Current Opinion in Clinical Nutrition and Metabolic Care最新文献_第2页

Plant-based diets and child growth. 植物性饮食和儿童成长。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2025-05-01 Epub Date: 2025-03-19 DOI: 10.1097/MCO.0000000000001119

Rosan Meyer, Jennifer Lp Protudjer

{"title":"Plant-based diets and child growth.","authors":"Rosan Meyer, Jennifer Lp Protudjer","doi":"10.1097/MCO.0000000000001119","DOIUrl":"10.1097/MCO.0000000000001119","url":null,"abstract":"Purpose of review: The EAT-Lancet Commission on Healthy Diets from Sustainable Food Systems recommended a diet that is higher in plant-based food in 2019. Whilst plant-based diets have been followed in many regions of the world, the planetary concern and the published health benefits has increased the uptake of such diets. This review sets out to explore the impact on growth in children following a plant-based diet.Recent findings: Twelve observational studies were published between 2017 and 2024, assessing the impact of vegan and vegetarian diets compared to omnivorous diets in children. Ten studies found no significant difference in growth parameters between children on the plant-based diet vs. the omnivorous diet, however there is a trend of lower growth parameters including undernutrition, but also lower rates of overweight in children on a plant-based diet. One study found that that children were shorter on a vegan diet and another found that infants born to mothers following a vegan diet had significantly lower weight. None of the studies assessed children that received professional dietary advice.Summary: Overall, growth is comparable in children following a plant-based diet, but a higher risk for undernutrition has been highlighted. Children can follow a plant-based diet and establish good growth with the help of a qualified healthcare professional understanding macro and micronutrient provision on such a diet.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"274-283"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sarcopenia and frailty in critical illness. 骨骼肌减少症和危重疾病中的虚弱。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2025-05-01 Epub Date: 2025-03-12 DOI: 10.1097/MCO.0000000000001123

Marielle Johanna Maria Magdalena van der Steen-Dieperink, Wilhelmina Aria Christina Koekkoek, Imre Willemijn Kehinde Kouw

{"title":"Sarcopenia and frailty in critical illness.","authors":"Marielle Johanna Maria Magdalena van der Steen-Dieperink, Wilhelmina Aria Christina Koekkoek, Imre Willemijn Kehinde Kouw","doi":"10.1097/MCO.0000000000001123","DOIUrl":"10.1097/MCO.0000000000001123","url":null,"abstract":"Purpose of review: Sarcopenia and frailty are common conditions, associated with worse clinical outcomes during critical illness. Recent studies on sarcopenia and frailty in ICU patients are presented in this review, aiming to identify accurate diagnostic tools, investigate the effects on clinical and functional outcomes, and propose possible effective interventions.Recent findings: The recent change of the sarcopenia definition underlines the importance of muscle strength over mass, this is however challenging to assess in ICU patients. There is currently no unified sarcopenia definition, nor standard frailty assessment tool; Clinical Frailty Scale is most frequently used in the ICU. Meta-analyses show worse clinical and functional outcomes for frail as well as sarcopenic patients admitted to the ICU, regardless of admission diagnosis. Frailty is a dynamic condition, worsening in severity by the time of hospital discharge, but showing improvement by 6 months post-ICU. Therapeutic interventions for frailty and sarcopenia remain limited. Although mobilization strategies show promise in improving functional and cognitive outcomes, inconsistent outcomes are reported. Heterogeneity in definitions, patient populations, and care practices challenge interpretation and comparison of study results and recognition of beneficial interventions. This highlights the need for more research.Summary: The importance of preexisting sarcopenia and frailty is recognized in ICU patients and associated with worse clinical outcomes. Multidimensional interventions are most promising, including patient-tailored mobilization and nutrition.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"192-199"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disease associated malnutrition in pediatrics - what is new? 儿科疾病相关营养不良——有什么新发现？

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2025-05-01 Epub Date: 2025-02-13 DOI: 10.1097/MCO.0000000000001115

