Adalimumab-induced facial erysipelas and its successful resolution with azithromycin in a 19-year-old female.

IF 1.3 Q2 DERMATOLOGY
Dermatology Reports Pub Date : 2025-08-22 Epub Date: 2025-02-21 DOI:10.4081/dr.2025.10278
Caterina Mariarosaria Giorgio, Anna Balato, Gaetano Licata, Giuseppe Argenziano, Vittorio Tancredi, Eugenia Veronica Di Brizzi
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引用次数: 0

Abstract

A 19-year-old female with severe hidradenitis suppurativa (HS), treated with adalimumab for 10 months, developed facial erysipelas following an episode of pharyngitis. The infection presented with fever, severe cough, and a rapidly progressing erythematous plaque with edema on the left cheek, forehead, and periocular region. Laboratory tests confirmed a streptococcal infection. Due to allergies and intolerance to first-line antibiotics, azithromycin was administered, leading to complete resolution. This case highlights the increased risk of severe infections in immunosuppressed patients and underscores the importance of careful antibiotic selection and close monitoring for infections in patients receiving TNF-α inhibitors.

Abstract Image

阿达木单抗致面部丹毒及阿奇霉素成功治疗一例19岁女性。
一名患有严重化脓性汗腺炎(HS)的19岁女性,经阿达木单抗治疗10个月后,在咽炎发作后出现面部丹毒。感染表现为发热,严重咳嗽,左脸颊,前额和眼周区域出现迅速发展的红斑斑块伴水肿。实验室检查证实是链球菌感染。由于对一线抗生素过敏和不耐受,给予阿奇霉素,导致完全解决。该病例强调了免疫抑制患者严重感染的风险增加,并强调了谨慎选择抗生素和密切监测接受TNF-α抑制剂患者感染的重要性。
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来源期刊
Dermatology Reports
Dermatology Reports DERMATOLOGY-
CiteScore
1.40
自引率
0.00%
发文量
74
审稿时长
10 weeks
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