Current Medical Mycology最新文献

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Antifungal activity of Gracilaria corticata methanol extract against Trichophyton mentagrophytes, Microsporum canis, and Microsporum gypseum on rat dermatophytosis models. 龙须菜甲醇提取物对毛癣菌、犬微孢子虫和埃及微孢子虫在大鼠皮肤真菌病模型上的抗真菌活性。
Current Medical Mycology Pub Date : 2023-03-01 DOI: 10.18502/CMM.2023.150672
Asiyeh Shojaee, Alireza Jahandideh, Ayatollah Nasrollahi Omran, Nakisa Sohrabi Haghdoost, Mehrzad Khosravi
{"title":"Antifungal activity of <i>Gracilaria corticata</i> methanol extract against <i>Trichophyton mentagrophytes</i>, <i>Microsporum canis</i>, and <i>Microsporum gypseum</i> on rat dermatophytosis models.","authors":"Asiyeh Shojaee,&nbsp;Alireza Jahandideh,&nbsp;Ayatollah Nasrollahi Omran,&nbsp;Nakisa Sohrabi Haghdoost,&nbsp;Mehrzad Khosravi","doi":"10.18502/CMM.2023.150672","DOIUrl":"10.18502/CMM.2023.150672","url":null,"abstract":"<p><strong>Background and purpose: </strong>Dermatophytosis is one of the most prevalent zoonotic diseases. Increased resistance of dermatophytosis-causing pathogens against antidermatophytic agents highlights the need for alternative medicine with higher efficiency and lower side effects. In the present study, the <i>in vitro</i> antifungal activities of different concentrations of <i>Gracilaria corticata</i> methanol extract against <i>Trichophyton mentagrophytes</i>, <i>Microsporum canis</i>, and <i>Microsporum gypseum</i> were assessed and their efficacy was evaluated in rat dermatophytosis models.</p><p><strong>Materials and methods: </strong>The broth microdilution and well diffusion methods were used to determine the <i>in vitro</i> antidermatophytic activity. The <i>in vivo</i> study was carried out using 40 dermatophytosis-infected adults male Wistar rats. The animals were divided into 4 groups (5% and 10% <i>G. corticata</i> ointment, terbinafine, and Vaseline) and treated with ointment until complete recovery. The percentage of wound closure was calculated for each group.</p><p><strong>Results: </strong>The results revealed that <i>G. corticata</i> methanol extract was effective to varying extents against the tested dermatophytes. The highest inhibitory activity of <i>G. corticata</i> was found against <i>T. mentagrophytes</i> with minimum inhibitory concentration and minimum fungicidal concentration values of 4 and 9 µg mL<sup>-1</sup>, respectively. The <i>in vivo</i> experiment revealed that 10% <i>G. corticata</i> ointment significantly accelerated skin lesions reduction and completely cured <i>M. gypseum</i>, <i>T. mentagrophytes</i>, and <i>M. canis</i> infections after 19, 25, and 38 days, respectively.</p><p><strong>Conclusion: </strong>The methanol extract of <i>G. corticata</i> exhibited significant antifungal activity <i>in vitro</i> and <i>in vivo</i>, suggesting that it could be used as an alternative to antidermatophytic therapy in a dose-dependent manner.</p>","PeriodicalId":10863,"journal":{"name":"Current Medical Mycology","volume":"9 1","pages":"14-20"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49689172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enablers of Candida auris persistence on medical devices and their mode of eradication. 耳念珠菌在医疗器械上持续存在的促成因素及其根除模式。
Current Medical Mycology Pub Date : 2023-03-01 DOI: 10.18502/CMM.2023.150673
Kingsley Chukwuemeka Nwachukwu, Ebubechukwu Nwarunma, Chinaza David Uchenna, Ositadinma Chinyere Ugbogu
{"title":"Enablers of <i>Candida auris</i> persistence on medical devices and their mode of eradication.","authors":"Kingsley Chukwuemeka Nwachukwu,&nbsp;Ebubechukwu Nwarunma,&nbsp;Chinaza David Uchenna,&nbsp;Ositadinma Chinyere Ugbogu","doi":"10.18502/CMM.2023.150673","DOIUrl":"10.18502/CMM.2023.150673","url":null,"abstract":"<p><p><i>Candida auris</i> is an emerging pathogen predominantly isolated from immunocompromised patients, hospitalized for a long time. It inhabits the skin surfaces of patients causing ear, wound, and systemic infections; if not treated properly, it could lead to severe mortality. Apart from being a skin pathogen, <i>C. auris</i> colonizes the surfaces of medical devices. Medical devices are hospital tools and components often utilized for the diagnosis and treatment of diseases associated with