Current Opinion in Clinical Nutrition and Metabolic Care最新文献_第3页

Ethical imperatives in global nutrition care: reducing inequities in gastroenterology. 全球营养保健的伦理责任：减少胃肠病学的不公平现象。

IF 3.8 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-09-01 Epub Date: 2026-05-07 DOI: 10.1097/MCO.0000000000001231

Rosa Burgos, Diana Cárdenas

{"title":"Ethical imperatives in global nutrition care: reducing inequities in gastroenterology.","authors":"Rosa Burgos, Diana Cárdenas","doi":"10.1097/MCO.0000000000001231","DOIUrl":"10.1097/MCO.0000000000001231","url":null,"abstract":"Purpose of review: Malnutrition is a major concern in patients with digestive disorders. This review examines the ethical imperatives for addressing inequities in nutritional care, specifically focusing on disease-related malnutrition (DRM). It explores the implementation of a human rights-based approach to clinical practice to bridge the gaps between duty-bearers and rights-holders in the management of malnutrition.Recent findings: DRM persists as a neglected crisis affecting 30-50% of hospitalized patients, particularly those with gastrointestinal and oncological conditions. Recent research identifies educational attainment as a super-determinant of diet quality, exerting a more powerful influence than income alone. Systemic barriers remain significant: mandatory screening is frequently unavailable across care settings, and a widespread knowledge gap persists among healthcare professionals. However, the emergence of the Cartagena and Vienna Declarations has established nutritional care as a human right, providing a new legal and ethical paradigm to tackle these disparities.Summary: Reducing inequities requires integrating nutritional care into Universal Health Coverage and mandating standardized screening and diagnosis using Global Leadership Initiative on Malnutrition (GLIM) criteria. Strategic alternatives include educational reform, interdisciplinary support teams, and patient empowerment. Ensuring equitable access to medical nutrition is essential to uphold human dignity and fulfill the right to health.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"489-493"},"PeriodicalIF":3.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scores to monitor inflammatory effects of a diet: a useful concept? 用分数来监测饮食对炎症的影响：一个有用的概念？

IF 3.8 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-09-01 Epub Date: 2026-08-06 DOI: 10.1097/MCO.0000000000001247

Stephan Bischoff

{"title":"Scores to monitor inflammatory effects of a diet: a useful concept?","authors":"Stephan Bischoff","doi":"10.1097/MCO.0000000000001247","DOIUrl":"10.1097/MCO.0000000000001247","url":null,"abstract":"Purpose of review: The Dietary Inflammatory Index (DII) was developed to quantify the inflammatory potential of dietary patterns based on their effects on inflammatory biomarkers. Growing evidence links low-grade inflammation to chronic diseases such as obesity, cardiovascular disease, diabetes, and cancer. This review summarizes current evidence regarding the clinical and epidemiological relevance of the DII and evaluates its potential as a tool for nutritional assessment and disease prevention.Recent findings: Recent studies demonstrate consistent associations between higher DII scores and adverse cardiometabolic outcomes, including atherosclerosis, metabolic liver disease, obesity, and increased cardiovascular mortality. Anti-inflammatory dietary patterns, particularly the Mediterranean diet, are associated with lower DII scores, reduced inflammatory markers, and improvements in metabolic parameters and quality of life. Emerging evidence also suggests benefits in cancer survivors, patients with depression, and individuals with chronic inflammatory conditions. Methodological advances, including the energy-adjusted DII (E-DII) and the pediatric C-DII, have improved the applicability and predictive value of the index.Summary: The DII provides a useful framework for assessing the relationship between diet and inflammation across populations and clinical settings. Current evidence supports its value in identifying dietary patterns associated with chronic inflammation and related diseases. Although causal relationships remain to be fully established, the DII may contribute to personalized nutrition strategies and support prevention and management approaches for inflammation-related disorders. Further long-term interventional studies are needed to strengthen its clinical utility and prognostic significance.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":"29 5","pages":"448-452"},"PeriodicalIF":3.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic health in a changing world: widening the lens to climate, cities, and place. 不断变化的世界中的代谢健康：将镜头扩大到气候、城市和地方。

IF 3.5 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-07-01 Epub Date: 2026-06-04 DOI: 10.1097/MCO.0000000000001239

