Current Opinion in Clinical Nutrition and Metabolic Care最新文献_第6页

Measuring nutrient content in human milk: are we there yet? 测量母乳中的营养成分：我们做到了吗？

IF 3.8 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-05-01 Epub Date: 2026-02-18 DOI: 10.1097/MCO.0000000000001214

Donna T Geddes, Lisa Stinson

{"title":"Measuring nutrient content in human milk: are we there yet?","authors":"Donna T Geddes, Lisa Stinson","doi":"10.1097/MCO.0000000000001214","DOIUrl":"10.1097/MCO.0000000000001214","url":null,"abstract":"Purpose of review: Precise nutrient quantification is essential for developing reference values, guiding fortification strategies and preventing growth deficits, particularly in preterm infants. This review examines current methodologies for measuring nutrient content in human milk, evaluating accuracy, practicality, and limitations of existing analytical approaches.Recent findings: Current analytical methods for human milk nutrients demonstrate a trade-off between accuracy and clinical practicality. While some methods provide the high accuracy for macronutrient measurement, they require large sample volumes and extensive laboratory time. Alternative approaches such as spectroscopic and colorimetric methods offer improved efficiency and smaller sample requirements but with varying degrees of accuracy. Significant methodological challenges persist across all approaches, including the lack of standardized sampling protocols that account for temporal variation in milk composition, and difficulties in adapting analytical technologies originally designed for other matrices. These limitations are particularly problematic for micronutrient analysis, where sample degradation and storage conditions could impact results.Summary: While multiple analytical approaches for human milk exist, significant methodological limitations compromise accuracy and clinical utility. The field requires standardized workflows encompassing rigorous sampling protocols, validated storage conditions, and comprehensive method validation. Future developments should bridge the gap between research-grade accuracy and clinical practicality.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"299-305"},"PeriodicalIF":3.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146212493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anabolic resistance in cancer cachexia: a role for sex and chemotherapy. 癌症恶病质中的合成代谢抵抗：性和化疗的作用。

IF 3.8 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-05-01 Epub Date: 2026-02-23 DOI: 10.1097/MCO.0000000000001219

Tanner Jenkins, Quan Zhang, James A Carson

{"title":"Anabolic resistance in cancer cachexia: a role for sex and chemotherapy.","authors":"Tanner Jenkins, Quan Zhang, James A Carson","doi":"10.1097/MCO.0000000000001219","DOIUrl":"10.1097/MCO.0000000000001219","url":null,"abstract":"Purpose of review: The purpose of this review is to highlight recently published research that can provide insight into how either sex or chemotherapeutics can impact cancer regulation of muscle anabolic resistance. Critical knowledge gaps are emphasized that are linked to cancer and treatment disruptions to muscle anabolic signaling. We speculate and propose a rationale for estrogen's protective effect against cancer-induced muscle anabolic resistance in females. Furthermore, there is growing evidence that many cancer treatments have the potential to exacerbate muscle anabolic resistance in both males and females. We present current evidence and speculate on how nutritional interventions could serve as key modulators of cancer-induced anabolic resistance in these conditions.Recent findings: Recently published studies have reinforced that sex impacts the regulation of cancer cachexia in several established preclinical models, with males often developing more severe cachexia when compared to females. Importantly, recent research has established these sex differences at the transcriptomic level. Recent research has also strengthened the link between hypogonadism as a driver of cancer cachexia in preclinical models. Furthermore, chemotherapy has the potential to exacerbate muscle anabolic resistance.Summary: There is a growing body of literature that provides a strong rationale for further investigation into the impact of sex and chemotherapy on the cancer regulation of muscle anabolic resistance.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":"29 3","pages":"277-286"},"PeriodicalIF":3.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategies to reduce malnutrition in children: what works in low-resource settings? 减少儿童营养不良的战略：在资源匮乏的环境中什么有效？

IF 3.5 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-05-01 Epub Date: 2025-12-23 DOI: 10.1097/MCO.0000000000001193

