Prevalence and Causes of Vitamin D Deficiency in a Cohort of Greek HIV-Infected Individuals: A Prospective, Single Center, Observational Study.

IF 0.8 4区医学 Q4 IMMUNOLOGY

Current HIV Research Pub Date : 2024-01-01 DOI:10.2174/011570162X302844240605104855

Theodoros Androutsakos, Marianna Politou, Sofia Boti, Theodoros Pittaras, Athanasios Kontos, Theodore Kordossis, Abraham Pouliakis, George Panayiotakopoulos

{"title":"Prevalence and Causes of Vitamin D Deficiency in a Cohort of Greek HIV-Infected Individuals: A Prospective, Single Center, Observational Study.","authors":"Theodoros Androutsakos, Marianna Politou, Sofia Boti, Theodoros Pittaras, Athanasios Kontos, Theodore Kordossis, Abraham Pouliakis, George Panayiotakopoulos","doi":"10.2174/011570162X302844240605104855","DOIUrl":null,"url":null,"abstract":"Background: Vitamin D deficiency and/or insufficiency (hypovitaminosis D) has been associated with several disorders including autoimmune diseases, like type 1 diabetes mellitus; cardiovascular diseases; neoplasms; obesity; insulin resistance, and type 2 diabetes mellitus. This problem is common in southern European countries, especially in elderly and institutionalized persons. In HIV-infected individuals, hypovitaminosis D has been correlated with various complications like tuberculosis, hyperparathyroidism, bone mass loss, premature atherosclerosis, and systemic arterial hypertension, deterioration of immune function, progression of the disease and overall mortality.Objective: The objective of this study was to examine the prevalence and causes of hypovitaminosis D in a cohort of Greek HIV-infected patients, as well as possible complications associated with it.Methods: All patients attending our HIV unit for a period of 5 months were included in this study. Vitamin D status, medical anamnes, and laboratory tests were obtained at baseline; patients were followed for 3 years and HIV-related complications were noted. No patient received vitamin D supplementation during the follow-up period.Results: Hypovitaminosis D was common, with 83.7% of the patients showing levels below 30 ng/dl and 55.4% below 20 ng/dl. After multivariable analysis, age and duration of treatment were the only significant factors for low vitamin D levels. During follow-up, 26 patients exhibited a total of 34 HIV-related complications, the most common being pneumonocystis jiroveci pneumonia (PCP). Hypovitaminosis D showed a positive correlation with overall complications, PCP as well as wasting syndrome.Conclusion: Overall, our study shows that hypovitaminosis D is common in HIV-infected individuals and should probably be treated as soon as possible to protect these patients from serious HIVrelated complications like PCP or wasting syndrome.","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":" ","pages":"240-248"},"PeriodicalIF":0.8000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current HIV Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/011570162X302844240605104855","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Vitamin D deficiency and/or insufficiency (hypovitaminosis D) has been associated with several disorders including autoimmune diseases, like type 1 diabetes mellitus; cardiovascular diseases; neoplasms; obesity; insulin resistance, and type 2 diabetes mellitus. This problem is common in southern European countries, especially in elderly and institutionalized persons. In HIV-infected individuals, hypovitaminosis D has been correlated with various complications like tuberculosis, hyperparathyroidism, bone mass loss, premature atherosclerosis, and systemic arterial hypertension, deterioration of immune function, progression of the disease and overall mortality.

Objective: The objective of this study was to examine the prevalence and causes of hypovitaminosis D in a cohort of Greek HIV-infected patients, as well as possible complications associated with it.

Methods: All patients attending our HIV unit for a period of 5 months were included in this study. Vitamin D status, medical anamnes, and laboratory tests were obtained at baseline; patients were followed for 3 years and HIV-related complications were noted. No patient received vitamin D supplementation during the follow-up period.

Results: Hypovitaminosis D was common, with 83.7% of the patients showing levels below 30 ng/dl and 55.4% below 20 ng/dl. After multivariable analysis, age and duration of treatment were the only significant factors for low vitamin D levels. During follow-up, 26 patients exhibited a total of 34 HIV-related complications, the most common being pneumonocystis jiroveci pneumonia (PCP). Hypovitaminosis D showed a positive correlation with overall complications, PCP as well as wasting syndrome.

Conclusion: Overall, our study shows that hypovitaminosis D is common in HIV-infected individuals and should probably be treated as soon as possible to protect these patients from serious HIVrelated complications like PCP or wasting syndrome.

查看原文本刊更多论文

希腊 HIV 感染者队列中维生素 D 缺乏症的患病率和原因：一项前瞻性单中心观察研究。

背景：维生素 D 缺乏和/或不足（维生素 D 不足症）与多种疾病有关，包括自身免疫性疾病（如 1 型糖尿病）、心血管疾病、肿瘤、肥胖、胰岛素抵抗和 2 型糖尿病。这一问题在南欧国家很常见，尤其是在老年人和养老院老人中。在艾滋病毒感染者中，维生素 D 不足与各种并发症有关，如结核病、甲状旁腺功能亢进、骨量减少、过早动脉粥样硬化和全身动脉高血压、免疫功能恶化、疾病进展和总死亡率：本研究旨在探讨希腊艾滋病病毒感染者群体中维生素 D 过低的发生率和原因、相关因素以及可能出现的并发症：本研究纳入了所有在本院艾滋病科就诊 5 个月的患者。基线调查包括维生素 D 状态、病史和实验室检查；对患者进行为期 3 年的随访，并记录与 HIV 相关的并发症。在随访期间，没有患者接受维生素 D 补充剂：结果：维生素 D 缺乏症很常见，83.7% 的患者维生素 D 水平低于 30ng/dl，55.4% 的患者低于 20ng/dl。经过多变量分析，年龄和治疗时间是导致维生素 D 水平低的唯一重要因素。在随访期间，26 名患者共出现了 34 种与艾滋病相关的并发症，其中最常见的是肺孢子菌肺炎（PCP）。维生素 D 过低与总体并发症、肺孢子虫肺炎以及消瘦综合征呈正相关：总之，我们的研究表明，维生素 D 过低在艾滋病病毒感染者中很常见，应该尽快治疗，以防止这些患者出现与艾滋病病毒相关的严重并发症，如 PCP 或消瘦综合征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current HIV Research 医学-病毒学

CiteScore

1.90

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current HIV Research covers all the latest and outstanding developments of HIV research by publishing original research, review articles and guest edited thematic issues. The novel pioneering work in the basic and clinical fields on all areas of HIV research covers: virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and transmission, anti-retroviral therapy and adherence, drug discovery, the latest developments in HIV/AIDS vaccines and animal models, mechanisms and interactions with AIDS related diseases, social and public health issues related to HIV disease, and prevention of viral infection. Periodically, the journal invites guest editors to devote an issue on a particular area of HIV research of great interest that increases our understanding of the virus and its complex interaction with the host.