human skin. The mechanism of survival and persistence of <i>C. auris</i> on medical devices has remained unclear and is a serious concern for clinicians. The persistence of <i>C. auris</i> on medical devices has deterred its effective elimination, hindered the treatment of infections, and increased its antifungal resistance. Evidence has shown that a few surface molecules on the cell wall of <i>C. auris</i> and the extracellular matrix of the biofilm are responsible for its persistence and exist as enablers. Due to the increased cases of ear, skin, and systemic infections as well as death resulting from the spread of <i>C. auris</i> in hospitals, there is a need to study these enablers. This review focused on the identification of the enablers and aimed to evaluate them in relation to their ability to induce persistence in <i>C. auris</i>. In order to reduce the spread of or completely eliminate <i>C. auris</i> and its enablers in hospitals, the efficacy of disinfection and sterilization methods were compared.</p>","PeriodicalId":10863,"journal":{"name":"Current Medical Mycology","volume":"9 1","pages":"36-43"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49689174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Port implantation-related bloodstream infection caused by Wickerhamomyces myanmarensis: A case report. 缅甸Wickehamomyces myanmarnsis引起的与港口植入相关的血液感染:一例报告。
Current Medical Mycology Pub Date : 2023-03-01 DOI: 10.18502/CMM.2023.150671
Ali Aminasnafi, Sadegh Khodavaisy, Maryam Moslem, Marziye Esmaeilpour Jouneghani, Fatemeh Sarbandi, Mahsa Falahatinejad, Bahareh Bashardoust, Hamid Badali, Neda Kiasat
{"title":"Port implantation-related bloodstream infection caused by <i>Wickerhamomyces myanmarensis</i>: A case report.","authors":"Ali Aminasnafi,&nbsp;Sadegh Khodavaisy,&nbsp;Maryam Moslem,&nbsp;Marziye Esmaeilpour Jouneghani,&nbsp;Fatemeh Sarbandi,&nbsp;Mahsa Falahatinejad,&nbsp;Bahareh Bashardoust,&nbsp;Hamid Badali,&nbsp;Neda Kiasat","doi":"10.18502/CMM.2023.150671","DOIUrl":"10.18502/CMM.2023.150671","url":null,"abstract":"<p><strong>Background and purpose: </strong><i>Wickerhamomyces myanmarensis</i> is a new opportunistic yeast previously named <i>Pichai myanmarensis</i>, which belongs to the order Saccharomycetales. Since its discovery, one environmental isolate of <i>W. myanmarensis</i> has been reported from Myanmar, and one clinical sample from Iran.</p><p><strong>Case report: </strong>We report a case of bloodstream infection related to an implantable venous access port. <i>W. myanmarensis</i> was isolated from patient's blood after chemotherapy, which was meant to control and heal T-cell lymphoblastic lymphoma. Broth dilution minimum inhibitory concentrations were performed according to the CLSI M27-A3 document. The patient recovered with intravenous voriconazole and was discharged with the recommended prescription of oral voriconazole as a maintenance drug.</p><p><strong>Conclusion: </strong>So far, only one case of <i>W. myanmarensis</i> fungemia has been reported in the world in 2019. This is the second case of bloodstream infection with this yeast from a patient undergoing chemotherapy in Iran.</p>","PeriodicalId":10863,"journal":{"name":"Current Medical Mycology","volume":"9 1","pages":"32-35"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49689175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predominance of Trichophyton tonsurans causing tinea capitis: A 12-year retrospective study in the north of Iran. 发毛癣菌引起头癣的优势:伊朗北部一项为期12年的回顾性研究。
Current Medical Mycology Pub Date : 2023-03-01 DOI: 10.18502/CMM.2023.345026.1395
Mohammad T Hedayati, Firoozeh Kermani, Javad Javidnia, Mahmood Moosazadeh, Mohsen Nosratabadi, Maryam Salimi, Sabrieh Asadi, Elham Mosayebi, Zohreh Hajheydari, Masoud Golpour, Ghasem Rahmatpour Rokni, Armaghan Kazemi Nejad, Tahereh Shokohi, Felix Bongomin
