Dermatology ReportsPub Date : 2025-05-23Epub Date: 2024-12-10DOI: 10.4081/dr.2024.10007
Chiara Frattini, Alberto Corrà, Elena Biancamaria Mariotti, Cristina Aimo, Valentina Ruffo di Calabria, Alessandro Magnatta, Simone Landini, Lavinia Quintarelli, Alice Verdelli, Marzia Caproni
{"title":"Stevens-Johnson syndrome/toxic epidermal necrolysis induced by lamotrigine in a patient with a cerebral cavernous malformation: a case report.","authors":"Chiara Frattini, Alberto Corrà, Elena Biancamaria Mariotti, Cristina Aimo, Valentina Ruffo di Calabria, Alessandro Magnatta, Simone Landini, Lavinia Quintarelli, Alice Verdelli, Marzia Caproni","doi":"10.4081/dr.2024.10007","DOIUrl":"10.4081/dr.2024.10007","url":null,"abstract":"<p><p>Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but serious cutaneous reactions characterized by epidermal and mucocutaneous detachment, most often drug-induced. SJS and TEN are considered the opposite extremes of the same spectrum of disease, where the percentage of skin involvement is <10% in SJS and >30% in TEN; the in-between range is called an SJS/TEN overlap. We present the case of a 64-year-old patient who was treated with lamotrigine, an anti-epileptic drug, and developed SJS/TEN. After being hospitalized and recovering for three days due to the worsening of the clinical presentation, he was transferred to a burn center. Making an early diagnosis and identifying the appropriate drug is crucial for setting the correct treatment and reducing mortality. Advanced supportive care is required.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dermatology ReportsPub Date : 2025-05-23Epub Date: 2024-10-23DOI: 10.4081/dr.2024.10143
Lina Al-Soufi, Aya Marashli, Rahaf Chukri HajBakri, Zuheir Al-Shehabi
{"title":"Cutaneous mastocytosis: diagnostic challenges and dietary influences.","authors":"Lina Al-Soufi, Aya Marashli, Rahaf Chukri HajBakri, Zuheir Al-Shehabi","doi":"10.4081/dr.2024.10143","DOIUrl":"10.4081/dr.2024.10143","url":null,"abstract":"<p><p>Cutaneous mastocytosis (CM) is a rare condition characterized by abnormal mast cell proliferation in the skin. We present the case of a 65-year-old man with recurrent urticaria-like rashes persisting for more than eight years. Despite multiple misdiagnoses as insect bites, examination and biopsy revealed mast cell infiltration. The patient's unique lifestyle, particularly his frequent seafood consumption, adds an intriguing dimension to the case. Treatment with systemic antihistamines and corticosteroids provided symptomatic relief, but long-term follow-up showed the persistence of clinical lesions, indicating that the treatment did not adequately address the underlying cause of the disease. A notable improvement in disease control was observed when the patient's diet was adjusted, suggesting a potential link between food and cutaneous mastocytosis. To our knowledge, this is the first documented case of maculopapular cutaneous mastocytosis in Syria.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"17 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dermatology ReportsPub Date : 2025-05-23Epub Date: 2024-11-08DOI: 10.4081/dr.2024.10169
Fortunato Cassalia, Andrea Danese, Carmine D'Acunto, Antonio Russo, Corrado Zengarini, Ignazio Stanganelli, Francesco Cusano, Fabrizio Fantini, Salvatore Amato, Davide Melandri, Cesare Massone, Anna Belloni Fortina
{"title":"Call for regulation of social media health content: an initiative of the Italian Association of Hospital Dermatologists (ADOI).","authors":"Fortunato Cassalia, Andrea Danese, Carmine D'Acunto, Antonio Russo, Corrado Zengarini, Ignazio Stanganelli, Francesco Cusano, Fabrizio Fantini, Salvatore Amato, Davide Melandri, Cesare Massone, Anna Belloni Fortina","doi":"10.4081/dr.2024.10169","DOIUrl":"10.4081/dr.2024.10169","url":null,"abstract":"<p><p>Social media platforms have become an indispensable part of modern society, with approximately 59.9% of the global population actively engaging on these platforms. In the realm of healthcare, and particularly in dermatology, a specialty that relies heavily on visual assessment and patient education, social media serves as a powerful conduit for disseminating information. The ability to share visual content makes these platforms uniquely suited to raising awareness about skin health, promoting preventive measures, and encouraging early detection of dermatological conditions. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dermatology ReportsPub Date : 2025-05-23Epub Date: 2024-10-23DOI: 10.4081/dr.2024.10010
Christian Ciolfi, Jacopo Tartaglia, Francesca Pampaloni, Laura Fagotto, Andrea Sechi, Mauro Alaibac
