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Recognizing ophiasis pattern in discoid lupus: a rare diagnostic challenge. 在盘状狼疮中识别狼疮模式：一个罕见的诊断挑战。
IF 2.3
Dermatology Reports Pub Date : 2025-07-23 DOI: 10.4081/dr.2025.10431
Lamia Alakrash, Sara Alrabiah, Sawsan Alharthi
{"title":"Recognizing ophiasis pattern in discoid lupus: a rare diagnostic challenge.","authors":"Lamia Alakrash, Sara Alrabiah, Sawsan Alharthi","doi":"10.4081/dr.2025.10431","DOIUrl":"https://doi.org/10.4081/dr.2025.10431","url":null,"abstract":"<p><p>Lupus erythematosus is an autoimmune condition that can present in both cutaneous and systemic forms, with discoid lupus erythematosus (DLE) being the most prevalent type of chronic cutaneous lupus. Although the ophiasis pattern is well documented in alopecia areata, we present a rare case of DLE exhibiting this pattern in a 51-year-old Saudi female patient with a complex medical history, including systemic lupus erythematosus (SLE). This case underscores the importance of recognizing atypical presentations of DLE, which can lead to misdiagnosis and delays in treatment. We aim to enhance awareness among dermatologists regarding the diverse manifestations of DLE and encourage further investigation into such rare patterns.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute generalized exanthematous pustulosis triggered by dupilumab. dupilumab引发的急性全身性脓疱病。
IF 2.3
Dermatology Reports Pub Date : 2025-07-23 DOI: 10.4081/dr.2025.10219
Caterina Mariarosaria Giorgio, Gaetano Licata, Giuseppe Argenziano, Vittorio Tancredi, Anna Balato, Eugenia Veronica Di Brizzi
{"title":"Acute generalized exanthematous pustulosis triggered by dupilumab.","authors":"Caterina Mariarosaria Giorgio, Gaetano Licata, Giuseppe Argenziano, Vittorio Tancredi, Anna Balato, Eugenia Veronica Di Brizzi","doi":"10.4081/dr.2025.10219","DOIUrl":"10.4081/dr.2025.10219","url":null,"abstract":"<p><p>Dear Editor, We present a rare but clinically significant case of acute generalized exanthematous pustulosis (AGEP) following the administration of dupilumab in a patient with refractory atopic dermatitis (AD). While dupilumab is widely regarded as a safe and effective biologic agent for moderate-to-severe AD across age groups - including adolescents, adults, and increasingly children - emerging reports underscore the need to remain vigilant for uncommon, severe cutaneous reactions. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mixed-pattern, essential syphilitic alopecia, uveitis, and papillitis in an immunocompetent patient with neurosyphilis. 混合型，原发性梅毒性脱发，葡萄膜炎和乳头炎在免疫功能正常的神经梅毒患者。
IF 2.3
Dermatology Reports Pub Date : 2025-07-22 DOI: 10.4081/dr.2025.10371
Sumeetha Swaminathan, Irina Lerman, Kathleen Mannava, Luca Zatreanu, Anna De Benedetto
{"title":"Mixed-pattern, essential syphilitic alopecia, uveitis, and papillitis in an immunocompetent patient with neurosyphilis.","authors":"Sumeetha Swaminathan, Irina Lerman, Kathleen Mannava, Luca Zatreanu, Anna De Benedetto","doi":"10.4081/dr.2025.10371","DOIUrl":"https://doi.org/10.4081/dr.2025.10371","url":null,"abstract":"<p><p>Syphilitic alopecia (SA) and ocular syphilis (OS) are rare manifestations of syphilis, typically reported together in immunocompromised patients. We present a unique case of mixed-pattern, essential, SA of the scalp and OS in the form of anterior uveitis in an otherwise immunocompetent, HIV-negative, 46-year-old female. Briefly, the patient initially presented with sudden-onset scalp hair loss that was initially diagnosed as atypical alopecia areata but failed to respond to typical alopecia areata-directed therapy. Concurrently, the patient developed ocular and neurologic symptoms, and the diagnosis of syphilis was rendered based on the constellation of clinical findings and cerebrospinal fluid/serologic testing. Syphilis-directed therapy resulted in the reversal of ocular and neurologic symptoms, as well as rapid scalp hair regrowth. This case highlights the importance of considering diagnosis of syphilis in the differential diagnosis for atypical alopecia.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stevens-Johnson syndrome and toxic epidermal necrolysis in Saudi Arabia: a retrospective cross-sectional multicenter study. 史蒂文斯-约翰逊综合征和中毒性表皮坏死松解在沙特阿拉伯：一项回顾性横断面多中心研究。
IF 2.3
Dermatology Reports Pub Date : 2025-07-18 DOI: 10.4081/dr.2025.10275
Rayan Alkhodair, Yazeed Alowairdhi, Abdulrahman Alfawzan, Ali Alghamdi