{"title":"Predominance of <i>Trichophyton tonsurans</i> causing tinea capitis: A 12-year retrospective study in the north of Iran.","authors":"Mohammad T Hedayati,&nbsp;Firoozeh Kermani,&nbsp;Javad Javidnia,&nbsp;Mahmood Moosazadeh,&nbsp;Mohsen Nosratabadi,&nbsp;Maryam Salimi,&nbsp;Sabrieh Asadi,&nbsp;Elham Mosayebi,&nbsp;Zohreh Hajheydari,&nbsp;Masoud Golpour,&nbsp;Ghasem Rahmatpour Rokni,&nbsp;Armaghan Kazemi Nejad,&nbsp;Tahereh Shokohi,&nbsp;Felix Bongomin","doi":"10.18502/CMM.2023.345026.1395","DOIUrl":"10.18502/CMM.2023.345026.1395","url":null,"abstract":"<p><strong>Background and purpose: </strong>Among different clinical entities of dermatophytosis, tinea capitis (TC) is considered a major public health challenge in the world, especially in regions with poor health and low income. Therefore, this study aimed to provide a retrospective analysis of the patients suspected of TC who were referred to the medical mycology laboratory of Mazandaran, a northern province of Iran.</p><p><strong>Materials and methods: </strong>A retrospective analysis was performed on the patients suspected of TC who were referred to the medical mycology laboratory from July 2009 to April 2022. Hair roots and skin scrapings were collected from the participants. The laboratory diagnosis was confirmed by direct microscopic examination and culture. Finally, 921 out of 11095 (8.3%) patients were suspected of TC.</p><p><strong>Results: </strong>Based on the findings, TC was confirmed in 209 out of 921 patients (22.7%). In terms of gender, 209 TC patients (75.1%) were male. Moreover, the male to female ratio of TC patients was 1:3.0. <i>Trichophyton tonsurans</i> (146/174, 83.91%) was the most etiological agent, followed by <i>T. mentagrophytes</i> (13/174, 7.47%), <i>T. violaceum</i> (9/174, 5.17%), <i>Microsporum canis</i> (3/174, 1.71%), <i>T. verrucosum</i> (2/174, 1.15%) and <i>T. rubrum</i> (1/174, 0.57%). Besides, endothrix (77.0%) was the most prevalent type of hair invasion.</p><p><strong>Conclusion: </strong>The results revealed the predominance of <i>T. tonsurans</i>, as a causative agent of TC. Despite the prevalence of TC, the absence of appropriate consideration highlights that it is a neglected complication among children.</p>","PeriodicalId":10863,"journal":{"name":"Current Medical Mycology","volume":"9 1","pages":"21-27"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49689176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening of proteases produced by Aspergillus micromycetes active against proteins of the hemostasis system. 筛选对止血系统的蛋白质具有活性的小曲霉产生的蛋白酶。
Current Medical Mycology Pub Date : 2023-03-01 DOI: 10.18502/CMM.2023.150674
Daria Surkova, Viktoria Lavrenova, Sergey Klyagin, Anna Shestakova, Alexander Osmolovsky
{"title":"Screening of proteases produced by <i>Aspergillus</i> micromycetes active against proteins of the hemostasis system.","authors":"Daria Surkova,&nbsp;Viktoria Lavrenova,&nbsp;Sergey Klyagin,&nbsp;Anna Shestakova,&nbsp;Alexander Osmolovsky","doi":"10.18502/CMM.2023.150674","DOIUrl":"10.18502/CMM.2023.150674","url":null,"abstract":"<p><strong>Background and purpose: </strong>For these intents, proteases cardiovascular disease is the primary cause of death; hence, accurate diagnosis and treatment are urgently required are regarded as prospective agents . High substrate specificity is needed for an effective enzyme, which makes <i>Aspergillus</i> micromycetes, known for producing proteases with precise action, biotechnologically promising. This study mainly aimed to look at the possibilities of <i>Aspergillus</i> species, which had never been mentioned in terms of general proteolytics.</p><p><strong>Materials and methods: </strong>Every species was cultivated in two-stage submerged conditions with two different nitrogen sources; whereupon, proteolytic activity in culture fluid was determined. Chromogenic peptide substrates and fibrin plates were used to evaluate the thrombin, plasmin, factor Xa, urokinase, protein C-like, activating activities towards hemostasis proteins, as well as fibrinolytic and plasminogen-activating activities of these species.</p><p><strong>Results: </strong>It was found that <i>A. aureolatus</i> and <i>A. tennesseensis</i> are active proteolytics exhibiting plasmin-like activities (116.17 and 87.09 U×10<sup>-3</sup>, respectively), factor Xa-like activity (76.27 and 77.92 U×10<sup>-3</sup>, respectively) and urokinase activity (85.99 and 59.91 U×10<sup>-3</sup>, respectively). The thrombin-like activity was found for <i>A. tabacinus</i> (50.37 U×10<sup>-3</sup>), and protein C-like activity was noticeable for <i>A. creber</i>, <i>A. jensenii</i>, <i>A. protuberus</i>, and <i>A. ruber</i> (62.90, 65.51, 73.37, and 111.85 U×10<sup>-3</sup>, respectively). Additionally, more than half of species had the ability to directly activate plasminogen or operate as fibrinolytics.