Dermatology Reports最新文献_第6页

New-onset alopecia areata during calcitonin gene-related peptide inhibitor therapy: first reported case. 降钙素基因相关肽抑制剂治疗期间新发斑秃：首例报道。

IF 1

Dermatology Reports Pub Date : 2026-08-24 DOI: 10.4081/dr.2026.10802

Luca Valtellini, Mauro Barbareschi, Silvia Mariel Ferrucci, Angelo Valerio Marzano, Andrea Sechi

引用次数: 0

Melanoma arising in nevus spilus: a systematic review and report of two new cases. 外溢性痣引起的黑色素瘤：两例新病例的系统回顾和报告。

IF 1

Dermatology Reports Pub Date : 2026-07-31 DOI: 10.4081/dr.2026.10842

Monia Di Prete, Behnaz Abdollahzadeh, Paola Pasquini, Angela Ferrari, Pasquale Frascione, Maria Concetta Fargnoli, Carlo Cota

{"title":"Melanoma arising in nevus spilus: a systematic review and report of two new cases.","authors":"Monia Di Prete, Behnaz Abdollahzadeh, Paola Pasquini, Angela Ferrari, Pasquale Frascione, Maria Concetta Fargnoli, Carlo Cota","doi":"10.4081/dr.2026.10842","DOIUrl":"https://doi.org/10.4081/dr.2026.10842","url":null,"abstract":"Nevus spilus (NS) is a melanocytic lesion characterized by multiple darker macules or papules within a lighter-brown background patch. It is generally considered benign, but rarely melanoma may arise within NS. This association is controversial and poorly quantified. We systematically reviewed the literature on melanoma arising in NS and describe two additional reports. Clinical, histopathologic, molecular, and outcome data were extracted from all eligible cases. The aim of our study was to analyze the clinicopathological patterns, risk factors, and management implications. A total of 39 cases met inclusion criteria, suggesting that melanoma arising in NS is rare but not anecdotal. Most cases occurred in large, congenital, zosteriform lesions; the predominant location was the trunk, followed by the lower and upper limbs; the most common histotype was superficial spreading melanoma (SSM). Favorable outcomes were associated with early detection and thinner lesions, whereas thicker or nodular melanomas and delayed diagnosis correlated with poorer prognosis. Molecular data were limited but suggested possible heterogeneity, with infrequent BRAF/NRAS mutations. The risk of melanoma arising in NS appears to be subtype-dependent rather than uniform. Routine prophylactic excision of NS lesions is not supported by current evidence. A structured clinical and dermoscopic follow-up - particularly for larger, congenital, and segmental lesions - may represent a balanced management strategy, facilitating earlier identification of malignant transformation and ultimately improving patient outcomes. Further molecular profiling studies are needed to clarify pathogenetic mechanisms and refine risk stratification.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148789289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum periostin levels in mycosis fungoides: associations with clinical subtype and disease stage. 蕈样真菌病血清骨膜素水平：与临床亚型和疾病分期的关系

IF 1

Dermatology Reports Pub Date : 2026-07-31 DOI: 10.4081/dr.2026.10904

Ramazan Çetin, Müge Güler Özden

{"title":"Serum periostin levels in mycosis fungoides: associations with clinical subtype and disease stage.","authors":"Ramazan Çetin, Müge Güler Özden","doi":"10.4081/dr.2026.10904","DOIUrl":"https://doi.org/10.4081/dr.2026.10904","url":null,"abstract":"Serum biomarkers with diagnostic and staging relevance in mycosis fungoides (MF) remain limited. In this prospective case-control study, we evaluated serum periostin levels in 40 patients with MF and 40 matched healthy controls, and assessed their associations with clinical subtype and disease stage. Serum periostin was measured by enzyme-linked immunosorbent assay (ELISA), and comparisons were performed using non-parametric tests. Serum periostin levels were significantly higher in patients with MF than in controls (p<0.0001). Receiver operating characteristic (ROC) analysis demonstrated moderate discrimination for MF, with an area under the curve (AUC) of 0.77 (95% confidence interval [CI], 0.67-0.88); the optimal cut-off was 7.50 ng/mL, yielding 74.36% sensitivity and 70.00% specificity. Periostin levels also differed significantly across clinical subtypes (Kruskal-Wallis, p<0.0001), with higher levels in patch and plaque disease than in tumor-stage disease. In addition, serum periostin was significantly higher in early-stage MF (IA-IIA) than in advanced-stage disease (IIB and above) (p=0.035). These findings support serum periostin as a supportive biomarker reflecting clinical subtype and stage in MF, warranting further validation.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148789277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world effectiveness and safety of lebrikizumab in adults with moderate-to-severe atopic dermatitis: a retrospective observational study with focus on head and neck involvement. lebrikizumab治疗成人中度至重度特应性皮炎的有效性和安全性：一项针对头颈部病变的回顾性观察性研究

