Current HIV Research最新文献

{"title":"Low Levels of Cortisol are Associated with HIV Infection in Older People: A Hormonal Substudy in the OVER50 Cohort.","authors":"Diana Hernandez-Sanchez, Silvia Martinez-Couselo, Manel Puig-Domingo, Ana Martinez, Sandra Gonzalez, Patricia Echeverria, Anna Bonjoch, Jordi Puig, Eugenia Negredo","doi":"10.2174/011570162X314729240822092738","DOIUrl":"10.2174/011570162X314729240822092738","url":null,"abstract":"<p><strong>Introduction: </strong>People with the human immunodeficiency virus (PWH) who were diagnosed long ago are more prone to age-related conditions and comorbidities than the general population. We hypothesized that older PWH have endocrine abnormalities that may influence the patient's health status.</p><p><strong>Methods: </strong>Mean hormonal values across the thyrotropic, somatotropic, corticotropic, and gonadal axis, and percentage of subjects with abnormal values, were compared between PWH aged ≥50 years (n=30) and people without HIV (n=30) (Over50 cohort). Clinical factors were also analyzed as independent variables.</p><p><strong>Results: </strong>PWH had a higher prevalence of comorbidities (36.67% PWH and 20.69% controls had ≥3 comorbidities). Male PWH exhibited lower estradiol levels than male controls (29.75±7.68 pg/mL vs. 35.45 ± 10.04 pg/mL; p = 0.0041). Abnormal concentrations of testosterone were found in 35% of male PWH compared to 55% of male controls (mostly above reference values). Cortisol levels were significantly lower among PWH (9.97 ± 4.33 μg/dL vs. 13.56 ± 3.39 μg/dL; p = 0.002); 16.6% of PWH exhibited abnormally low levels (<5 μg/dL), compared to 0% of controls, and 3 PWH met criteria for a definitive diagnosis of adrenal insufficiency (<3.6 μg/dL). For the somatotropic axis, growth hormone (GH) levels were significantly lower in male PWH than in controls (p = 0.0394). No significant differences were found in relation to the thyroid axis.</p><p><strong>Conclusion: </strong>Hormones are generally similar between the chronic PWH who are receiving ART treatment and the general control population, except for cortisol in both sexes and testosterone and estradiol in men. Some special attention should be given to cortisol in PWH due to a presumably higher risk of adrenal complications.</p>","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":" ","pages":"318-328"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of a Mobile Health Intervention for Providing a Continuum of HIV Services for MSM: Pilot Study of the WeTest Program in 3 Cities in China.","authors":"Zhihui Zhu, Xiaoyan Lu, Pan Gao, Xiaodong Wang, Xuejiao Hu, Nianhua Xie, Cong Liu, Yue Zhao, Yanqiu Zhao, Zhen Dai, Hongbo Zhang, Jun Wang, Yehuan Sun, Tao Liu, Shufang Sun, Cui Yang, Nickolas Zaller, Zhihua Zhang, Don Operario","doi":"10.2174/011570162X280190240105063449","DOIUrl":"10.2174/011570162X280190240105063449","url":null,"abstract":"<p><strong>Background: </strong>Men who have sex with men (MSM) in China have a high risk for HIV infection but experience suboptimal rates of HIV testing and service engagement due to various social and structural barriers. We developed a mobile health (mHealth) intervention entitled \"WeTest-Plus\" (WeTest+) as a user-centered \"one-stop service\" approach for delivering access to comprehensive information about HIV risk, HIV self-testing, behavioral and biomedical prevention, confirmatory testing, treatment, and care.</p><p><strong>Objective: </strong>The goal of the current study was to investigate the feasibility of WeTest+ to provide continuous HIV services to high-risk MSM.</p><p><strong>Methods: </strong>Participants completed a 3-week pilot test of WeTest+ to examine acceptability, feasibility, and recommendations for improvement. Participants completed a structured online questionnaire and qualitative exit interviews facilitated by project staff. \"Click-through\" rates were assessed to examine engagement with online content.</p><p><strong>Results: </strong>28 participants were included, and the average age was 27.6 years (standard deviation = 6.8). Almost all participants (96.4%) remained engaged with the WeTest+ program over a 3-week observational period. The majority (92.9%) self-administered the HIV self-test and submitted their test results through the online platform. Overall click-through rates were high (average 67.9%). Participants provided favorable comments about the quality and relevance of the WeTest+ information content, the engaging style of information presentation, and the user-centered features.</p><p><strong>Conclusion: </strong>This pilot assessment of WeTest+ supports the promise of this program for promoting HIV self-testing and linkage to in-person services for MSM in China. Findings underscore the utility of a user-centered approach to mHealth program design.