Narjis Fatima Hussain, Zulfiqar A Bhutta

{"title":"Strategies to reduce malnutrition in children: what works in low-resource settings?","authors":"Narjis Fatima Hussain, Zulfiqar A Bhutta","doi":"10.1097/MCO.0000000000001193","DOIUrl":"10.1097/MCO.0000000000001193","url":null,"abstract":"Purpose of review: Child malnutrition in low-and-middle-income countries remains persistently high, driven by converging biological, social, economic, environmental, and conflict-related factors. As progress slows and vulnerabilities intensify, this review synthesises emerging evidence from recent years to identify effective strategies and future directions for reducing undernutrition in resource-constrained settings.Recent findings: Recent literature demonstrates that nutrition-sensitive interventions, including women's empowerment, social protection, WASH, immunisation, kitchen gardens, and biofortification, address key underlying drivers of child malnutrition and contribute to improved growth and dietary diversity. Building on these foundations, nutrition-specific strategies such as antenatal micronutrient supplementation, optimal infant and young child feeding practices, fortified complementary foods, and emerging approaches like microbiota-directed foods and fermentation have shown measurable gains in growth and nutritional status. Across the evidence base, integrated and multisectoral delivery models consistently outperform standalone programs, with particularly strong results when nutrition is combined with health services, social protection, community-based platforms, or climate- and conflict-responsive strategies.Summary: Current evidence underscores a shift toward integrated, layered, and context-responsive programming as the most effective path to reducing child malnutrition. Future research should prioritise implementation models that bridge nutrition-specific and nutrition-sensitive domains, strengthen health and community systems, and adapt to climate and humanitarian pressures.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"334-343"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145827107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence-guided nutritional therapy in the ICU. 人工智能引导的ICU营养治疗。

IF 3.8 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-03-01 Epub Date: 2025-11-24 DOI: 10.1097/MCO.0000000000001189

Dongshen Peng, Thanaphong Phongpreecha, Nima Aghaeepour

{"title":"Artificial intelligence-guided nutritional therapy in the ICU.","authors":"Dongshen Peng, Thanaphong Phongpreecha, Nima Aghaeepour","doi":"10.1097/MCO.0000000000001189","DOIUrl":"10.1097/MCO.0000000000001189","url":null,"abstract":"Purpose of review: Critical care nutrition remains a high-stakes and error-prone domain, particularly given the complex metabolic demands and heterogeneity of ICU populations. This review explores recent progress in integrating artificial intelligence with nutritional therapy in ICUs, highlighting its evolution and potential benefits in precision-guided support, along with current implementation challenges.Recent findings: Widely used in adult and neonatal ICUs, parenteral nutrition faces persistent challenges including ordering errors, practice variability, and insufficient robust long-term outcome evidence. Recent advances in machine learning have demonstrated considerable potential in predicting nutrition-related complications (e.g. neonatal morbidities, cholestasis, feeding intolerances, and malnutrition), optimizing nutrient delivery through dynamic, real-time recommendations, and enhancing clinical decision-making with large language models (LLMs) that synthesize clinical guidelines and patient data into actionable insights. However, future studies must establish causal relationships between optimal parenteral nutrition and long-term outcomes while addressing confounding factors and ingredient heterogeneity.Summary: Artificial intelligence-driven nutrition therapies have the potential to significantly improve the precision, safety, and personalization of ICU nutrition practices. Continued development and validation using standardized, comprehensive, longitudinal datasets, and validation in comparative clinical trials will be critical to realizing this transformative potential.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"193-201"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145596157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skeletal muscle protein turnover and mitochondrial responses to omega-3 fatty acid supplementation: an update. 骨骼肌蛋白质周转和线粒体对omega-3脂肪酸补充的反应：最新进展。

IF 3.8 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-03-01 Epub Date: 2026-01-06 DOI: 10.1097/MCO.0000000000001196