Koen Huysentruyt, Jessie M Hulst, Konstantinos Gerasimidis, Koen F Joosten

{"title":"Disease associated malnutrition in pediatrics - what is new?","authors":"Koen Huysentruyt, Jessie M Hulst, Konstantinos Gerasimidis, Koen F Joosten","doi":"10.1097/MCO.0000000000001115","DOIUrl":"10.1097/MCO.0000000000001115","url":null,"abstract":"Purpose of review: Disease associated malnutrition (DAM) remains an important concern in the care of hospitalized children and children with a chronic disease. This review focused on pediatric literature published since 2023 on the prevalence, assessment and treatment of DAM in different settings.Recent findings: The prevalence of DAM depends on a variety of factors. Studies focused on the relationship between different assessment methods of DAM and sarcopenia in hospitalized children and children with an underlying disease and clinical outcomes. Several papers focused on exploring the interplay between nutritional management and the evolving metabolic phases of critically ill children. Some studies explored feeding intolerance and barriers to administering enteral nutrition, micronutrient assessment and whether continuous versus intermittent feeding was superior in pediatric intensive care.Summary: In hospitalized children and chronically ill children, nutritional assessment and assessment of frailty and/or sarcopenia is best done using a comprehensive approach integrating anthropometrics, nutrition focused history and physical examination. Adequate nutritional support for critically ill children is challenging and needs to be tailored to the specific phases of critical illness. Intermittent feeding may offer potential advantages in inducing ketosis and circadian rhythm alignment but requires careful management to prevent nutritional deficits.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"289-296"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of lifestyle factors across the life course on sarcopenia and physical frailty. 生命过程中生活方式因素对肌肉减少症和身体虚弱的影响。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2025-05-01 Epub Date: 2025-02-05 DOI: 10.1097/MCO.0000000000001111

Daphne Zihui Yang, Joanne Kua, Wee Shiong Lim

{"title":"The impact of lifestyle factors across the life course on sarcopenia and physical frailty.","authors":"Daphne Zihui Yang, Joanne Kua, Wee Shiong Lim","doi":"10.1097/MCO.0000000000001111","DOIUrl":"10.1097/MCO.0000000000001111","url":null,"abstract":"Purpose of review: Muscle health helps maintain locomotor capacity, a key component of intrinsic capacity, which is required for healthy ageing. Sarcopenia is characterized by the age-related decline in muscle mass and strength leading to impaired physical performance, and has been described as a biological substrate of physical frailty. Both sarcopenia and physical frailty share phenotypic features of weakness and slowness, lead to common adverse outcomes, and have potential for reversal through early identification and intervention. The purpose of this review is to present recent evidence for the impact of lifestyle interventions across the life course on sarcopenia and physical frailty.Recent findings: Resistance exercise alone or combined with balance and aerobic training as part of a multicomponent exercise program and high-quality diets incorporating adequate protein remain the mainstay of treatment for sarcopenia and physical frailty. Reducing sedentary time and increasing physical activity, adherence to Mediterranean diet, increasing vegetable and caffeinated beverage intake, cardiovascular risk factor modification, improving sleep hygiene and depressive symptoms may also contribute to slowing down age-related decline in muscle health.Summary: Lifestyle interventions such as physical activity, diet, sleep and mental health are effective against sarcopenia and physical frailty. Targeting lifestyle modifications in early to midlife may retard further decline in locomotor capacity and optimize intrinsic capacity of older persons, reducing the risk of sarcopenia, physical frailty and their attendant negative health outcomes.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"208-223"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving the quality of donor human milk to take advantage of more of the health benefits of mother's own milk composition. 提高供体母乳的质量，更多地利用母亲自己的母乳成分带来的健康益处。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2025-05-01 Epub Date: 2025-02-18 DOI: 10.1097/MCO.0000000000001116