</p>","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":" ","pages":"158-169"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139680823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Older PLHIV are at Higher Cardiovascular risk with Poor Quality of Life","authors":"Muhammed Shabil, Krishna Murti, V Udaya Kumar, Rishkesh Kumar, Nitesh Kumar, Sameer Dhingra, Vipan Kumar Parihar, V Ravichandiran, Krishna Pandey","doi":"10.2174/011570162x277586231218104922","DOIUrl":"https://doi.org/10.2174/011570162x277586231218104922","url":null,"abstract":"Background::: People with HIV (PLHIV) face increased cardiovascular disease (CVD) risk due to inflammation and immune activation. Aging further amplifies this risk. Limited data exist on CVD risk in older PLHIV in India despite 2.14 million PLHIV with higher CVD risk factors. Methods::: In a cross-sectional study in Bihar, India, 73 PLHIV and 30 control participants were enrolled. Demographics, social factors, clinical information, and CVD risk factors were collected. HbA1c levels and lipid profiles were analyzed, and 10-year CVD risk scores were calculated using the Framingham risk score (FRS) and Qrisk3. Quality of life (QoL) was assessed using WHOQOL- HIV-BREF. Results::: Results showed higher LDL levels in non-HIV older participants and higher HDL levels in younger PLHIV participants. BMI differed significantly, with higher BMI in non-HIV older individuals and lower BMI in younger PLHIV individuals. Older PLHIV participants had significantly higher mean FRS and Q-Risk scores compared to older non-PLHIV and younger PLHIV groups. Among older PLHIV participants, six had higher CVD risk per FRS, while none in the other groups were classified as high CVD risk. Psychological, social relations and spirituality domains were highly deteriorated in older PLHIV, scoring 44.48, 42.72, and 41.2, respectively. The physical domain scored 57.6, and the environment scored 52.72 in the WHOQOL-HIV bref. Conclusion::: In conclusion, older PLHIV in Bihar, India, face higher CVD risk compared to younger PLHIV and non-HIV individuals. FRS and Q-Risk scores effectively assessed CVD risk, identifying higher risk in older PLHIV. Age and BMI were significant predictors of high CVD risk. These findings emphasize CVD risk assessment and tailored management for older PLHIV. The QoL assessment findings indicate moderate deterioration in psychological, social relations, and spirituality domains among older PLHIV individuals. These results suggest greater challenges in psychological well-being, social interactions, and spirituality compared to the overall sample. Further research with larger samples and longitudinal designs is needed to confirm and extend these findings.","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":"126 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139031322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WITHDRAWN: Analysis of the Efficacy of Drilling Decompression Autologous Bone Marrow and Allogeneic Bone Grafting in the Treatment of HIV-positive Patients with Early Osteonecrosis of the Femoral Head","authors":"Li Shengtao, Wang Jie, Ma Rui, Zhao Changsong, Pu Yu, He Min, Gao Zhengrong, Quan Xuemin, Zhang Qiang","doi":"10.2174/011570162X253808231025111220","DOIUrl":"10.2174/011570162X253808231025111220","url":null,"abstract":"<p><p>The article has been withdrawn at the request of the author of the journal Current HIV Research (CHIVR).</p><p><p>Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php</p><p><strong>Bentham science disclaimer: </strong>It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere\u0000must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the\u0000authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright\u0000of their article is transferred to the publishers if and when the article is accepted for publication.</p>","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71479207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NIH HIV Reagent Program: A Valuable Resource for HIV Research","authors":"Khalid Timani, Sujatha Rashid, Rebecca Bradford, Joseph Leonelli","doi":"10.2174/1570162x2104231226194230","DOIUrl":"https://doi.org/10.2174/1570162x2104231226194230","url":null,"abstract":"<jats:sec> <jats:title /> <jats:p /> </jats:sec>","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":"15 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139365305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet the Co-Editor","authors":"Roberto Di Santo","doi":"10.2174/1570162x2103230821160901","DOIUrl":"https://doi.org/10.2174/1570162x2103230821160901","url":null,"abstract":"","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135517247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WITHDRAWN: Long-term Survival Analysis of 30 Maintenance Hemodialysis Patients with HIV Infection in a Single-center in China","authors":"Wenwen Ren,&nbsp;Guiju Gao,&nbsp;Yajuan Fang,&nbsp;Tongtong Wang,&nbsp;Chunyu Zhu,&nbsp;Jiang Xiao,&nbsp;Fang Wang,&nbsp;Liang Ni,&nbsp;Di Yang","doi":"10.2174/1570162X21666230428163809","DOIUrl":"https://doi.org/10.2174/1570162X21666230428163809","url":null,"abstract":"<p><p>The article has been withdrawn at the request of the author of the journal Current HIV Research (CHIVR).