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Metronidazole-induced linear immunoglobulin A disease in a patient suffering from ulcerative colitis: a case report and focused review of the literature 甲硝唑诱导的溃疡性结肠炎患者的线性免疫球蛋白A疾病:一例报告和文献综述
Dermatology Reports Pub Date : 2023-08-29 DOI: 10.4081/dr.2023.9831
Stefano Buffon, Michele Parietti, Andrea Carugno, Elisa Robustelli Test, Angelo Valerio Marzano, Paolo Sena, Pamela Vezzoli
{"title":"Metronidazole-induced linear immunoglobulin A disease in a patient suffering from ulcerative colitis: a case report and focused review of the literature","authors":"Stefano Buffon, Michele Parietti, Andrea Carugno, Elisa Robustelli Test, Angelo Valerio Marzano, Paolo Sena, Pamela Vezzoli","doi":"10.4081/dr.2023.9831","DOIUrl":"https://doi.org/10.4081/dr.2023.9831","url":null,"abstract":"Linear immunoglobulin (Ig) A disease (LAD) is a rare autoimmune blistering dermatosis caused by linear deposition of IgA1 along the dermoepidermal junction of skin and mucosae. It can affect both children and adults. Although idiopathic in most cases, it can also be associated with infections, malignancies, or drug administration. Among medications, antibiotics are most commonly responsible, particularly vancomycin. We report the case of a 51-year-old female patient who developed mucocutaneous LAD after oral metronidazole administration, which was confirmed by histopathological examination and direct immunofluorescence of one of the bullous lesions. Lesions rapidly cleared after metronidazole discontinuation and a short course of oral methylprednisolone and dapsone. To our knowledge, this is the third reported case of metronidazole-induced LAD, and the first in which metronidazole was not administered in combination with other antibiotics such as ceftriaxone.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136283194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delayed breast cellulitis post nipple-sparing mastectomy surgery. 保留乳头乳房切除术后迟发性乳腺蜂窝织炎。
IF 2.3
Dermatology Reports Pub Date : 2023-08-29 eCollection Date: 2024-09-02 DOI: 10.4081/dr.2024.9793
Vittoria Cioppa, Pietro Rubegni, Ernesto De Piano
{"title":"Delayed breast cellulitis post nipple-sparing mastectomy surgery.","authors":"Vittoria Cioppa, Pietro Rubegni, Ernesto De Piano","doi":"10.4081/dr.2024.9793","DOIUrl":"10.4081/dr.2024.9793","url":null,"abstract":"","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"16 3","pages":"9793"},"PeriodicalIF":2.3,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Definitive histology control after Mohs micrographic surgery: pleonastic or not? 莫氏显微摄影手术后明确的组织学控制:增生与否?
Dermatology Reports Pub Date : 2023-08-29 DOI: 10.4081/dr.2023.9827
Ernesto De Piano, Vittoria Cioppa, Valentina Ongaro, Filomena Russo, Pietro Rubegni, Clelia Miracco
{"title":"Definitive histology control after Mohs micrographic surgery: pleonastic or not?","authors":"Ernesto De Piano, Vittoria Cioppa, Valentina Ongaro, Filomena Russo, Pietro Rubegni, Clelia Miracco","doi":"10.4081/dr.2023.9827","DOIUrl":"https://doi.org/10.4081/dr.2023.9827","url":null,"abstract":"Not available","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136283375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delayed breast cellulitis post nipple-sparing mastectomy surgery 保留乳头乳房切除术后迟发性乳腺蜂窝织炎
IF 1.1
Dermatology Reports Pub Date : 2023-08-29 DOI: 10.4081/dr.2023.9793
Vittoria Cioppa, Pietro Rubegni, E. De Piano
{"title":"Delayed breast cellulitis post nipple-sparing mastectomy surgery","authors":"Vittoria Cioppa, Pietro Rubegni, E. De Piano","doi":"10.4081/dr.2023.9793","DOIUrl":"https://doi.org/10.4081/dr.2023.9793","url":null,"abstract":"Not available","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42101161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Definitive histology control after Mohs micrographic surgery: pleonastic or not? 莫氏显微摄影手术后明确的组织学控制：增生与否？
IF 2.3
Dermatology Reports Pub Date : 2023-08-29 eCollection Date: 2024-09-02 DOI: 10.4081/dr.2024.9827
Ernesto De Piano, Vittoria Cioppa, Valentina Ongaro, Filomena Russo, Pietro Rubegni, Clelia Miracco
{"title":"Definitive histology control after Mohs micrographic surgery: pleonastic or not?","authors":"Ernesto De Piano, Vittoria Cioppa, Valentina Ongaro, Filomena Russo, Pietro Rubegni, Clelia Miracco","doi":"10.4081/dr.2024.9827","DOIUrl":"10.4081/dr.2024.9827","url":null,"abstract":"","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"16 3","pages":"9827"},"PeriodicalIF":2.3,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blastic plasmacytoid dendritic cell neoplasm: a short review and update. 大疱性浆细胞树突状细胞瘤：简短回顾与最新进展。