Megan R Beggs, Sharon Unger, Deborah L O'Connor

{"title":"Improving the quality of donor human milk to take advantage of more of the health benefits of mother's own milk composition.","authors":"Megan R Beggs, Sharon Unger, Deborah L O'Connor","doi":"10.1097/MCO.0000000000001116","DOIUrl":"10.1097/MCO.0000000000001116","url":null,"abstract":"Purpose of review: Pasteurized donor human milk (PDHM) is the recommended supplement when there is inadequate volume of mother's own milk (MOM) for very low birth weight (<1500 g, VLBW) infants. Differences in the composition of these milks may impact growth, morbidities or long-term development of infants. The aim of this review is to highlight current trends in understanding compositional differences between MOM and PDHM, technological advances in processing PDHM, and infant outcomes when VLBW infants are fed these milks.Recent findings: Reported differences in the composition between MOM and PDHM are due to several factors including when and how milk is collected, sampled for analysis, and processed. Systematic reviews and primary research studies demonstrate that PDHM reduces the risk of necrotizing enterocolitis in VLBW infants but is also associated with slower postnatal growth. Work is ongoing to determine if alternative approaches to processing PDHM can improve milk composition and thereby infant growth and neurodevelopment and reduce morbidity.Summary: PDHM is a key component of feeding VLBW infants when there is inadequate volume of MOM. Recent developments aim to optimize this source of nutrition and bioactive compounds for VLBW infants while further understanding limitations of its use.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"250-256"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fighting frailty, (osteo)sarcopenia, and fatigue: importance of unified definitions, accurate target identification, and high-quality clinical trials. 对抗虚弱、（骨）肌减少症和疲劳：统一定义、准确目标识别和高质量临床试验的重要性。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2025-05-01 Epub Date: 2025-04-03 DOI: 10.1097/MCO.0000000000001121

Barbara S van der Meij, Mariëlle P K J Engelen

引用次数: 0

Emerging concepts in introducing foods for food allergy prevention. 介绍食物过敏预防的新概念。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2025-05-01 Epub Date: 2025-03-07 DOI: 10.1097/MCO.0000000000001126

Carina Venter, Marion Groetch

{"title":"Emerging concepts in introducing foods for food allergy prevention.","authors":"Carina Venter, Marion Groetch","doi":"10.1097/MCO.0000000000001126","DOIUrl":"10.1097/MCO.0000000000001126","url":null,"abstract":"Purpose of review: This review focuses on the latest information regarding the role of complementary feeding practices and food allergen introduction in the prevention of food allergies.Recent findings: Early introduction of food allergens for food allergy prevention is recommended by food allergy prevention guidelines and is supported by the latest randomized controlled trials. Diet diversity is recommended, supported by the latest studies from Asia. A European study indicated that diet diversity after the first year of life may still be important for food allergy prevention. The latest systematic reviews indicate there may be an association between ultra-processed food intake and food allergy development. Plant based foods and fiber play an important role in modulating the gut microbiome which has been associated with reduced food allergy outcomes. However, increased intake of food allergens within a diverse diet raises questions about excessive calorie and protein intake but can be managed by focusing on infant satiety cues.Summary: The latest studies clearly indicate and further supports that introduction of food allergies should not be delayed once complementary feeding is commenced. A diverse diet is recommended to further support the prevention of food allergies.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"263-273"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential of creatine monohydrate supplementation in the management of osteosarcopenia. 一水肌酸补充剂在骨质疏松症治疗中的潜力。

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2025-05-01 Epub Date: 2025-02-21 DOI: 10.1097/MCO.0000000000001118

Darren G Candow, Ben Kirk, Philip D Chilibeck, Gustavo Duque

{"title":"The potential of creatine monohydrate supplementation in the management of osteosarcopenia.","authors":"Darren G Candow, Ben Kirk, Philip D Chilibeck, Gustavo Duque","doi":"10.1097/MCO.0000000000001118","DOIUrl":"10.1097/MCO.0000000000001118","url":null,"abstract":"Purpose of review: Osteosarcopenia is an age-related condition characterized by reductions in bone mineral, muscle/lean mass, strength and functional ability which increases the risk of falls, fractures, frailty and premature mortality. One main contributing factor to osteosarcopenia is malnutrition. The purpose was to review recent evidence of creatine monohydrate (CrM) supplementation in older adults and to discuss the potential to manage osteosarcopenia.Recent findings: Accumulating research shows that CrM supplementation, primarily when combined with exercise training, has the potential to serve as a viable intervention in the management of osteosarcopenia. Collectively, CrM supplementation during exercise training in older adults led to greater improvements in whole-body lean mass, lower-limb muscle density and bone geometry and muscle strength (primarily upper-body) compared to exercise training alone. However, no study has investigated the effects of CrM, with and without exercise training, in older adults with osteosarcopenia.Summary: Given the positive findings of CrM on measures of muscle and bone in healthy older adults, there is potential for CrM to be added as an adjunct to exercise training in the management of osteosarcopenia. However, randomized clinical trials are needed to confirm the safety and efficacy of this nutrient in this clinical population.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"235-239"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