IF 1

Dermatology Reports Pub Date : 2026-07-30 DOI: 10.4081/dr.2026.10460

Edoardo Mortato, Claudia Paganini, Marina Talamonti, Virginia Maffei, Alfredo Belcastro, Cosimo Di Raimondo, Lorenzo Tofani, Luca Bianchi, Marco Galluzzo

{"title":"Real-world effectiveness and safety of lebrikizumab in adults with moderate-to-severe atopic dermatitis: a retrospective observational study with focus on head and neck involvement.","authors":"Edoardo Mortato, Claudia Paganini, Marina Talamonti, Virginia Maffei, Alfredo Belcastro, Cosimo Di Raimondo, Lorenzo Tofani, Luca Bianchi, Marco Galluzzo","doi":"10.4081/dr.2026.10460","DOIUrl":"https://doi.org/10.4081/dr.2026.10460","url":null,"abstract":"Lebrikizumab, an anti-interleukin (IL)-13 monoclonal antibody, is a promising treatment for moderate-to-severe atopic dermatitis (AD). We conducted a single-center, retrospective study in 21 adults with moderate-to-severe AD who were biologic-naïve and had failed or were intolerant to conventional systemic therapies. Patients received lebrikizumab 500 mg at weeks 0 and 2, then 250 mg every 2 weeks; those achieving complete remission at week 16 transitioned to monthly dosing. Assessments at baseline, weeks 6, 16, and 24 showed significant improvement in Eczema Area and Severity Index (EASI), pruritus and sleep Numeric Rating Scale (NRS), and Dermatology Life Quality Index (DLQI) scores (all p<0.001). At week 16, 77.7% achieved EASI-75 and 27.7% reached EASI-90. Three patients transitioned to monthly dosing after remission. Only two mild cases of keratoconjunctivitis were reported, with no treatment interruptions. These findings support lebrikizumab as an effective, well-tolerated option for biologic-naïve patients with moderate-to-severe AD, including those with challenging head and neck involvement.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148789321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Follicular-predominant pretibial Flegel's disease: a unilateral folliculocentric presentation expanding the dermoscopic spectrum. 以卵泡为主的胫前Flegel病：单侧以卵泡为中心的表现，扩大了皮肤镜的范围。

IF 1

Dermatology Reports Pub Date : 2026-07-24 DOI: 10.4081/dr.2026.10675

Caterina Mariarosaria Giorgio, Patrizia Maddalena, Gaetano Licata

引用次数: 0

Comparison between physician assessment and artificial intelligence analysis in digital dermoscopy: evaluation of 71 dermoscopic cases. 数字皮肤镜医师评估与人工智能分析的比较——附71例皮肤镜病例分析。

IF 1

Dermatology Reports Pub Date : 2026-07-23 DOI: 10.4081/dr.2026.10872

Entela Shkodrani, Alert Xhaja, Martin Shameti, Barbara Shkodrani

{"title":"Comparison between physician assessment and artificial intelligence analysis in digital dermoscopy: evaluation of 71 dermoscopic cases.","authors":"Entela Shkodrani, Alert Xhaja, Martin Shameti, Barbara Shkodrani","doi":"10.4081/dr.2026.10872","DOIUrl":"https://doi.org/10.4081/dr.2026.10872","url":null,"abstract":"Artificial intelligence (AI)-based dermoscopic analysis is increasingly being used to assist dermatologists in the early detection and monitoring of pigmented skin lesions. However, discrepancies between AI-generated assessments and clinical evaluation may occur. This retrospective study aimed to evaluate the level of agreement between dermatologist assessment and AI-generated analysis in the dermoscopic evaluation of skin lesions. The study included 71 dermoscopic cases examined at two time points between September 2024 and January 2026 at a dermatologic clinic in Tirana, Albania. Dermoscopic images were acquired using a digital dermoscopy platform equipped with an integrated AI algorithm for automated lesion analysis. Agreement between the dermatologist and the AI system was observed in 58 cases (81.7%), whereas 13 cases (18.3%) demonstrated discordance. The 95% confidence interval for the agreement rate was 72.7%-90.7%, indicating a high level of concordance between clinical assessment and AI-based evaluation. These findings suggest that AI-assisted dermoscopic analysis demonstrates substantial agreement with clinical evaluation and may serve as a valuable supportive tool in dermatologic practice. Nevertheless, the observed discordant cases highlight the continuing importance of clinical expertise and established dermoscopic criteria in guiding patient management. AI systems should therefore be regarded as complementary decision-support tools rather than independent diagnostic systems.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148561137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dupilumab as a targeted therapeutic strategy for Th2-driven cutaneous manifestations in Kimura disease. Dupilumab作为木村病中th2驱动皮肤表现的靶向治疗策略。

