Dermatology Reports最新文献

{"title":"Why do cat flea infestations often occur on the upper limbs and trunk? Fleas do not fly.","authors":"Stefano Veraldi, Rossana Schianchi, Italo Francesco Aromolo, Gianluca Nazzaro","doi":"10.4081/dr.2025.10593","DOIUrl":"https://doi.org/10.4081/dr.2025.10593","url":null,"abstract":"<p><p>Dear Editor, Some species of fleas belonging to the genera Ctenocephalides, Pulex, and Xenopsylla can infest human skin. Multiple, isolated or clustered, roundish, erythematous, pruritic papules are the most typical clinical presentation of flea infestation. These lesions are very often located on the legs and ankles, as fleas are wingless but have powerful hind legs that allow them to leap up to 30 cm from the ground. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"18 3","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of dysplastic nevus by Italian dermatologists: a survey of the Italian Association of Hospital Dermatologists (ADOI).","authors":"Luca Fania, Gianluca Pistore, Antonio Perasole, Davide Strippoli, Francesco Ricci, Giovanni Di Lella, Tonia Samela, Davide Melandri, Marzia Caproni, Giovanna Galdo, Carlo Cota, Cesare Massone","doi":"10.4081/dr.2025.10627","DOIUrl":"10.4081/dr.2025.10627","url":null,"abstract":"<p><p>Dysplastic nevus (DN) represents a diagnostic and management challenge due to low interobserver agreement among pathologists and the absence of universally accepted guidelines. This nationwide cross-sectional survey aimed to investigate the current surgical management of DN among Italian dermatologists and to explore the use of diagnostic tools. A structured questionnaire was distributed to members of the Italian Association of Hospital Dermatologists (ADOI) and included four sections: i) demographic and professional information; ii) use of diagnostic instruments for the evaluation and follow-up of pigmented lesions; iii) surgical practices and communication with dermatopathologists; and iv) clinical and therapeutic management of DN stratified by low-grade or high-grade dysplasia and by margin status. A total of 190 dermatologists (response rate: 11.9%) completed the questionnaire. Most respondents opted for observation in cases of low-grade DN with clear margins (97.9%), while 68.9% recommended re-excision when margins were involved. For high-grade DN with clear margins, 64.2% preferred observation, whereas 35.8% performed re-excision. In cases of high-grade DN with positive margins, nearly all respondents (96.3%) indicated re-excision. Dermoscopy was universally used (99.5%), video-dermoscopy was applied by 77.4% of respondents, and reflectance confocal microscopy (RCM) by only 7.4%, with higher adoption in Central Italy and among mid-career dermatologists. Surgical removal was most often performed by elliptical excision (76.3%). The answers revealed substantial heterogeneity in management practices, particularly for high-grade DN with negative margins, and limited uptake of advanced diagnostic tools. These results underscore the need for updated, evidence-based national guidelines to standardize care, optimize resource allocation, and reduce unnecessary surgical procedures.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145539523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syphilis, the great mimicker: an inverted diagnostic pathway that still hits the mark.","authors":"Barbara Cocuroccia, Francesca Passarelli, Enzo Palese, Alessandra Latini, Francesca Di Tullio, Filomena Russo","doi":"10.4081/dr.2025.10577","DOIUrl":"10.4081/dr.2025.10577","url":null,"abstract":"<p><p>Dear Editor, Syphilis, the \"great mimicker\", remains a diagnostic challenge despite reliable serologic assays and updated management guidelines. Its wide variety of clinical and dermatological manifestations often leads to misdiagnosis, especially when lesions are atypical. We present a case in which secondary syphilis was diagnosed through an inverted pathway, with histopathology preceding clinical suspicion and serologic confirmation. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13637453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145539513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indonesian pineapple allergen extract for skin prick test as an alternative diagnostic tool in atopic dermatitis.","authors":"Cita Rosita Sigit Prakoeswa, Damayanti Damayanti, Sylvia Anggraeni, Menul Ayu Umborowati, Mochammad Ayyub Arachman, Trisniartami Setyaningrum","doi":"10.4081/dr.2025.10004","DOIUrl":"10.4081/dr.2025.10004","url":null,"abstract":"<p><p>Several fruits have been identified as allergens and potential triggers for exacerbation of atopic dermatitis (AD). This study evaluated pineapple allergy and sensitization among adult patients with AD and examined the diagnostic accuracy of a locally produced pineapple allergen extract in skin prick tests (SPTs). A total of 30 adult patients with AD, with a mean age of 36.07±10.81 years, were enrolled in the study. Firstly, SPT was performed using a standard pineapple allergen extract manufactured by Astromed® (Astromed Inc., West Warwick, Rhode Island, USA). Subsequently, a second SPT was carried out with the pineapple allergen extract produced by the Teaching Industry Allergen Dr. Soetomo General Academic Hospital, Universitas Airlangga (Surabaya, Indonesia). Data were analyzed for diagnostic test accuracy and agreement. The local pineapple SPT had a sensitivity of 33.33% and a specificity of 100%. The test exhibited a positive predictive value (PPV) of 100%, whereas the negative predictive value (NPV) was 93.10%. The agreement between the standard SPT and the local SPT was statistically significant, exhibiting moderate concordance (p=0.002). The Indonesian pineapple allergen extract for SPT can serve as an alternative diagnostic tool to assess pineapple allergy and sensitization in AD patients.