Current Opinion in Clinical Nutrition and Metabolic Care最新文献_第4页

Interrupting glioblastoma malignant circuitry: plasticity traps, synaptic blockade, and myeloid reprogramming. 阻断胶质母细胞瘤恶性回路：可塑性陷阱、突触阻断和髓细胞重编程。

IF 3.5 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-07-01 Epub Date: 2026-01-08 DOI: 10.1097/MCO.0000000000001208

Hong Sheng Cheng, Carol Tang, Nguan Soon Tan

{"title":"Interrupting glioblastoma malignant circuitry: plasticity traps, synaptic blockade, and myeloid reprogramming.","authors":"Hong Sheng Cheng, Carol Tang, Nguan Soon Tan","doi":"10.1097/MCO.0000000000001208","DOIUrl":"10.1097/MCO.0000000000001208","url":null,"abstract":"Purpose of review: Despite advances in targeted therapy and immunotherapy, glioblastoma (GBM) remains a therapeutic challenge because of its intrinsic adaptability, driven by intratumoural heterogeneity, cell-state plasticity, tumour-stroma crosstalk, and an immunosuppressive tumour microenvironment. The aggressive mesenchymal subtype, linked to treatment resistance and poor prognosis, exemplifies these adaptive mechanisms. Recent studies identify tractable oncogenic dependencies within these processes, opening routes to subtype-informed, multiaxis therapies.Recent findings: GBM exploits extrachromosomal DNA (ecDNA) and structural variants to rewire enhancer networks, reinforcing therapy-resistant mesenchymal states with distinct kinase dependencies (e.g. p38 MAPK signalling, STAT3). Tumour cells further hijack neuronal activity, glutamate/GABA, and long-range neuromodulatory (e.g. cholinergic) inputs, to promote growth, with synaptically enriched regions exhibiting immune suppression and mesenchymal enrichment. Myeloid-derived ligands (e.g. TNF and Oncostatin M) can drive proneural to mesenchymal transition, while Thrombospondin-1-mediated synaptic remodelling suppresses T-cell function, mechanistically coupling neural connectivity to immune evasion.Summary: The resilience of GBM arises from the interplay of epigenetic plasticity, neural circuit co-option, and myeloid-skewed immunosuppression. A coordinated strategy, kinome-guided targeting plus circuit disruption and myeloid reprogramming, offers a credible path to contain adaptation and improve outcomes.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"353-360"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Metabolic plasticity and the path to clinical utility. 编辑：代谢可塑性和临床应用之路。

IF 3.8 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-07-01 Epub Date: 2026-06-04 DOI: 10.1097/MCO.0000000000001233

Anastasia Z Kalea, Dorothy Klimis-Zacas

引用次数: 0

Beyond the scale: a systems-level reframing of obesity and metabolic care. 在规模之外：肥胖和代谢护理的系统级重构。

IF 3.5 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-07-01 Epub Date: 2026-06-04 DOI: 10.1097/MCO.0000000000001241

Leonidas G Karagounis, Lia Bally

引用次数: 0

Nutrition and gut-brain axis: opposing effects of dietary fiber and Western-style diets on Alzheimer's disease. 营养与肠脑轴：膳食纤维与西式饮食对阿尔茨海默病的相反作用。

IF 3.8 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-07-01 Epub Date: 2026-03-18 DOI: 10.1097/MCO.0000000000001223