</p><p><strong>Conclusion: </strong>New proteolytic strains were discovered, offering hope for the therapy of cardiovascular disorders. The high specificity and activity of fungal enzymes make them useful in a variety of fields, including medicine and diagnostics.</p>","PeriodicalId":10863,"journal":{"name":"Current Medical Mycology","volume":"9 1","pages":"8-13"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49689178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aspergillus fumigatus cerebral abscess following hemodialysis: A case report. 血液透析后烟曲霉脑脓肿1例报告。
Current Medical Mycology Pub Date : 2022-12-01 DOI: 10.32598/CMM.2023.1323
Tanu Sagar, Lata Sheoran, Ajay Prajapati, Bembem Khuraijam, Partha Pratin Jana, P N Pandey, Sonal Saxena
{"title":"<i>Aspergillus fumigatus</i> cerebral abscess following hemodialysis: A case report.","authors":"Tanu Sagar,&nbsp;Lata Sheoran,&nbsp;Ajay Prajapati,&nbsp;Bembem Khuraijam,&nbsp;Partha Pratin Jana,&nbsp;P N Pandey,&nbsp;Sonal Saxena","doi":"10.32598/CMM.2023.1323","DOIUrl":"https://doi.org/10.32598/CMM.2023.1323","url":null,"abstract":"<p><strong>Background and purpose: </strong>Cerebral aspergillosis is a notorious disease that causes rapid clinical deterioration and carries a poor prognosis. Therefore, it requires timely diagnosis and prompt management.</p><p><strong>Case report: </strong>This study reports a case of fungal cerebral abscess in a 26years old man following hemodialysis,2 months afterdengue-induced acute kidney disease. <i>Aspergillus fumigatus</i> was recovered from a brain abscess specimen that was subjected to a parietal craniotomy. The patient was successfully treated with oral Voriconazole 400mg BD for 2 days, followed by 200 mg BD for 3months.</p><p><strong>Conclusion: </strong>Hemodialysis patients are at high risk offungal infections due to the frequent use of catheters or the insertion of needles to access the bloodstream. Therefore, a high index of suspicion of fungal infection is required in patients with hemodialysis by the clinician for early diagnosis and treatment.</p>","PeriodicalId":10863,"journal":{"name":"Current Medical Mycology","volume":"8 4","pages":"32-36"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41110707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Candida colonization index, molecular identification, and antifungal susceptibility pattern of Candida species isolated from critically ill pediatric patients: A single-center study in Iran. 从危重儿科患者中分离的念珠菌定植指数、分子鉴定和抗真菌易感性模式的评估:伊朗的一项单中心研究。
Current Medical Mycology Pub Date : 2022-12-01 DOI: 10.32598/CMM.2023.1372
Amirhossein Davari, Mohammad Taghi Hedayati, Jalal Jafarzadeh, Bahram Nikmanesh, Mojtaba Nabili, Amir Ali Hamidieh, Mahdi Abastabar, Nasim Ahmadi, Abdullah M S Al-Hatmi, Maryam Moazeni
{"title":"Evaluation of <i>Candida</i> colonization index, molecular identification, and antifungal susceptibility pattern of <i>Candida</i> species isolated from critically ill pediatric patients: A single-center study in Iran.","authors":"Amirhossein Davari,&nbsp;Mohammad Taghi Hedayati,&nbsp;Jalal Jafarzadeh,&nbsp;Bahram Nikmanesh,&nbsp;Mojtaba Nabili,&nbsp;Amir Ali Hamidieh,&nbsp;Mahdi Abastabar,&nbsp;Nasim Ahmadi,&nbsp;Abdullah M S Al-Hatmi,&nbsp;Maryam Moazeni","doi":"10.32598/CMM.2023.1372","DOIUrl":"https://doi.org/10.32598/CMM.2023.1372","url":null,"abstract":"<p><strong>Background and purpose: </strong>Given the high mortality rate of invasive candidiasis in hospitalized pediatric patients, it is crucial to establish a predictive system to achieve early diagnosis and treatment of patients who are likely to benefit from early antifungal treatment. This study aimed to assess the <i>Candida</i> colonization index, species distribution, and antifungal susceptibility pattern of <i>Candida</i> strains isolated from pediatric patients with high <i>Candida</i> colonization index (CI).