Current HIV Research最新文献

{"title":"Design, <i>In Silico</i>, and <i>In vitro</i> Evaluation of Polymer-Based Drug Conjugates Incorporated with Derivative of Cinnamic Acid, Zidovudine, and 4-Aminosalicylic Acid against Pseudo-HIV-1.","authors":"T Naki, W M R Matshe, O Obisesan, M O Balogun, S O Oselusi, S S Ray, B A Aderibigbe","doi":"10.2174/011570162X334858241008071722","DOIUrl":"10.2174/011570162X334858241008071722","url":null,"abstract":"<p><strong>Background: </strong>The incorporation of anti-HIV drugs into polymer to form polymer-drug conjugates has been reported to result in improved therapeutic activity. Zidovudine, an anti-HIV drug, was explored alone and in combination with known drug molecules using polyamidoaminebased carriers.</p><p><strong>Objective: </strong>Polymer-drug conjugates incorporated with zidovudine, cinnamic acid, and 4-aminosalicylic acid were prepared and evaluated for their potential efficacy in vitro against pseudo- HIV-1.</p><p><strong>Methods: </strong>Aqueous Michael addition polymerization reaction was employed to prepare the conjugates. The conjugates were incorporated with zidovudine, cinnamic acid, and 4-aminosalicylic acid. They were characterized by SEM/EDX, XRD, FTIR, NMR, LC-MS, particle size analysis, <i>in vitro</i> analysis, computational studies, and <i>in silico</i> toxicity predictions.</p><p><strong>Results: </strong>The conjugates displayed spherically shaped morphology. The in vitro findings showed that polymer-drug conjugates, T15 and T16, with a single drug were effective against pseudo- HIV-1 at high concentrations of 111.11 and 333.33 μg/mL, respectively. Molecular docking studies supported the <i>in vitro</i> results. Additionally, SwissADME, ProTox-II, and GUSAR (General Unrestricted Structure-Activity Relationships) analyses revealed that these compounds have promising antiviral potential.</p><p><strong>Conclusion: </strong>The prepared polymer-drug conjugates with a single drug showed promising effects against the Pseudo-HIV-1, and the conjugates displayed features that make them potential anti- HIV therapeutics that require further studies.</p>","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":" ","pages":"374-390"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Resveratrol in a Randomized Clinical Trial on Drug-Induced Hyperlipidemia and Psychiatric Factors in People Living with HIV.","authors":"Bahar Ahmadi-Mousavi, Somayyeh Karami-Mohajeri, Fatemeh Dabaghzadeh, Motahareh Soltani, Zohreh Oghabian, Hamid Sharifi","doi":"10.2174/011570162X301403241104043813","DOIUrl":"10.2174/011570162X301403241104043813","url":null,"abstract":"<p><strong>Introduction: </strong>People living with HIV (PLHIV) suffer from a range of consequences related to infection, including hyperlipidemia and neurologic and sleep disorders. Supplements containing phenolic compounds with high antioxidant properties can reduce these side effects. Resveratrol is a phenolic compound that improves the symptoms of diabetes, cancer, and viral infections. This study aimed to evaluate the effects of resveratrol on hyperlipidemia and neurological problems in PLHIV in Iran.</p><p><strong>Methods: </strong>In this double-blind, randomized clinical trial, 41 PLHIV were randomly assigned to two groups: a placebo group (n=21) and a resveratrol group (n=20). Triglyceride and cholesterol levels were determined for all the subjects before and one month after they used the medication. Additionally, standard questionnaires were used to evaluate the quality of sleep, stress, depression, and quality of life of the participants. The data were analyzed via analysis of covariance in Stata 17.0.</p><p><strong>Results: </strong>The study population did not significantly differ in terms of age (p=0.49), sex (p=0.09), marital status (p=0.90), level of education (p=0.90), duration of HIV infection (p=0.54), or mode of HIV transmission (p=0.51). The administration of resveratrol did not affect psychological parameters or blood cholesterol (p=0.091) or triglyceride (p=0.932) levels.</p><p><strong>Conclusion: </strong>The administration of resveratrol did not affect cholesterol or triglyceride levels or the rates of depression, anxiety, sleep quality, or quality of life in PLHIV. The resveratrol supplementation in a large-scale clinical study involving more patients for a longer course of treatment may have had more significant effects on the serum levels of lipids and psychological factors.