even fewer cases have involved multiple lesions, making this report particularly noteworthy. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13637445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of calcium serum level in clinical manifestation and progress of psoriasis vulgaris in a patient with Fahr's syndrome. 血清钙水平在Fahr综合征寻常型银屑病临床表现及进展中的作用
IF 1
Dermatology Reports Pub Date : 2026-09-01 Epub Date: 2025-10-28 DOI: 10.4081/dr.2025.10614
Migena Vargu, Sabina Dedej, Petrit Vargu, Eriselda Kurushi, Anxhela Nisi, Samuele Vargu
{"title":"The role of calcium serum level in clinical manifestation and progress of psoriasis vulgaris in a patient with Fahr's syndrome.","authors":"Migena Vargu, Sabina Dedej, Petrit Vargu, Eriselda Kurushi, Anxhela Nisi, Samuele Vargu","doi":"10.4081/dr.2025.10614","DOIUrl":"10.4081/dr.2025.10614","url":null,"abstract":"<p><p>Fahr's syndrome is a rare entity characterized by symmetrical and bilateral non-atherosclerotic intracerebral calcifications in the basal ganglia. This entity is usually asymptomatic or may present mainly with neuro-neuropsychiatric and dermatological manifestations. Secondary bilateral striopallidodentate calcinosis (BSPDC) presentations are associated with various diseases. We describe a case of psoriasis vulgaris associated with secondary BSPDC due to hypoparathyroidism. Laboratory tests revealed hypocalcemia, hyperphosphatemia, and a low parathormone serum level; on cerebral computed tomography (CT), bilateral basal ganglia calcification was observed. Correction of calcium deficiency restored the calcium-phosphate balance and led to an improvement in psoriatic lesions. Psoriasis vulgaris is a common condition that may be associated with disturbances in calcium metabolism. Dermatologists should be aware that investigating cases resistant to conventional therapies can uncover underlying systemic disorders that significantly affect patients' quality of life.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13583523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145376545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-TIF-1γ-positive dermatomyositis associated with colorectal adenocarcinoma: a case report. 结直肠腺癌伴抗- tif -1γ阳性皮肌炎1例
IF 1
Dermatology Reports Pub Date : 2026-09-01 Epub Date: 2025-09-23 DOI: 10.4081/dr.2025.10489
Sofia Spagnolini, Arlind Kalaja, Stefano Macchi, Ignazio Stanganelli, Maria Beatrice De Felici Del Giudice
{"title":"Anti-TIF-1γ-positive dermatomyositis associated with colorectal adenocarcinoma: a case report.","authors":"Sofia Spagnolini, Arlind Kalaja, Stefano Macchi, Ignazio Stanganelli, Maria Beatrice De Felici Del Giudice","doi":"10.4081/dr.2025.10489","DOIUrl":"10.4081/dr.2025.10489","url":null,"abstract":"<p><p>Dermatomyositis (DM) is a rare autoimmune disease characterized by inflammatory involvement of the skin and muscles, often associated with malignancy, particularly in the presence of anti-transcription intermediary factor 1 gamma (TIF-1γ) antibodies. This case report describes a 57-year-old Senegalese man with anti-TIF-1γ-positive DM and colorectal adenocarcinoma with liver metastases, presenting with severe dermatological symptoms such as ulcerations, the \"red on white\" sign, and scalp pustulosis, as well as systemic features including dysphagia and muscle weakness. Diagnosis was confirmed through clinical evaluation, serological testing, and histopathology. Treatment with corticosteroids, intravenous immunoglobulin (IVIG), and surgical tumor resection led to significant improvement. This case underscores the importance of recognizing DM's dermatological signs, conducting thorough malignancy screening, and implementing a multidisciplinary approach for effective management and improved outcomes, given the rarity of the association with colorectal cancer.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13637456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psoriasiform eruption induced by dupilumab successfully treated with upadacitinib. upadacitinib成功治疗dupilumab诱导的银屑病状喷发。
IF 1
Dermatology Reports Pub Date : 2026-09-01 Epub Date: 2025-10-16 DOI: 10.4081/dr.2025.10588