</p><p><strong>Materials and methods: </strong>This study was carried out at the Children's Medical Center in Tehran-Iran. In total, 661 samples were collected from 83 patients. The <i>Candida</i> CI was calculated according to the descriptions of previous studies. The isolates were identified using polymerase chain reaction-based techniques. The Clinical and Laboratory Standard Institute protocol M60 was used to conduct the antifungal susceptibility test.</p><p><strong>Results: </strong>A colonization index greater than 0.5 was confirmed in 29 cases (58% of positive samples) with two children developing candidemia. <i>Candida albicans</i> (n=53, 49.5%) was the most common <i>Candida</i> species in patients with CI > 0.5. Except for acute lymphoblastic leukemia, no risk factors were linked to a high index in colonized children (<i>P</i> > 0.05). Twelve isolates (7.01%) were multi-azole resistant with high MICs against both isavuconazole and ravuconazole and seven strains (4.09%) were echinocandins resistant.</p><p><strong>Conclusion: </strong>In pediatric intensive care units, patients are at risk of fungal infection, particularly candidemia. In this study, more than half of the children with positive yeast cultures had CI > 0.5, and 6.8% developed candidemia.</p>","PeriodicalId":10863,"journal":{"name":"Current Medical Mycology","volume":"8 4","pages":"15-21"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41110708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new record of Scedosporium dehoogii isolated from paddy field soil in Iran: Phylogeny and antifungal susceptibility profiles. 从伊朗稻田土壤中分离的一个新记录:系统发育和抗真菌药敏谱。
Current Medical Mycology Pub Date : 2022-12-01 DOI: 10.32598/CMM.2023.1368
Javad Javidnia, Hamid Badali, Iman Haghani, Mahdi Abastabar
{"title":"A new record of <i>Scedosporium dehoogii</i> isolated from paddy field soil in Iran: Phylogeny and antifungal susceptibility profiles.","authors":"Javad Javidnia,&nbsp;Hamid Badali,&nbsp;Iman Haghani,&nbsp;Mahdi Abastabar","doi":"10.32598/CMM.2023.1368","DOIUrl":"https://doi.org/10.32598/CMM.2023.1368","url":null,"abstract":"<p><strong>Background and purpose: </strong><i>Scedosporium</i> species are ubiquitous environmental fungi, which are considered emerging agents that trigger disease in humans and animals. The present study aimed to determine <i>Scedosporium dehoogii</i> strain isolated from paddy field soil samples using semi-selective media and evaluate its antifungal susceptibility profile.</p><p><strong>Materials and methods: </strong>Three paddy field soil samples were collected during an investigation for the isolation of <i>Scedosporium</i> species in Mazandaran province, Iran. Morphological and molecular analyses based on ITS-rDNA sequencing were performed. Furthermore, <i>in vitro</i> antifungal susceptibility testing for conventional drugs and novel imidazole (luliconazole) was performed based on Clinical and Laboratory Standards Institute M38-A3 guidelines.</p><p><strong>Results: </strong>In this study, <i>S. dehoogii</i> was isolated from the soil in paddy fields. Based on the results, itraconazole and luliconazole showed the least and most antifungal activity against this isolate, respectively.</p><p><strong>Conclusion: </strong>Based on the findings, molecular identification was essential for distinguishing the species of <i>S. dehoogii</i>. Remarkably, luliconazole showed potent activity against this strain.</p>","PeriodicalId":10863,"journal":{"name":"Current Medical Mycology","volume":"8 4","pages":"27-31"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41126711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antifungal activity of essential oils against itraconazole-resistant pathogenic Candida isolated from vulvovaginal candidiasis. 精油对外阴阴道念珠菌病中分离的伊曲康唑耐药致病性念珠菌的抗真菌活性。
Current Medical Mycology Pub Date : 2022-12-01 DOI: 10.32598/CMM.2023.1359
Ali Abdul Hussein S Al-Janabi