Erica Hinckson

{"title":"Metabolic health in a changing world: widening the lens to climate, cities, and place.","authors":"Erica Hinckson","doi":"10.1097/MCO.0000000000001239","DOIUrl":"10.1097/MCO.0000000000001239","url":null,"abstract":"Purpose of review: Individual-level interventions emphasizing diet, clinical management, and structured exercise have been the typical approach to addressing metabolic health. Growing evidence suggests that broader environmental factors that shape metabolic risk have been overlooked. In this opinion paper, metabolic health is reframed within the context of climate change, urbanization, physical activity, and local knowledge, highlighting them as interconnected determinants of metabolic wellbeing.Recent findings: Physical activity and metabolic processes are greatly influenced by neighbourhood urban design, transport infrastructure, and climate effects such as extreme heat. Evidence shows that greener neighbourhoods that support walking, cycling, and public transport are associated with more favourable cardiometabolic outcomes. Critical to the integration of such approaches for embedding physical activity into everyday life are insights from Indigenous and local communities that take a relational, place-based approach to movement and wellbeing.Summary: Addressing modern metabolic health may require a paradigm shift from an individual to a systems-level approach. It is proposed that, to achieve this, physical activity, climate resilience, urban design, and Indigenous/local knowledge should be considered together to create more equitable, sustainable, and metabolically supportive environments. This framing, therefore, has important implications for research, clinical practice, policy, and next steps.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":"29 4","pages":"391-394"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148155718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reframing obesity through the gut microbiota: functional dysbiosis and metabolic disease. 通过肠道菌群重塑肥胖：功能失调和代谢疾病。

IF 3.8 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-07-01 Epub Date: 2026-05-18 DOI: 10.1097/MCO.0000000000001230

Alaa Hamdan, Ziad Al Nabhani

{"title":"Reframing obesity through the gut microbiota: functional dysbiosis and metabolic disease.","authors":"Alaa Hamdan, Ziad Al Nabhani","doi":"10.1097/MCO.0000000000001230","DOIUrl":"10.1097/MCO.0000000000001230","url":null,"abstract":"Purpose of review: Obesity and its metabolic complications remain major global health challenges. Beyond excess caloric intake, emerging evidence implicates diet-induced gut microbiota dysfunction as a modulator of metabolic homeostasis. This review examines recent advances in understanding how functional alterations of the gut microbiota contribute to obesity pathogenesis.Recent findings: Current data indicate that obesity is characterized less by specific microbial taxa and more by disruption of key microbial functions. Diet-induced dysbiosis alters short-chain fatty acid production, bile acid metabolism, tryptophan-derived signaling, and intestinal barrier integrity. These changes promote metabolic endotoxemia, impair enteroendocrine hormone secretion, and disrupt gut-brain and gut-liver communication, contributing to adipose tissue inflammation, hepatic steatosis, and insulin resistance. Experimental and clinical studies further suggest that microbiota-targeted interventions, including dietary fiber enrichment, prebiotics, synbiotics, and fecal microbiota transplantation, can partially restore microbial metabolic function and improve selected metabolic outcomes.Summary: Obesity is increasingly conceptualized as a state of diet-driven functional gut microbiota disruption. Targeting microbial metabolic pathways rather than individual taxa may offer a promising adjunctive strategy to complement established therapies for obesity-related metabolic disease.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"377-384"},"PeriodicalIF":3.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13258111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A viewpoint review of recent policy changes and public health initiatives to combat obesity. 对最近对抗肥胖的政策变化和公共卫生举措的观点综述。

IF 3.5 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-07-01 Epub Date: 2026-04-27 DOI: 10.1097/MCO.0000000000001228

Yih-Kai Chan, Nerolie Stickland

{"title":"A viewpoint review of recent policy changes and public health initiatives to combat obesity.","authors":"Yih-Kai Chan, Nerolie Stickland","doi":"10.1097/MCO.0000000000001228","DOIUrl":"10.1097/MCO.0000000000001228","url":null,"abstract":"Purpose of review: Obesity is a growing public health issue worldwide affecting one in three adults in Australia and two in five adults in the United States. Globally, the prevalence of obesity has doubled or even tripled in many countries over the past two decades, predominately driven by urbanization, sedentary lifestyles and increased consumption of high-calorie processed foods. The aim of this viewpoint article is to highlight recent policy changes and public health Initiatives to curb this obesity epidemic.Recent findings: Traditional strategies that focus on individual behaviour have proven insufficient and broader public health policy models to address both societal and environmental contributors to obesity have emerged. Recent public health initiatives directed their focus on promoting healthier lifestyles through policies, family-based interventions, dietary education and sustained community support. Effective obesity prevention requires collaborative efforts across policy, healthcare and community sectors to mitigate its far-reaching physical, psychological and economic impacts from individual to population levels.Summary: Policy and public health efforts against obesity are evolving into comprehensive systems-oriented models. They combine regulation, fiscal tools, healthcare integration, education campaigns, measurement systems and equity-focused approaches. Together, they form a layered strategy aimed at preventing obesity, supporting individuals living with it and ensuring accountability across sectors.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"385-390"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic rebound and weight cycling following incretin mimetic drug withdrawal: a cause for concern? 促肠促素类药物停药后代谢反弹和体重循环：值得关注的原因吗？