Jack E Hayden, Colleen S Deane

{"title":"Skeletal muscle protein turnover and mitochondrial responses to omega-3 fatty acid supplementation: an update.","authors":"Jack E Hayden, Colleen S Deane","doi":"10.1097/MCO.0000000000001196","DOIUrl":"10.1097/MCO.0000000000001196","url":null,"abstract":"Purpose of review: To critically review recent findings related to the effects of omega-3 fatty acid supplementation on skeletal muscle, with a particular focus on skeletal muscle protein turnover and mitochondrial function.Recent findings: Evidence indicates that omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may support skeletal muscle health by influencing muscle protein synthesis (MPS), mitochondrial function, and redox balance. However, recent meta-analyses reveal inconsistent effects of omega-3 fatty acid supplementation on basal and stimulus-induced MPS, likely due to methodological variability. Omega-3 fatty acid supplementation is seemingly more beneficial in clinical cohorts and preclinical data suggests omega-3s may reduce oxidative stress.Summary: Omega-3 fatty acid supplementation is a promising nutritional strategy for supporting skeletal muscle health, via the modulation of MPS and mitochondrial function. However, large-scale trials in a variety of healthy and clinical populations using sustainable sources of omega-3 fatty acids are required before a consensus on efficacy can be made.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"136-140"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Read this before planning a new nutrition trial in critically ill patients! 在计划对危重病人进行新的营养试验之前，请阅读本文！

IF 3.5 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-03-01 Epub Date: 2026-02-05 DOI: 10.1097/MCO.0000000000001204

Michael P Casaer, Adam Deane

引用次数: 0

Nutritional therapy and a stepwise approach in critical illness: aligning provision with metabolic phases. 危重疾病的营养治疗和逐步方法：与代谢阶段相一致。

IF 3.5 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-03-01 Epub Date: 2025-12-03 DOI: 10.1097/MCO.0000000000001186

Christian Stoppe, Zheng-Yii Lee, Yaseen M Arabi

{"title":"Nutritional therapy and a stepwise approach in critical illness: aligning provision with metabolic phases.","authors":"Christian Stoppe, Zheng-Yii Lee, Yaseen M Arabi","doi":"10.1097/MCO.0000000000001186","DOIUrl":"10.1097/MCO.0000000000001186","url":null,"abstract":"Purpose of review: Nutritional therapy is fundamental in critical care, yet conventional one-size-fits-all feeding strategies might overlook the dynamic metabolic shifts and patient variability inherent to critical illness. This review proposes a stepwise, phase-adapted strategy aiming to align nutrition therapy with three-step conceptual model of metabolic phases: acute catabolic, stabilization, and recovery.Recent findings: Randomized controlled trials have consistently shown no benefit - and potential harm - from early full-dose energy or protein delivery, particularly in patients with severe organ failure. The acute catabolic phase is characterized by systemic inflammation, stress hormone surges, and insulin resistance, where permissive underfeeding minimizes metabolic burden. In the stabilization phase, declining inflammatory markers and improving organ functions support cautious escalation of nutrition, though biomarkers like hyperglycemia and hypophosphatemia may signal unreadiness to target nutrition. In the recovery phase, inflammation resolves, and mobility improves requiring higher energy and protein delivery alongside physical rehabilitation. Patients may regress to earlier phases, necessitating nutrition de-escalation.Summary: This stepwise, phase-adapted nutritional strategy - start low, advance judiciously, and individualize throughout - offers a precision framework aimed at aligning feeding with metabolic capacity and minimizes risks of over- or underfeeding. Future priorities include validating biomarkers, identifying metabolic phenotypes, and testing adaptive nutrition algorithms in optimizing nutritional therapy.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"184-192"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiometabolic benefits of replacing saturated fatty acids with unsaturated fatty acids. 用不饱和脂肪酸代替饱和脂肪酸对心脏代谢的益处。

IF 3.8 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-03-01 Epub Date: 2025-12-29 DOI: 10.1097/MCO.0000000000001195