{"title":"Rilzabrutinib-induced transition from pemphigus vulgaris to pemphigus foliaceous: a case report and literature review.","authors":"Christian Ciolfi, Jacopo Tartaglia, Francesca Pampaloni, Laura Fagotto, Andrea Sechi, Mauro Alaibac","doi":"10.4081/dr.2024.10010","DOIUrl":"10.4081/dr.2024.10010","url":null,"abstract":"<p><p>The discovery of the role of Bruton's Tyrosine Kinase (BTK) in inflammation and autoimmunity has recently led to the development of BTK inhibitors for the treatment of autoimmune diseases, including pemphigus vulgaris. We herein present the case of a patient affected by pemphigus vulgaris, refractory to conventional immunosuppressive therapies and to multiple courses of rituximab, who was treated with rilzabrutinib and achieved disease control, but whose immunological profile switched from pemphigus vulgaris to pemphigus foliaceus after drug discontinuation. Furthermore, we reviewed the literature to better characterize the phenotypic transitions from pemphigus vulgaris to pemphigus foliaceus reported so far. The factors underlying this transition are largely unknown, although it has been postulated that immunosuppressive therapies may be more effective against anti-desmoglein 3 (DSG3) antibodies compared to anti-desmoglein 1 (DSG1). However, further studies are needed to clearly define the effect of rilzabrutinib (and immunosuppressive therapies in general) on anti-DSG1 and anti-DSG3 antibodies.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"17 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A large unilateral basal cell carcinoma treated with Hedgehog inhibitor sonidegib: a case report.","authors":"Maria Alessandra Mattioli, Valentina Benzecry, Giulia Murgia, Nerina Denaro, Angelo Valerio Marzano, Emanuela Passoni, Gianluca Nazzaro","doi":"10.4081/dr.2024.10152","DOIUrl":"10.4081/dr.2024.10152","url":null,"abstract":"<p><p>Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer. BCCs are categorized into \"easy-to-treat\" and \"difficult-to-treat\" groups, with the latter including all BCCs that are challenging to manage due to technical, patient-related, or tumor-related factors, such as locally advanced BCCs. In this report, we describe an 84-year-old patient with an extensive, unilateral BCC. Following a decision by the multidisciplinary skin cancer board, the patient was successfully treated with a daily dose of 200 mg of sonidegib, an inhibitor of the Hedgehog pathway, for eight months, acquiring complete clinical and histopathological remission. No significant side effects were reported. The follow-up period of 24 months has shown no negative results.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dermatology ReportsPub Date : 2025-05-23Epub Date: 2024-12-05DOI: 10.4081/dr.2024.10084
Francesca Magri, Luca Fania, Tonia Samela, Francesco Ricci, Giovanni Di Lella, Angelo Massimiliano D'Erme, Giovanna Galdo, Francesco Cusano, Antonio Perasole, Damiano Abeni, Luigi Naldi, Cesare Massone
{"title":"Lack of communication between dermatologists and histopathologists in real-life settings: a survey of the Italian Association of Hospital Dermatologists (ADOI).","authors":"Francesca Magri, Luca Fania, Tonia Samela, Francesco Ricci, Giovanni Di Lella, Angelo Massimiliano D'Erme, Giovanna Galdo, Francesco Cusano, Antonio Perasole, Damiano Abeni, Luigi Naldi, Cesare Massone","doi":"10.4081/dr.2024.10084","DOIUrl":"10.4081/dr.2024.10084","url":null,"abstract":"<p><p>Skin cancer incidence is increasing worldwide. Clear communication between dermatologists and histopathologists, along with the possibility of sharing clinical images, is critically important. This survey aims to depict the level of communication between dermatologists and histopathologists in clinical practice in Italy. A group of histopathologists participating in monthly online meetings was recruited to participate in our survey. We collected information regarding dermatologists' habits in providing or not providing clinical and dermatoscopic images of melanocytic/keratinocytic lesions. A total of 63 histopathologists agreed to participate. Fewer than 15% of histopathologists receive routine clinical or dermatoscopic images from dermatologists after the surgical excision of a melanocytic lesion, while clinical and dermoscopic images of non-melanoma skin cancers (NMSC) are sent in fewer than 10% of cases. Our survey revealed that, in Italy, the communication between dermatologists and pathologists is far from being optimal.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fortunato Cassalia, Paolo Del Fiore, Andrea Danese, Michele Soldà, Vincenzo Furfaro, Simone Mocellin
{"title":"Diagnostic challenges and importance of early multidisciplinary intervention in acral melanoma: a case report.","authors":"Fortunato Cassalia, Paolo Del Fiore, Andrea Danese, Michele Soldà, Vincenzo Furfaro, Simone Mocellin","doi":"10.4081/dr.2025.10332","DOIUrl":"https://doi.org/10.4081/dr.2025.10332","url":null,"abstract":"<p><p>Acral melanoma (AM) is a rare subtype of melanoma that occurs on acral sites such as the palms, soles, and subungual regions. Due to its atypical presentation and frequent lack of pigmentation in the amelanotic variant (AAM), diagnosis is often delayed, leading to a poor prognosis. We present the case of a 69-year-old woman with a chronic nail lesion that was initially misdiagnosed as onychomycosis and treated with partial onychectomy without histological evaluation. The lesion persisted, and subsequent dermatological evaluation revealed an ulcerated exophytic mass, which was confirmed as an acral nodular melanoma with a Breslow thickness of 7.5 mm. Despite surgical amputation, the patient's management was complicated by wound infection and limited therapeutic options due to comorbidities. This case highlights the diagnostic challenges of AM and emphasizes the importance of early histopathological assessment and multidisciplinary collaboration for timely intervention and improved outcomes.