Current pharmaceutical design最新文献

{"title":"Identification of Bioactive Ingredients and Mechanistic Pathways of Xuefu Zhuyu Decoction in Ventricular Remodeling: A Network Pharmacology, Molecular Docking and Molecular Dynamics Simulations.","authors":"Xiaocui Tian, Hongyang Chi, Xinyu Liu, Zehua Zhang, Zhiming Li, Shiqi Yin, Qi Qiu","doi":"10.2174/0113816128375610250608071339","DOIUrl":"https://doi.org/10.2174/0113816128375610250608071339","url":null,"abstract":"<p><strong>Background: </strong>Xuefu Zhuyu Decoction (XFZYD) is clinically used in China to promote blood circulation, resolve blood stasis, and alleviate ventricular remodeling (VR). However, its molecular mechanisms remain unclear.</p><p><strong>Objective: </strong>This study investigates the active components and underlying molecular mechanisms of XFZYD in treating VR.</p><p><strong>Methods: </strong>Targets of XFZYD's active components and VR-related targets were identified. A protein-protein interaction (PPI) network and a drug-ingredient-target network were constructed. GO functional annotation and KEGG pathway enrichment analysis were performed to explore biological functions. Hub targets and their corresponding active ingredients were validated through molecular docking and molecular dynamics (MD) simulations.</p><p><strong>Results: </strong>A total of 1,089 active ingredients with high gastrointestinal absorption (GI) and drug-likeness (DL ≥ 2) were identified. Five hundred and thirty-eight common targets were shared between XFZYD and VR, with 10 core targets, including AKT1, STAT3, TP53, EGFR, SRC, TNF, MAPK3, CTNNB1, IL6, and VEGFA. GO analysis revealed XFZYD's influence on wound healing, oxygen response, epithelial cell proliferation, and receptor signaling. KEGG analysis highlighted key pathways such as PI3K-Akt signaling, lipid and atherosclerosis, and fluid shear stress. Molecular docking revealed that active ingredients display favorable interactions with the hub genes, with binding energies from -9.5 to -6.0 kcal/mol. These interactions were further validated through MD simulations, demonstrating stable binding throughout the 100 ns simulation period.</p><p><strong>Conclusion: </strong>XFZYD exhibits therapeutic effects on VR through multiple active components and pathways, providing a scientific basis for its clinical application and further research.</p>","PeriodicalId":10845,"journal":{"name":"Current pharmaceutical design","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corticosteroids for Nerve Regeneration: A Narrative Review.","authors":"Mohammed H Karrar Alsharif, Nagi M Bakhit, Juman M Almasaad, Mehmet Emin Onger","doi":"10.2174/0113816128374388250603063716","DOIUrl":"https://doi.org/10.2174/0113816128374388250603063716","url":null,"abstract":"<p><p>Despite the use of advanced microsurgical techniques, around one-third of peripheral nerve injuries still show inadequate functional regeneration and incomplete healing. Peri- and intraneural nerve damage leads to pathophysiologic alterations, including morphological and metabolic changes, where the nerve is disrupted. Animal research shows no proven adjustment drugs for peripheral nerve regeneration, but studies suggest medicines can speed up regeneration using functional and histological parameters after nerve injury. Factors affecting nerve regeneration effectiveness include injury type, age, regeneration time, procedures, and materials. Complete regeneration and functional recovery are rarely achieved, regardless of the kind of pharmaceutical therapy used, necessitating further research into nerve regeneration. Future research could enhance corticosteroid doses with additional drugs, increasing clinical use. This review explores the mechanism of action of corticosteroids Dexamethasone, Betamethasone, and Methylprednisolone in peripheral nerve regeneration experiments, highlighting the potential for enhanced nerve injury.