</p><p><p>Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial\u0000Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php</p><p><strong>Bentham science disclaimer: </strong>It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously\u0000submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere\u0000must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting\u0000the article for publication the authors agree that the publishers have the legal right to take appropriate action against the\u0000authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright\u0000of their article is transferred to the publishers if and when the article is accepted for publication</p>","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10439208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet the Editorial Advisory Board Member","authors":"M. Aliyu","doi":"10.2174/1570162x2102230627125640","DOIUrl":"https://doi.org/10.2174/1570162x2102230627125640","url":null,"abstract":"","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":"1 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44088406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Erectile Dysfunction (ED) among People Living with HIV in Tehran, Iran.","authors":"SeyedAli Dehghan Manshadi, Ali Keyhani Pirdehi, Elnaz Shahmohamadi, Malihe Hasan Nezhad, Faezeh Abbaspour, Sona Mahrokhi, SeyedAhmad SeyedAlinaghi","doi":"10.2174/011570162X270146231205105957","DOIUrl":"10.2174/011570162X270146231205105957","url":null,"abstract":"<p><strong>Background: </strong>Sexual problems are rarely addressed in human immunodeficiency virus (HIV) management, even though overt sexual dysfunctions are more prevalent in people living with HIV. This study aimed to ascertain the prevalence of erectile dysfunction (ED) among HIVinfected men in a stable clinical state, examine the relationship between antiretroviral therapy (ART) exposure and sexual dysfunction, and identify the associated risk factors.</p><p><strong>Method: </strong>This cross-sectional study recruited HIV-positive males who visited the Voluntary Counseling and Testing (VCT) center of Imam Khomeini Hospital (Tehran) in 2020. The International Index of Erectile Function (IIEF) questionnaire was used to evaluate the ED in participants. Sociodemographic and clinical data were also collected.</p><p><strong>Results: </strong>Of 65 patients who participated in this study, 27.7% had ED. The mean age of participants with and without ED was 39.4±11.5 and 40.4±7.6 years old, respectively. No significant difference was observed between patients with and without ED concerning the sociodemographic status and the use of ART drugs.</p><p><strong>Conclusion: </strong>The prevalence of ED is relatively high among men living with HIV. Future research is recommended among HIV-positive males to identify the underlying causes and explore the potential impact that associated psychological distress could have on sexual dysfunction.</p>","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":" ","pages":"361-366"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138498045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Observational Study of Genetic Diversity of HIV-1 <i>vpu</i> in Rapid Progressors in India.","authors":"Poonam Gupta,&nbsp;Arvind Rai,&nbsp;Charoo Hans,&nbsp;Mohammad Husain","doi":"10.2174/1570162X21666230221152633","DOIUrl":"https://doi.org/10.2174/1570162X21666230221152633","url":null,"abstract":"<p><strong>Background: </strong>The genetic diversity in HIV-1 genes affects viral pathogenesis in HIV-1 positive patients. Accessory genes of HIV-1, including <i>vpu</i>, are reported to play a critical role in HIV pathogenesis and disease progression. <i>Vpu</i> has a crucial role in CD4 degradation and virus release. The sequence heterogeneity in the <i>vpu</i> gene may affect disease progression in patients, therefore, the current study was undertaken to identify the role of <i>vpu</i> in patients defined as rapid progressors.</p><p><strong>Objective: </strong>The objective of the study was to identify the viral determinants present on <i>vpu</i> that may be important in disease progression in rapid progressors.</p><p><strong>Methods: </strong>Blood samples were collected from 13 rapid progressors. DNA was isolated from PBMCs and <i>vpu</i> was amplified using nested PCR. Both strands of the gene were sequenced using an automated DNA Sequencer. The characterization and analysis of <i>vpu</i> was done using various bioinformatics tools.</p><p><strong>Results: </strong>The analysis revealed that all sequences had intact ORF and sequence heterogeneity was present across all sequences and distributed all over the gene. The synonymous substitutions, however, were higher than nonsynonymous substitutions. The phylogenetic tree analysis showed an evolutionary relationship with previously published Indian subtype C sequences. Comparatively, the cytoplasmic tail_{(77 - 86)} showed the highest degree of variability in these sequences as determined by Entropy- one tool.</p><p><strong>Conclusion: </strong>The study showed that due to the robust nature of the protein, the biological activity of the protein was intact and sequence heterogeneity may promote disease progression in the study population.</p>","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":"21 2","pages":"99-108"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10131960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}