Current Opinion in Clinical Nutrition and Metabolic Care最新文献_第5页

Exposure to food proteins: from basic knowledge on the requirements to subgroup specificities. 接触食物蛋白质：从基本知识的要求到亚组特异性。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2025-01-01 Epub Date: 2024-12-12 DOI: 10.1097/MCO.0000000000001088

Rajavel Elango, Claire Gaudichon

引用次数: 0

Nutritional specificity of frailty: from epidemiological and clinical evidence to potential mechanisms. 虚弱的营养特异性：从流行病学和临床证据到潜在机制。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2025-01-01 Epub Date: 2024-12-12 DOI: 10.1097/MCO.0000000000001079

Laetitia Lengelé, Natasha A Grande de França, Philipe de Souto Barreto, Yves Rolland

{"title":"Nutritional specificity of frailty: from epidemiological and clinical evidence to potential mechanisms.","authors":"Laetitia Lengelé, Natasha A Grande de França, Philipe de Souto Barreto, Yves Rolland","doi":"10.1097/MCO.0000000000001079","DOIUrl":"https://doi.org/10.1097/MCO.0000000000001079","url":null,"abstract":"Purpose of review: Considering the ageing of the population, age-related syndromes, such as frailty, are prominent. In this context, nutrition is a modifiable factor considered a key nonpharmacological approach to prevention and treatment. Yet, its contribution to the frailty pathophysiology is conflicting in the literature. This paper discusses the recent literature (January 2023-June 2024) on the implication of nutrition in frailty management.Recent findings: Malnutrition is one of the main frailty risk factors. Proteins are the targeted macronutrient for their effects on muscle anabolism, not only in terms of quantity consumed but also in terms of sources. The diversity in plant and animal sources demonstrates better results than relying on a single source. More globally, anti-inflammatory and antioxidant diets are associated with a lower risk of frailty, like the Mediterranean Diet and specific food groups, like seafood, nuts, and seeds. Nutrition is pivotal in frailty prevention and treatment, and multidomain interventions providing exercises seem to yield even better results.Summary: Diverse protein sources and anti-inflammatory and antioxidant diets associated with exercises are the primary recommendations for frailty prevention and treatment. However, there is a need to evaluate how to achieve and maintain this healthy behaviour in real life.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":"28 1","pages":"1-5"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What's new about hydration in dementia? 痴呆症中的水合作用有什么新发现？

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2025-01-01 Epub Date: 2024-12-04 DOI: 10.1097/MCO.0000000000001089

Xenophon Theodoridis, Kalliopi Anna Poulia, Michail Chourdakis

{"title":"What's new about hydration in dementia?","authors":"Xenophon Theodoridis, Kalliopi Anna Poulia, Michail Chourdakis","doi":"10.1097/MCO.0000000000001089","DOIUrl":"10.1097/MCO.0000000000001089","url":null,"abstract":"Purpose of review: The aim of this study was to conduct a review of the literature published over the past 18 months and present the latest findings on hydration in individuals with dementia.Recent findings: A systematic review identified sarcopenia, polypharmacy, delayed oral transit, and poor rinsing ability as markers of eating-drinking-swallowing difficulties in early-stage dementia. A cross-sectional study found a high prevalence of dehydration (57-68%) among dementia patients, associated with hypertension, diabetes, chronic kidney disease, dysphagia, and cognitive decline. An analysis of national dementia care guidelines showed that only the UK and Switzerland addressed assisted nutrition and hydration. \"Jelly Drops,\" a hydrating product for dementia patients, received innovation awards. A study on US Physician Orders for Life Sustaining Treatment forms highlighted inconsistent terminology for end-of-life nutrition and hydration, calling for clearer language to aid decision-making.Summary: The new hydration-related recommendations in the ESPEN 2024 guidelines for dementia reflect a more individualized, proactive, and comprehensive approach to managing hydration. These guidelines emphasize the importance of early detection, personalized interventions, and consistent monitoring to ensure that dehydration is identified and treated promptly. Furthermore, the current literature supports the need for a specific terminology for dementia management using nutrition and hydration to improve patients' health outcomes.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":"28 1","pages":"20-24"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formula protein versus human milk protein and the effects on growth in preterm born infants. 配方奶蛋白与人乳蛋白的比较及其对早产儿生长的影响。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2025-01-01 Epub Date: 2024-11-11 DOI: 10.1097/MCO.0000000000001084