Yuhai Zhao, Nicolas G Bazan

{"title":"Nutrition and gut-brain axis: opposing effects of dietary fiber and Western-style diets on Alzheimer's disease.","authors":"Yuhai Zhao, Nicolas G Bazan","doi":"10.1097/MCO.0000000000001223","DOIUrl":"10.1097/MCO.0000000000001223","url":null,"abstract":"Purpose of review: This review summarizes how diet shapes the gut-brain axis and contributes to Alzheimer's disease (AD) pathology, emphasizing the contrasting effects of Western-style diets and dietary fiber.Recent findings: Western diets rich in sugar and saturated fat disrupt gut microbial balance, increase intestinal permeability, and promote systemic inflammation, oxidative stress, and lipid metabolic imbalance, all of which accelerate neurodegeneration. In contrast, dietary fiber supports microbial diversity, improves lipid and glucose metabolism, and reduces neuroinflammation through both short-chain fatty acid (SCFA)-dependent and independent pathways involving bile acids, microbial lipids, and immune modulation. Recent animal and clinical data show that mixed-fiber supplementation can restore metabolic stability and cognitive function. In the 5xFAD mouse model (a transgenic AD model overexpressing five familial AD mutations), adding low-dose fiber to a high-sugar diet reshaped gut microbiota and improved AD-like pathology, identifying a reproducible set of fiber-sensitive bacterial taxa.Summary: Dietary patterns exert opposing effects on gut-brain communication. Nutrient excess drives dysbiosis and neuroinflammation, while dietary fiber promotes metabolic balance and neuronal resilience. Understanding these context-dependent microbial and metabolic interactions may guide precision dietary strategies for AD prevention and therapy.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"421-430"},"PeriodicalIF":3.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13258096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mitochondrial side of frailty. 线粒体虚弱的一面。

IF 3.5 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-05-01 Epub Date: 2025-10-03 DOI: 10.1097/MCO.0000000000001175

Emanuele Marzetti, Rosa Di Lorenzo, Anna Picca

{"title":"The mitochondrial side of frailty.","authors":"Emanuele Marzetti, Rosa Di Lorenzo, Anna Picca","doi":"10.1097/MCO.0000000000001175","DOIUrl":"10.1097/MCO.0000000000001175","url":null,"abstract":"Purpose of review: Frailty, a prevalent geriatric condition marked by reduced physiological reserve and greater vulnerability to stressors, is increasingly linked to mitochondrial dysfunction. This review summarizes current evidence on mitochondrial quality control, bioenergetics, and signaling in frailty, with emphasis on biomarker discovery and translational potential.Recent findings: Preclinical and human studies have shown that impaired mitochondrial biogenesis, altered dynamics, and defective mitophagy contribute to frailty, sarcopenia, and immune dysregulation. Frail older adults exhibit reduced mitochondrial DNA content, diminished mitochondrial respiratory capacity, elevated reactive oxygen species generation, and distinctive metabolomic changes. Potential biomarkers include mitochondria-derived vesicles, circulating metabolites, and measures of peripheral blood mononuclear cell respiration, which may enable early detection of functional decline. Multivariate profiling approaches have identified sex-specific and shared molecular signatures converging on mitochondrial pathways. Interventions promoting mitochondrial health, including resistance training and targeted immunomodulation, hold promise in slowing frailty progression.Summary: Mitochondrial dysfunction lies at the intersection of musculoskeletal, metabolic, and immune changes underpinning frailty. While integrative biomarker panels have defined metabolic signatures, early diagnosis and personalized therapies remain unmet needs. Longitudinal studies are required to establish causality, refine biomarker utility, and guide precision medicine strategies to preserve mitochondrial function, extend healthspan, and improve quality of life in aging populations.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"224-230"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An update on probiotics in paediatrics. 儿科益生菌的最新进展。

IF 3.5 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-05-01 Epub Date: 2025-12-03 DOI: 10.1097/MCO.0000000000001192

Maria Zemła, Maja Kotowska-Bąbol, Hania Szajewska

{"title":"An update on probiotics in paediatrics.","authors":"Maria Zemła, Maja Kotowska-Bąbol, Hania Szajewska","doi":"10.1097/MCO.0000000000001192","DOIUrl":"10.1097/MCO.0000000000001192","url":null,"abstract":"Purpose of review: Probiotics are widely used in paediatrics, but efficacy varies by strain and indication. In 2023, the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Special Interest Group on Gut Microbiota and Modifications issued strain-specific recommendations for gastrointestinal disorders. This review summarises studies published since 2024 to assess whether new evidence warrants changes to these recommendations.Recent findings: Lacticaseibacillus rhamnosus GG (LGG) and Saccharomyces boulardii are recommended for preventing antibiotic-associated diarrhoea. LGG, S. boulardii , Limosilactobacillus reuteri DSM 17938, or the combination of L. rhamnosus 19070-2 and L. reuteri DSM 12246 may be considered in acute gastroenteritis. For infant colic, recommendations include L. reuteri DSM 17938 or Bifidobacterium lactis BB-12 in breast-fed infants; for functional abdominal pain, L. reuteri DSM 17938 or LGG. No probiotics are recommended for constipation. For prevention of necrotising enterocolitis, weak recommendations include LGG or a combination of B. infantis BB-02, B. lactis BB-12 and Streptococcus thermophilus TH-4. There is no recommendation for or against probiotic-supplemented formulas.Summary: Recent trials have not provided sufficient evidence to justify changes to the ESPGHAN recommendations. Evidence for probiotic use in paediatrics is confined to a few strains and indications. Larger multicentre studies with standardised preparations and clearly defined outcomes are still needed.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"320-326"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional strategies and their influence on growth and body composition in moderate and late preterm infants: a systematic review of recent literature. 营养策略及其对中度和晚期早产儿生长和身体组成的影响：近期文献的系统综述。