IF 2.3
Dermatology Reports Pub Date : 2023-08-11 eCollection Date: 2024-05-07 DOI: 10.4081/dr.2023.9781
Cesare Massone, Giulia Rivoli, Simona Sola, Emanuele Angelucci
{"title":"Blastic plasmacytoid dendritic cell neoplasm: a short review and update.","authors":"Cesare Massone, Giulia Rivoli, Simona Sola, Emanuele Angelucci","doi":"10.4081/dr.2023.9781","DOIUrl":"https://doi.org/10.4081/dr.2023.9781","url":null,"abstract":"<p><p>Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic neoplasm (less than 1% of primary cutaneous lymphomas and acute leukemia) with a highly aggressive clinical course and frequent skin, bone marrow and central nervous system involvement. Even though there is often an early response to chemotherapy, leukemic dissemination relapses are very common and result in poor outcomes, with a median overall survival of 8 to 14 months in the first-line setting using standard combination chemotherapy regimens. Almost 90% of patients experience skin involvement as their initial site of infection, where BPDCN may stay restricted for weeks or even months until a swift secondary phase involving multiple organs takes place. Consequently, it is crucial to suspect and identify early skin lesions, as well as to conduct and report a skin biopsy as soon as possible. In order to diagnose and treat BPDCN, a multidisciplinary strategy involving collaboration between pathologists, hematologists, and dermatologists is unquestionably essential.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"16 Suppl 2","pages":"9781"},"PeriodicalIF":2.3,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blastic plasmacytoid dendritic cell neoplasm: a short review and update 母浆细胞样树突状细胞肿瘤:综述与最新进展
Dermatology Reports Pub Date : 2023-08-11 DOI: 10.4081/dr.2021.9781
Cesare Massone, Giulia Rivoli, Simona Sola, Emanuele Angelucci
{"title":"Blastic plasmacytoid dendritic cell neoplasm: a short review and update","authors":"Cesare Massone, Giulia Rivoli, Simona Sola, Emanuele Angelucci","doi":"10.4081/dr.2021.9781","DOIUrl":"https://doi.org/10.4081/dr.2021.9781","url":null,"abstract":"Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic neoplasm (less than 1% of primary cutaneous lymphomas and acute leukemia) with a highly aggressive clinical course and frequent skin, bone marrow and central nervous system (CNS) involvement. Despite a frequent initial response to chemotherapy, relapses with eventual leukemic dissemination are extremely common, leading to poor outcomes and a median overall survival (OS) ranging from 8 to 14 months in first line setting, with standard combination chemotherapy regimens. The skin is the first affected site (in almost 90% of patients) where BPDCN may remain confined for weeks or even months (sanctuary?) until a rapid second step with multiorgan involvement occurs. Therefore, it is of uppermost importance to suspect and recognize early skin lesions and to perform and report a skin biopsy as soon as possible. A multidisciplinary approach with coordination among dermatologists, pathologists and hematologists is definitively crucial in diagnosis and management of BPDCN.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135397364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Langerhans cell histiocytosis presenting as a blueberry muffin rash 朗格汉斯细胞组织细胞增多症表现为蓝莓松饼疹
Dermatology Reports Pub Date : 2023-08-09 DOI: 10.4081/dr.2023.9791
Shahad F. Alanazi, Yara Jazzar, Tala Beidas, Haya Soufan, Khaled A. Mohajer, Abdulmalik Alhammad
{"title":"Langerhans cell histiocytosis presenting as a blueberry muffin rash","authors":"Shahad F. Alanazi, Yara Jazzar, Tala Beidas, Haya Soufan, Khaled A. Mohajer, Abdulmalik Alhammad","doi":"10.4081/dr.2023.9791","DOIUrl":"https://doi.org/10.4081/dr.2023.9791","url":null,"abstract":"Langerhans cells, often referred to as the “macrophages of the skin”, are dendritic cells that normally reside in the epidermis and papillary dermis. Just like macrophages, they function as antigen-presenting cells that activate naive T cells. Certain mutations such as those involving the BRAF gene can cause unopposed production of Langerhans Cells, which is known as Langerhans Cell Histiocytosis (LCH). LCH triggers an inflammatory immune response that causes systemic manifestations such as fever and fatigue, as well as other manifestations depending on the affected organs. The pathogenesis behind LCH remains poorly understood. It is still unknown whether it is a neoplastic process or a reactive cancer-mimicking illness. Diagnosis of LCH is confirmed by biopsy, and treatment is largely dependent on the extent and severity of the disease. Common treatments include corticosteroids, excision, radiation, and chemotherapy. We present a case of a 1-year-old Saudi male with LCH.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135696865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combination of cyclosporine A and methylprednisolone to treat pediatric Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome. 联合使用环孢素 A 和甲基强的松龙治疗小儿史蒂文斯-约翰逊综合征/毒性表皮坏死重叠综合征。