Mattia Minghini, Natale Schettini, Lucrezia Pacetti, Chiara Bocchi, Alessandro Borghi
{"title":"Psoriasiform eruption induced by dupilumab successfully treated with upadacitinib.","authors":"Mattia Minghini, Natale Schettini, Lucrezia Pacetti, Chiara Bocchi, Alessandro Borghi","doi":"10.4081/dr.2025.10588","DOIUrl":"10.4081/dr.2025.10588","url":null,"abstract":"<p><p>Psoriasiform eruptions are increasingly reported as adverse events during treatment of atopic dermatitis (AD) with interleukin (IL)-4/IL-13 inhibitors, including dupilumab. These reactions may represent a possible overlap manifestation between AD and psoriasis (PSO), which are two conditions that, according to recent literature, could lie along a clinical spectrum and share certain clinical, pathogenetic, and histological features. We describe the case of a 30-year-old male with lifelong AD who developed psoriasiform plaques on his elbows and knees during dupilumab therapy. After discontinuation of dupilumab and initiation of upadacitinib 15 mg/day, the patient achieved substantial improvement of both AD and psoriasiform eruptions at 6 months. This case highlights dupilumab-induced psoriasiform eruptions and underscores the therapeutic challenges associated with these clinical pictures. Upadacitinib appears to be a possible and effective treatment option for these presentations.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13637448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Papular acantholytic dyskeratosis of the genitocrural area with positive direct immunofluorescence in a man affected by lichen sclerosus et atrophicus: a clinicopathological challenge. 直接免疫荧光阳性的男性生殖器农村区丘疹棘突性角化不良：一个临床病理挑战。
IF 1
Dermatology Reports Pub Date : 2026-09-01 Epub Date: 2025-11-17 DOI: 10.4081/dr.2025.10658
Diana Sacchi, Viviana Lora, Alessandra Latini, Monia Di Prete, Carlo Cota
{"title":"Papular acantholytic dyskeratosis of the genitocrural area with positive direct immunofluorescence in a man affected by lichen sclerosus et atrophicus: a clinicopathological challenge.","authors":"Diana Sacchi, Viviana Lora, Alessandra Latini, Monia Di Prete, Carlo Cota","doi":"10.4081/dr.2025.10658","DOIUrl":"10.4081/dr.2025.10658","url":null,"abstract":"<p><p>Dear Editor, Papular acantholytic dyskeratosis (PAD) is a rare, sporadic, persistent disease of adulthood, localized to the genitocrural and anogenital regions. It was proposed as a new entity by Chorzelski et al. in 1984, based on the case of a 23-year-old woman with multiple, dome-shaped, white papules grouped on her vulva, which revealed histopathologically an epidermal proliferation with acantholysis and dyskeratosis, resembling both Haley-Haley (HHD) and Darier diseases (DD). Since then, PAD was reported as an asymptomatic/slightly itchy eruption of multiple white to skin-colored papules, coalescing to plaques, more commonly around the vulva. Cases among males were fewer. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145539538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Not all scabies come with a… burrow. 不是所有的疥疮都有洞。
IF 1
Dermatology Reports Pub Date : 2026-09-01 Epub Date: 2025-11-04 DOI: 10.4081/dr.2025.10338
Pietro Pasquale Cozza, Valeria Falcomatà, Antonino De Caridi, Alessia Chiarello, Antonella Tammaro, Stefano Dastoli
{"title":"Not all scabies come with a… burrow.","authors":"Pietro Pasquale Cozza, Valeria Falcomatà, Antonino De Caridi, Alessia Chiarello, Antonella Tammaro, Stefano Dastoli","doi":"10.4081/dr.2025.10338","DOIUrl":"10.4081/dr.2025.10338","url":null,"abstract":"<p><p>Dear Editor, Bullous scabies is one of the rarest variants of scabies. Scabies is an itchy skin disease caused by Sarcoptes scabies var. hominis. Recently, it was included in the World Health Organization roadmap for neglected tropical diseases from 2021 to 2030. The prevalence of scabies is very high in poor populations, causing elevated mortality rates. Data regarding prevalence reported about 200 million cases of scabies worldwide in 2015. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13637451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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