Dermatology Reports最新文献_第10页

Hidradenitis suppurativa: state-of-the-art review and update. 化脓性汗腺炎：最新的回顾和更新。

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Dermatology Reports Pub Date : 2026-05-11 Epub Date: 2025-08-27 DOI: 10.4081/dr.2025.10328

Marco Virone, Elena Zappia, Alberto Di Caro, Davide Carlesimo, Nicoletta Bernardini, Giovanni Pellacani, Antonio Giovanni Richetta, Steven Paul Nisticò, Annunziata Dattola

{"title":"Hidradenitis suppurativa: state-of-the-art review and update.","authors":"Marco Virone, Elena Zappia, Alberto Di Caro, Davide Carlesimo, Nicoletta Bernardini, Giovanni Pellacani, Antonio Giovanni Richetta, Steven Paul Nisticò, Annunziata Dattola","doi":"10.4081/dr.2025.10328","DOIUrl":"10.4081/dr.2025.10328","url":null,"abstract":"Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by painful nodules, abscesses, and draining tunnels in areas such as the axillae, groin, and inframammary regions. It typically emerges in early adulthood, with a global prevalence of approximately 1%, though regional variations exist. HS significantly affects patients' quality of life and imposes considerable socioeconomic burdens. It is frequently associated with metabolic syndrome, inflammatory arthritis, and inflammatory bowel disease, reflecting its underlying systemic inflammatory nature. The pathogenesis of HS involves innate immune mechanisms, including macrophages, neutrophils, interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and granulocyte colony-stimulating factor, alongside adaptive immune responses mediated by T cells (IL-17, interferon [IFN]-γ) and B cells, which contribute to autoantibody formation and tertiary lymphoid structures. Chronic inflammation results in irreversible tissue damage, tunnel formation, and severe scarring. Treatment strategies vary based on disease severity. Early inflammatory stages benefit from pharmacological therapies, while later stages require a combination of medical and surgical interventions, with surgery often necessary for advanced cases. The introduction of targeted biologic therapies, including TNF-α (adalimumab) and IL-17 inhibitors (secukinumab, bimekizumab), has expanded treatment options beyond traditional antibiotic regimens. Effective management focuses on early intervention to prevent irreversible damage, control symptoms such as pain, and address systemic comorbidities. A timely diagnosis, along with a multidisciplinary and personalized approach, is essential for improving patient outcomes and quality of life.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13487732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rate of growth of Merkel cell carcinoma: a unique photographic evidence. 默克尔细胞癌的生长速度：一种独特的摄影证据。

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Dermatology Reports Pub Date : 2026-05-11 Epub Date: 2025-07-25 DOI: 10.4081/dr.2025.10457

Eleonora Bearzi, Simona Sola, Carlotta Defferrari, Stefano Chiodi, Nicola Di Meo, Cesare Massone

引用次数: 0

Stevens-Johnson syndrome and toxic epidermal necrolysis in Saudi Arabia: a retrospective cross-sectional multicenter study. 史蒂文斯-约翰逊综合征和中毒性表皮坏死松解在沙特阿拉伯：一项回顾性横断面多中心研究。

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Dermatology Reports Pub Date : 2026-05-11 Epub Date: 2025-07-18 DOI: 10.4081/dr.2025.10275