</p>","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":" ","pages":"417-424"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and Analysis of Differentially Expressed Genes Associated with Ferroptosis and HIV in PASMCs Based on Bioinformatics.","authors":"Tong Lu, Linna Guo, Yong Ma, Lijie Yao, Li Li, Wenshan Bian, Miao Xiu, Yang Jiang, Yongtao Li, Haifeng Jin","doi":"10.2174/011570162X304876240821062047","DOIUrl":"10.2174/011570162X304876240821062047","url":null,"abstract":"<p><strong>Background: </strong>HIV-associated pulmonary arterial hypertension (HIV-PAH), a rare and fatal condition within the pulmonary arterial hypertension spectrum, is linked to HIV infection. While ferroptosis, an iron-dependent cell death form, is implicated in various lung diseases, its role in HIVPAH development remains unclear.</p><p><strong>Methods: </strong>Leveraging Gene Expression Omnibus data, we identified differentially expressed genes (DEGs) in pulmonary arterial smooth muscle cells, including HIV-related DEGs (HIV-DEGs) and ferroptosis-related HIV-DEGs (FR-HIV-DEGs). PPI network analysis of FR-HIV-DEGs using CytoHubba in Cytoscape identified hub genes. We conducted functional and pathway enrichment analyses for FR-HIV-DEGs, HIV-DEGs, and hub genes. Diagnostic value assessment of hub genes utilized ROC curve analysis. Key genes were further screened, and external validation was performed. Additionally, we predicted a potential ceRNA regulatory network for key genes.</p><p><strong>Results: </strong>1372 DEGs were found, of which 228 were HIV-DEGs, and 20 were FR-HIV-DEGs. TP53, IL6, PTGS2, IL1B (downregulated), and PPARG (upregulated) were the five hub genes that were screened. TP53, IL6, and IL1B act as ferroptosis drivers, PTGS2 as a ferroptosis marker, and PPARG as a ferroptosis inhibitor. Enrichment analysis indicated biological processes enriched in \"response to oxidative stress\" and pathways enriched in \"human cytomegalovirus infection.\" Key genes IL6 and PTGS2 exhibited strong predictive value <i>via</i> ROC curve analysis and external validation. The predicted ceRNA regulatory network identified miRNAs (has-mir-335-5p, has-mir-124-3p) targeting key genes and lncRNAs (XIST, NEAT1) targeting these miRNAs.</p><p><strong>Conclusion: </strong>This study advances our understanding of potential mechanisms in HIV-PAH pathogenesis, emphasizing the involvement of ferroptosis. The findings offer valuable insights for future research in HIV-PAH.</p>","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":" ","pages":"308-317"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV Stigma, Sexual Identity Stigma and Online Coping Strategy of Gay, Bisexual and Queer People Living with HIV: A Moderated Mediation Study.","authors":"Muhammad Ashraff Ahmad, Azmawaty Mohamad Nor, Harris Shah Abd Hamid","doi":"10.2174/011570162X300696240530095046","DOIUrl":"10.2174/011570162X300696240530095046","url":null,"abstract":"<p><strong>Introduction: </strong>Living with HIV/AIDS is more difficult for gay, bisexual, and queer (GBQ) people as they face stigma on both the disease and sexuality, which puts significant stress on coping with stressors, and online platforms have become an alternative coping channel.</p><p><strong>Methods: </strong>This study investigated the use of online coping strategies in moderating the HIV stigma mediated by sexual identity stigma on mental health in Malaysia. 123 GBQ people living with HIV between the ages of 20 and 39 participated in the study, responding to the HIV Stigma - Short Form Scale, adapted China MSM Stigma Scale, Online Coping Inventory, and DASS-21.</p><p><strong>Result: </strong>Results were analyzed using OLS, and logistic regression path modeling showed a statistically significant indirect effect of sexual identity stigma mediating HIV stigma on depressive (ab = 0.1362), anxiety (ab = 0.1259), and stress (ab = 0.1636) levels. Problem-focused online coping strategy was found to moderate the indirect association between HIV stigma and depression levels via sexual identity stigma at low (β = 0.2110, SE = 0.0741, p<.05) and moderate levels (β = 0.1168, SE = 0.0465, p<.05). The findings demonstrated the compounding link between HIV and sexual identity stigmas on mental health and how online coping strategies can be used as a helpful coping resource to manage depressive symptoms for this community and mental health practitioners.