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of keloid combined with bullous pemphigoid.","authors":"Ying Zhang, Yiyi Gong, Xiangguang Shi, Huyan Chen, Yining Wei, Wenyu Wu, Mengguo Liu","doi":"10.4081/dr.2025.10484","DOIUrl":"10.4081/dr.2025.10484","url":null,"abstract":"<p><p>Keloids and bullous pemphigoid (BP) are two clinically and pathophysiologically distinct dermatologic disorders - the former is characterized by abnormal scar formation due to excessive collagen deposition, whereas the latter is an autoimmune blistering disease. We report a case of a 67-year-old man with a 19-year history of abdominal keloids and the subsequent appearance of vesicular skin lesions. Histopathologic examination revealed both keloidal fibrosis and subepidermal blister formation. Serum testing demonstrated elevated anti-BP180 antibody levels. Initial treatment with topical and systemic agents, including neomycin, glycyrrhizin, spironolactone, and minocycline, resulted in limited improvement. Subsequently, dupilumab - a monoclonal antibody against the interleukin (IL)-4 receptor α - was introduced. After 2 months of dupilumab therapy, the vesicular lesions resolved, keloids stabilized, serum anti-BP180 antibody levels normalized, and the Dermatology Life Quality Index (DLQI) score decreased from 11 to 2.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13560475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From skin to thyroid: incidental finding of dual-variant papillary thyroid carcinoma in a patient with squamous cell carcinoma.","authors":"Patrick Silvetti, Domenico Di Maria, Ignazio Stanganelli","doi":"10.4081/dr.2025.10587","DOIUrl":"10.4081/dr.2025.10587","url":null,"abstract":"<p><p>Dear Editor, The occurrence of multiple primary neoplasms in a single patient is rare but well documented, and the incidental discovery of a previously undiagnosed thyroid carcinoma during lymph node dissection for another primary malignancy presents a unique diagnostic challenge. Previous reports have described incidental detection of papillary thyroid carcinoma during neck dissection for squamous cell carcinoma (SCC) of the tongue, via Tc-99m prostate-specific membrane antigen imaging in a patient with a negative fine-needle aspiration (FNA) result, and during oncologic staging for esophageal cancer. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13637452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilobed flap for reconstruction of wide-sized temporal forehead defect.","authors":"Angelo Massimiliano D'Erme, Giovanni Bagnoni, Andrea Paradisi","doi":"10.4081/dr.2025.10103","DOIUrl":"10.4081/dr.2025.10103","url":null,"abstract":"<p><p>We present the case of an 82-year-old woman with a basal cell carcinoma, whose excision resulted in a 6×4 cm defect, which was reconstructed using a bilobed flap. The aim of this flap was to maintain the aesthetic boundaries of the forehead, either keeping symmetry with the contralateral side with minimal distortion, or taking advantage of the best color match of adjacent tissue.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatosurgical pearls: melolabial advancement flap for tension-free closure of a basal cell carcinoma defect under the eyelid.","authors":"Georgi Tchernev, Konstantin Georgiev Tchernev, Simona Kordeva","doi":"10.4081/dr.2025.10649","DOIUrl":"10.4081/dr.2025.10649","url":null,"abstract":"<p><p>A 73-year-old man presented to the dermatology department with a history of a tumor in the right infraorbital region, present for approximately 2-3 years, which had shown progressive enlargement in recent months. Dermatological examination revealed a nodular, tumor-like lesion, elevated above the surrounding skin, with visible telangiectasias and crusts, clinically suspected to be basal cell carcinoma. Family history of skin cancer was unremarkable. The patient denied frequent sun exposure during child- or adulthood. Routine blood tests showed mild anemia, dyslipidemia, and hyperuricemia. Surgical excision of the lesion was recommended. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13637458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145539544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between serum leptin level and the atherogenic index of plasma in psoriatic patients.","authors":"Samer A Dhaher, Budoor O Yousif, Nazar S Haddad","doi":"10.4081/dr.2026.10817","DOIUrl":"https://doi.org/10.4081/dr.2026.10817","url":null,"abstract":"<p><p>Psoriatic patients have increased cardiometabolic risk and elevated serum leptin levels; however, the association between these factors remains unknown. In this report, serum leptin and the atherogenic index of plasma (AIP) were measured in a cross-sectional study of 100 patients with psoriasis. The results showed that the mean ± standard deviation (SD) serum leptin was 19.9±9.7 ng/mL. AIP was 0.3±0.06; 46% of patients were classified as low risk, 15% as intermediate risk, and 39% as high risk. Leptin levels increased with age, body mass index (BMI), and AIP and were associated with a twofold increase in the likelihood of elevated AIP (odds ratio [OR]=2.0; p=0.025). AIP was an independent predictor for higher leptin levels. These data suggest that serum leptin and AIP are linked in psoriasis and may reflect a shared inflammatory mechanism that contributes to increased cardiovascular risk.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurocutaneous system: Is the skin a big eye with deep brain connections?","authors":"Fortunato Cassalia, Andrea Danese, Paolo Del Fiore","doi":"10.4081/dr.2026.10930","DOIUrl":"https://doi.org/10.4081/dr.2026.10930","url":null,"abstract":"<p><p>Traditionally recognised as the body's largest organ, the skin acts as a protective barrier and primary sensory interface with the external environment. Recent advances in dermatology and neuroscience have revealed a sophisticated neuroendocrine network within the skin, suggesting that the skin's role extends far beyond mere protection and sensation. In this article, we propose an innovative perspective by conceptualising the skin as a \"big eye\" in close communication with the central nervous system (CNS). Central to this concept is the idea that all nerve endings in the skin converge into a single extended nerve, like the optic nerve, which we can imagine as a \"cutaneous nerve\". This nerve could act as a conduit for the transmission of sensory and emotional information from the skin to the CNS. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}