Dermatology Reports最新文献_第3页

Translation and validation of patient-oriented eczema measure in the Greek language 以患者为导向的湿疹测量的希腊语翻译和验证

Dermatology Reports Pub Date : 2023-10-11 DOI: 10.4081/dr.2023.9689

Garyfallia Stefanou, Stamatis Gregoriou, Mihalis Bakakis, Styliani Mastraftsi, Alexandros Stratigos, Stathis Kontodimas, Konstantinos Sfaelos, Georgia Kourlaba

引用次数: 0

Analysis of pediatric outpatient visits uncovers disparities in molluscum contagiosum treatment across medical specialties in the United States 对儿科门诊就诊的分析揭示了美国不同医学专业对传染性软疣治疗的差异

Dermatology Reports Pub Date : 2023-10-11 DOI: 10.4081/dr.2023.9851

Karan Rajalingam, Wei-Shen Chen, Ann Lin

{"title":"Analysis of pediatric outpatient visits uncovers disparities in molluscum contagiosum treatment across medical specialties in the United States","authors":"Karan Rajalingam, Wei-Shen Chen, Ann Lin","doi":"10.4081/dr.2023.9851","DOIUrl":"https://doi.org/10.4081/dr.2023.9851","url":null,"abstract":"Molluscum contagiosum (MC) is a common viral infection that affects the skin of children. This study compared demographic data and treatment patterns for MC patients across US medical specialties. Using the National Ambulatory Medical Care Survey database from 2000 to 2016, we found an average of 471,383 pediatric MC visits yearly. Most visits were made by Caucasians (91.0%) or non-Hispanics (82.9%). Pediatricians handled most cases (46.5%), followed by dermatologists (36.8%) and family medicine physicians (10.6%). Dermatologists saw more Caucasian patients (95% vs. 84%) and more patients with private insurance (83% vs. 73%) than pediatricians. Patients living in non-metropolitan areas were more likely to visit family medicine physicians (55.0%) than pediatricians (26.4%) or dermatologists (16.3%). Pediatricians favored spontaneous resolution (70%) over dermatologists (38%). Pediatricians mainly used terpenoids (12%), steroids (4%), and imiquimod (4%), while dermatologists preferred terpenoids (20%), imiquimod (12%), and curettage (10%). Pediatricians oversee most MC cases, but treatment strategies significantly differ from the best-practice guidelines.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136098187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When the diagnosis is written in the DNA: a case of erythropoietic protoporphyria in a patient with a chromosome 18 deletion 当诊断被写进DNA时:一例18号染色体缺失患者的红细胞生成性原卟啉症

Dermatology Reports Pub Date : 2023-09-13 DOI: 10.4081/dr.2023.9784

Sara Rovaris, Giuseppe La Rosa, Sara Mezzana, Francesco Tonon, Luigi Mori, Eugenio Monti, Giuseppe Mazzeo, Piergiacomo Calzavara-Pinton, Mariachiara Arisi

引用次数: 0

Discoid lupus erythematosus associated with chronic granulomatous disease 盘状红斑狼疮伴慢性肉芽肿病

Dermatology Reports Pub Date : 2023-09-13 DOI: 10.4081/dr.2023.9837

Ana Carolina De Almeida Figueiredo, Ana Luísa Matos, Joana Calvão, José Carlos Cardoso

引用次数: 0

Discoid lupus erythematosus associated with chronic granulomatous disease.

IF 2.3

Dermatology Reports Pub Date : 2023-09-13 eCollection Date: 2024-09-02 DOI: 10.4081/dr.2024.9837

Ana Carolina de Almeida Figueiredo, Ana Luísa Matos, Joana Calvão, José Carlos Cardoso

引用次数: 0

Extraocular cutaneous sebaceous carcinoma in a patient with Muir-Torre syndrome: special emphasis on histologic and dermoscopic features Muir-Torre综合征患者的眼外皮肤皮脂腺癌:特别强调组织学和皮肤镜特征

Dermatology Reports Pub Date : 2023-09-13 DOI: 10.4081/dr.2023.9832

Francesco Savoia, Matelda Medri, Davide Melandri, Lucia Domeniconi, Emilia Crisanti, Andrea Sechi, Ignazio Stanganelli