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cesare Ariasi, Carlo Cota, Cesare Massone, Carmine D'Acunto, Pietro Danese, Maurizio Lombardo, Davide Melandri, Francesca Scarpellini, Rosa Rinaldi, Paola Pasquini, Paolo Incardona, Piergiacomo Calzavara-Pinton, Paola Monari
{"title":"Retrospective multicenter study on severely dysplastic melanocytic nevi: evaluating the need for re-excision and the risk of recurrence or progression.","authors":"Cesare Ariasi, Carlo Cota, Cesare Massone, Carmine D'Acunto, Pietro Danese, Maurizio Lombardo, Davide Melandri, Francesca Scarpellini, Rosa Rinaldi, Paola Pasquini, Paolo Incardona, Piergiacomo Calzavara-Pinton, Paola Monari","doi":"10.4081/dr.2025.10349","DOIUrl":"https://doi.org/10.4081/dr.2025.10349","url":null,"abstract":"<p><p>Severely dysplastic melanocytic nevi (SMD) are histologically challenging lesions with no consensus on optimal management. While complete excision is widely recommended, the necessity of additional reexcision remains debated. This retrospective, multicenter observational cohort study evaluated the risk of recurrence and disease progression in patients with SMD by comparing those who underwent a single complete excision to those who underwent a secondary widening procedure with 5 mm margins. A total of 226 patients (230 SMD lesions) were included, with diagnoses based on the 2018 World Health Organization (WHO) criteria. Among them, 13.5% underwent re-excision despite clear margins, while 86.5% were followed clinically. Over a minimum 5-year follow-up period, no patient in either group experienced recurrence at the excision site or progression to melanoma. These findings suggest that complete excision with clear margins is sufficient for managing SMD, with no added benefit from routine re-excision. Avoiding unnecessary surgical procedures could reduce patient anxiety, healthcare costs, and surgical morbidity. Given the lack of standardized guidelines, further prospective studies are needed to refine clinical decision-making for SMD management.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ilaria Demofonte, Emanuele Miraglia, Giovanni Pellacani, Sandra Giustini
{"title":"Urbach-Wiethe syndrome: report of two clinical cases.","authors":"Ilaria Demofonte, Emanuele Miraglia, Giovanni Pellacani, Sandra Giustini","doi":"10.4081/dr.2025.10230","DOIUrl":"https://doi.org/10.4081/dr.2025.10230","url":null,"abstract":"<p><p>Urbach-Wiethe syndrome, also known as lipoid proteinosis (LP), is a rare genodermatosis clinically characterized by mucocutaneous lesions, dysphonia with onset in early childhood, and, sometimes, neurological complications. Clinical signs, as well as the severity of the disease, are highly variable, while its course is usually slowly progressive. The typical primary sign is hoarse crying, due to laryngeal infiltration, at birth or during early childhood. Alterations of the skin and mucous membranes develop within the first two years of life. The skin lesions initially appear on the face and limbs and usually resolve by healing. Infiltration of the respiratory system can cause upper respiratory tract infections, hoarseness or aphonia, dysphagia, and even airway obstruction. Dystonia, epileptic seizures, and learning disorders may be observed in affected children. Treatment remains a major challenge since no standardized therapies exist, but oral acitretin appears to be effective in improving skin manifestations. We report two clinical cases of young women suffering from LP, presenting with dermatological, otorhinolaryngological, and neurological symptoms, currently referred to our Rare Cutaneous Syndrome Center at the Policlinico Umberto I in Rome (Italy).</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesco Drago, Serena Varesano, Astrid Herzum, Giulia Ciccarese
{"title":"Pityriasis rosea manifesting only with a herald patch.","authors":"Francesco Drago, Serena Varesano, Astrid Herzum, Giulia Ciccarese","doi":"10.4081/dr.2025.10326","DOIUrl":"https://doi.org/10.4081/dr.2025.10326","url":null,"abstract":"<p><p>Dear Editor, Pityriasis rosea (PR) is an acute, self-limited exanthematous disease associated with the endogenous systemic reactivation of human herpesvirus (HHV)-6 and/or HHV-7. The disease typically begins with a single erythematous plaque called the \"herald patch\" (HP), followed by a secondary generalized, symmetrical eruption. Rarely, PR can be limited only to the herald patch. The clinical and laboratory features of these atypical PR have been poorly investigated. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}