Rayan Alkhodair, Yazeed Alowairdhi, Abdulrahman Alfawzan, Ali Alghamdi

{"title":"Stevens-Johnson syndrome and toxic epidermal necrolysis in Saudi Arabia: a retrospective cross-sectional multicenter study.","authors":"Rayan Alkhodair, Yazeed Alowairdhi, Abdulrahman Alfawzan, Ali Alghamdi","doi":"10.4081/dr.2025.10275","DOIUrl":"10.4081/dr.2025.10275","url":null,"abstract":"Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are a spectrum of life-threatening mucocutaneous conditions. Despite having a lower incidence rate than other dermatological conditions, SJS/TEN has a high mortality rate. SJS/TEN is usually caused by newly administered medications, particularly antibacterials and anticonvulsants. Little research data on SJS/TEN in Saudi Arabia has been published. We aimed to bridge this gap by reviewing and investigating the etiologies, risk factors, interventions, and outcomes of patients diagnosed with SJS/TEN. This is a retrospective cross-sectional study conducted in National Guard hospitals in Riyadh and Jeddah from January 2015 to July 2023. We reviewed all dermatology medical records diagnosed as SJS/TEN through clinical assessment and histopathology, confirmed by a dermatology consultant. Additionally, we excluded all non-Saudi patients and those referred to our center with outside reports without histopathology from the National Guard hospitals. This study included 25 patients diagnosed with the SJS/TEN spectrum between January 2015 and July 2023. Nearly two-thirds of the patients were male (n=15, 60%), and the average age was 45.96 years. Almost half of the culprit agents were antibiotics. Six of the 25 patients died (24%). Four were males, all over 50 years old, and one female was 6 years old. All these patients had TEN, except for one with SJS. Septic shock was the cause of death in 4 patients. Given the evident high risk for patients contracting this condition, prospective research and analysis to understand the correlation between SJS/TEN, mortality, and treatment are warranted.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13339900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mixed-pattern, essential syphilitic alopecia, uveitis, and papillitis in an immunocompetent patient with neurosyphilis. 混合型，原发性梅毒性脱发，葡萄膜炎和乳头炎在免疫功能正常的神经梅毒患者。

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Dermatology Reports Pub Date : 2026-05-11 Epub Date: 2025-07-22 DOI: 10.4081/dr.2025.10371

Sumeetha Swaminathan, Irina Lerman, Kathleen Mannava, Luca Zatreanu, Anna De Benedetto

引用次数: 0

Psoriasis treatments in Europe during the 19th century. 19世纪欧洲牛皮癣的治疗。

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Dermatology Reports Pub Date : 2026-05-11 Epub Date: 2025-09-05 DOI: 10.4081/dr.2025.10288

Flavio Stocco, Carlo Cota, Maria Concetta Fargnoli, Viviana Lora

{"title":"Psoriasis treatments in Europe during the 19th century.","authors":"Flavio Stocco, Carlo Cota, Maria Concetta Fargnoli, Viviana Lora","doi":"10.4081/dr.2025.10288","DOIUrl":"10.4081/dr.2025.10288","url":null,"abstract":"Psoriasis is a dermatological disorder whose clinical manifestations have attracted the interest of physicians since ancient times. Hippocrates of Kos in the 5th century B.C. and later Galen in the 1st century A.D. were the first to refer to skin lesions characterized by scales and itching. In the 19th century, dermatology progressed, gaining scientific autonomy and leading to improvements both in the clinical study of psoriasis and in the search for new treatment methodologies. The dermatological schools established in this century, located in London, Paris, and Vienna, dedicated themselves to studying skin diseases, adopting unique methodological approaches, and creating dermatological nomenclature. The English school focused on the objective description of lesions, while the French school was the first to approach the study of evolutionary processes, formulating theories not always based on experimental methods. Finally, the Austrian school based its research entirely on the study of diseases through the use of instruments and laboratory tests. Representatives of all three schools played a crucial role in the scientific progress of dermatology, leading to the subsequent evolution and improvement of therapies, which gradually replaced the use of ancient remedies and archaic administration methods. The treatments promoted by the different 19th-century European dermatologists reflected both their scientific thinking and the medical beliefs of the time. For this reason, the following historical-medical reconstruction of the evolution of psoriasis therapies in the 19th century can contribute to enriching the studies of dermatology.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"18 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13339903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Getting even: occurrence of histopathological primitive melanoma diagnoses 3 years after the COVID-19 lockdown. 报复：在COVID-19封锁三年后，组织病理学原始黑色素瘤诊断的发生。

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Dermatology Reports Pub Date : 2026-05-11 Epub Date: 2025-07-23 DOI: 10.4081/dr.2025.10318

Francesco Ricci, Gianluca Pistore, Giovanni Di Lella, Luca Fania, Francesca Ricci, Siavash Rahimi, Annarita Panebianco, Cristina Fortes, Damiano Abeni