{"title":"Extraocular cutaneous sebaceous carcinoma in a patient with Muir-Torre syndrome: special emphasis on histologic and dermoscopic features","authors":"Francesco Savoia, Matelda Medri, Davide Melandri, Lucia Domeniconi, Emilia Crisanti, Andrea Sechi, Ignazio Stanganelli","doi":"10.4081/dr.2023.9832","DOIUrl":"https://doi.org/10.4081/dr.2023.9832","url":null,"abstract":"Cutaneous sebaceous carcinoma can be classified into periocular and extraocular and can occur as part of Muir Torre syndrome. It is usually a pink-red or yellow solitary nodule, mainly located in the head and neck region. According to the Literature, dermoscopy is characterized in most cases by yellow color, polymorphic vessels and ulceration. We performed a review of the Literature and we found 14 papers describing the dermoscopic features of 33 sebaceous carcinomas, to which we added a case that we have recently observed. Compared to the data of the Literature and in particular to the latest published reviews, we found that milky-red areas are frequently observed in CSC (47% of the cases) and can be added to the main dermoscopic features for the diagnosis. Histology showed, in our case, some features that were consistent with a cutaneous sebaceous carcinoma with a secretory pattern, and other features that were instead consistent with a non-secretory pattern. This was probably due to the fact that the lesion we observed was a moderately differentiated and not well-differentiated cutaneous sebaceous carcinoma. The presence of a cutaneous sebaceous carcinoma should always alert the clinician on the possible association with Muir-Torre syndrome and immunohistochemistry for mismatch repair genes defects can help in the diagnostic pathway.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135780957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of cutaneous variant of intravascular large B-cell lymphoma in which dermoscopy revealed telangiectasias associated with erythematous induration 皮肤变异体血管内大b细胞淋巴瘤病例，皮肤镜检查显示毛细血管扩张伴红斑硬化

Dermatology Reports Pub Date : 2023-09-13 DOI: 10.4081/dr.2023.9731

Shigeru Koizumi, Yaei Togawa, Yuka Saeki, Ryo Shimizu, Michiyo Nakano

引用次数: 0

Biologics and small molecules treatment for moderate-to-severe atopic dermatitis patients with comorbid conditions and special populations: an Italian perspective 具有合并症和特殊人群的中重度特应性皮炎患者的生物制剂和小分子治疗:意大利视角

Dermatology Reports Pub Date : 2023-09-13 DOI: 10.4081/dr.2023.9839

Alba Guglielmo, Maria Ludovica Deotto, Luigi Naldi, Giuseppe Stinco, Alessandro Pileri, Bianca Maria Piraccini, Anna Belloni Fortina, Andrea Sechi

{"title":"Biologics and small molecules treatment for moderate-to-severe atopic dermatitis patients with comorbid conditions and special populations: an Italian perspective","authors":"Alba Guglielmo, Maria Ludovica Deotto, Luigi Naldi, Giuseppe Stinco, Alessandro Pileri, Bianca Maria Piraccini, Anna Belloni Fortina, Andrea Sechi","doi":"10.4081/dr.2023.9839","DOIUrl":"https://doi.org/10.4081/dr.2023.9839","url":null,"abstract":"This comprehensive review offers a detailed look at atopic dermatitis (AD) treatment in Italy, focusing primarily on the use of biologics and small molecules. In response to advancing knowledge of AD's causes and treatments, there's a global need for updated guidelines to provide physicians with a more comprehensive clinical perspective, facilitating personalized treatment strategies. Dupilumab, a groundbreaking biologic, gained approval as a significant milestone. Clinical trials demonstrated its ability to significantly reduce AD severity scores, with an impressive 37% of patients achieving clear or nearly clear skin within just 16 weeks of treatment. Real-world studies further support its efficacy across various age groups, including the elderly, with a safety profile akin to that of younger adults. Tralokinumab, a more recent approval, shows promise in clinical trials, particularly among younger populations. However, its real-world application, especially in older individuals, lacks comprehensive data. JAK inhibitors like Upadacitinib, baricitinib, and abrocitinib hold substantial potential for AD treatment. Nevertheless, data remains limited for patients over 75, with older adults perceived to carry a higher risk profile. Integrated safety analyses revealed individuals aged 60 and above experiencing major adverse cardiovascular events and malignancies, underscoring the need for cautious consideration. While these therapies offer promise, especially among younger patients, further research is essential to determine their safety and efficacy in various populations, including pediatric, geriatric, and those with comorbidities. This review highlights the evolving landscape of AD treatment, with biologics and small molecules emerging as potent tools to enhance the quality of life for AD-affected individuals.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135786172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring adult-onset actinic prurigo in Thailand 探索泰国成人发病的光化性痒疹