{"title":"Stevens-Johnson syndrome and toxic epidermal necrolysis in Saudi Arabia: a retrospective cross-sectional multicenter study.","authors":"Rayan Alkhodair, Yazeed Alowairdhi, Abdulrahman Alfawzan, Ali Alghamdi","doi":"10.4081/dr.2025.10275","DOIUrl":"https://doi.org/10.4081/dr.2025.10275","url":null,"abstract":"<p><p>Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are a spectrum of life-threatening mucocutaneous conditions. Despite having a lower incidence rate than other dermatological conditions, SJS/TEN has a high mortality rate. SJS/TEN is usually caused by newly administered medications, particularly antibacterials and anticonvulsants. Little research data on SJS/TEN in Saudi Arabia has been published. We aimed to bridge this gap by reviewing and investigating the etiologies, risk factors, interventions, and outcomes of patients diagnosed with SJS/TEN. This is a retrospective cross-sectional study conducted in National Guard Hospitals in Riyadh and Jeddah from January 2015 to July 2023. We reviewed all dermatology medical records diagnosed as SJS/TEN through clinical assessment and histopathology, confirmed by a dermatology consultant. Additionally, we excluded all non-Saudi patients and those referred to our center with outside reports without histopathology from the national guard hospitals. This study included 25 patients diagnosed with the SJS/TEN spectrum between January 2015 and July 2023. Nearly two-thirds of the patients were male (n=15, 60%), and the average age was 45.96 years. Almost half of the culprit agents were antibiotics. Six of the 25 patients died (24%). Four were males, all over 50 years old, and one female was 6 years old. All these patients had TEN, except for one with SJS. Septic shock was the cause of death in 4 patients. Given the evident high risk for patients contracting this condition, prospective research and analysis to understand the correlation between SJS/TEN, mortality, and treatment are warranted.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Diagnosis and epidemiologic overview of the spectrum of skin diseases in Central, Northeast, and Southern Ethiopia. 更正：埃塞俄比亚中部、东北部和南部皮肤病谱的诊断和流行病学概述。
IF 2.3
Dermatology Reports Pub Date : 2025-07-15 DOI: 10.4081/dr.2025.10530
The Publisher
{"title":"Correction: <i>Diagnosis and epidemiologic overview of the spectrum of skin diseases in Central, Northeast, and Southern Ethiopia</i>.","authors":"The Publisher","doi":"10.4081/dr.2025.10530","DOIUrl":"10.4081/dr.2025.10530","url":null,"abstract":"<p><p>In the published Article titled \"Diagnosis and epidemiologic overview of the spectrum of skin diseases in Central, Northeast, and Southern Ethiopia\" (DOI: 10.4081/dr.2024.10114), the order of the authors was incorrect, and the 10th author (Frehiwot Daba) was mistakenly omitted.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":"17 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dermoscopy of kaposiform hemangioendothelioma: a case report. 卡样血管内皮瘤的皮肤镜检查1例。
IF 2.3
Dermatology Reports Pub Date : 2025-07-11 DOI: 10.4081/dr.2025.10363
Filomena Barbato, Maria Maddalena Nicoletti, Gaetano Licata, Eugenia Veronica Di Brizzi, Giuseppe Argenziano, Caterina Mariarosaria Giorgio
{"title":"Dermoscopy of kaposiform hemangioendothelioma: a case report.","authors":"Filomena Barbato, Maria Maddalena Nicoletti, Gaetano Licata, Eugenia Veronica Di Brizzi, Giuseppe Argenziano, Caterina Mariarosaria Giorgio","doi":"10.4081/dr.2025.10363","DOIUrl":"https://doi.org/10.4081/dr.2025.10363","url":null,"abstract":"<p><p>Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor of infancy, characterized by an infiltrative, firm, and ill-defined plaque that may be associated with Kasabach-Merritt phenomenon. While the diagnosis is primarily clinical and histopathological, dermoscopy may provide valuable insights into its microstructural features. We present the case of a newborn with congenital KHE involving the lumbar and right gluteal region, focusing on its dermoscopic characteristics. The lesion exhibited a homogeneous, grayish-blue background with no discernible vascular structures, a feature that may aid in differentiating KHE from other vascular tumors. The findings contribute to the understanding of dermoscopic patterns in KHE, highlighting its potential role in early diagnosis.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary cutaneous marginal zone lymphoma in a patient with multiple sclerosis under fingolimod therapy. 芬戈莫德治疗下多发性硬化症患者的原发性皮肤边缘区淋巴瘤。
IF 2.3
Dermatology Reports Pub Date : 2025-07-11 DOI: 10.4081/dr.2025.10237
Thilo Gambichler, Sera Selina Weyer-Fahlbusch, Markus Werner, Ulrika Schade, Lieselotte Bissels, Laura Susok
{"title":"Primary cutaneous marginal zone lymphoma in a patient with multiple sclerosis under fingolimod therapy.","authors":"Thilo Gambichler, Sera Selina Weyer-Fahlbusch, Markus Werner, Ulrika Schade, Lieselotte Bissels, Laura Susok","doi":"10.4081/dr.2025.10237","DOIUrl":"https://doi.org/10.4081/dr.2025.10237","url":null,"abstract":"<p><p>Dear Editor, Increased prevalence of cancer, in particular lymphomas, has been observed in patients with multiple sclerosis (MS) treated with fingolimod. We report the first case of primary cutaneous marginal zone lymphoma (PCMZL) that developed under long-term fingolimod therapy for MS. [...].</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dermatologic surgery rounds: double rotation (Yin-Yang) flap for reconstruction of a circular skin defect after BCC removal in the scalp region. 皮肤外科轮次：双旋转（阴阳）皮瓣重建圆形皮肤缺损后，BCC在头皮区域去除。