IF 1

Dermatology Reports Pub Date : 2026-07-22 DOI: 10.4081/dr.2026.10839

Gaetano Licata, Anna Balato, Giuseppe Argenziano, Caterina Mariarosaria Giorgio

引用次数: 0

Unilateral facial flushing and anhidrosis: a case of idiopathic Harlequin syndrome with successful botulinum toxin treatment. 单侧面部潮红和无汗：特发性丑角综合征一例成功的肉毒杆菌毒素治疗。

IF 1

Dermatology Reports Pub Date : 2026-07-21 DOI: 10.4081/dr.2026.10912

Pasquale Sorrentino, Gaetano Licata, Maria Maddalena Nicoletti, Margherita Malaspina, Giuseppe Argenziano, Eugenia Veronica Di Brizzi, Caterina Mariarosaria Giorgio

引用次数: 0

Could an intra-procedural dermoscopic approach be necessary for obtaining radical treatment of actinic keratosis cancerization field if combined with ablative CO₂ laser? 如果联合烧蚀CO2激光，术内皮肤镜是否有必要对光化性角化病癌变区进行根治性治疗？

IF 1

Dermatology Reports Pub Date : 2026-07-21 DOI: 10.4081/dr.2026.10638

Pietro Pasquale Cozza, Luigi Bennardo, Steven Paul Nisticò, Marco Marcasciano, Antonella Tammaro, Antonino De Caridi, Elena Zappia, Valeria Falcomatà

{"title":"Could an intra-procedural dermoscopic approach be necessary for obtaining radical treatment of actinic keratosis cancerization field if combined with ablative CO2 laser?","authors":"Pietro Pasquale Cozza, Luigi Bennardo, Steven Paul Nisticò, Marco Marcasciano, Antonella Tammaro, Antonino De Caridi, Elena Zappia, Valeria Falcomatà","doi":"10.4081/dr.2026.10638","DOIUrl":"https://doi.org/10.4081/dr.2026.10638","url":null,"abstract":"Actinic keratosis (AK) is a common skin disorder resulting from chronic sun exposure, which can be treated with various treatment modalities, including ablative CO2 laser. Dermoscopic evaluation is fundamental in diagnosis and post-procedural follow-up. This study aimed to achieve radical clearance of AK cancerization fields through a combined approach using an ablative CO2 laser and intra-procedural dermoscopy, rather than a pre- and post-procedural approach only. Twenty patients with 25 AKs were included in the study. Treatment with ablative CO2 laser through a dermoscopic intra-procedural approach was performed for every patient with Olsen grade I or II AK. The results of this study showed that 100% of patients treated with this method achieved clinical clearance at follow-up, and 92% had no clinical recurrence after 2 months. The intra-procedural dermoscopic approach demonstrated to be useful to extend laser ablation to the AK cancerization field. According to the results of our study and after a comprehensive literature review, we conclude that intra-procedural dermatoscopy combined with ablative CO2 laser therapy can be considered a valid alternative to CO2 laser therapy alone.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148548165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hidradenitis suppurativa characterized by type 2-skewed inflammatory features when associated with atopic dermatitis: critical appraisal of a dupilumab-treated case report. 化脓性汗腺炎与特应性皮炎相关时以2型偏斜炎症特征为特征：对dupilumab治疗病例报告的批判性评估。

IF 1

Dermatology Reports Pub Date : 2026-07-15 DOI: 10.4081/dr.2026.10292

Niccolò Gori, Elena Ippoliti, Flaminia Antonelli, Ludovica Manieri, Ketty Peris

引用次数: 0