IF 3.5 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-07-01 Epub Date: 2026-05-14 DOI: 10.1097/MCO.0000000000001232

Sarah E Alexander, Erin J Howden

{"title":"Metabolic rebound and weight cycling following incretin mimetic drug withdrawal: a cause for concern?","authors":"Sarah E Alexander, Erin J Howden","doi":"10.1097/MCO.0000000000001232","DOIUrl":"10.1097/MCO.0000000000001232","url":null,"abstract":"Purpose of the review: Incretin mimetic drugs (IMDs) induce rapid weight loss and improve cardiometabolic health. However, over 50% of users discontinue and then reinitiate therapy within two years. This drug cycling drives weight loss-regain cycling, which adversely affects body composition and metabolic health.Recent findings: Cessation of IMD therapy leads to a rapid and near-complete reversal of weight loss and cardiometabolic improvement within one year and early IMD discontinuation is associated with increased cardiometabolic risk. Concerningly, up to 40% of the weight lost on these therapies is attributed to lean mass loss. Weight cycling compounds these effects and may worsen body composition and metabolic profiles beyond baseline. Supervised exercise programmes attenuate weight regain and may have a lasting 'legacy' effect on metabolic markers.Summary: The benefits of IMDs are short-lived following drug cessation and the loss of lean mass that occurs with IMDs may increase the risk of sarcopenia. Incorporating supervised exercise programmes during and after therapy may preserve lean mass, promote healthier body composition and attenuate some of the observed metabolic rebound. Clinicians should weigh the risks and benefits of short-term, or cyclical use of IMDs, particularly in those with low initial muscle mass reserves or metabolically vulnerable cohorts.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"395-402"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147927435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteomics for precision nutrition: current evidence and future directions. 精确营养的蛋白质组学：目前的证据和未来的方向。

IF 3.8 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-07-01 Epub Date: 2026-04-17 DOI: 10.1097/MCO.0000000000001226

Mirko Marino, Cristian Del Bo', Patrizia Riso

{"title":"Proteomics for precision nutrition: current evidence and future directions.","authors":"Mirko Marino, Cristian Del Bo', Patrizia Riso","doi":"10.1097/MCO.0000000000001226","DOIUrl":"10.1097/MCO.0000000000001226","url":null,"abstract":"Purpose of review: This review critically evaluates proteomics research applied to clinical nutrition and metabolism published between mid-2024 and early-2026, examining whether recent advances have moved the field closer to clinically actionable precision nutrition applications.Recent findings: Large prospective cohort studies show that circulating proteomic signatures reflect dietary patterns and are associated with incident cardiometabolic, hepatic, and neurodegenerative outcomes. In most analyses, these signatures capture plausible biological pathways, but their incremental predictive value beyond established risk models appears modest. Interventional studies confirm that circulating proteins respond to dietary modification, but these trials are considerably smaller than epidemiological cohorts and proteomic-guided randomized allocation has rarely been implemented to date. Although multiomics integration and machine-learning approaches have expanded discovery and improved pathway modeling, independent validation, cross-platform consistency, and clinically meaningful risk reclassification remain inconsistently demonstrated across studies.Summary: Diet-proteome associations are biologically coherent and reproducible at the population level. Nevertheless, translation into individualized dietary prescription remains to be demonstrated at scale. Robust evidence of cross-platform consistency, formal clinical utility, and outcome-driven trials incorporating proteomic-guided interventions will be key to enabling circulating proteomics to support routine precision nutrition practice.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"361-367"},"PeriodicalIF":3.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13258099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glutathione precursors: a new opportunity for dietary interventions in obesity and metabolic health? 谷胱甘肽前体：饮食干预肥胖和代谢健康的新机遇？

IF 3.5 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-07-01 Epub Date: 2026-06-04 DOI: 10.1097/MCO.0000000000001240

Dimitrios Draganidis, Anastasia Rosvoglou, Ioannis G Fatouros, Athanasios Z Jamurtas