</p>","PeriodicalId":10845,"journal":{"name":"Current pharmaceutical design","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Phenylpropanoid from Croton velutinus (Euphorbiaceae) as Potential Anticancer Natural Product Targeting MAPKs: Mini-review with Docking Approach.","authors":"Renata A de Abrantes, Natalia F de Sousa, Ana Paula G M Farias, Samia S Duarte, Lucas S Abreu, Eudes S Velozo, Marcelo S da Silva, Pablo R da Silva, Josean F Tavares, Juan C R Gonçalves, Marcos T Scotti, Luciana Scotti, Marianna V Sobral","doi":"10.2174/0113816128357765250603105759","DOIUrl":"https://doi.org/10.2174/0113816128357765250603105759","url":null,"abstract":"<p><p>Cancer encompasses a group of diseases characterized by uncontrolled cell growth and the ability to invade or spread to other parts of the body. It is considered a major public health issue, being the second leading cause of death worldwide. A crucial signaling pathway altered in many cancers is the Mitogen- Activated Protein Kinase (MAPK) pathway, which is associated with the regulation of cell proliferation, differentiation, and survival, playing a central role in the development and maintenance of malignant tumors. Natural products have made significant contributions to pharmacotherapy, particularly in the field of cancer treatment. The Euphorbiaceae family, comprising approximately 300 genera and over 5,000 species, is known for its rich diversity of bioactive compounds. Croton velutinus (Euphorbiaceae), a species predominantly found in Northeast Brazil, has recently garnered attention due to its novel phenylpropanoids isolated from its roots. Among these, (E)-4-(1-epoxy-7,8-propen) phenylbenzoate (CV2) has demonstrated potential cytotoxic activity against various human tumor cell lines, including B16F10, MCF-7, HL60, HCT-116, and HepG2. This mini-review aims to highlight the antitumor activity of phenylpropanoids derived from the Euphorbiaceae family. Furthermore, through molecular docking studies, we explored the binding efficacy of CV2 with MAPKs (ERK, JNK, p38), comparing it to 25 other phenylpropanoid compounds reported in the literature, revealing promising interactions that could be further investigated for therapeutic applications.</p>","PeriodicalId":10845,"journal":{"name":"Current pharmaceutical design","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer Management Using Photodynamic Therapy: Fundamentals, Mechanism and Advances.","authors":"Mitul Lovras, Shivam Rajput, Sathvik Belagodu Sridhar, Javedh Shareef, Rishabha Malviya","doi":"10.2174/0113816128364893250603035546","DOIUrl":"https://doi.org/10.2174/0113816128364893250603035546","url":null,"abstract":"<p><p>PDT is a common and minimally invasive treatment used for certain types of cancer. Photodynamic therapy involves the generation of reactive oxygen species, resulting in cellular apoptosis and disruption of the tumor microenvironment. This review presents a comprehensive examination of recent developments in Photodynamic Therapy (PDT), detailing its mechanisms, the importance of photosensitizers, and their applications across various cancer types. Photosensitizers are essential in photodynamic therapy as they generate reactive oxygen species when exposed to light. Advanced photosensitizers demonstrate high conversion efficiency, improved tumor specificity, and reduced adverse effects. Recent advancements have led to the creation of photosensitizers that exhibit enhanced solubility, stability, and the ability to selectively accumulate in tumors. Combination therapies that incorporate PDT exhibit notable therapeutic outcomes, indicating substantial progress in the field. Recent developments in photodynamic therapy, particularly those that boost immune responses, show considerable promise in significantly enhancing the effectiveness of tumor elimination. These advancements have the potential to enhance the therapeutic application of photodynamic therapy, offering new possibilities for cancer treatment.</p>","PeriodicalId":10845,"journal":{"name":"Current pharmaceutical design","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Updated Review Deciphering the Inhibitory Potential of Erianin via Targeting Several Dysregulated Oncogenes in Several Human Carcinomas.","authors":"Pratibha Pandey, Seema Ramniwas, Lalji Baldaniya, G PadmaPriya, Khushboo Rani, Shivang Mishra, Irwanjot Kaur, Shivam Pandey, Sorabh Lakhanpal, Fahad Khan","doi":"10.2174/0113816128372087250528163929","DOIUrl":"10.2174/0113816128372087250528163929","url":null,"abstract":"<p><p>Numerous edible vegetables and fruits possess plant-based compounds with enormous anticarcinogenic attributes, including phenolic, vitamins, and alkaloid compounds. Cancer therapies mainly encompass surgery, chemotherapy, and radiation therapy, sometimes