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The role of calcium serum level in clinical manifestation and progress of psoriasis vulgaris in a patient with Fahr's syndrome. 血清钙水平在Fahr综合征寻常型银屑病临床表现及进展中的作用
IF 1
Dermatology Reports Pub Date : 2026-09-01 Epub Date: 2025-10-28 DOI: 10.4081/dr.2025.10614
Migena Vargu, Sabina Dedej, Petrit Vargu, Eriselda Kurushi, Anxhela Nisi, Samuele Vargu
{"title":"The role of calcium serum level in clinical manifestation and progress of psoriasis vulgaris in a patient with Fahr's syndrome.","authors":"Migena Vargu, Sabina Dedej, Petrit Vargu, Eriselda Kurushi, Anxhela Nisi, Samuele Vargu","doi":"10.4081/dr.2025.10614","DOIUrl":"10.4081/dr.2025.10614","url":null,"abstract":"<p><p>Fahr's syndrome is a rare entity characterized by symmetrical and bilateral non-atherosclerotic intracerebral calcifications in the basal ganglia. This entity is usually asymptomatic or may present mainly with neuro-neuropsychiatric and dermatological manifestations. Secondary bilateral striopallidodentate calcinosis (BSPDC) presentations are associated with various diseases. We describe a case of psoriasis vulgaris associated with secondary BSPDC due to hypoparathyroidism. Laboratory tests revealed hypocalcemia, hyperphosphatemia, and a low parathormone serum level; on cerebral computed tomography (CT), bilateral basal ganglia calcification was observed. Correction of calcium deficiency restored the calcium-phosphate balance and led to an improvement in psoriatic lesions. Psoriasis vulgaris is a common condition that may be associated with disturbances in calcium metabolism. Dermatologists should be aware that investigating cases resistant to conventional therapies can uncover underlying systemic disorders that significantly affect patients' quality of life.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13583523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145376545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary malignant melanoma with pseudovascular morphology: a diagnostic pitfall. 原发性恶性黑色素瘤伴假血管形态：一个诊断缺陷。
IF 1
Dermatology Reports Pub Date : 2026-09-01 Epub Date: 2025-11-19 DOI: 10.4081/dr.2025.10415
Monia Di Prete, Paola Pasquini, Elisa Melucci, Viviana Lora, Carlo Cota
{"title":"Primary malignant melanoma with pseudovascular morphology: a diagnostic pitfall.","authors":"Monia Di Prete, Paola Pasquini, Elisa Melucci, Viviana Lora, Carlo Cota","doi":"10.4081/dr.2025.10415","DOIUrl":"10.4081/dr.2025.10415","url":null,"abstract":"<p><p>Melanoma is a neoplasm with a heterogeneous clinical presentation and several histopathological variants have been described. Although histopathological evaluation remains the diagnostic gold standard, unusual morphology of some melanomas can lead to pathologic misinterpretation, as they can be confused with other non-melanocytic tumors. Here, we present a case of nodular melanoma with pseudovascular morphology characterized by uncommon empty branching slit-like spaces, reminiscent of rete testis vessels, for which we suggest the name of retiform melanoma to distinguish it from angiomatoid melanoma. Immunohistochemical analysis and ancillary molecular tests helped us characterizing this neoplasm, underscoring the need for clinical-morphological-molecular correlation for the correct diagnosis of unusual cases.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145548600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microinfusion of medications into the skin as a drug delivery technique: a narrative review. 将药物微滴入皮肤作为一种给药技术：述评。
IF 1
Dermatology Reports Pub Date : 2026-09-01 Epub Date: 2025-11-04 DOI: 10.4081/dr.2025.10306
Khalid Nabil Nagshabandi, Raed Alojayri, Abdulaziz Alghufaili, Mona Alkallabi
{"title":"Microinfusion of medications into the skin as a drug delivery technique: a narrative review.","authors":"Khalid Nabil Nagshabandi, Raed Alojayri, Abdulaziz Alghufaili, Mona Alkallabi","doi":"10.4081/dr.2025.10306","DOIUrl":"10.4081/dr.2025.10306","url":null,"abstract":"<p><p>Microinfusion of medications into the skin (MMP®) is an innovative method that employs tattoo devices to administer pharmaceuticals transdermally. This technique facilitates the formation of microchannels in the skin, allowing for localized drug deposition with minimal systemic absorption and fewer adverse effects. A literature search was conducted using PubMed and Google Scholar to identify studies discussing the application of MMP as a transdermal drug delivery method, covering publications up to October 2025. All studies identified through the literature search were summarized in chronological order from the earliest (2013) to the most recent (2025). This arrangement was chosen to illustrate the progressive evolution of the MMP technique and its expanding clinical applications over time. Our research found 14 studies that evaluated the effectiveness of the tattoo machine for transdermal drug administration. Eight studies focused on MMP for alopecia treatments, demonstrating notable improvements in androgenetic alopecia, alopecia areata, and frontal fibrosing alopecia, with minimal adverse reactions reported. Six studies investigated its role in treating scars and striae, showing significant lesion improvement. One study examined its use with bleomycin in basal cell carcinoma treatment, and another assessed its impact on psoriasis vulgaris with cyclosporine A and methotrexate (MTX). MMP represents a promising, minimally invasive transdermal delivery system with a growing body of evidence supporting its application in alopecia, oncologic dermatology, and pigmentary disorders. The ability to uniformly distribute medications at targeted skin depths, combined with its favorable safety profile, highlights its potential as a valuable alternative to conventional delivery methods. Furthermore, the microneedling effect of the tattoo device itself may confer therapeutic benefits independent of pharmaceutical administration.