</p><p><strong>Conclusion: </strong>These findings can be beneficial to generate a better understanding of how double stigmas play a role in mental health and the types of online coping strategies adopted to process the stressors for GBQ individuals living with HIV in Malaysia.</p>","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":" ","pages":"181-194"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transmission Dynamics of Adolescent HIV is Very Different from Adults: A Longitudinal Study from India.","authors":"Suman Ganguly, Shibaji Gupta, Rahul Biswas, Debjani Guchhait","doi":"10.2174/011570162X313585240822113245","DOIUrl":"10.2174/011570162X313585240822113245","url":null,"abstract":"<p><strong>Introduction: </strong>Behavioral risk factors in adolescents make them vulnerable to human immunodeficiency virus (HIV). Although it is dissimilar to adults, adolescent HIV is less studied. This study aimed to determine various socio-demographic attributes and transmission dynamics associated with adolescent HIV in order to comment on how they differ from the overall epidemiology of HIV.</p><p><strong>Methods: </strong>A record-based, comparative study was conducted using data from adolescents (ALHIV) and adults registered in all HIV centers across the Indian state of West Bengal over four years. The socio-demographic profile and modes of HIV transmission were studied. Transmission dynamics were compared between adolescent and non-adolescent beneficiaries, as well as male and female HIV-positive adolescents. The association of adolescent HIV burden with child marriage and adolescent pregnancy rates was also tested.</p><p><strong>Results: </strong>More than 50% of AL-HIVs were students. While heterosexuality (87.17%) was the commonest route of HIV transmission in adults, parent-to-child transmission (PTCT) (51.69%) and blood transfusions (12.86%) were major routes in AL-HIVs; also, they were significantly more prone to get infected through these routes. PTCT was significantly lower, and transmission by needle syringes was higher in male adolescents than in their female counterparts. Districts with a higher prevalence of child marriage and adolescent pregnancy had a significantly higher burden of AL-HIV.</p><p><strong>Conclusion: </strong>The transmission dynamics of adolescent HIV are largely different from those of adults, with PTCT and sociocultural issues playing significant roles. It is, therefore, essential to design targeted interventions to tackle the unique challenges of HIV in adolescents for more effective and comprehensive campaigns against the pandemic.</p>","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":" ","pages":"361-367"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Characteristics of the Env Regions in HIV-1-Infected Subjects in Baoding City, Hebei Province, China.","authors":"Kunjing Geng, Wenchao Wei, Sisi Chen, Haoxi Shi, Weiguang Fan","doi":"10.2174/011570162X321660241127102018","DOIUrl":"10.2174/011570162X321660241127102018","url":null,"abstract":"<p><strong>Objectives: </strong>The envelope glycoprotein (Env) on the surface of the human immunodeficiency virus (HIV-1) is a crucial protein that mediates binding to host cell receptors and subsequent membrane fusion. Env, as the sole target for neutralizing antibodies, holds unique importance in vaccine design. Therefore, analyzing the genetic characteristics of the Env region offers reference data for vaccine and drug design.</p><p><strong>Methods: </strong>From December 2021 to December 2022, 145 newly diagnosed, HIV-1-infected individuals in Baoding City were recruited into this study. The HIV-1 env gene sequence was successfully obtained from 142 of the 145 blood specimens, and the sequences were submitted to the Quality Control Tool (http//:HIV-DB Sequence Quality Control Tool (lanl.gov)) to analyze the viral subtype. The coreceptor tropism was predicted using the Geno2pheno web tool with falsepositive rate (FPR) values of 5%-15%, and the net charges of the third variable (V3) loop were calculated by Variable Region Characteristics (lanl.gov).