Dermatology ReportsPub Date : 2025-08-22Epub Date: 2025-01-15DOI: 10.4081/dr.2025.10095
Francesca Romana Grippaudo, Giulia Ruggeri, Paola De Simone, Monia Di Prete, Guglielmo Tellan, Elena Rita Govoni, Emilia Migliano
{"title":"Melanoma in pregnancy: multidisciplinary treatment management and outcome.","authors":"Francesca Romana Grippaudo, Giulia Ruggeri, Paola De Simone, Monia Di Prete, Guglielmo Tellan, Elena Rita Govoni, Emilia Migliano","doi":"10.4081/dr.2025.10095","DOIUrl":"10.4081/dr.2025.10095","url":null,"abstract":"<p><p>Pregnancy-associated melanoma affects both maternal and fetal health. This study aims to demonstrate how a specialized center and a multidisciplinary approach can provide the best outcomes. From January 2006 to September 2023, a bicentric observational study was conducted at the Plastic Surgery Department of Policlinico Umberto I, Sapienza University of Rome, and at the Plastic and Regenerative Surgery Department of the San Gallicano Dermatological Institute IRCCS, Rome, Italy. Out of 6,800 melanoma cases, twenty pregnant women were selected: thirteen underwent only wide local excision (WLE), while seven also had sentinel node biopsy (SLNB). All preoperative, operative, and postoperative steps were performed to ensure the safety of mothers and fetuses. Two patients developed metastases, with one fatality from hepatic metastases. At 5-year follow-up overall survival was 86%, while disease-free survival in advanced-stage melanoma patients was 72%. No maternal or fetal complications related to surgery were reported. Additionally, early deliveries at 7 and 8 months did not result in neonatal complications. Surgical treatment should be conducted in centers with both surgeons and gynecologists, and special care is necessary for procedures on pregnant women. Based on our experience, pregnancy does not seem to be a negative prognostic factor for melanoma.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"17 3","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dermatology ReportsPub Date : 2025-08-22Epub Date: 2025-02-05DOI: 10.4081/dr.2025.10251
Claudio Farina, Marco Cavallini, Daniele Gambini, Michele Parietti, Alessandra Tebaldi, Davide Guarneri, Paolo Sena
{"title":"Autochthonous <i>Emergomyces pasteurianus</i> subcutaneous infection in an Italian immunocompromised patient: case report and review.","authors":"Claudio Farina, Marco Cavallini, Daniele Gambini, Michele Parietti, Alessandra Tebaldi, Davide Guarneri, Paolo Sena","doi":"10.4081/dr.2025.10251","DOIUrl":"10.4081/dr.2025.10251","url":null,"abstract":"<p><p>We describe the second case of infection by Emergomyces pasteurianus in Italy. The patient presented ulcerated nodular lesions primarily in the forehead, beneath the orbital and nasal areas, but also in the neck and fingers in the early stages. Treatment involved amphotericin B, followed by long-term itraconazole, which resulted in complete clinical resolution. A review of the literature is also included.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dermatology ReportsPub Date : 2025-08-22Epub Date: 2025-02-06DOI: 10.4081/dr.2025.10234
Francesco Ricci, Gianluca Pistore, Giovanni Di Lella, Luca Fania, Siavash Rahimi, Cristina Fortes, Annarita Panebianco, Damiano Abeni
{"title":"Synchronous melanomas: one on tattooed skin and one on healthy skin.","authors":"Francesco Ricci, Gianluca Pistore, Giovanni Di Lella, Luca Fania, Siavash Rahimi, Cristina Fortes, Annarita Panebianco, Damiano Abeni","doi":"10.4081/dr.2025.10234","DOIUrl":"10.4081/dr.2025.10234","url":null,"abstract":"<p><p>Tattooing is a widespread practice among the population, particularly among young people. With the increased popularity of tattoos, there have also been several reports of acute and chronic adverse events after tattooing. Malignant melanoma cases arising from tattoos have been increasingly described; however, there is no clear relationship between this practice and tumorigenesis. We present a case of two synchronous melanomas (one located on a decorative tattoo) and update the literature.