accompanied by rapid recurrence and significant side effects. Consequently, elucidating efficacious chemotherapeutic procedures are needed to diminish the likelihood of recurrence and metastasis. Erianin (Shihu, Traditional Chinese Medicine), a naturally occurring compound derived from Dendrobium chrysotoxum Lindl., has been documented to possess anticancer and antioxidative properties. This review presented an overview of Erianin's (ER) involvement in cancer and elucidated the molecular mechanisms underlying its anticancer effect via regulating signaling pathways, including PI3K/AKT, MEK, JNK, NRF2/PLOOH, JAK/STAT3, GSK3β, and NLRP3/ROS pathways. All these mechanisms ultimately induce apoptosis via targeting mainly invasion, migration, and angiogenesis. This review is thus intended to include all possible recent progress in the anticancer efficacy of erianin and to justify the necessity for further investigation into its anticancer properties in the future.</p>","PeriodicalId":10845,"journal":{"name":"Current pharmaceutical design","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, Molecular Docking, In Vitro and In Vivo Evaluation of Dimenhydrinate-Cyclodextrin Complex for Fast-Disintegrating Tablet.","authors":"Randa Khalid Samara, Rana M F Sammour, Veronique Seidel, Bazigha K Abdul Rasool","doi":"10.2174/0113816128398157250610113637","DOIUrl":"https://doi.org/10.2174/0113816128398157250610113637","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to formulate and evaluate dimenhydrinate (DMH) as fastdisintegrating tablets (FDTs) complexed with β-cyclodextrin (β-CD) to enhance its solubility, dissolution profile, and pharmacological performance.</p><p><strong>Methods: </strong>A DMH:β-CD inclusion complex was prepared at a 1:1 molar ratio using the kneading method. Characterization was performed through phase solubility studies, FTIR analysis, molecular docking, and in vitro dissolution testing. FDTs were developed using various superdisintegrants and assessed for quality attributes of a tablet, including hardness, friability, wetting time, water absorption ratio, and drug content.</p><p><strong>Results: </strong>Phase solubility and FTIR analyses confirmed the formation of a stable DMH:β-CD complex. Molecular docking indicated a binding affinity of -4.2 kcal/mol between β-CD and diphenhydramine. Among the FDT formulations, CP3 containing 9% crospovidone showed the best performance, with a disintegration time of 4.3 seconds and the highest drug release rate. In vivo pharmacological tests demonstrated enhanced sedative and antiemetic activities of the optimized FDTs compared to conventional DMH formulations.</p><p><strong>Discussion: </strong>The findings suggest that cyclodextrin-based complexation combined with orodispersible tablet technology can significantly enhance DMH's pharmacological efficacy and patient compliance. However, additional investigations on long-term stability, pharmacokinetics, and clinical scalability are warranted.</p><p><strong>Conclusion: </strong>The DMH:β-CD FDTs developed in this study offer promising improvements in solubility, dissolution, and therapeutic performance, indicating their potential for better clinical outcomes and patient acceptability.</p>","PeriodicalId":10845,"journal":{"name":"Current pharmaceutical design","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An in silico Approach for Identification of Novel Natural Selective ALR2 Inhibitors from Cynomorium songaricum for Treating Diabetic Complications.","authors":"Khalid Alshaghdali, Munazzah Tasleem, Talal Alharazi, Tolgahan Acar, Gamal Mohamed Elawad Ahmed, Emad Abboh, Kamal Yassin, Amre Nasr, Mohd Saeed, Dharmendra Kumar Yadav, Amir Saeed","doi":"10.2174/0113816128372035250526145207","DOIUrl":"https://doi.org/10.2174/0113816128372035250526145207","url":null,"abstract":"<p><strong>Introduction: </strong>Aldose reductase-2 (ALR2) is a key enzyme in the polyol pathway whose overexpression is implicated in several diabetic complications, including neuropathy, nephropathy, retinopathy, and atherosclerotic plaque formation. Under hyperglycemic conditions, the intracellular accumulation of sorbitol and the depletion of NADPH lead to osmotic imbalance and oxidative stress, driven by the formation of reactive oxygen species and advanced glycation end products. Although various ALR2 inhibitors have been developed, their clinical application has been hampered by nonselective inhibition of both ALR2 and the homologous enzyme ALR1.