Current Opinion in Clinical Nutrition and Metabolic Care最新文献_第10页

Muscle loss: does one size fit all? A comment on Bozzetti's paper. 肌肉流失：一刀切吗？对 Bozzetti 论文的评论。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2024-11-01 Epub Date: 2024-08-26 DOI: 10.1097/MCO.0000000000001072

Maria Cristina Gonzalez, Alfonso J Cruz-Jentoft, Stuart M Phillips, Carla M Prado

引用次数: 0

Sarcopenia: nothing is as it seems. Author's response to Gonzalez, Cruz-Jentoft, Phillips and Prado. 肌肉疏松症：一切都不尽如人意。作者对 Gonzalez、Cruz-Jentoft、Phillips 和 Prado 的回应。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2024-11-01 Epub Date: 2024-10-03 DOI: 10.1097/MCO.0000000000001073

Federico Bozzetti

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Prediabetes and insulin resistance: effect of vitamin D. 糖尿病前期和胰岛素抵抗：维生素 D 的影响。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2024-11-01 Epub Date: 2024-08-26 DOI: 10.1097/MCO.0000000000001070

Tetsuya Kawahara

{"title":"Prediabetes and insulin resistance: effect of vitamin D.","authors":"Tetsuya Kawahara","doi":"10.1097/MCO.0000000000001070","DOIUrl":"10.1097/MCO.0000000000001070","url":null,"abstract":"Purpose of review: The impact of vitamin D on improving insulin resistance in prediabetes remains controversial. The purpose of this review is to examine whether vitamin D supplementation improves insulin resistance in adults with prediabetes, and if so, to identify the mechanisms and the specific populations.Recent findings: Global prevalence of prediabetes is increasing, and prevention is a critical issue because these people with prediabetes will develop type 2 diabetes soon, which will put pressure on healthcare costs. Recent evidence on the effectiveness of vitamin D administration in improving insulin resistance and preventing the onset of type 2 diabetes in adults with prediabetes has been accumulating. The 2024 updated clinical practice guideline of the American Diabetes Association states that vitamin D administration to patients with prediabetes potentially benefits type 2 diabetes incidence in specific populations. There are also reports that vitamin D administration improves insulin resistance via increased serum osteocalcin levels, a marker of bone turnover.Summary: Vitamin D is likely to improve insulin resistance, which is already present at the time of prediabetes. However, the effectiveness may vary depending on ethnic differences and blood vitamin D levels at the start of administration.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"509-514"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial introductions. 编辑介绍。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2024-11-01 Epub Date: 2024-10-03 DOI: 10.1097/MCO.0000000000001076

引用次数: 0

Dietary protein in the ICU in relation to health outcomes. 重症监护室中的膳食蛋白质与健康结果的关系。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2024-11-01 Epub Date: 2024-08-01 DOI: 10.1097/MCO.0000000000001066

Danielle E Bear, Matthew J Summers, Lee-Anne S Chapple

{"title":"Dietary protein in the ICU in relation to health outcomes.","authors":"Danielle E Bear, Matthew J Summers, Lee-Anne S Chapple","doi":"10.1097/MCO.0000000000001066","DOIUrl":"10.1097/MCO.0000000000001066","url":null,"abstract":"Purpose of review: Critical care nutrition guidelines recommend provision of higher protein doses than recommended in health. These recommendations have been predominately based on lower quality evidence and physiological rationale that greater protein doses may attenuate the significant muscle loss observed in critically ill patients. This review discusses the mechanistic action of protein in the critically ill, details results from recent trials on health outcomes, discusses considerations for interpretation of trial results, and provides an overview of future directions.Recent findings: Two recent large clinical trials have investigated different protein doses and the effect on clinical outcome. Important findings revealed potential harm in certain sub-groups of patients. This harm must be balanced with the potential for beneficial effects on muscle mass and physical function given that two recent systematic reviews with meta-analyses demonstrated attenuation of muscle loss with higher protein doses. Utilizing biological markers such as urea: creatinine ratio or urea levels may prove useful in monitoring harm from higher protein doses.Summary: Future research should focus on prospectively investigating biological signatures of harm as well as taking into the consideration elements that will likely enhance the effectiveness of protein dose.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"479-485"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin D and muscle health: insights from recent studies. 维生素 D 与肌肉健康：近期研究的启示。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2024-11-01 Epub Date: 2024-09-04 DOI: 10.1097/MCO.0000000000001071