(Poly)phenol-gut microbiota interactions and their impact on human health. （聚）酚-肠道菌群相互作用及其对人体健康的影响

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2025-04-29 DOI: 10.1097/MCO.0000000000001132

Xiaohe Liu, Amnah Alharbi, Rachel Gibson, Ana Rodriguez-Mateos

{"title":"(Poly)phenol-gut microbiota interactions and their impact on human health.","authors":"Xiaohe Liu, Amnah Alharbi, Rachel Gibson, Ana Rodriguez-Mateos","doi":"10.1097/MCO.0000000000001132","DOIUrl":"https://doi.org/10.1097/MCO.0000000000001132","url":null,"abstract":"Purpose of review: (Poly)phenols are bioactive compounds in plant-based foods with well documented health benefits. Their metabolism in dependent on gut microbiota composition, diversity, and function, which modulate their bioavailability and physiological effects. This review examines recent insights into (poly)phenol-gut microbiota interactions, emphasizing their relevance in mediating health benefits and mechanisms of action.Recent findings: Recent studies have identified a high interindividual variability in (poly)phenol metabolism, explored microbial-derived metabolites with potential health benefits, and revealed bidirectional influences between (poly)phenols and gut microbiota composition. Advances in analytical techniques and large-scale studies have refined our understanding of these interactions, but inconsistencies remain in linking specific microbial signatures to health outcomes.Summary: Standardized methodologies and long-term studies are needed to clarify the impact of (poly)phenol-derived metabolites on human health. Future research should focus on personalized and targeted nutrition approaches to optimize (poly)phenol benefits.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiota in patients with metabolic, dysfunction-associated steatotic liver disease. 代谢、功能障碍相关脂肪变性肝病患者的肠道微生物群

IF 3 3区医学

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2025-04-24 DOI: 10.1097/MCO.0000000000001128

Lissette Duarte, Fabien Magne, Martin Gotteland

{"title":"Gut microbiota in patients with metabolic, dysfunction-associated steatotic liver disease.","authors":"Lissette Duarte, Fabien Magne, Martin Gotteland","doi":"10.1097/MCO.0000000000001128","DOIUrl":"https://doi.org/10.1097/MCO.0000000000001128","url":null,"abstract":"Purpose of review: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent condition that can progress to fibrosis, steatohepatitis, and hepatocellular carcinoma. This review examines recent advances concerning the role of gut microbiota in MASLD and microbiota-focused interventions to positively impact disease outcome.Recent findings: Dysbiotic microbiota and a compromised gut barrier facilitate the translocation of microbial-associated molecular patterns and harmful metabolites into the portal circulation and liver, where they exacerbate inflammatory and fibrogenic processes. Conversely, other bacterial metabolites have protective effects in the liver. Therefore, microbiota homeostasis is essential for maintaining liver health.Summary: Levels of harmful bacterial metabolites including ethanol, NH3, trimethylamine-L-oxide, 2-oleylglycerol, and litocholic acid are often increased in patients with MASLD. Conversely, short-chain fatty acids, indole derivatives, histidine, and the acids taurodeoxycholic, 3-succinylcholic, and hyodeoxycholic are decreased. The main aim of current interventions/treatments is to reduce harmful metabolites and increase beneficial ones. These interventions include drugs (pemafibrate, metformin, obeticholic acid), natural compounds (silymarin, lupeol, dietary fiber, peptides), exogenous bacteria (probiotics, gut symbionts), special diets (Mediterranean diet, time-restricted feeding), as well as microbiota transplantation, and phage therapy. Most improve gut permeability, liver inflammation, and fibrosis through microbiota regulation, and are promising alternatives for MASLFD management. However, most results come from animal studies, while clinical trials in MASLD patients are lacking. Further research is therefore needed in this area.","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0