Ulf Risérus, Michael Fridén

{"title":"Cardiometabolic benefits of replacing saturated fatty acids with unsaturated fatty acids.","authors":"Ulf Risérus, Michael Fridén","doi":"10.1097/MCO.0000000000001195","DOIUrl":"10.1097/MCO.0000000000001195","url":null,"abstract":"Purpose of review: To inform about the current evidence on the potential cardiometabolic benefits of replacing saturated fatty acids with unsaturated fatty acids. This review will highlight the recent data from prospective cohort studies that have used substitution analyses to evaluate cardiometabolic [with a focus on cardiovascular disease (CVD)] and total mortality risk when replacing intakes of saturated fatty acids (SFA) with either monounsaturated fatty acids (MUFA) or polyunsaturated fatty acids (PUFA).Recent findings: Results from recent, prospective cohort studies suggest that replacing SFA (e.g. from butter, meats, or palm oil) with unsaturated fats, particularly PUFA from vegetable oils, nuts, and fatty fish, are not only associated with reduced all-cause mortality and CVD risk but also from other cardiometabolic diseases.Summary: The current evidence supports replacing SFA with unsaturated fatty acids from MUFA and PUFA on all-cause mortality and CVD risk. Replacing foods rich in SFA such as butter, red meat, and processed red meat with either plant-based MUFA or PUFA-rich sources such as vegetable oils, nuts, or fatty fish is associated with lower risk of all-cause mortality and CVD. These recent findings accord with international dietary recommendations, and also support the use of more plant-based diets for public health.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"131-135"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145854860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is enhanced recovery after surgery feasible, effective and well tolerated in emergency surgery and ICU? 在急诊外科和ICU中增强术后恢复是否可行、有效和耐受性良好？

IF 3.5 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-03-01 Epub Date: 2026-01-05 DOI: 10.1097/MCO.0000000000001201

Maria Wobith, Rahel Maria Strobel, Arved Weimann

{"title":"Is enhanced recovery after surgery feasible, effective and well tolerated in emergency surgery and ICU?","authors":"Maria Wobith, Rahel Maria Strobel, Arved Weimann","doi":"10.1097/MCO.0000000000001201","DOIUrl":"10.1097/MCO.0000000000001201","url":null,"abstract":"Purpose of review: Perioperative management within an enhanced recovery after surgery (ERAS) protocol is increasingly implemented worldwide not only for abdominal, but all types of major surgery. The available evidence regarding ERAS in critical illness is limited. The purpose of this review is to discuss the feasibility, effectiveness, and safety of ERAS with special regard to the application in emergency surgery and intensive care settings.Recent findings: ERAS has been increasingly applied after emergency and trauma surgery as well as in the ICU. Despite the inherent challenges posed by critical illness and limited patient engagement, given some adaptations implementation of ERAS treatment bundles may be feasible. Recent guidelines providing recommendations are available.Summary: ERAS may be feasible after emergency surgery and in the ICU in an interdisciplinary approach. Patient-centered effectiveness may be expected even when active patient engagement is not feasible as in mechanically ventilated patients. With special regard to patients with organ failure effectiveness and safety have to be elucidated. Therefore, implementation should weigh potential risks and benefits carefully.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"177-183"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145905601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elovanoids: linking nutrition to neuroprotection. Elovanoids：将营养与神经保护联系起来。

IF 3.8 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1097/MCO.0000000000001198

Nicolas G Bazan

{"title":"Elovanoids: linking nutrition to neuroprotection.","authors":"Nicolas G Bazan","doi":"10.1097/MCO.0000000000001198","DOIUrl":"10.1097/MCO.0000000000001198","url":null,"abstract":"Purpose of review: Elovanoids are homeostatic lipid mediators derived from the very long-chain n-3 polyunsaturated fatty acids, which are in turn derived from docosahexaenoic acid (DHA). The aim of this review is to summarize the latest research on these lipid mediators.Recent findings: Elovanoids beneficially modulate thioredoxin reductase 1, a key component in the activation of the cellular glutathione antioxidant system. Elovanoids prevent oligomeric amyloid-beta-induced senescence and inflammaging in retinal pigment epithelium and other cells. Rod cells' ability to use DHA to produce elovanoid precursors is decreased in age-related macular degeneration, a disease that causes photoreceptor loss and blindness.Summary: Elovanoids are molecular guardians of nervous system integrity that introduce a new aspect of neuroprotective signaling by serving as an initial line of defense when neural cell homeostasis is jeopardized. Appropriate diet contributes to healthy aging by providing the precursor (DHA) that favors elovanoid-mediated neuroprotection in conditions including stroke, traumatic brain injury, macular degeneration, Alzheimer's, and Parkinson's.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"111-122"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0