Akiko Kuwabara, Mai Matsumoto, Yoichi Hatamoto, Satoshi Fujita

{"title":"Vitamin D and muscle health: insights from recent studies.","authors":"Akiko Kuwabara, Mai Matsumoto, Yoichi Hatamoto, Satoshi Fujita","doi":"10.1097/MCO.0000000000001071","DOIUrl":"10.1097/MCO.0000000000001071","url":null,"abstract":"Purpose of review: The purpose of this review is to critically evaluate the effects of vitamin D on muscle mass and physical/muscle function in middle-aged and older adults, based on recent human studies, including cross-sectional, observational, and intervention studies. Vitamin D, beyond its well established role in bone health, has shown potential in influencing muscle physiology, making it a nutrient of interest in the context of sarcopenia and related chronic conditions.Recent findings: The review states how vitamin D affects muscle function, emphasizing its role in muscle cell proliferation, differentiation, and key signaling pathways. Additionally, the review of recent human studies revealed an inconsistent relationship between vitamin D and sarcopenia and related indices, with mixed results regarding muscle mass and strength. Variability in supplementation dose, duration, and baseline 25-hydroxyvitamin D levels may contribute to these inconsistencies.Summary: While animal studies indicate vitamin D's effectiveness in muscle growth, cross-sectional, observational, and intervention studies do not show clear benefits of maintaining efficient vitamin D levels on muscle mass or function in humans. Although vitamin D impacts muscle health, it is insufficient alone, emphasizing the need for a multifaceted approach to sarcopenia prevention and management.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"499-506"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin D in the critically ill - update 2024. 重症患者的维生素 D - 2024 年更新。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2024-11-01 Epub Date: 2024-08-26 DOI: 10.1097/MCO.0000000000001068

Christina Geiger, James Dayre McNally, Kenneth B Christopher, Karin Amrein

{"title":"Vitamin D in the critically ill - update 2024.","authors":"Christina Geiger, James Dayre McNally, Kenneth B Christopher, Karin Amrein","doi":"10.1097/MCO.0000000000001068","DOIUrl":"10.1097/MCO.0000000000001068","url":null,"abstract":"Purpose of review: This review aims to summarize the latest publications on vitamin D focused on critically ill patients.Recent findings: Vitamin D deficiency is common in critically ill patients (children and adults) and associated with a higher risk for mortality and morbidity as well as sepsis, acute respiratory failure, acute renal failure and prolonged ICU stay. As it is an inexpensive substance with a wide safety margin, acute treatment in form of a loading dose in addition to ongoing maintenance therapy is an interesting option in the ICU. The potential benefit of acute native (biologically inactive) vitamin D treatment has not fully been answered but even a small survival benefit demonstrable in very large analyses could be relevant to critical care. To date, less than 5000 patients cumulative have been enrolled in randomized controlled trials concerning vitamin D, with substantial heterogeneity in trial design regarding population (with or without deficiency, coronavirus disease 2019, different age groups, underlying illnesses), metabolite, dosing, outcome, and more.Summary: More research is needed, but vitamin D supplementation represents a simple intervention with an excellent safety profile. As adequate vitamin D is essential to the health of multiple organ systems, rapid normalization of deficiency states could translate to benefits across the wide range of diagnoses and organ dysfunctions experienced in the ICU setting. As a minimum, we recommend administering the standard daily dose of vitamin D3 in the critically ill patient.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"515-522"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-chain n-3 polyunsaturated fatty acid supplementation and neuromuscular function in older adults. 补充长链 n-3 多不饱和脂肪酸与老年人的神经肌肉功能。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2024-11-01 Epub Date: 2024-08-05 DOI: 10.1097/MCO.0000000000001065

