Assessment of Pregnancy Status in Patients with Acquired Immunodeficiency Syndrome and their Partners.

IF 0.8 4区 医学 Q4 IMMUNOLOGY
Mehmet Cabalak, Oya Soylu Karapınar, Cigdem El
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引用次数: 0

Abstract

Background: HIV is a globally prevalent infection for which there is currently no cure or vaccine. As the number of individuals with HIV infection increases, so does the number of individuals wishing to have children despite being infected. This situation has highlighted issues related to couples where one partner is infected while the other is not (serodiscordant couples) and couples where both partners are positive. Major issues include pregnancy complications, transmission to the child, and potential side effects of the ART treatment on the health of the child. Women living with HIV who become pregnant or contract the virus during pregnancy are at risk for both maternal and perinatal morbidity and mortality, especially if the virus is not adequately controlled. Additionally, there is a risk of vertical transmission through breastfeeding during pregnancy and postpartum. To mitigate the consequences of HIV during pregnancy, it is ideal to start with prepregnancy counseling and plan pregnancies during periods of minimal viral load using appropriate methods.

Aims and objective: There are limited studies and shared experiences regarding fertility status and issues of HIV/AIDS patients, especially in Turkey. Hence, this study aimed to investigate the fertility status of HIV/AIDS patients and their partners followed up in our clinic, shed light on the encountered issues, and share our experiences.

Methods: This retrospective, observational, single-center cross-sectional study included HIV/AIDS patients and their partners followed at Hatay Mustafa Kemal University (MKÜ) Medical Faculty Hospital from January 2018 to December 2023. Demographic data of the patients, their sexual orientations, HIV/AIDS status of their partners and children, treatments received, CD4 cell counts, and viral load data were retrospectively obtained from the automation system of our hospital and patient files.

Results: Among the couples, there were 21 pairs where both partners were HIV positive, 10 pairs where the woman was HIV positive and the man was seronegative (serodiscordant), and 5 pairs where the man was HIV positive and the woman was seronegative. In our study, eight couples with both partners HIV positive had nine children, and six couples with women who were HIV positive (serodiscordant) had ten children. The five couples with men who were HIV positive (serodiscordant) had six children. No vertical transmission was observed in our study, but three patients did not attend regular follow-ups. During the follow-up period, no seroconversion was detected in the partners of serodiscordant patients. The average gestational age was 38 weeks, and the average birth weight was 2873 ± 349 grams.

Conclusion: Our study found no vertical transmission and no seroconversion in partners of serodiscordant couples. Issues related to pregnancy in HIV-positive couples can be managed with pre-pregnancy counseling by specialists, protective methods, appropriate ART, and perinatal follow- up.

获得性免疫缺陷综合征患者及其伴侣的妊娠状况评估。
背景:艾滋病毒是一种全球流行的感染,目前尚无治愈方法或疫苗。随着感染艾滋病毒的人数增加,尽管受到感染仍希望生育的人数也在增加。这种情况突出了与一方感染而另一方未感染的夫妇(血清不一致的夫妇)和双方都呈阳性的夫妇有关的问题。主要问题包括妊娠并发症、传染给儿童以及抗逆转录病毒治疗对儿童健康的潜在副作用。感染艾滋病毒的妇女怀孕或在怀孕期间感染该病毒,面临孕产妇和围产期发病率和死亡率的风险,特别是在病毒没有得到充分控制的情况下。此外,在怀孕期间和产后通过母乳喂养存在垂直传播的风险。为了减轻怀孕期间艾滋病毒的后果,最好从孕前咨询开始,并在病毒载量最小的时期使用适当的方法计划怀孕。目的和目标:关于艾滋病毒/艾滋病患者的生育状况和问题的研究和共同经验有限,特别是在土耳其。因此,本研究旨在调查在我诊所随访的HIV/AIDS患者及其伴侣的生育状况,揭示遇到的问题,分享我们的经验。方法:这项回顾性、观察性、单中心横断面研究纳入了2018年1月至2023年12月在哈塔伊穆斯塔法·凯末尔大学(MKÜ)医学院医院随访的HIV/AIDS患者及其伴侣。从我院自动化系统和患者档案中回顾性获取患者的人口统计资料、性取向、伴侣和子女的HIV/AIDS状况、接受的治疗、CD4细胞计数和病毒载量数据。结果:夫妻双方均为HIV阳性的有21对,女方为HIV阳性,男方为血清阴性(不一致)的有10对,男方为HIV阳性,女方为血清阴性的有5对。在我们的研究中,8对双方都是HIV阳性的夫妇有9个孩子,6对女性HIV阳性(血清不一致)的夫妇有10个孩子。男性HIV阳性(血清不一致)的5对夫妇有6个孩子。在我们的研究中没有观察到垂直传播,但有3例患者没有定期随访。在随访期间,血清不一致患者的伴侣中未检测到血清转换。平均胎龄38周,平均出生体重2873±349克。结论:本研究未发现血清不一致的夫妻无垂直传播和血清转化。艾滋病毒阳性夫妇的怀孕相关问题可以通过专家的孕前咨询、保护方法、适当的抗逆转录病毒治疗和围产期随访来管理。
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来源期刊
Current HIV Research
Current HIV Research 医学-病毒学
CiteScore
1.90
自引率
10.00%
发文量
81
审稿时长
6-12 weeks
期刊介绍: Current HIV Research covers all the latest and outstanding developments of HIV research by publishing original research, review articles and guest edited thematic issues. The novel pioneering work in the basic and clinical fields on all areas of HIV research covers: virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and transmission, anti-retroviral therapy and adherence, drug discovery, the latest developments in HIV/AIDS vaccines and animal models, mechanisms and interactions with AIDS related diseases, social and public health issues related to HIV disease, and prevention of viral infection. Periodically, the journal invites guest editors to devote an issue on a particular area of HIV research of great interest that increases our understanding of the virus and its complex interaction with the host.
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