Current Nanoscience最新文献

{"title":"Achievements and Difficulties with Batch and Optimization Investigations of Heavy Metal Adsorptive Removal Utilizing Enhanced Biomass-based Adsorption Materials","authors":"Mohamed Elfahaam, Mohamed N. Sanad, Mohamed Farouz","doi":"10.2174/0115734137282899240102085324","DOIUrl":"https://doi.org/10.2174/0115734137282899240102085324","url":null,"abstract":": Surface enhancement improves the porousness and surface area (SSA) of biomass materials, which boosts their adsorption capability. This work investigates recent advances in surface modification technologies of biomass-based materials for heavy metal adsorption, including Pb, As, Cr, Fe, Cd, Mn, Cu, Co, Hg, Ni, Zn, and their ions in waters/wastewaters. The chemical structure and surface properties of biomass were examined in connection with various surface modification approaches and their effects on the adsorption process. In addition, adsorption performance we assessed using various operating conditions, isotherms, kinetics, and computational and artificial intelligence methodologies. This study found that acid-activated Posidonia oceanica had the highest adsorption effectiveness of 631.13 mg/g to eliminate Pb2+, whereas H3PO4/furnace-modified oil palm biomass had the lowest (0.1576 mg/g) for removing Cd2+. Important insights into knowledge gaps for changing these materials for extremely effective adsorption performance were emphasized to improve the area.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139587979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Era in Colloidal Carriers Approach for Enhanced Transdermal Drug Delivery","authors":"Mridul Modgil, Abhishek Sharma","doi":"10.2174/0115734137287023240103063237","DOIUrl":"https://doi.org/10.2174/0115734137287023240103063237","url":null,"abstract":": Colloidal carriers are a promising type of carriers which play a crucial role in transdermal drug delivery and other topical applications. These carriers are usually present in the microscopic size, which offers different methods to enclose and deliver a diverse range of dynamic substances such as medicines, genes, and lipids. They offer distinct advantages by mimicking the natural structure of the skin's lipid bilayers using lipids and allowing the incorporation of different active compounds through the use of polymers. Recently, more advanced technology like artificial intelligence (AI) and machine learning (ML) has been adopted in the pharmaceutical field. The incorporation of artificial intelligence and machine learning techniques in colloidal carriers holds immense promise in revolutionizing the domain of drug delivery and nanomedicine. Machine learning algorithms can undergo training with the use of extensive datasets containing information on drug behavior within the human body, which can predict drug response within the body. Additionally, AI can be employed to anticipate various processes, thereby resulting in an enhanced delivery of medication using carriers. Many studies have shown the use of machine learning (ML) and artificial intelligence (AI) for optimizing the drug-carrying capacity via colloidal carriers. The present review concentrates on various categories of innovative colloidal vehicles in transdermal administration, alongside their penetration technique, benefit, and mechanism in the integumentary system. Outcomes from the different researches are critically assessed and showcase the potential of colloidal carriers to augment the penetration of drugs through the stratum corneum while minimizing adverse effects on the entire system with improved therapeutic effectiveness in various diseases.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139587852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cytotoxicity Effect of Chitosan-Encapsulated Ricin-Herceptin Immunotoxin Nanoparticles on Breast Cancer Cell Lines","authors":"Mohammad Hossein Golestani Poor, Shohreh Zare Karizi, Seyed Ali Mirhosseini, Mohammad Javad Motamedi, Fateme Frootan, Soghra Khani, Jafar Amani","doi":"10.2174/0115734137278545240102055626","DOIUrl":"https://doi.org/10.2174/0115734137278545240102055626","url":null,"abstract":"Background:: The use of targeted therapy has been increasing for cancer treatment. The aim of this study is to investigate chitosan-based ricin-Herceptin (rh) immunotoxin on breast cancer cell lines. background: The targeted therapy is growing for cancer treatment. The aim here is to investigate a chitosan based Ricin-Herceptin (rh) immunotoxin on breast cancer cell lines. Methods:: The gene construct encoding immunotoxin was designed, cloned, and expressed in