Current HIV Research最新文献_第6页

WITHDRAWN: Analysis of the Efficacy of Drilling Decompression Autologous Bone Marrow and Allogeneic Bone Grafting in the Treatment of HIV-positive Patients with Early Osteonecrosis of the Femoral Head 钻孔减压自体骨髓和异体骨移植治疗HIV阳性早期股骨头坏死患者的疗效分析。

IF 1 4区医学

Current HIV Research Pub Date : 2023-11-03 DOI: 10.2174/011570162X253808231025111220

Li Shengtao, Wang Jie, Ma Rui, Zhao Changsong, Pu Yu, He Min, Gao Zhengrong, Quan Xuemin, Zhang Qiang

{"title":"WITHDRAWN: Analysis of the Efficacy of Drilling Decompression Autologous Bone Marrow and Allogeneic Bone Grafting in the Treatment of HIV-positive Patients with Early Osteonecrosis of the Femoral Head","authors":"Li Shengtao, Wang Jie, Ma Rui, Zhao Changsong, Pu Yu, He Min, Gao Zhengrong, Quan Xuemin, Zhang Qiang","doi":"10.2174/011570162X253808231025111220","DOIUrl":"10.2174/011570162X253808231025111220","url":null,"abstract":"The article has been withdrawn at the request of the author of the journal Current HIV Research (CHIVR).Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.phpBentham science disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere\u0000must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the\u0000authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright\u0000of their article is transferred to the publishers if and when the article is accepted for publication.","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71479207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NIH HIV Reagent Program: A Valuable Resource for HIV Research 美国国立卫生研究院艾滋病毒试剂计划：艾滋病研究的宝贵资源

IF 1 4区医学

Current HIV Research Pub Date : 2023-07-01 DOI: 10.2174/1570162x2104231226194230

Khalid Timani, Sujatha Rashid, Rebecca Bradford, Joseph Leonelli

引用次数: 0

Meet the Co-Editor 与合作编辑见面

4区医学

Current HIV Research Pub Date : 2023-05-01 DOI: 10.2174/1570162x2103230821160901

Roberto Di Santo

引用次数: 0

WITHDRAWN: Long-term Survival Analysis of 30 Maintenance Hemodialysis Patients with HIV Infection in a Single-center in China 撤回:中国单中心30例HIV感染维持性血液透析患者的长期生存分析

IF 1 4区医学

Current HIV Research Pub Date : 2023-04-28 DOI: 10.2174/1570162X21666230428163809

Wenwen Ren, Guiju Gao, Yajuan Fang, Tongtong Wang, Chunyu Zhu, Jiang Xiao, Fang Wang, Liang Ni, Di Yang

{"title":"WITHDRAWN: Long-term Survival Analysis of 30 Maintenance Hemodialysis Patients with HIV Infection in a Single-center in China","authors":"Wenwen Ren, Guiju Gao, Yajuan Fang, Tongtong Wang, Chunyu Zhu, Jiang Xiao, Fang Wang, Liang Ni, Di Yang","doi":"10.2174/1570162X21666230428163809","DOIUrl":"https://doi.org/10.2174/1570162X21666230428163809","url":null,"abstract":"The article has been withdrawn at the request of the author of the journal Current HIV Research (CHIVR).Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial\u0000Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.phpBentham science disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously\u0000submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere\u0000must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting\u0000the article for publication the authors agree that the publishers have the legal right to take appropriate action against the\u0000authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright\u0000of their article is transferred to the publishers if and when the article is accepted for publication","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10439208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meet the Editorial Advisory Board Member 会见编辑咨询委员会成员

IF 1 4区医学

Current HIV Research Pub Date : 2023-03-01 DOI: 10.2174/1570162x2102230627125640

M. Aliyu

引用次数: 0

Prevalence of Erectile Dysfunction (ED) among People Living with HIV in Tehran, Iran. 伊朗德黑兰艾滋病毒感染者中勃起功能障碍(ED)的患病率。

IF 1 4区医学

Current HIV Research Pub Date : 2023-01-01 DOI: 10.2174/011570162X270146231205105957

SeyedAli Dehghan Manshadi, Ali Keyhani Pirdehi, Elnaz Shahmohamadi, Malihe Hasan Nezhad, Faezeh Abbaspour, Sona Mahrokhi, SeyedAhmad SeyedAlinaghi