{"title":"Getting even: occurrence of histopathological primitive melanoma diagnoses 3 years after the COVID-19 lockdown.","authors":"Francesco Ricci, Gianluca Pistore, Giovanni Di Lella, Luca Fania, Francesca Ricci, Siavash Rahimi, Annarita Panebianco, Cristina Fortes, Damiano Abeni","doi":"10.4081/dr.2025.10318","DOIUrl":"10.4081/dr.2025.10318","url":null,"abstract":"The COVID-19 lockdown in 2020 caused a significant delay in histopathological melanoma diagnoses in Rome, Italy, leading to an increase in Breslow thickness and more aggressive tumor characteristics in the following years. Although there was a partial recovery in the number of diagnoses in 2021 and 2022, melanoma thickness remained higher than pre-pandemic levels. In 2023, our analysis of primary melanoma cases from the Histopathology Registry of Istituto Dermopatico dell'Immacolata IRCCS in Rome showed that Breslow thickness had finally returned to, or even improved beyond, 2019 levels - indicating a resolution of the diagnostic delay. At the same time, the proportion of ulcerated and nodular melanomas declined. These findings underscore the long-term effects of pandemic-related diagnostic disruptions and highlight the importance of maintaining continuous screening programs, even during public health crises. Ongoing public education on melanoma awareness and early detection remains crucial to preventing future delays.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13487731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary cutaneous marginal zone lymphoma in a patient with multiple sclerosis under fingolimod therapy. 芬戈莫德治疗下多发性硬化症患者的原发性皮肤边缘区淋巴瘤。

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Dermatology Reports Pub Date : 2026-05-11 Epub Date: 2025-07-11 DOI: 10.4081/dr.2025.10237

Thilo Gambichler, Sera Selina Weyer-Fahlbusch, Markus Werner, Ulrika Schade, Lieselotte Bissels, Laura Susok

引用次数: 0

Hair greying associated with rosemary use: a cross-sectional study in Saudi Arabia. 迷迭香与头发变白有关：沙特阿拉伯的一项横断面研究。

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Dermatology Reports Pub Date : 2026-05-11 Epub Date: 2025-08-29 DOI: 10.4081/dr.2025.10126

Hamad J Aldhafiri, Hind Alshalhoob, Salma Mohammed Alshreef, Farah Abdullah Alassaf, Albatool Aljofan, Halah Omar Alamawi, Sara AlNowaiser, Hind M Almohanna

{"title":"Hair greying associated with rosemary use: a cross-sectional study in Saudi Arabia.","authors":"Hamad J Aldhafiri, Hind Alshalhoob, Salma Mohammed Alshreef, Farah Abdullah Alassaf, Albatool Aljofan, Halah Omar Alamawi, Sara AlNowaiser, Hind M Almohanna","doi":"10.4081/dr.2025.10126","DOIUrl":"10.4081/dr.2025.10126","url":null,"abstract":"The sociological and psychological consequences of premature hair greying (PHG) are significant. PHG has been linked to various intrinsic and extrinsic factors, including genetic predispositions and environmental influences. The widespread use of hair growth-stimulating products may impact the hair greying process. This cross-sectional study aimed to determine the prevalence of hair greying among rosemary users in the Saudi Arabian population. A self-administered questionnaire was distributed among the sample population in the form of an online survey. This questionnaire included sociodemographic data (e.g., age, gender, and education), the use of several types of rosemary, and the outcomes. A total of 994 participants completed the survey, the majority of whom were female (94.4%). Participants aged between 18 and 24 years represented 64% of the sample. Hair loss was reported by 75.4% of respondents. More than half (58.7%) reported using rosemary, particularly rosemary oil, as a treatment. Among those who used rosemary, 22.8% reported experiencing hair greying. Increasing age emerged as an independent risk factor for PHG. However, multivariate regression analysis showed that the use of rosemary oil was associated with a reduced likelihood of hair greying. Approximately 25% of rosemary users developed PHG, and individuals in the early to middle-age range with a bachelor's degree or higher had a 1.5 to 3.5 times greater risk of hair greying. Nevertheless, the use of rosemary oil appeared to mitigate this risk. Additional observational studies are needed to validate the high regional prevalence of hair greying, potentially associated with rosemary use.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13339901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Squamous cell carcinoma arising from chronic cutaneous leishmaniasis: a rare case report. 慢性皮肤利什曼病引起的鳞状细胞癌一例罕见报告。