Jacqueline Muts, Britt J van Keulen, Johannes B van Goudoever, Chris H P van den Akker

{"title":"Formula protein versus human milk protein and the effects on growth in preterm born infants.","authors":"Jacqueline Muts, Britt J van Keulen, Johannes B van Goudoever, Chris H P van den Akker","doi":"10.1097/MCO.0000000000001084","DOIUrl":"10.1097/MCO.0000000000001084","url":null,"abstract":"Purpose of review: This review aims to evaluate the latest available evidence on the differences between human milk proteins versus infant formula proteins and its effects on growth and development in preterm infants.Recent findings: High protein intake supports initial growth in preterm infants, although the long-term benefits remain unclear. Human milk requires adequate fortification to meet nutritional needs of preterm born infants. Formula feeding, with its higher protein content, may accelerate early weight gain but also increases the risk of necrotizing enterocolitis. Current evidence showed no significant advantages of human milk-derived fortifiers over bovine milk-derived fortifiers. Furthermore, studies published during the review period do not provide new evidence that alters the existing understanding of differences in neurodevelopmental outcomes between infants fed human milk and those fed formula.Summary: Both fortified human milk and preterm formula support growth in preterm infants, but human milk offers additional protective benefits, such as reducing the risk of necrotizing enterocolitis, making it the preferred option. Balancing immediate growth needs with potential long-term developmental outcomes remains crucial, highlighting the need for further research to determine the optimal protein intake for preterm infants.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":"28 1","pages":"33-38"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New dietary trends and alternative proteins: the emergence of novel food allergens. 新的饮食趋势和替代蛋白质：新型食物过敏原的出现。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2025-01-01 Epub Date: 2024-10-16 DOI: 10.1097/MCO.0000000000001081

Yara Awad, Hervé Bernard, Karine Adel-Patient, Stéphane Hazebrouck

{"title":"New dietary trends and alternative proteins: the emergence of novel food allergens.","authors":"Yara Awad, Hervé Bernard, Karine Adel-Patient, Stéphane Hazebrouck","doi":"10.1097/MCO.0000000000001081","DOIUrl":"10.1097/MCO.0000000000001081","url":null,"abstract":"Purpose of review: New dietary trends driven by environmental and health considerations will undoubtedly lead to the emergence of novel food allergens. Assessment of the allergenic risk of new or modified protein-containing food sources and ingredients, as well as surveillance of emerging food allergies, is then required.Recent findings: Developments of in silico and in vitro models apprehending protein capacity to cross-react with other homologous proteins and to induce a de novo allergic sensitization are ongoing to better integrate multiple parameters such as 3D structural information or major histocompatibility complex class II (MHC-II) presentation propensity. However, the effects of food matrices and food processing still need to be addressed in these models. Consequently, clinical and postmarket surveillance remain of critical importance to alert on emergent food allergies, which are modulated by regional dietary practices.Summary: Monitoring of the emergence of food allergens requires close collaborations between allergologists, consumers, patient associations and food safety authorities. We also need to get a consensus on an acceptable level of allergenic risk that offers the possibility to develop and market innovative and sustainable food products.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"44-49"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perioperative nutrition in older patients: what are the priorities? 老年患者围手术期的营养：重点是什么？

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2025-01-01 Epub Date: 2024-11-02 DOI: 10.1097/MCO.0000000000001085

Oya Gumuskaya, Sahnoun Skendri, Karen Birkenhead, Mitchell N Sarkies

{"title":"Perioperative nutrition in older patients: what are the priorities?","authors":"Oya Gumuskaya, Sahnoun Skendri, Karen Birkenhead, Mitchell N Sarkies","doi":"10.1097/MCO.0000000000001085","DOIUrl":"10.1097/MCO.0000000000001085","url":null,"abstract":"Purpose of review: This review aimed to synthesize recent literature on perioperative nutritional interventions for older patients.Recent findings: This review underscores the role of comprehensive preoperative optimization, strategic use of nutritional supplements focusing on calorie, protein, and fluid intake, and active involvement of health consumers in co-designing solutions. Tools like the Geriatric Nutritional Risk Index offer a prediction value for nutrition-related complications in preoperative patients, guiding management strategies. Oral nutritional supplements, particularly those rich in protein and carbohydrates, prevent weight loss and improve functional outcomes postsurgery. However, patient satisfaction with these interventions is inconsistent and often unmeasured. Evidence suggests that prolonged fluid deprivation is harmful and preoperative hydration protocols reduce surgical stress and improve recovery outcomes. Yet, the benefit of preoperative hydration remains under-researched. Multimodal interventions for frail older adults are increasingly considered more effective than single-aspect interventions, which involve combining prehabilitation programs targeting malnutrition with smoking cessation and stabilization of preexisting conditions.Summary: Comprehensive preoperative nutritional assessment, evidence-based interventions, and health consumer involvement are crucial for improving perioperative care for elderly patients. Implementing multimodal interventions, including nutritional support and proper hydration, can enhance recovery, reduce complications, and improve the quality of life for older surgical patients.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"6-13"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial introductions. 编辑介绍。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2025-01-01 Epub Date: 2024-12-12 DOI: 10.1097/MCO.0000000000001090