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13637450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recessive mosaicism in ABCA12 causes a unique phenotype of segmental congenital ichthyosiform erythroderma mimicking erythrokeratodermia variabilis. ABCA12的隐性镶嵌现象导致一种独特的节段性先天性鱼鳞状红皮病，类似变异性红角化皮病。
IF 1
Dermatology Reports Pub Date : 2026-09-01 Epub Date: 2025-11-03 DOI: 10.4081/dr.2025.10343
Yuzhi Ma, Jia Zhang, Zhirong Yao
{"title":"Recessive mosaicism in <i>ABCA12</i> causes a unique phenotype of segmental congenital ichthyosiform erythroderma mimicking erythrokeratodermia variabilis.","authors":"Yuzhi Ma, Jia Zhang, Zhirong Yao","doi":"10.4081/dr.2025.10343","DOIUrl":"10.4081/dr.2025.10343","url":null,"abstract":"<p><p>We report a unique case of a 1-year-old boy presenting with nonpruritic erythematous patches and mild keratotic plaques, partially following the lines of Blaschko and mainly involving the extremities. Next-generation sequencing (NGS) revealed a heterozygous missense mutation c.4724C>T (p.Thr1575Met) and a de novo mosaic deletion mutation c.6861_6869del (p.Leu2288_Gly2290del) in the ABCA12 (NM_173076.3) gene from the DNA of the patient's blood. Even more to the point, the lesional skin showed clinical improvement after 2 weeks of moisturizing treatment. Therefore, partial encapsulation treatment, widely used to enhance the percutaneous absorption of drugs, is suitable for mosaic ichthyosis given its localized skin lesions.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bullous pilomatricoma in young children. 儿童大疱性毛囊基质瘤。
IF 1
Dermatology Reports Pub Date : 2026-09-01 Epub Date: 2025-10-22 DOI: 10.4081/dr.2025.10305
Sadanori Furudate, Haruka Nakagawa, Yoshihide Asano
{"title":"Bullous pilomatricoma in young children.","authors":"Sadanori Furudate, Haruka Nakagawa, Yoshihide Asano","doi":"10.4081/dr.2025.10305","DOIUrl":"10.4081/dr.2025.10305","url":null,"abstract":"<p><p>Dear Editor, Pilomatricoma is a benign tumor characterized by differentiation from hair matrix cells to hair cortical cells. It commonly occurs on the head and neck in young individuals. Although blistering is rare, when present, it is typically observed on the upper arms, shoulders, and back. The condition is more frequently seen in teenagers and young adults; however, it is rare in young children. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13583514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145344137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of flat warts with trifarotene. 三胡萝卜素治疗扁平疣。
IF 1
Dermatology Reports Pub Date : 2026-09-01 Epub Date: 2025-11-10 DOI: 10.4081/dr.2025.10284
Gaetano Licata, Eugenia Veronica Di Brizzi, Elisabetta Fulgione, Graziella Babino, Vittorio Tancredi, Filomena Barbato, Giuseppe Argenziano, Caterina Mariarosaria Giorgio
{"title":"Treatment of flat warts with trifarotene.","authors":"Gaetano Licata, Eugenia Veronica Di Brizzi, Elisabetta Fulgione, Graziella Babino, Vittorio Tancredi, Filomena Barbato, Giuseppe Argenziano, Caterina Mariarosaria Giorgio","doi":"10.4081/dr.2025.10284","DOIUrl":"10.4081/dr.2025.10284","url":null,"abstract":"<p><p>This retrospective study explores the off-label use of trifarotene, a topical retinoid currently approved only for acne in individuals aged 12 years and older for the treatment of verrucae planae (flat warts). Our study included patients aged 3 to 45 years, demonstrating a high safety and tolerability profile due to the minimal systemic absorption of trifarotene. The therapy allowed for the rapid resolution of warts, avoiding invasive and potentially scarring treatments, particularly crucial for pediatric patients and young adults. These findings suggest that trifarotene may provide a cosmetically favorable and effective alternative for managing flat warts, warranting further investigation.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145539603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delayed papular dermatitis after a jellyfish sting. 水母蜇伤后迟发性丘疹性皮炎。
IF 1
Dermatology Reports Pub Date : 2026-09-01 Epub Date: 2025-10-15 DOI: 10.4081/dr.2025.10591
Teodor Aleksiev
{"title":"Delayed papular dermatitis after a jellyfish sting.","authors":"Teodor Aleksiev","doi":"10.4081/dr.2025.10591","DOIUrl":"10.4081/dr.2025.10591","url":null,"abstract":"<p><p>Dear Editor, Jellyfish stings are among the most common marine envenomations worldwide, particularly in coastal tourist regions. They typically cause immediate pain, erythema, and linear urticarial wheals. Although acute effects are well characterized, delayed cutaneous reactions remain under-recognized. These may occur days to weeks later and often mimic insect bites, eczema, or lichen planus. We report a case of delayed papular dermatitis 10 days after a jellyfish sting and briefly review the literature. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13560473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurothekeoma: a pediatric case report and literature review. 神经瘤：一个儿科病例报告和文献复习。