</p><p><strong>Method: </strong>In this study, we employed a comprehensive in silico approach to evaluate the inhibitory potential of natural compounds from Cynomorium songaricum against ALR2. Our workflow integrated with ADMET, molecular docking with scoring function and glide XP, molecular dynamics (MD) simulations, PCA, FEL, and MM/GBSA. Through this analysis, four natural compounds of C. songaricum (Compound Name: p-Coumaric acid, Vanillic acid, 4-Oxoniobenzoate, and Phloroglucinol) displayed significant bonds formation including hydrogen and hydrophobic bonds with the target protein.</p><p><strong>Results: </strong>These bonds exhibited the ligand stability. Further, the MD simulation analysis, followed by postsimulation analysis, verified the dynamic stability of these four natural compounds and compared them with the native ligand of the target protein. These natural compounds exhibit particularly stable binding within the ALR2 selectivity pocket, demonstrating an inhibitory effect over ALR1 when compared with the reference inhibitor, Epalrestat.</p><p><strong>Conclusion: </strong>These promising in silico findings suggest that CID: 8468 and CID: 135 merit further evaluation through in vitro, in vivo, and clinical studies as potential selective inhibitors for the treatment of diabetic complications.</p>","PeriodicalId":10845,"journal":{"name":"Current pharmaceutical design","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shashen Maidong Decoction's Effects on Chronic Bronchitis: A Multi-Method Approach.","authors":"Wenchao Zhou, Yaqin Hu, Yun Qiu, Hao Zheng, Juan Jiang, Jiangyi Luo, Juanjiang Wu, Hanwen Yuan, Xudong Zhou, Liming Gong, Yixing Qiu, Wei Wang","doi":"10.2174/0113816128363449250526092829","DOIUrl":"https://doi.org/10.2174/0113816128363449250526092829","url":null,"abstract":"<p><strong>Background: </strong>Shashen Maidong Decoction (SSMDD) is a traditional Chinese medicine (TCM) formula used for treating chronic bronchitis (CB).</p><p><strong>Objectives: </strong>This study aims to explore the mechanism of SSMDD against CB, focusing on its active components and their impact on Interleukin 6 (IL-6), a key inflammatory factor.</p><p><strong>Materials and methods: </strong>Network pharmacology, a method that helps identify potential active components and their interactions in a biological network, was used to predict SSMDD's effects. Molecular docking, a computational approach for predicting the binding affinity between small molecules and target proteins, was utilized to elucidate the mechanisms of action. Transcriptomic analysis, ELISA, and western blot assays were subsequently implemented for mechanism validation.</p><p><strong>Results: </strong>Network pharmacology analysis identified quercetin and kaempferol as key active components of SSMDD, with a high affinity for IL-6. Transcriptomic data confirmed the regulation of inflammation-related pathways by SSMDD, aligning with the predicted targets. In the ELISA determination, compared with the model group, the IL-6 levels in the samples treated with quercetin and kaempferol were reduced by 55% and 36%, respectively. The western blot results showed that the expression of IL-6 protein in these samples decreased by 33% and 25%, respectively.</p><p><strong>Conclusion: </strong>SSMDD exhibits anti-inflammatory activity against CB by targeting IL-6. This study provides a deeper understanding of the mechanisms through which SSMDD exerts its therapeutic effects on CB. Moreover, these findings also suggest that SSMDD may offer insights for future treatments of other inflammatory diseases, potentially improving patient outcomes and developing novel therapeutic strategies. Future studies should explore the effects of additional targets and active compounds within SSMDD and evaluate its broader applications in inflammatory conditions.