{"title":"Prevalence of Erectile Dysfunction (ED) among People Living with HIV in Tehran, Iran.","authors":"SeyedAli Dehghan Manshadi, Ali Keyhani Pirdehi, Elnaz Shahmohamadi, Malihe Hasan Nezhad, Faezeh Abbaspour, Sona Mahrokhi, SeyedAhmad SeyedAlinaghi","doi":"10.2174/011570162X270146231205105957","DOIUrl":"10.2174/011570162X270146231205105957","url":null,"abstract":"Background: Sexual problems are rarely addressed in human immunodeficiency virus (HIV) management, even though overt sexual dysfunctions are more prevalent in people living with HIV. This study aimed to ascertain the prevalence of erectile dysfunction (ED) among HIVinfected men in a stable clinical state, examine the relationship between antiretroviral therapy (ART) exposure and sexual dysfunction, and identify the associated risk factors.Method: This cross-sectional study recruited HIV-positive males who visited the Voluntary Counseling and Testing (VCT) center of Imam Khomeini Hospital (Tehran) in 2020. The International Index of Erectile Function (IIEF) questionnaire was used to evaluate the ED in participants. Sociodemographic and clinical data were also collected.Results: Of 65 patients who participated in this study, 27.7% had ED. The mean age of participants with and without ED was 39.4±11.5 and 40.4±7.6 years old, respectively. No significant difference was observed between patients with and without ED concerning the sociodemographic status and the use of ART drugs.Conclusion: The prevalence of ED is relatively high among men living with HIV. Future research is recommended among HIV-positive males to identify the underlying causes and explore the potential impact that associated psychological distress could have on sexual dysfunction.","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":" ","pages":"361-366"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138498045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Observational Study of Genetic Diversity of HIV-1 vpu in Rapid Progressors in India. 印度HIV-1 vpu快速进展者遗传多样性的观察研究

IF 1 4区医学

Current HIV Research Pub Date : 2023-01-01 DOI: 10.2174/1570162X21666230221152633

Poonam Gupta, Arvind Rai, Charoo Hans, Mohammad Husain

{"title":"An Observational Study of Genetic Diversity of HIV-1 vpu in Rapid Progressors in India.","authors":"Poonam Gupta, Arvind Rai, Charoo Hans, Mohammad Husain","doi":"10.2174/1570162X21666230221152633","DOIUrl":"https://doi.org/10.2174/1570162X21666230221152633","url":null,"abstract":"Background: The genetic diversity in HIV-1 genes affects viral pathogenesis in HIV-1 positive patients. Accessory genes of HIV-1, including vpu, are reported to play a critical role in HIV pathogenesis and disease progression. Vpu has a crucial role in CD4 degradation and virus release. The sequence heterogeneity in the vpu gene may affect disease progression in patients, therefore, the current study was undertaken to identify the role of vpu in patients defined as rapid progressors.Objective: The objective of the study was to identify the viral determinants present on vpu that may be important in disease progression in rapid progressors.Methods: Blood samples were collected from 13 rapid progressors. DNA was isolated from PBMCs and vpu was amplified using nested PCR. Both strands of the gene were sequenced using an automated DNA Sequencer. The characterization and analysis of vpu was done using various bioinformatics tools.Results: The analysis revealed that all sequences had intact ORF and sequence heterogeneity was present across all sequences and distributed all over the gene. The synonymous substitutions, however, were higher than nonsynonymous substitutions. The phylogenetic tree analysis showed an evolutionary relationship with previously published Indian subtype C sequences. Comparatively, the cytoplasmic tail(77 - 86) showed the highest degree of variability in these sequences as determined by Entropy- one tool.Conclusion: The study showed that due to the robust nature of the protein, the biological activity of the protein was intact and sequence heterogeneity may promote disease progression in the study population.","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":"21 2","pages":"99-108"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10131960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Better Predictive Value of Lymphocyte Count and Hemoglobin for CD4 Level of HIV Patients. 淋巴细胞计数和血红蛋白对HIV患者CD4水平的预测价值。

IF 1 4区医学

Current HIV Research Pub Date : 2023-01-01 DOI: 10.2174/1570162X21666221222104349