IF 2.3
Dermatology Reports Pub Date : 2023-06-19 eCollection Date: 2023-06-07 DOI: 10.4081/dr.2023.9656
Shinta Trilaksmi Dewi, Laily Noor Qomariah, Widya Khairunisa Sarkowi, Monika Puspitasari, Miya Khalidah, Marcella Anggatama, Dwinanda Almira Rizkiani, Kristiana Etnawati, Sri Awalia Febriana
{"title":"Combination of cyclosporine A and methylprednisolone to treat pediatric Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome.","authors":"Shinta Trilaksmi Dewi, Laily Noor Qomariah, Widya Khairunisa Sarkowi, Monika Puspitasari, Miya Khalidah, Marcella Anggatama, Dwinanda Almira Rizkiani, Kristiana Etnawati, Sri Awalia Febriana","doi":"10.4081/dr.2023.9656","DOIUrl":"10.4081/dr.2023.9656","url":null,"abstract":"<p><p>The treatment of epidermal necrolysis in pediatric patients remains a major challenge. Cyclosporine A has emerged as a promising therapy for epidermal necrolysis in adults; however, its efficacy in children is unclear. We present the case of a boy with Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome who was initially resistant to methylprednisolone monotherapy but improved after receiving the combination of cyclosporine A and methylprednisolone. Published reports on the use of cyclosporine A for pediatric epidermal necrolysis are also briefly reviewed.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"15 2","pages":"9656"},"PeriodicalIF":2.3,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4d/82/dr-15-2-9656.PMC10327664.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9811484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Environmental factors in autoimmune bullous diseases with a focus on seasonality: new insights. 关注季节性自身免疫性大疱性疾病的环境因素：新见解。
IF 1.1
Dermatology Reports Pub Date : 2023-06-14 eCollection Date: 2023-09-12 DOI: 10.4081/dr.2023.9641
Roberto D'Astolto, Lavinia Quintarelli, Alberto Corrà, Marzia Caproni, Luca Fania, Giovanni Di Zenzo, Biagio Didona, Giulia Gasparini, Emanuele Cozzani, Claudio Feliciani
{"title":"Environmental factors in autoimmune bullous diseases with a focus on seasonality: new insights.","authors":"Roberto D'Astolto,&nbsp;Lavinia Quintarelli,&nbsp;Alberto Corrà,&nbsp;Marzia Caproni,&nbsp;Luca Fania,&nbsp;Giovanni Di Zenzo,&nbsp;Biagio Didona,&nbsp;Giulia Gasparini,&nbsp;Emanuele Cozzani,&nbsp;Claudio Feliciani","doi":"10.4081/dr.2023.9641","DOIUrl":"https://doi.org/10.4081/dr.2023.9641","url":null,"abstract":"<p><p>Autoimmune bullous diseases are a heterogeneous group of rare conditions clinically characterized by the presence of blisters and/or erosions on the skin and the mucous membranes. Practically, they can be divided into two large groups: the pemphigoid group and the pemphigus group, depending on the depth of the autoimmune process on the skin. A family history of autoimmune diseases can often be found, demonstrating that genetic predisposition is crucial for their development. Moreover, numerous environmental risk factors, such as solar radiation, drugs, and infections, are known. This study aimed to evaluate how seasonality can affect the trend of bullous pemphigoid and pemphigus vulgaris, especially considering the number of hospitalizations recorded over the course of individual months. The total number of hospitalizations in the twelve months of the year was evaluated. Moreover, blood chemistry assay and, for some patients, enzyme-linked immunosorbent assay were executed to evaluate antibodies. Regarding the severity of the disease, the bullous pemphigoid area index and the pemphigus disease area index score systems were used. Results showed a complex interplay between environmental factors such as seasons and autoimmune conditions.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"15 3","pages":"9641"},"PeriodicalIF":1.1,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8d/e5/dr-15-3-9641.PMC10518530.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41118298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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