</p>","PeriodicalId":10845,"journal":{"name":"Current pharmaceutical design","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astragalus Injection Modulates the Pharmacokinetics of Doxorubicin and CYP450 Enzymes.","authors":"Wenjun Shi, Tian Liu, Kaihe Wang, Leixin Mu, Li Ji, Yanling Li, Yi Zhang, Qun Ma","doi":"10.2174/0113816128362829250527023843","DOIUrl":"https://doi.org/10.2174/0113816128362829250527023843","url":null,"abstract":"<p><strong>Background: </strong>Doxorubicin (DOX) is a widely used anthracycline antibiotic for the treatment of breast cancer, liver cancer, lymphoma, and other malignant tumors. However, its clinical application is limited by the side effects and drug resistance. Astragalus injection has been combined with DOX in the treatment of cancer, which improves the curative effect and reduces drug resistance. This study investigated the interaction between DOX and Astragalus injection and elucidated the potential mechanism.</p><p><strong>Methods: </strong>The pharmacokinetics of DOX injection (7 mg/kg, intraperitoneal injection) with or without Astragalus injection (4.25 mL/kg/day for 14 days, intraperitoneal injection) were investigated in plasma from male Sprague-Dawley rats (n = 6) by UPLC-MS/MS. The group without the Astragalus injection was set as the control group. Additionally, the effects of Astragalus injection on CYP450 enzyme activities were assessed using a rat liver microsome incubation system with cocktail probe drugs.</p><p><strong>Results: </strong>Astragalus injection significantly increased the Cmax (2090.01 ± 99.60 vs. 5262.77 ± 111.15 ng/mL) and AUC0-t (1190.23 ± 104.43 vs. 3777.27 ± 130.55 μg/L × h) and prolonged the t1/2α (0.09 ± 0.02 vs. 0.14 ± 0.04 h) of DOX. Astragalus injection significantly inhibited the activity of CYP1A2, CYP2C9, CYP2E1, and CYP3A4, and enhanced the activity of CYP2D1 with a metabolic elimination rate of 30.11 ± 2.67% vs. 19.66 ± 3.41%, 35.95 ± 2.57% vs. 23.26 ± 3.57%, 13.43 ± 2.56% vs. 9.06 ± 2.51%, 47.90 ± 6.30% vs. 25.87 ± 2.55%, 17.62 ± 1.49% vs. 24.12 ± 2.91%, respectively (p < 0.05).</p><p><strong>Conclusion: </strong>The co-administration of DOX and Astragalus injection alters the systemic exposure of DOX by affecting the metabolism of DOX and the activity of CYP450 enzymes. These findings highlight the importance of drug-drug interactions when combining Astragalus injection with DOX and provide a basis for optimizing combination therapies to address DOX resistance and toxicity.</p>","PeriodicalId":10845,"journal":{"name":"Current pharmaceutical design","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing Antibiotic Delivery: Harnessing 3D-Printing Technology to Combat Bacterial Resistance.","authors":"Shubham Singh, Mohit Kumar, Deeksha Choudhary, Dikshant -, Devesh Kumar, Shruti Chopra, Amit Bhatia","doi":"10.2174/0113816128365632250524160128","DOIUrl":"https://doi.org/10.2174/0113816128365632250524160128","url":null,"abstract":"<p><p>Antibiotic resistance poses a significant threat to public health, rendering many life-saving medications ineffective as pathogenic microorganisms develop resistance spontaneously. This results in infections that are difficult to treat, with limited or no treatment options. Traditionally, addressing this challenge involves developing new pharmaceuticals, a lengthy and costly process. However, a more efficient approach lies in improving drug delivery methods, which can be quicker and more economical. In recent years, 3D printing technology has emerged as a groundbreaking, industry-accepted technique that enables the affordable, simple, and rapid manufacturing of pharmaceuticals. This technology supports iterative design-build-test cycles, facilitating the development of a wide range of products, from simple 3D-printed tablets to complex medical devices, tailored for diverse applications. This article explores innovative strategies in the search for novel antibiotics, the development of more effective preventative measures, and, crucially, a deeper understanding of the ecology of antibiotics and antibiotic resistance. It provides an overview of these issues' historical and current status, emphasizing the potential of 3D printing to address antibiotic resistance. Additionally, it discusses how to expand conceptual frameworks in response to recent advancements in chemotherapy, antimicrobials, and antibiotic resistance. The article highlights various notable efforts in utilizing 3D printing to develop antimicrobial dosage forms and medical devices, offering insights into future possibilities.</p>","PeriodicalId":10845,"journal":{"name":"Current pharmaceutical design","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}