E. coli BL21 (DE3). The expressed proteins were isolated by the nickel-nitrilotriacetic acid column and were analyzed by the Western-blotting. The cytotoxicity of immunotoxin was assayed on breast cell line MCF-7 and using MTT assay at 24 and 48 h treatment. Results:: The immunotoxins extrication rate, size, loading percentage, and electric charge of nanoparticles were reported appropriately as 78%, 151.5 nm, 83.53%, and +11.1 mV, respectively. The encapsulated immunotoxins led to the death of 70% and 78% of MCF-7 cells at 24 and 48 h treatment, respectively. The noncapsulated counterparts at equal doses killed 53% and 62% of cancer cells at the same time points. Conclusion:: The chitosan-immunotoxins impose potential cytotoxic effects on cancer cells. other: Keywords: Herceptin, HER2, Ricin, Targeted therapy, Breast Cancer, Nanoparticles","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139587975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Facile Synthesis of Bimetallic Copper-Silver Nanocomposite and Their Application in Ascorbic Acid Detection","authors":"Ridhu Varshini Murugan, Gokul Sridharan, Raji Atchudan, Sandeep Arya, Deepak Nallaswamy, Ashok Sundramoorthy","doi":"10.2174/0115734137281377240103062220","DOIUrl":"https://doi.org/10.2174/0115734137281377240103062220","url":null,"abstract":"Background:: An important antioxidant, ascorbic acid, must be detected in several industrial samples collected from food, pharmaceuticals, and water treatment plants. Herein, we reported a method to produce a bimetallic copper-silver (Cu-Ag) nanocomposite and used it in the development of very sensitive and selective electrochemical sensor for the detection of ascorbic acid. Methods:: A simple chemistry concept was used during the synthesis process to reduce the cost while minimizing the use of dangerous chemicals and minimizing the environmental impact. The Strobilanthes kunthiana leaves extract effectively reduced the copper and silver ions, resulting in the creation of an extremely stable and evenly distributed Cu-Ag nanocomposite. Results:: As-prepared bimetallic Cu-Ag nanocomposite exhibited outstanding electrochemical activity against ascorbic acid oxidation. The nanocomposite was examined using field emission scanning electron microscopy (FE-SEM), energy dispersive spectroscopy (EDS), elemental mapping (EMap) and X-ray diffraction analysis (XRD) to ascertain its composition, structure, and stability. Using cyclic voltammetry (CV), the electrochemical performance of the nanocomposite and also the detection of ascorbic acid were carried out. The bimetallic Cu-Ag nanocomposite also exhibited better long-term stability and fouling resistance, making it appropriate for use in real-world applications and complex sample matrices. Conclusion:: The bimetallic Cu-Ag nanocomposite coated electrode was used to detect the concentration of ascorbic acid by amperometry. As a result, this study offered a simple chemical method for creating a bimetallic copper-silver nanocomposite with superior electrochemical qualities for the accurate detection of ascorbic acid. conclusion: Its potential use as an electrochemical sensor for the detection of ascorbic acid opens doors for a variety of industries, including biological diagnostics, judging the quality of food, and environmental monitoring. As a result, this study offers a green method for creating a bimetallic copper-silver nanocomposite with superior electrochemical qualities for the accurate detection of ascorbic acid. The created nanocomposite has a lot of potential for improving ascorbic acid detection methods while upholding sustainable material synthesis. other: NA","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139587854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Approaches for the Treatment of Rheumatoid Arthritis: An Outlook","authors":"Priyanka Kumari, Sanjay Jain, Shivani Saraf, Ankita Tiwari, Pritish Panda, Amit Verma","doi":"10.2174/0115734137264937231214071646","DOIUrl":"https://doi.org/10.2174/0115734137264937231214071646","url":null,"abstract":"Background: Rheumatoid arthritis (RA) is an inflammatory disease that causes pannus, thickened synovium, joint bone reabsorption, and acute impairment, and increases the death rate. Many people with RA now live better lives as a result of recent improvements in treatment, which have dramatically slowed the disease's course. However, a significant portion of patients continue to either be non-responsive to existing treatments or have developed a resistance to them. Nanotechnology is becoming a more and more intriguing tool for investigating novel strategies, ranging