Dermatology Reports Pub Date : 2023-09-12 DOI: 10.4081/dr.2023.9810

Siripan Sangmala, Chanisada Wongpraparat, Narumol Silpa-archa, Chayada Chaiyabutr

{"title":"Exploring adult-onset actinic prurigo in Thailand","authors":"Siripan Sangmala, Chanisada Wongpraparat, Narumol Silpa-archa, Chayada Chaiyabutr","doi":"10.4081/dr.2023.9810","DOIUrl":"https://doi.org/10.4081/dr.2023.9810","url":null,"abstract":"Actinic prurigo (AP) is an uncommon photodermatosis. In European and native American populations, AP is more frequently found in young women and shows clinical improvement or remission in adulthood. The clinical symptoms of AP in Asians differ in that the condition usually occurs in adults (adult-onset AP) and is clinically persistent. The objective of this study is to investigate the characteristics and outcomes of patients with AP in Thailand. A total of 15 cases diagnosed AP were reviewed. All cases were adult-onset AP (mean age of onset was 45.5 years). Male predominated (66.7%). Mostly of them presented with papules on face and upper extremities. Mucositis was presented in 2 patients. Phototesting revealed decreased MED for UVA alone in 3 patients and decreased MED for both UVA and UVB in 3 patients. Nine patients who had normal MED were further performed photoprovocation test and showed positive UVA photoprovocation in 5 patients; positive both UVA and UVB photoprovocation in 4 patients. Systemic immunosuppressant was prescribed in 60% of patients. Median time to clinical improvement was 8.6 months. Complete clinical remission was found in only 3 patients. Adult-onset AP has different clinical features and responds differently to treatment, compared to classical AP.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135827803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of interleukin 7 and platelet-derived growth factor BB mRNA expression as potential markers in erythema nodosum leprosum 白细胞介素7和血小板衍生生长因子BB mRNA表达作为麻风结节性红斑潜在标志物的分析

Dermatology Reports Pub Date : 2023-09-12 DOI: 10.4081/dr.2023.9773

Fitri Kadarsih Banjar, Farida Tabri, Sri Vitayani Muchtar, Mochammad Hatta, Khaeruddin Djawad, Farida Ilyas, Sitti Musafirah, Muhammad Nasrum Massi, Agussalim Bukhari, Andi Alfian Zainuddin

{"title":"Analysis of interleukin 7 and platelet-derived growth factor BB mRNA expression as potential markers in erythema nodosum leprosum","authors":"Fitri Kadarsih Banjar, Farida Tabri, Sri Vitayani Muchtar, Mochammad Hatta, Khaeruddin Djawad, Farida Ilyas, Sitti Musafirah, Muhammad Nasrum Massi, Agussalim Bukhari, Andi Alfian Zainuddin","doi":"10.4081/dr.2023.9773","DOIUrl":"https://doi.org/10.4081/dr.2023.9773","url":null,"abstract":"Introduction: Erythema Nodosum Leprosum (ENL) is an immunological complication of leprosy characterized by acute inflammation of the skin, nerves, and other organs. Identifying laboratory parameters are important to early diagnosis of leprosy reactions. Various cytokine biomarkers have been examined and only a few studies have reported on angiogenesis in leprosy. This study aims to understanding the pathomechanism of ENL by examined IL-7 and PDGF-BB mRNA expression that can be the development and consideration of new effective therapies to prevent reactions, recurrences, and defects in leprosy. Materials and Methods: The study used a cross-sectional analytic design. Sampling was done by peripheral blood from the patient and measuring mRNA expression with specific primers RT-PCR. Results: The expression of mRNA IL-7 and PDGF-BB was significantly different between multibasilar patients without reaction and with ENL reaction, where there was increased expression in ENL patients. This could be used as the development of potential biomarkers in ENL and development of new therapeutic intervention pathways in ENL.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135879067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0