{"title":"Antifungal activity of essential oils against itraconazole-resistant pathogenic <i>Candida</i> isolated from vulvovaginal candidiasis.","authors":"Ali Abdul Hussein S Al-Janabi","doi":"10.32598/CMM.2023.1359","DOIUrl":"https://doi.org/10.32598/CMM.2023.1359","url":null,"abstract":"<p><strong>Background and purpose: </strong>Fungal infection by species of pathogenic <i>Candida</i> with antifungal resistance is currently a serious problem. Treatment with new medications is becoming more challenging to manage this type of infection. The present study aimed to investigate the antifungal effect of essential oils (EOs) against itraconazole-resistant species of pathogenic <i>Candida</i>.</p><p><strong>Materials and methods: </strong>Seven essential oils were tested on 15 clinical isolates of itraconazole-resistant <i>Candida</i> from patients with vulvovaginal candidiasis. The antifungal action of selected EOs was evaluated using the disc diffusion method with the determination of the minimum inhibitory concentration (MIC) of effective Eos.</p><p><strong>Results: </strong>Radish EO was the most effective type against all <i>Candida</i> isolates with MICs between 3.125% and 6.25% (v/v) .It also had a stronger effect than itraconazole. Six other EOs showed antifungal effects at varying concentrations and were dependent upon the type of isolate. Low concentrations of these six EOs were more effective against many isolates than their high concentrations. Moreover, camphor and linseed EOs were less effective on isolates.</p><p><strong>Conclusion: </strong>Radish EO has a strong antifungal activity against itraconazole-resistance species of <i>Candida</i>, even more than itraconazole. The antifungal action of some EOs can be increased through the use of low concentrations.</p>","PeriodicalId":10863,"journal":{"name":"Current Medical Mycology","volume":"8 4","pages":"22-26"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41118187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First report of tinea corporis caused by Trichophyton quinckeanum in Iran and its antifungal susceptibility profile. 伊朗首次报道奎肯毛癣菌引起的体癣及其抗真菌药敏特性。
Current Medical Mycology Pub Date : 2022-12-01 DOI: 10.32598/CMM.2023.1344
Seyed Reza Aghili, Raheleh Alehashemi, Mahdi Abastabar, Farhad Niknejad, Iman Haghani, Fatemeh Livani, Amineh Kashiri, Javad Javidnia, Mohsen Nosratabadi
{"title":"First report of tinea corporis caused by Trichophyton quinckeanum in Iran and its antifungal susceptibility profile.","authors":"Seyed Reza Aghili,&nbsp;Raheleh Alehashemi,&nbsp;Mahdi Abastabar,&nbsp;Farhad Niknejad,&nbsp;Iman Haghani,&nbsp;Fatemeh Livani,&nbsp;Amineh Kashiri,&nbsp;Javad Javidnia,&nbsp;Mohsen Nosratabadi","doi":"10.32598/CMM.2023.1344","DOIUrl":"https://doi.org/10.32598/CMM.2023.1344","url":null,"abstract":"<p><strong>Background and purpose: </strong><i>Trichophyton quinckeanum</i>, a known zoophilic dermatophyte responsible for favus form in rodents and camels, is occasionally reported to cause human infections.</p><p><strong>Case report: </strong>This study aimed to report a case of tinea corporis caused by <i>T. quinckeanum</i> that experienced annular erythematous pruritic plaque with abundant purulent secretions. In June 2021, a 15-year-old girl with an erythematous cup shape lesion on the right wrist bigger than 3 cm in diameter was examined for tinea corporis. Since March, 2016 her family has kept several camels at home. Direct examination of skin scraping and purulent exudates revealed branching septal hyaline hyphae and arthrospore. Morphological evaluation of the recovered isolate from the culture and sequencing of ITS1-5.8S rDNA-ITS2 region resulted in the identification of <i>T. quinckeanum</i>. Antifungal susceptibility testing showed that this isolate had low minimum inhibitory concentration (MIC) values for luliconazole, terbinafine, and tolnaftate, but high MICs to itraconazole, fluconazole, posaconazole, miconazole, isavuconazole, ketoconazole, clotrimazole, and griseofulvin. However, the patient was successfully treated with oral terbinafine and topical ketoconazole.</p><p><strong>Conclusion: </strong>It can be said that <i>T. quinckeanum</i> is often missed or misidentified due to its morphological similarity to <i>T. mentagrophytes</i>/<i>T. interdigitale</i> or other similar species. This dermatophyte species is first reported as the cause of tinea corporis in Iran. As expected, a few months after our study, <i>T. quinckeanum</i> was detected in other areas of Iran, in a few cases.</p>","PeriodicalId":10863,"journal":{"name":"Current Medical Mycology","volume":"8 4","pages":"37-41"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41110292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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