IF 3.8 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-05-01 Epub Date: 2026-01-08 DOI: 10.1097/MCO.0000000000001206

Anne H Lafeber, Lorijn C D de Kraker, Johannes B van Goudoever, Femke de Groof

{"title":"Nutritional strategies and their influence on growth and body composition in moderate and late preterm infants: a systematic review of recent literature.","authors":"Anne H Lafeber, Lorijn C D de Kraker, Johannes B van Goudoever, Femke de Groof","doi":"10.1097/MCO.0000000000001206","DOIUrl":"10.1097/MCO.0000000000001206","url":null,"abstract":"Purpose of review: While moderate and late preterm infants (MLPTI, gestational age 32 0/7-36 6/7 weeks) represent the largest group of preterm infants worldwide, studies on nutritional needs remain scarce. This review evaluated the latest evidence on nutritional strategies for MLPTI and their effect on growth and body composition.Recent findings: For the first time, specific recommended nutritional intakes were defined by a group of experts, resulting in a recommended protein intake of 3.1-3.5 g/kg/day and a recommended energy intake of 127-130 kcal/kg/day. However, most MLPTI fail to meet these targets in the first week of life. Higher early protein and energy intakes were associated with improved weight gain, head growth, and reduced extra-uterine growth restriction in the first months of life, but data beyond those first months were limited. Feeding type also influenced outcomes: infants who were exclusively fed mother's milk showed lower fat mass and higher lean mass compared to those receiving formula.Summary: Nutrition in MLPTI is critical for early growth and body composition. Breastfeeding support and adequate early protein and energy intake appear beneficial for early growth. Further longitudinal studies are needed to clarify the lasting impact of early nutrition on growth and body composition in MLPTI.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"291-298"},"PeriodicalIF":3.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin D supplementation in infancy: a revisited systematic review. 婴儿补充维生素D：一个重新审视的系统评价。

IF 3.8 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-05-01 Epub Date: 2026-02-10 DOI: 10.1097/MCO.0000000000001212

Francis B Mimouni, Aviad Agam, Iris Arad, Joseph Mendlovic

{"title":"Vitamin D supplementation in infancy: a revisited systematic review.","authors":"Francis B Mimouni, Aviad Agam, Iris Arad, Joseph Mendlovic","doi":"10.1097/MCO.0000000000001212","DOIUrl":"10.1097/MCO.0000000000001212","url":null,"abstract":"Purpose of review: To systematically evaluate recent evidence on vitamin D supplementation during infancy, focusing on optimal dosing, population variability, and emerging nonskeletal effects. The review emphasizes current controversies and gaps that remain in translating evidence into policy and clinical practice.Recent findings: Recent randomized trials and meta-analyses confirm that daily supplementation of 400 IU vitamin D maintains adequate 25-hydroxyvitamin D levels in most healthy, term infants. However, higher doses (600-1200 IU) may be required for infants at elevated risk of deficiency, including those with limited sunlight exposure, darker skin pigmentation, or residing in northern latitudes. Evidence for extra-skeletal benefits, such as immune modulation or respiratory protection, remains inconclusive. Methodological heterogeneity, differing baseline vitamin D status, and variable adherence complicate comparisons across studies.Summary: Current evidence supports universal vitamin D supplementation during infancy to prevent deficiency and ensure skeletal health. The benefit of higher doses or supplementation beyond infancy remains uncertain. Future studies should clarify dose-response relationships, long-term safety, and potential systemic effects, while integrating population-specific determinants of deficiency into clinical and public health guidelines.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"313-319"},"PeriodicalIF":3.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Growth differentiation factor 15 as a biomarker of frailty: evidence from recent studies. 生长分化因子15作为脆弱的生物标志物：来自最近研究的证据。