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A bibliometric study of the top 100 most cited articles on melanoma: insights into research trends and characteristics.","authors":"Jinhao Zhang, Xiangze Meng, Yun Wang, Wei Liu","doi":"10.4081/dr.2025.10435","DOIUrl":"https://doi.org/10.4081/dr.2025.10435","url":null,"abstract":"<p><p>Improving insights into the current research and literature on melanoma is useful for healthcare providers to apply the latest advancements for offering better care to patients. Herein, this bibliometric study analyzed the characteristics and trends in melanoma research through the top-cited articles. The top 100 most cited articles on melanoma were published between 1969 and 2020, and the average number of citations was 36.8-893.9 (mean 176.8). Notably, the frequencies of the main key words, including antineoplastic agents, genetics, randomized controlled trials, metastatic melanoma, BRAF, and monoclonal antibodies, during 2010-2020 were significantly higher than those during 1969-2009. Specifically, the main study topics after 2010 were drug research aspects, such as drug safety, drug efficacy, drug resistance, drug withdrawal, cytotoxic T lymphocyte-associated protein 4 (CTLA-4), programmed cell death 1/programmed death-ligand 1 (PD-1/PD-L1), ipilimumab, nivolumab, trametinib, dabrafenib, vemurafenib, and various drug adverse effects. The emergence of immunotherapy caused a burst of citations and substantially changed the distribution of the top-cited articles.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Oral isotretinoin for the treatment of dermatologic conditions other than acne: a case series.","authors":"Abdulrahman Janahi, Maria Alsannaa, Zahra Abdulla, Saad Alotaibi, Ameen Alawadhi, Jawaher Aljalahma","doi":"10.4081/dr.2025.10075","DOIUrl":"https://doi.org/10.4081/dr.2025.10075","url":null,"abstract":"<p><p>Dermatophyte infections, also known as tinea, along with viral warts, are common skin conditions that can be difficult to treat, especially when they recur or resist standard therapies. Isotretinoin, a medication traditionally used for acne, has recently shown promise as an adjuvant therapy for these conditions. This retrospective case-series study included four adult patients with persistent or recurrent tinea infections (tinea cruris and tinea corporis) or viral warts (genital and facial) who were treated with oral isotretinoin in addition to standard therapies. The patients' demographics, clinical presentations, treatment regimens, and responses were analyzed. All four patients showed significant clinical improvement after starting isotretinoin. Two patients with viral warts achieved complete clearance, and two patients with tinea infections experienced notable improvement. No severe side effects were reported. This case series suggests that isotretinoin may be a promising adjunctive therapy for patients with persistent or recurrent tinea infections and viral warts. However, further quantitative controlled studies are needed to confirm these findings and establish optimal treatment protocols. This study provides preliminary evidence for the potential benefit of using isotretinoin as an adjunctive therapy for recalcitrant tinea infections and viral warts. Further research is warranted to explore its efficacy and safety in larger populations.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Georgi Tchernev, Konstantin Georgiev Tchernev, Simona Kordeva
{"title":"Dermatologic surgery rounds: cheek advancement flap for lateral nasal defect reconstruction after basal cell carcinoma removal.","authors":"Georgi Tchernev, Konstantin Georgiev Tchernev, Simona Kordeva","doi":"10.4081/dr.2025.10443","DOIUrl":"https://doi.org/10.4081/dr.2025.10443","url":null,"abstract":"<p><p>A 75-year-old female presented to the dermatology department with a primary complaint of a solitary tumor formation located on the dorsum nasi region, slightly toward the left sidewall. The lesion was round, approximately 1 cm in diameter, prominent above the surrounding skin, with multiple telangiectasias and a characteristic pearly edge. The patient had a history of histologically verified basal cell carcinoma in the nasal region, previously excised with clean resection margins. Additional tumorous lesions can be seen in the right cheek and the superior labial region of the face. A clinical diagnosis of basal cell carcinoma was established, and surgical excision under local anesthesia with lidocaine was recommended to the patient.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea D'Arino, Maria Concetta Fargnoli, Pasquale Frascione, Chiara Assorgi, Annunziata Dattola, Viviana Lora, Matteo Megna, Flavia Pigliacelli, Emanuele Vagnozzi, Diego Orsini