IF 1.3
Dermatology Reports Pub Date : 2025-07-09 DOI: 10.4081/dr.2025.10420
Georgi Tchernev, Simona Kordeva
{"title":"Dermatologic surgery rounds: double rotation (Yin-Yang) flap for reconstruction of a circular skin defect after BCC removal in the scalp region.","authors":"Georgi Tchernev, Simona Kordeva","doi":"10.4081/dr.2025.10420","DOIUrl":"https://doi.org/10.4081/dr.2025.10420","url":null,"abstract":"<p><p>An 84-year-old male came to the dermatology department with primary complaints of a tumor formation located on the vertex of the scalp. The surrounding skin showed mild sun damage, but no surgical scars or additional malignancies were noted. A clinical diagnosis of basal cell carcinoma was established, and surgical excision under local anesthesia with lidocaine was recommended.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of a topical polyphenol-based formulation in palmoplantar psoriasis: an observational study. 局部多酚基制剂治疗掌跖牛皮癣的疗效：一项观察性研究。
IF 2.3
Dermatology Reports Pub Date : 2025-07-08 DOI: 10.4081/dr.2025.10333
Simone Amato, Annunziata Dattola, Luigi Bennardo, Martina Tolone, Steven Paul Nisticò
{"title":"Efficacy of a topical polyphenol-based formulation in palmoplantar psoriasis: an observational study.","authors":"Simone Amato, Annunziata Dattola, Luigi Bennardo, Martina Tolone, Steven Paul Nisticò","doi":"10.4081/dr.2025.10333","DOIUrl":"https://doi.org/10.4081/dr.2025.10333","url":null,"abstract":"<p><p>This single-arm observational study evaluated the efficacy and safety of a novel topical formulation containing a complex mixture of polyphenols (CMP) - a proprietary blend rich in oleocanthal and oleuropein aglycone (each >60%), along with hydroxytyrosol and other extra virgin olive oil (EVOO)-derived polyphenols - combined with triticum vulgare germ (TVG) oil, betaine, propanediol, and tocopheryl acetate in patients with mild palmoplantar psoriasis (PPP). Twenty participants (aged 20-55) applied the formulation twice daily for 8 days, with assessments conducted on days 0 (baseline), 5, and 8. Participants underwent a 60-day follow-up to assess the durability of benefits and potential late-onset adverse events. Clinical evaluations measured lesion extent, keratinization, inflammation, desquamation, and infiltration. A patient-reported questionnaire evaluated quality of life (QoL) and symptom burden. By day 8, the mean lesion extent had decreased by approximately 40%, inflammation had improved by about 50%, and desquamation had resolved fully in most cases. Patient-reported outcomes improve alongside clinical measures. At day 60, these improvements persisted in 85% of participants, and no adverse events emerged. The formulation's mechanism of action is hypothesized to involve the concerted antioxidant and anti-inflammatory activities of polyphenols (oleocanthal, oleuropein aglycone, and hydroxytyrosol) in synergy with TVG oil's supportive lipid matrix and other excipients. These findings suggest that EVOO-derived polyphenols formulated in TVG oil may serve as a valuable adjunct for managing PPP with good tolerability and sustained benefits.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Purpura following laser hair removal: a case report. 激光脱毛后紫癜1例报告。
IF 2.3
Dermatology Reports Pub Date : 2025-07-01 DOI: 10.4081/dr.2025.10295
Kalliopi Papadopoulou, Eleni Paschalidou, Despoina Kosta, Kalliopi Karamanolaki
{"title":"Purpura following laser hair removal: a case report.","authors":"Kalliopi Papadopoulou, Eleni Paschalidou, Despoina Kosta, Kalliopi Karamanolaki","doi":"10.4081/dr.2025.10295","DOIUrl":"https://doi.org/10.4081/dr.2025.10295","url":null,"abstract":"<p><p>Laser hair removal (LHR) is a reliable and safe technique for the long-term reduction of unwanted hair. Common adverse effects involve momentary discomfort, transient erythema, and perifollicular edema, while the occurrence of purpura is infrequent. A 25-year-old Greek woman with skin type IV developed purpura on her lower extremities 48 hours after her first alexandrite laser session. A positive response to a laser hair removal provocation test was identified, aiding in diagnosis. Treatment with orally administered corticosteroids and antihistamines led to complete resolution within 7 days. Purpura following laser hair removal is a rare side effect, and its underlying cause remains unclear. Physician awareness of such adverse reactions can streamline patient care, reducing the need for unnecessary tests and offering improved management protocols.</p>","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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