Zheng-Rong Gao, Zheng Yuan, Chang-Song Zhao, Ru-Gang Zhao, Qiang Zhang

{"title":"Better Predictive Value of Lymphocyte Count and Hemoglobin for CD4 Level of HIV Patients.","authors":"Zheng-Rong Gao, Zheng Yuan, Chang-Song Zhao, Ru-Gang Zhao, Qiang Zhang","doi":"10.2174/1570162X21666221222104349","DOIUrl":"10.2174/1570162X21666221222104349","url":null,"abstract":"Objective: HIV patients are prone to infection and difficult to treat, which mainly manifests itself in decreased CD4+ T cells in the body. Therefore, the predictive value of lymphocyte count and hemoglobin for CD4+ levels in HIV patients was discussed in the prospective study.Methods: 125 HIV patients (aged >18 or < 80 years) were recruited. Pearson chi-square test was used to explore the correlation between CD4+ content and blood-related parameters in HIV patients. Univariate and multivariate logistic regression analyses were used to calculate ORs for each variable. In addition, receiver ROC curves were constructed to assess each factor's accuracy and sensitivity in diagnosing CD4+.Results: Lymphocyte count and hemoglobin were significantly correlated with CD4+. In terms of multivariate logistic regression level, there was a significant correlation between lymphocyte count (OR = 3.170, 95% CI: 1.442-6.969, P = 0.004), hemoglobin (OR = 2.545, 95% CI: 1.148- 5.646, P = 0.022) and CD4+ content in HIV patients. Based on the neural network model, the level of lymphocyte and hemoglobin might be the predictive indexes of CD4+ level. We find the high-risk warning indicator of CD4+ level: 3 < lymphocyte (109/L) < 3.6, and 150 < hemoglobin (g/L) < 200.Conclusion: Better predictive value of lymphocyte count and hemoglobin for CD4+ level of HIV patients.","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":"21 1","pages":"73-80"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9724074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Late Diagnosis at Entry on Care in an HIV Clinic in Mexico City: Possibly COVID-19 Pandemic Impact. 墨西哥城一家艾滋病诊所的入院诊断过晚：COVID-19大流行的可能影响。

IF 1 4区医学

Current HIV Research Pub Date : 2023-01-01 DOI: 10.2174/1570162X21666230717150555

Cesar Ivan Elizalde-Barrera, Carlos Virgilio Juarez-Mendoza

{"title":"Late Diagnosis at Entry on Care in an HIV Clinic in Mexico City: Possibly COVID-19 Pandemic Impact.","authors":"Cesar Ivan Elizalde-Barrera, Carlos Virgilio Juarez-Mendoza","doi":"10.2174/1570162X21666230717150555","DOIUrl":"10.2174/1570162X21666230717150555","url":null,"abstract":"Background: HIV late-stage diagnoses have an important impact on mortality. Unfortunately, a significant number of patients are still diagnosed at late stages. On the other hand, the coronavirus disease 2019 (COVID-19) pandemic has created an unprecedented crisis in healthcare systems worldwide, including HIV care services. The aim of this study was to compare time-trends in HIV late diagnosis, prevalence, and initial CD4 cell counts of newly diagnosed HIV-positive individuals at the entry to HIV care in a General Hospital in Mexico City and to assess the Covid-19 pandemic possible effects on late diagnosis prevalence.Methods: We retrospectively analyzed the data of HIV-infected patients (January 1999 to December 2021) to assess the prevalence of Late presentation (LP, CD4 count < 350 cells/mm3) and presentation with advanced HIV disease (AHIVD CD4 count < 200 cells/mm3). Differences across time were evaluated, focusing on years of the Covid-19 pandemic.Results: We included 348 newly diagnosed HIV-positive individuals, of which 255 (73.2%) patients entered into care with LP, and 158 (45.4%) were on AHIVD. The proportion of patients with LP and AHIVD decreased significantly across the study period. Nevertheless, we found an increase in this proportion in the years 2020 (70% and 53%) and 2021 (86% and 68%).Conclusion: Despite the progressive decrease in late diagnosis prevalence in our population, it remains high. Even more, our results documented a possible increase in the prevalence of late diagnosis associated with the COVID-19 pandemic. These findings highlight the need to prioritize interventions to evaluate and reverse pandemic effects on people living with HIV care.","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":" ","pages":"248-253"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9827173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alarming Rise of Primary HIV Drug Resistance in Major Regions of Russia. 俄罗斯主要地区原发性艾滋病毒耐药性惊人上升。

IF 0.8 4区医学

Current HIV Research Pub Date : 2023-01-01 DOI: 10.2174/011570162X271430231201075335

Dmitry Kireev, Alina Kirichenko, Aleksey Lebedev, Marina Bobkova

引用次数: 0