引用次数: 0

Assessment of micronutrients - searching for the evidence. 评估微量营养素--寻找证据。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2024-11-01 Epub Date: 2024-10-03 DOI: 10.1097/MCO.0000000000001074

Manfred Eggersdorfer, Karin Amrein

引用次数: 0

Nutrition in pediatric end-stage liver disease. 小儿终末期肝病的营养问题。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2024-11-01 Epub Date: 2024-09-11 DOI: 10.1097/MCO.0000000000001063

Tejas S Desai, Jessie M Hulst, Robert Bandsma, Sagar Mehta

{"title":"Nutrition in pediatric end-stage liver disease.","authors":"Tejas S Desai, Jessie M Hulst, Robert Bandsma, Sagar Mehta","doi":"10.1097/MCO.0000000000001063","DOIUrl":"10.1097/MCO.0000000000001063","url":null,"abstract":"Purpose of review: The aim of this review is to outline recent studies relating to nutritional status and outcomes in pediatric end-stage liver disease.Main findings: Pediatric patients with chronic and end-stage liver disease are at high risk of malnutrition. Given additional growth demands in children and the inherent complications of chronic liver disease, achieving adequate nutrition in these patients remains a challenge. In addition, while guidelines on nutrition in chronic liver disease exist, global approaches and definitions of malnutrition vary. Recent literature has focused on sarcopenia and nutrition-related transplant outcomes, with some studies exploring nutritional assessment and management. Pediatric studies however continue to lag adult research, with limited prospective and interventional studies.Summary: Optimizing nutrition in pediatric end-stage liver disease remains a challenge, however understanding of the mechanisms and clinical manifestations of malnutrition in this population is improving. Despite these efforts, high quality studies to determine optimal nutrition strategies and interventions are lacking behind adult evidence and should be the focus of future research.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"492-498"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress in physiologically based pharmacokinetic-pharmacodynamic models of amino acids in humans. 基于生理学的人体氨基酸药代动力学-药效学模型的研究进展。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2024-11-01 Epub Date: 2024-08-02 DOI: 10.1097/MCO.0000000000001067

Taylor J McColl, David C Clarke

{"title":"Progress in physiologically based pharmacokinetic-pharmacodynamic models of amino acids in humans.","authors":"Taylor J McColl, David C Clarke","doi":"10.1097/MCO.0000000000001067","DOIUrl":"10.1097/MCO.0000000000001067","url":null,"abstract":"Purpose of review: Amino acids are critical to health, serving both as constituents of proteins and in signaling and metabolism. Amino acids are consumed as nutrients, supplements, and nutraceuticals. Much remains to be learned about amino acid function. Physiologically based pharmacokinetic and pharmacodynamic (PBPK-PD) modeling is an emerging tool for studying their complex biology. This review highlights recent PBPK-PD models developed to study amino acid physiology and metabolism and discusses their potential for addressing unresolved questions in the field.Recent findings: PBPK-PD models provided several insights. They revealed the interplay between the mechanisms by which leucine governs skeletal muscle protein metabolism in healthy adults. The models also identified optimal dosing regimens of amino acid supplementation to treat sickle-cell disease and recurrent hypoglycemia, and to minimize drug side effects in seizure disorders. Additionally, they characterized the effects of novel anticancer drugs that seek to deprive cancer cells of amino acids. Future models may inform treatment strategies for sarcopenia, characterize distinctions between animal- and plant-based nutrition, and inform nutrient-drug interactions in Parkinson's disease.Summary: PBPK-PD models are powerful tools for studying amino acid physiology and metabolism, with applications to nutrition, pharmacology, and their interplay.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"465-471"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0