from treating various disease states to tackling complicated conditions. Objective: The primary goal of the work was to outline the research activities on versatile nanocarriers, like polymeric micelles, nanoparticles, liposomes, etc., with controlled/sustained drug release patterns fabricated to elevate the effectiveness of drug delivery. Method: This review mainly focuses on emerging strategies to deliver various nanocarriers encapsulating anti-rheumatic drugs, enzymes, genes, phytoconstituents, etc. It also includes up-todate progress regarding patents and clinical trials filed for the treatment of RA. Results: In most of the recent studies, nanocarrier-based drug delivery has gained attention worldwide and led to the development of new approaches for treating RA. A better understanding of pathophysiology and signalling pathways helps to select the antirheumatic drug. The encapsulation of active moiety into the novel nanocarrier enhances the solubility of insoluble drugs. It restricts the exposure of the drug to the non-inflamed site using various targeting strategies, like active, passive, or biomimetic targeting and stimuli-responsive carrier systems to enhance the drug delivery mechanism. Conclusion: A brief description of current RA treatments using nanocarrier technology is provided in this paper, along with predictions for potential enhancements to the nanotherapeutic regimen.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139590695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Convergence of Graphene Quantum Dots and Peptides: Novel Strategy for Cellular Targeting in Cancer","authors":"Dilpreet Singh, Balak Das Kurmi, Amrinder Singh","doi":"10.2174/0115734137288288240108073034","DOIUrl":"https://doi.org/10.2174/0115734137288288240108073034","url":null,"abstract":"In recent years, the convergence of two distinct nanomaterials, graphene quantum dots (GQDs) and peptides, has ushered in a new era of innovation in cancer therapeutics and biomedical research. GQDs, quasi-zero-dimensional graphene structures, have garnered significant attention due to their remarkable physicochemical properties, including excellent photoluminescence, high surface area, and biocompatibility [1]. Meanwhile, peptides, short amino acid sequences, have proven themselves as versatile molecular entities with a crucial role in cellular targeting, signaling, and communication. The convergence of these two domains, GQDs and peptides, has opened up exciting opportunities for developing novel nanocarriers and therapeutic platforms for the effective treatment of cancer [2]. The ligation of GQDs and peptides capitalizes on the unique properties of both components. GQDs exhibit exceptional optical properties, making them suitable for imaging and sensing applications [3]. Their high surface area allows for efficient drug loading, while their biocompatibility ensures minimal cytotoxicity. On the other hand, peptides offer molecular specificity, allowing for precise targeting of cancer cells and tissues. By combining these properties, GQD-peptide nanostructures can deliver therapeutic payloads to cancer sites with remarkable accuracy [4].","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139587861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence Integration with Nanotechnology: A New Frontier for Sustainable and Precision Agriculture","authors":"Sumel Ashique, Amisha Raikar, Sabahat Jamil, Lavanya Lakhminarayana, Shilpa Amit Gajbhiye, Sneha De, Shubneesh Kumar","doi":"10.2174/0115734137275111231206072049","DOIUrl":"https://doi.org/10.2174/0115734137275111231206072049","url":null,"abstract":": Addressing the challenges posed by climate change, surging population, rival demands on land for renewable fuel manufacturing, and adverse soil conditions is crucial for ensuring global food security. Achieving sustainable solutions necessitates the integration of multidisciplinary knowledge, such as materials technology and informatics. The convergence of precision agriculture with nanotechnology and artificial intelligence (AI) offers promising prospects for sustainable food production. Through real-time responsiveness to crop growth using advanced technologies, such as nanotechnology and AI, farmers can optimize resource allocation and make informed decisions. Newer opportunities for sustainable food production arise through the integration of precision agriculture, nanotechnology, and artificial intelligence. This convergence enables farmers to dynamically respond to crop growth variations using advanced techniques. By combining nanotechnology and informatics methods with existing models for nutrient cycling and crop productivity, it becomes possible to enhance critical aspects, such as precision targeting, efficient absorption, effective distribution, optimized nutrient assimilation, and long-term effects on soil microbial communities. This integration offers significant potential for improving agriculture and addressing sustainability challenges in food production. Ultimately, this synergy allows for the development of nanoscale agrochemicals that offer a balance between safety and functionality, ensuring optimal performance in agricultural systems.