Oliver Hayman, Emilie Combet, Oliver C Witard, Stuart R Gray

{"title":"Long-chain n-3 polyunsaturated fatty acid supplementation and neuromuscular function in older adults.","authors":"Oliver Hayman, Emilie Combet, Oliver C Witard, Stuart R Gray","doi":"10.1097/MCO.0000000000001065","DOIUrl":"10.1097/MCO.0000000000001065","url":null,"abstract":"Purpose of review: This review aims to explore the latest research investigating the effects of marine-derived long-chain n -3 polyunsaturated fatty acid (LC n -3 PUFA) supplementation on neuromuscular function in older adults.Recent findings: Ageing results in a decline in skeletal muscle strength and mass. There is growing evidence that LC n -3 PUFA supplementation increases muscle strength and mass in healthy older adults, yet the mechanisms underlying these effects remain elusive. Recent studies investigating LC n -3 PUFA supplementation have demonstrated effects on neuromuscular function such as increases in the compound muscle action potential (M-wave) amplitude and surface electromyography alongside increases in muscular strength. Therefore, evidence suggests that LC n -3 PUFA may elicit a beneficial effect at the neuromuscular junction and possess neuroprotective properties in older adults.Summary: LC n -3 PUFA supplementation may increase or maintain neuromuscular function throughout the ageing process. Further research is warranted to investigate the long-term effects LC n -3 PUFA supplementation on neuromuscular outcomes such as single motor unit properties and cortical/supraspinal networks, utilizing state-of-the-art techniques in neuromuscular physiology.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"486-491"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in nutritional science and physiological function: an editorial review. 营养科学与生理功能的进展：编辑评论》。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2024-11-01 Epub Date: 2024-10-03 DOI: 10.1097/MCO.0000000000001069

Carla M Prado, Philip J Atherton

引用次数: 0

Dietary protein splanchnic uptake and digestibility via stable isotope tracers. 通过稳定同位素示踪剂了解膳食蛋白质的脾脏吸收和消化率。

IF 3.5 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2024-09-01 Epub Date: 2024-07-24 DOI: 10.1097/MCO.0000000000001061

Jake Cox, Daniel James Wilkinson, Philip James Atherton, Kenneth Smith

{"title":"Dietary protein splanchnic uptake and digestibility via stable isotope tracers.","authors":"Jake Cox, Daniel James Wilkinson, Philip James Atherton, Kenneth Smith","doi":"10.1097/MCO.0000000000001061","DOIUrl":"10.1097/MCO.0000000000001061","url":null,"abstract":"Purpose of review: Dietary proteins are broken down into peptides across the gastrointestinal tract, with skeletal muscle being a primary deposition site for amino acids in the form of incorporation into, for example, metabolic and structural proteins. It follows that key research questions remain as to the role of amino acid bioavailability, of which protein digestibility and splanchnic sequestration (absorption and utilization) of amino acids are determining factors, impact upon muscle protein synthesis (MPS) in clinical states.Recent findings: Elevated splanchnic amino acid uptake has been implicated in anabolic resistance (i.e. attenuated anabolic responses to protein intake) observed in ageing, though it is unclear whether this limits MPS. The novel 'dual stable isotope tracer technique' offers a promising, minimally invasive approach to quantify the digestion of any protein source(s). Current work is focused on the validation of this technique against established methods, with scope to apply this to clinical and elderly populations to help inform mechanistic and interventional insights.Summary: Considerations should be made for all facets of protein quality; digestibility of the protein, absorption/utilization and subsequent peripheral bioavailability of amino acids, and resultant stimulation of MPS. Stable isotope tracer techniques offer a minimally invasive approach to achieve this, with wide-ranging clinical application.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"451-456"},"PeriodicalIF":3.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11309348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0