IF 1
Dermatology Reports Pub Date : 2026-09-01 Epub Date: 2025-09-25 DOI: 10.4081/dr.2025.10444
Enrico Melis, Francesco Bellinato, Paolo Gisondi, Sokol Sina
{"title":"Neurothekeoma: a pediatric case report and literature review.","authors":"Enrico Melis, Francesco Bellinato, Paolo Gisondi, Sokol Sina","doi":"10.4081/dr.2025.10444","DOIUrl":"10.4081/dr.2025.10444","url":null,"abstract":"<p><p>Dear Editor, Neurothekeoma is a rare, benign, soft tissue tumor that primarily affects the dermis. Initially described as a variant of nerve sheath myxoma, it was later recognized as a distinct entity because of its histopathological and immunohistochemical differences, as it is thought to be derived from fibroblast. It is most commonly observed in children and young adults, is more frequent in females, and typically arises in the head, neck, and upper extremities. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13560476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
True leukonychia: case reports and review of the literature. 真性白甲：病例报告及文献回顾。
IF 1
Dermatology Reports Pub Date : 2026-09-01 Epub Date: 2025-09-24 DOI: 10.4081/dr.2025.10405
Azhar Ahmed, Mohammed Alahmadi, Ascia Almowaled, Hind Almohanna
{"title":"True leukonychia: case reports and review of the literature.","authors":"Azhar Ahmed, Mohammed Alahmadi, Ascia Almowaled, Hind Almohanna","doi":"10.4081/dr.2025.10405","DOIUrl":"10.4081/dr.2025.10405","url":null,"abstract":"<p><p>Leukonychia refers to the whitening of the nail plate. We identified 22 cases reported in the literature. This study presents two cases of idiopathic leukonychia from Saudi Arabia, which, to our knowledge, are the first reported cases in the region. The first case involves a 26-year-old male with a decade-long history of white discoloration affecting all fingernails. He exhibited low vitamin B12 and elevated thyroid-stimulating hormone levels. The second case involves a 23-year-old female with asymptomatic white discoloration on five fingernails and a positive family history of leukonychia in her younger brother. This case series contributes to the limited knowledge of true leukonychia and emphasizes the importance of recognizing its benign nature and distinguishing it from other nail disorders.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13560474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prevalence of epidermal skin malignancies in people living with oculocutaneous albinism attending the Universitas Academic Hospital, Bloemfontein, South Africa. 在南非布隆方丹大学学术医院就诊的皮肤白化病患者中表皮皮肤恶性肿瘤的患病率。
IF 1
Dermatology Reports Pub Date : 2026-09-01 Epub Date: 2025-12-04 DOI: 10.4081/dr.2025.10038
Lehlohonolo Makhakhe, Brigitte-Jane Oliver, Maserame Motloung, Zoleka Ngaka, Zandile Motaung, Mbali Chabeli, Zinhle Ncwane, Ogechi Mokotedi
{"title":"The prevalence of epidermal skin malignancies in people living with oculocutaneous albinism attending the Universitas Academic Hospital, Bloemfontein, South Africa.","authors":"Lehlohonolo Makhakhe, Brigitte-Jane Oliver, Maserame Motloung, Zoleka Ngaka, Zandile Motaung, Mbali Chabeli, Zinhle Ncwane, Ogechi Mokotedi","doi":"10.4081/dr.2025.10038","DOIUrl":"10.4081/dr.2025.10038","url":null,"abstract":"<p><p>Oculocutaneous albinism (OCA) is a group of heterogeneous genetic disorders caused by absent or reduced melanin biosynthesis in epidermal melanocytes. Patients with OCA are prone to certain types of epidermal skin cancers, pre-malignant skin lesions, and eye-related symptoms and signs. The study aimed to evaluate the prevalence of common epidermal skin cancers and pre-malignant skin lesions in patients living with OCA attending an academic hospital in Bloemfontein, Free State Province (South Africa). This research focused on individuals referred within the public health sector. We evaluated all patients with this specific condition across the entire Free State province of South Africa and in Lesotho. The study was conducted as a cross-sectional, retrospective review of the medical records of all patients known to the clinic, as well as those referred with OCA, from January 2017 to January 2019. A total of 36 patients were included in this study, with 11 (30.6%) males and 25 (69.4%) females. Thirty-two (88.9%) had a history of active or past epidermal skin cancers or pre-malignant skin lesions, while the remaining 4 (11.1%) had no history of secondary skin pathology. The distribution of the pathology was notable in relation to sun exposure, with the face being the most commonly affected site in 31 (96.9%) of the assessed cases. OCA has been identified as a risk factor for solar keratosis, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC).</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145741419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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