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139517891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical Sensors Go Nano: Carbon Nanomaterials for Ultrasensitive Heavy Metal Analysis","authors":"Qingwei Zhou, Li Fu, Jiangwei Zhu","doi":"10.2174/0115734137281774231214054405","DOIUrl":"https://doi.org/10.2174/0115734137281774231214054405","url":null,"abstract":"Background: Heavy metal contamination of food and the environment is a major concern worldwide. Conventional detection techniques like atomic absorption spectroscopy (AAS), inductively coupled plasma-optical emission spectrometry (ICP-OES) and inductively coupled plasma-mass spectrometry (ICP-MS) have limitations including high costs and insufficient sensitivity. Electrochemical sensors based on carbon nanomaterials have emerged as an attractive alternative for rapid, affordable, and ultrasensitive heavy metal analysis. Methods: This review summarizes recent advances in using carbon nanomaterials like ordered mesoporous carbon, carbon nanotubes, graphene and carbon dots for electrochemical sensing of toxic heavy metals. Synthesis methods, characterization techniques, functionalization strategies and detection mechanisms are discussed. Results: High surface area, electrical conductivity and electrocatalytic activity of carbon nanomaterials enable preconcentration of metal ions and signal amplification at electrode interfaces. This results in remarkably low detection limits down to parts per trillion levels. Functionalization with metal nanoparticles, molecularly imprinted polymers and other nanocomposites further improves sensor selectivity and sensitivity. These sensors have been applied for the quantitative detection of arsenic, mercury, lead, cadmium, chromium, and other toxic metals in lab samples Conclusion: Electrochemical sensors based on carbon nanotubes, graphene, mesoporous carbon, and carbon dots are rapidly emerging as an ultrasensitive, cost-effective alternative to conventional techniques for on-site screening of heavy metal contamination in food and environment. Further validation using real-world samples and integration into portable field testing kits can enable widespread deployment.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139375669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet the Editorial Board Member","authors":"T. Burnouf","doi":"10.2174/157341372001230926123938","DOIUrl":"https://doi.org/10.2174/157341372001230926123938","url":null,"abstract":"","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139129145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemical and Preclinical Evaluation with Synthesis and Docking Study of Pyridopyrimidines and Selenium Nanoparticle Drugs for Cancer Targeting","authors":"Zafer S. Alshehri, Faez F. Alshehri, Sherien F. Belasy, Eman A. El-Hefny, Magdy S. Aly, Ahmed A. El-Sayed, Nasser A. Hassan","doi":"10.2174/0115734137276989231205102152","DOIUrl":"https://doi.org/10.2174/0115734137276989231205102152","url":null,"abstract":": The coding method of spatial light modulator is the core key of spatial light field modulation technology, and the needs of the modulation algorithm are different under the specified mode and application requirements. This paper first reviews the progress made in recent years in light field control algorithms for digital micromirror devices (DMDs) and liquid crystal spatial light modulators (LC-SLM). Based on existing algorithms, the impact of optimization methods is analyzed. Then, the application areas of the different algorithms are summarized, and the characteristics of the control algorithms are analyzed. In addition, this review highlights innovative breakthroughs achieved by using various coding schemes and spatial light modulators (SLM) to manipulate the light field. Finally, critical future challenges facing emerging control algorithm technologies are outlined, while prospects for developing SLM control algorithms are proposed.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139063960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}