{"title":"Efficacy and safety of risankizumab in patients with erythrodermic and sub-erythrodermic psoriasis: a case series.","authors":"Andrea D'Arino, Maria Concetta Fargnoli, Pasquale Frascione, Chiara Assorgi, Annunziata Dattola, Viviana Lora, Matteo Megna, Flavia Pigliacelli, Emanuele Vagnozzi, Diego Orsini","doi":"10.4081/dr.2025.10379","DOIUrl":"https://doi.org/10.4081/dr.2025.10379","url":null,"abstract":"<p><p>Erythrodermic psoriasis (EP) is a severe and complex form of psoriasis. While risankizumab, an interleukin (IL)-23 inhibitor, has demonstrated efficacy in patients with moderate-to-severe plaque psoriasis, its effectiveness in patients with EP remains less explored. The literature contains several small studies and case reports that provide evidence for the potential use of biologic therapies in the treatment of erythrodermic psoriasis. This case series suggests that risankizumab may represent an effective and sustainable treatment option for patients with a history of EP.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vincenzo Piccolo, Teresa Russo, Carlo Mazzatenta, Giuseppe Argenziano, Julia Nowowiejska, Mario Cutrone, Markus Danielsson Darlington, Aimilios Lallas, Ramon Grimalt, Andrea Bassi
{"title":"Self-induced discoloration of the face with red exogenous pigment detected by dermoscopy: a novel type of dermatitis artefacta in the COVID-19 era.","authors":"Vincenzo Piccolo, Teresa Russo, Carlo Mazzatenta, Giuseppe Argenziano, Julia Nowowiejska, Mario Cutrone, Markus Danielsson Darlington, Aimilios Lallas, Ramon Grimalt, Andrea Bassi","doi":"10.4081/dr.2025.10477","DOIUrl":"https://doi.org/10.4081/dr.2025.10477","url":null,"abstract":"<p><p>Dear Editor, Dermatitis artefacta (DA) is a condition on the border of psychiatry and dermatology, characterized by patients intentionally causing skin lesions to pretend that they are ill. DA is a very challenging entity to diagnose, as it can mimic many other disorders and is usually recognized only after exclusion of all other diseases. Herein, we report three cases of a novel cutaneous condition that could fall into the spectrum of DA. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rate of growth of Merkel cell carcinoma: a unique photographic evidence.","authors":"Eleonora Bearzi, Simona Sola, Carlotta Defferrari, Stefano Chiodi, Nicola Di Meo, Cesare Massone","doi":"10.4081/dr.2025.10457","DOIUrl":"https://doi.org/10.4081/dr.2025.10457","url":null,"abstract":"<p><p>Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin tumor, mainly linked to Merkel Cell Polyomavirus (MCPyV) and less often to ultraviolet exposure. Additional risk factors include advanced age and immunosuppression. Although MCC is known to grow rapidly, its exact growth rate has not been described yet. We report a case of a 73-year-old man who developed de novo MCC on the lower eyelid while undergoing immunotherapy with nivolumab. Clinical photographs document the absence of disease in March 2024 and the appearance of a 7 mm papule in October 2024. Histology confirmed the diagnosis. This case represents rare visual evidence of MCC's rapid progression, suggesting an estimated growth rate of approximately 1 mm/month. A controversial aspect is that MCC developed despite ongoing treatment with a PD-1 checkpoint inhibitor, currently recommended for this cancer. Although anecdotal, this case highlights MCC's progression and the need for further research and new therapies.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesco Ricci, Gianluca Pistore, Giovanni Di Lella, Luca Fania, Francesca Ricci, Siavash Rahimi, Annarita Panebianco, Cristina Fortes, Damiano Abeni
{"title":"Getting even: occurrence of histopathological primitive melanoma diagnoses three years after the COVID-19 lockdown.","authors":"Francesco Ricci, Gianluca Pistore, Giovanni Di Lella, Luca Fania, Francesca Ricci, Siavash Rahimi, Annarita Panebianco, Cristina Fortes, Damiano Abeni","doi":"10.4081/dr.2025.10318","DOIUrl":"https://doi.org/10.4081/dr.2025.10318","url":null,"abstract":"<p><p>The COVID-19 lockdown in 2020 caused a significant delay in histopathological melanoma diagnoses in Rome, Italy, leading to an increase in Breslow thickness and more aggressive tumor characteristics in the following years. Although there was a partial recovery in the number of diagnoses in 2021 and 2022, melanoma thickness remained higher than pre-pandemic levels. In 2023, our analysis of primary melanoma cases from the Histopathology Registry of Istituto Dermopatico dell'Immacolata (IDI)-IRCCS in Rome showed that Breslow thickness had finally returned to, or even improved beyond, 2019 levels - indicating a resolution of the diagnostic delay. At the same time, the proportion of ulcerated and nodular melanomas declined. These findings underscore the long-term effects of pandemic-related diagnostic disruptions and highlight the importance of maintaining continuous screening programs, even during public health crises. Ongoing public education on melanoma awareness and early detection remains crucial to preventing future delays.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}