{"title":"Glutathione precursors: a new opportunity for dietary interventions in obesity and metabolic health?","authors":"Dimitrios Draganidis, Anastasia Rosvoglou, Ioannis G Fatouros, Athanasios Z Jamurtas","doi":"10.1097/MCO.0000000000001240","DOIUrl":"10.1097/MCO.0000000000001240","url":null,"abstract":"Purpose of review: Obesity is a major risk factor for the development of metabolic disorders, including insulin resistance, hepatic steatosis and metabolic syndrome. The mechanistic link between obesity and metabolic complications largely relay on chronic inflammation and redox status disturbances driven by excess adiposity and reduced glutathione (GSH) levels. This article reviews the latest evidence on the therapeutic potential of glutathione precursors N-acetylcysteine (NAC) and glycine in mitigating metabolic complications associated with obesity.Recent findings: NAC demonstrates promising benefits in improving insulin resistance, reducing hepatic steatosis, and mitigating cellular senescence mainly through its antioxidant and anti-inflammatory properties. Glycine, on the other hand, may support metabolic health by enhancing detoxification pathways and improving key metabolic markers in obesity. However, research on this field is limited and predominantly based on animal models and small-scale human trials.Summary: These findings highlight the need for continued investigation on the role of glutathione precursors as part of a broader strategy for the prevention and management of metabolic diseases linked to obesity. In particular, large-scale randomized controlled studies are required to validate the efficacy, safety and optimal dosages for these supplements.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"371-376"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148014005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interactions between nutrition, GLP-1 secretion, and composition of the gut microbiome. 营养、GLP-1分泌和肠道微生物组成之间的相互作用。

IF 3.5 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-07-01 Epub Date: 2026-05-20 DOI: 10.1097/MCO.0000000000001235

Afroditi Kouraki, Daniel McWilliams, Ana M Valdes

{"title":"Interactions between nutrition, GLP-1 secretion, and composition of the gut microbiome.","authors":"Afroditi Kouraki, Daniel McWilliams, Ana M Valdes","doi":"10.1097/MCO.0000000000001235","DOIUrl":"10.1097/MCO.0000000000001235","url":null,"abstract":"Purpose of review: Glucagon-like peptide-1 (GLP-1) is a key incretin hormone regulating insulin secretion, appetite, and energy balance. Recent research highlights complex interactions between dietary composition, gut microbiome metabolism and GLP-1 secretion. Understanding these relationships is increasingly important given the widespread clinical use of GLP-1 receptor agonists for obesity and type 2 diabetes and the growing interest in microbiome-targeted nutritional strategies.Recent findings: Recent studies demonstrate that microbial metabolites mediate many nutritional effects on GLP-1 secretion. Fermentation of dietary fibres generates short-chain fatty acids (SCFAs) that stimulate GLP-1 secretion through FFAR2/FFAR3 signalling. Additional microbial metabolites can regulate enteroendocrine signalling, including indole derivatives, N-acyl glycines and bile acid metabolites. Human and preclinical studies show that dietary interventions such as β-glucan supplementation, fermentable carbohydrate diets, probiotics, polyphenols and plant polysaccharides can influence GLP-1 secretion through microbiome-dependent mechanisms.Summary: Evidence supports an interaction between nutrition, the gut microbiome and GLP-1 signalling. Microbial metabolites link dietary substrates to GLP-1 secretion and diet shapes the microbial communities producing them. Integrating microbiome profiling with dietary interventions may help optimise metabolic therapies and explain variability in responses to GLP-1-based treatments.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"410-420"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perioperative drug pharmacokinetics in patients with obesity. 肥胖患者围手术期药物的药代动力学。

IF 3.5 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2026-07-01 Epub Date: 2026-04-17 DOI: 10.1097/MCO.0000000000001225

Damien Rousseleau, Luc De Baerdemaeker

{"title":"Perioperative drug pharmacokinetics in patients with obesity.","authors":"Damien Rousseleau, Luc De Baerdemaeker","doi":"10.1097/MCO.0000000000001225","DOIUrl":"10.1097/MCO.0000000000001225","url":null,"abstract":"Purpose of review: Obesity-related changes in body composition and organ function modify drug pharmacokinetics and pharmacodynamics, challenging standard dosing strategies. This review summarizes recent data on perioperative pharmacokinetics in patients with obesity and discusses implications for anesthetic drug dosing.Recent findings: Recent data confirm that excess adiposity induces drug-specific alterations in distribution, hepatic clearance, and renal elimination. Lipophilic agents exhibit increased volumes of distribution with risk of accumulation, whereas hydrophilic drugs are prone to excessive plasma exposure when dosed according to total body weight. Recent clinical and pharmacokinetic studies have generated dosing data for several perioperative agents in patients with obesity, including remimazolam, ciprofol, and intravenous lidocaine. In contrast, pharmacokinetic evidence remains limited for other commonly used drugs, notably ketamine, magnesium sulfate, and dexamethasone. The incidence of sleep apnea is high in obese patients and restrictive use or avoiding of opioids is advised. Studies evaluating multimodal and opioid-free anesthesia in patients with obesity report heterogeneous outcomes, reflecting uncertainty in dosing strategies and comparator regimens.Summary: Perioperative drug dosing in patients with obesity requires an individualized approach based on pharmacokinetic principles and clinical titration. Further obesity-specific pharmacokinetic and pharmacodynamic studies are needed to support safe and effective management in this population.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"403-409"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0