</p><p><strong>Results: </strong>The results showed that half of the patients were infected with the CCR5-tropic virus (50.0%, 71/142). In HIV-1 subtype CRF01_AE infection, the use of CXCR4 is expected to predominate, while in HIV-1 subtype CRF07_BC infection, CCR5 coreceptors are expected to be used predominantly. Sequence analysis of the V3 loop region revealed that subtypes CRF01_AE and CRF07_BC have similar median net charges (~3.0). Furthermore, GPGQ was found to be the major terminal tetrapeptide of the CRF07_ BC and CRF01_AE strains in this study.</p><p><strong>Conclusion: </strong>These findings enhance our understanding of the characteristics of the HIV-1 epidemic and provide important implications for HIV-1 vaccine design and clinical treatment.</p>","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":" ","pages":"409-416"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Metabolism in Men who Live with HIV Aged 50 years and Over: Impact of Infection Duration.","authors":"Bilge Caglar, Emre Durcan, Ridvan Karaali, Ilker Inanc Balkan, Sibel Yildiz Kaya, Hakan Yavuzer, Dildar Konukoglu, Gokhan Aygun, Nese Saltoglu, Iclal Nur Bulut, Kerim Sonmezoglu, Pinar Kadioglu, Bilgul Mete, Omer Fehmi Tabak","doi":"10.2174/011570162X273667231213061301","DOIUrl":"10.2174/011570162X273667231213061301","url":null,"abstract":"<p><strong>Background: </strong>Early diagnosis and effective antiretroviral therapy (ART) lead to similar life expectancy in people living with HIV (PLWH) compared to the general population. This population faces problems such as decreased bone mineral density (BMD) and increased fracture risk. The aim of this study was to determine the prevalence of osteoporosis in men aged 50 years and over who were PLWH and to determine risk factors and changes in bone metabolism with bone turnover markers.</p><p><strong>Methods: </strong>79 male PLWH aged 50 years and over were followed up in our outpatient clinic between May 2021 and October 2021. The patients' demographic, clinical, laboratory, and DEXA data were analyzed. Serum levels of bone turnover markers were measured.</p><p><strong>Results: </strong>The prevalence of osteopenia, osteoporosis, and normal BMD was found to be 55.7%, 13.9%, and 30.4%, respectively. A correlation was found between low BMD and low body mass index, elapsed time since diagnosis of HIV infection, high rate of use of ART, and long usage time of tenofovir disoproxil fumarate + protease inhibitor. A one-year increase in HIV infection duration was associated with an increased risk of low BMD by 1.246.</p><p><strong>Conclusion: </strong>Compared to studies conducted on the general population, the prevalence of osteoporosis in male PLWH aged 50 years and older was two times higher. The limited effect of the duration of ART use on low BMD may be due to the patients' histories of replacement therapy. Therefore, to eliminate the negative effects of ART on BMD, it may be beneficial to start replacement therapy when necessary.</p>","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":" ","pages":"65-71"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139566408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of HIV and Syphilis Co-infected Cases, Data from a University Hospital.","authors":"Süheyla Kömür, Damla Ertürk, Sezin Sevdimbaş, Ferit Kuşcu, Ayşe Seza İnal, Behice Kurtaran, Aslıhan Candevir, Yeşim Taşova","doi":"10.2174/011570162X313718240514042111","DOIUrl":"10.2174/011570162X313718240514042111","url":null,"abstract":"<p><strong>Background: </strong>HIV and syphilis are sexually transmitted infections with overlapping risk factors, potentially leading to increased HIV transmission and treatment challenges. Understanding the clinical management of syphilis co-infection among people living with HIV is crucial for public health interventions.</p><p><strong>Objective: </strong>This retrospective cohort study aimed to assess the prevalence of syphilis co-infection, clinical characteristics, treatment response, and public health implications among people living with HIV in southern Turkey.</p><p><strong>Methods: </strong>Records of 1352 people living with HIV 18 years and older, followed at a tertiary infectious diseases clinic between 2013 and 2023, were analyzed. Data on demographics, clinical stage of syphilis and HIV/AIDS, laboratory parameters, treatment response, and co-infections were collected. Statistical analyses were performed using SPSS 20.0 software.