IF 3.8 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-05-01 Epub Date: 2026-01-28 DOI: 10.1097/MCO.0000000000001213

Shuli Lian, Yves Rolland, Philipe de Souto Barreto

{"title":"Growth differentiation factor 15 as a biomarker of frailty: evidence from recent studies.","authors":"Shuli Lian, Yves Rolland, Philipe de Souto Barreto","doi":"10.1097/MCO.0000000000001213","DOIUrl":"10.1097/MCO.0000000000001213","url":null,"abstract":"Purpose of review: Growth differentiation factor 15 (GDF15), a stress- response protein of the TGF-β superfamily, has emerged as a potential biomarker of frailty. This review aims to summarize recent evidence on the association between GDF15 and frailty.Recent findings: Emerging data from 14 recent studies, including seven longitudinal and seven cross-sectional investigations, support GDF15 as a promising biomarker for frailty. Longitudinal studies indicate that elevated GDF15 levels are associated with an increased risk of developing frailty and with adverse outcomes related to frailty over follow-up periods of up to 13 years, across both community-dwelling and clinical populations, such as patients with cardiometabolic diseases or postknee replacement. The predictive value of GDF15 appears to vary depending on the frailty assessment tool used. Cross-sectional analyses corroborate longitudinal findings by showing that GDF15 levels are associated to frailty severity across diverse populations (e.g., community-dwelling, acutely hospitalized patients) in a dose--response manner.Summary: GDF15 represents a promising biomarker for frailty, reflecting physical decline and risk of future frailty. Future research should address sex-specific effects, standardize assay protocols and frailty assessments, and explore the clinical utility of GDF15 to detect people at increased risk of decline in intrinsic capacity and frailty in a life course perspective.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":"29 3","pages":"214-223"},"PeriodicalIF":3.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolution of the gut microbiome in infancy: recent advances. 婴儿期肠道微生物群的进化：最新进展。

IF 3.8 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-05-01 Epub Date: 2026-01-19 DOI: 10.1097/MCO.0000000000001209

Ana Enríquez-Belenguer, Eduard Flores Ventura, Anna Valls-Verdoy, María Carmen Collado

{"title":"Evolution of the gut microbiome in infancy: recent advances.","authors":"Ana Enríquez-Belenguer, Eduard Flores Ventura, Anna Valls-Verdoy, María Carmen Collado","doi":"10.1097/MCO.0000000000001209","DOIUrl":"10.1097/MCO.0000000000001209","url":null,"abstract":"Purpose of review: The early-life gut microbiome is a dynamic ecosystem that alongside other niches, such as the oral and skin microbiomes, undergoes rapid assembly and genetic evolution from birth through to adulthood. Although it was originally considered to be a passive colonisation process, recent findings suggest that early microbial development is a co-evolving, host-modulated process influenced by multiple factors, including maternal microbiota, mode of delivery, human milk, feeding practices, environmental exposure, and genetics, highlighting the timeliness of this review.Recent findings: In recent years, high-resolution sequencing and longitudinal multiomics have enabled the detailed observation of the early stages of microbial adaptation, assembly, strain transmission, diversification, and horizontal gene transfer in the early stages of life. New data also reveal maternal-foetal microbial signalling via metabolites and extracellular vesicles, as well as the evolutionary role of human milk oligosaccharides, and the involvement of phages, plasmids, and mobile genetic elements in infant gut microbial evolution.Summary: This review provides a summary of advances during gestation, birth, breastfeeding and infancy. However, further research is required into microbial evolution, and predicting its clinical significance, as well as the role of artificial intelligence tools. Understanding early microbial adaptation processes could transform nutrition, precision medicine, and paediatric care.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"327-333"},"PeriodicalIF":3.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0