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Dermatology Reports Pub Date : 2026-05-11 Epub Date: 2025-09-05 DOI: 10.4081/dr.2025.10187

Lina Al-Soufi, Aya Marashli, Mohammad Adi, Zuheir Al-Shehabi

{"title":"Squamous cell carcinoma arising from chronic cutaneous leishmaniasis: a rare case report.","authors":"Lina Al-Soufi, Aya Marashli, Mohammad Adi, Zuheir Al-Shehabi","doi":"10.4081/dr.2025.10187","DOIUrl":"10.4081/dr.2025.10187","url":null,"abstract":"Leishmaniasis is a parasitic disease transmitted by sandflies, commonly manifesting as cutaneous or mucocutaneous lesions. While cutaneous leishmaniasis (CL) is widespread in endemic regions, its link to malignancies like squamous cell carcinoma (SCC) remains uncertain. We report a rare case of SCC developing directly on a CL lesion, contributing to the ongoing debate regarding this potential association. A 75-year-old man from an endemic region presented with a red papule following an insect bite. Despite receiving 6 sessions of intralesional therapy, the lesion worsened due to a one-year lapse in follow-up and use of alternative therapies. Biopsy confirmed moderately differentiated SCC, leading to surgical removal and recovery without complications. The development of SCC on a previous CL lesion is rare but notable, as chronic infections can trigger malignancy. Although no definitive link has been established between CL and SCC, this case underscores the need for monitoring persistent leishmaniasis lesions, especially in mismanaged cases. It also emphasizes the importance of timely diagnosis and treatment of CL to avoid complications such as SCC. Further research is needed to determine the mechanisms underlying this rare association.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"18 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13339904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148344094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical features, safety, and efficacy of combining Q-switched Nd:YAG laser and FOB^® Tri-White Serum in melasma treatment. 调q Nd:YAG激光联合FOB®三白血清治疗黄褐斑的临床特点、安全性和疗效。

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Dermatology Reports Pub Date : 2026-05-11 Epub Date: 2025-09-02 DOI: 10.4081/dr.2025.10270

Thi Xuan Tam Huynh, Bay Quach Thi

{"title":"Clinical features, safety, and efficacy of combining Q-switched Nd:YAG laser and FOB® Tri-White Serum in melasma treatment.","authors":"Thi Xuan Tam Huynh, Bay Quach Thi","doi":"10.4081/dr.2025.10270","DOIUrl":"10.4081/dr.2025.10270","url":null,"abstract":"Melasma is a benign skin condition characterized by hyperpigmented patches, primarily affecting the face, and significantly reducing patients' quality of life. Treatment is challenging due to its recurrent nature, with no single modality proving universally effective. The combination of Q-switched Nd:YAG laser treatment and FOB® Tri-White Serum (Hong Nhung Cosmetics Co., Ltd., Can Tho, Vietnam) may represent a promising new therapeutic approach. This cross-sectional descriptive study involved 85 female patients with melasma treated at two dermatological centers between July 2023 and June 2024. Patients underwent four Q-switched Nd:YAG laser sessions (1064 nm, 1.5-1.7 J/cm2) at 3-week intervals and applied FOB® Tri-White Serum twice or three times daily. Treatment effectiveness was assessed using the Melasma Area and Severity Index (MASI) score and the Felix Von Luschan skin color chart. Data were analyzed using Stata 17.0 MP, with p<0.05 considered statistically significant. The mean MASI score improved significantly from 7.5±4.7 to 4.9±3.5 (p<0.05), with a 69.4% response rate. Younger patients (<45 years), individuals with a shorter disease duration (≤36 months), and cases of mild-to-moderate melasma exhibited more favorable outcomes. Adverse effects from both the laser and serum were mild and transient. The combination of Q-switched Nd:YAG laser and FOB® Tri-White Serum is a safe and effective treatment for melasma, demonstrating significant improvement in pigmentation with minimal side effects. Further research is needed to validate these findings with larger sample sizes and control groups.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13339902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0