</p><p><strong>Results: </strong>Among the people living with HIV, 103 (7.6%) were diagnosed with syphilis. Most cases were male (97.1%), with a median age of 33 (IQR 28-49) years. Heterosexual transmission was predominant (60.2%), with a history of condomless sexual intercourse in 90.3% of cases. The majority (88.3%) were asymptomatic with latent syphilis. Syphilis was diagnosed concurrently with HIV in 77.7% of cases. Serological response to syphilis treatment was observed in 46.8% of patients, while 53.2% showed a serofast reaction. Neurosyphilis was rare, diagnosed in only one patient. Co-infections with hepatitis B and C were detected in 3.9% and 1.9% of patients, respectively.</p><p><strong>Conclusion: </strong>Syphilis co-infection among people living with HIV is a significant public health concern in southern Turkey. Routine screening for syphilis, along with comprehensive education on sexually transmitted infection prevention, is essential for early detection and optimal management. Further research is needed to improve treatment outcomes and address emerging challenges in HIV-syphilis co-infection management.</p>","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":" ","pages":"153-157"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA Expression in Exosome Extracellular Vesicles as Targets for Personalized Medicine in Diffuse Large B Cell Lymphoma Patients with HIV Infection.","authors":"Yadiel Corrales Cruz, Corey Suthumphong, Allen Caobi, Mickensone Andre, Janelle Vicens, Andrea D Raymond, Marco Ruiz","doi":"10.2174/011570162X288575240821201433","DOIUrl":"10.2174/011570162X288575240821201433","url":null,"abstract":"<p><p>Extracellular Vesicles (EVs), more specifically exosomes (xEVs), have been associated with Diffuse Large B-cell Lymphoma (DLBCL). These xEVs contain a variety of biomolecules, such as proteins and nucleic acids (e.g., microRNA, LncRNA, and DNA). The expressions of these vesicles in the setting of Human Immunodeficiency Virus (HIV) have been linked to disease progression. Studies have explored the use of EVs in more practical clinical settings. Several studies have found that biomolecules within xEVs can serve to detect disease progression. The biomolecule content within xEVs is useful in prognostication and has even been associated with mechanisms of resistance for some DLBCL treatment modalities. This review article explores the role of xEV biomolecule content in DLBCL progression in the context of HIV infection and its applied use in practical disease management.</p>","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":" ","pages":"354-360"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotyping and Antiretroviral Drug Resistance Mutations among HIV Patients in Southern Santa Catarina, Brazil.","authors":"Chaiana Esmeraldino Mendes Marcon, Aline Daiane Schlindwein, Luis Fernando de Macedo Brigido, Giselle Ibette Lopez-Lopes, Gabriela Bastos Cabral, Fabiana Schuelter-Trevisol","doi":"10.2174/011570162X296948240802075249","DOIUrl":"10.2174/011570162X296948240802075249","url":null,"abstract":"<p><strong>Introduction: </strong>Therapeutic measures have been successful in increasing survival rates and quality of life of HIV/AIDS-infected people. However, some people fail to respond to antiretroviral therapy (HAART) because of viral resistance-associated mutations.</p><p><strong>Objective: </strong>To identify virus genotype and the presence of mutations that alter the susceptibility to HAART, and factors associated with the occurrence of these mutations.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on adults living with HIV attending a specialized outpatient clinic in southern Santa Catarina, Brazil. The participants were interviewed and had blood samples collected for analysis. Those with detectable viral load were genotyped.</p><p><strong>Results: </strong>Out of the 629 patients recruited, 127 subjects were included due to having a detectable viral load. The most common mutations were M184V and K103N. HIV-1 subtype C was the most prevalent strain. Resistance to HAART was associated with modification in the treatment regimen (p <0.001).</p><p><strong>Conclusion: </strong>This study concluded that the circulating subtype virus was subtype C and that the mutations K103N and M184V were the most prevalent strains in southern Santa Catarina, Brazil.</p>","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":" ","pages":"230-239"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}