Current diabetes reviews最新文献

{"title":"The Potential of Ozone Therapy as an Adjunct to Periodontal Treatment in Diabetes Mellitus: A Biomarker Scoping Review.","authors":"Elisa Grillo Araújo, Domitilla Marchiori Sant'Anna Leal de Oliveira, Sérgio Bruzadelli Macedo, Cristine Miron Stefani, Loise Pedrosa Salles","doi":"10.2174/0115733998353396250416114716","DOIUrl":"https://doi.org/10.2174/0115733998353396250416114716","url":null,"abstract":"<p><strong>Background: </strong>Periodontitis is a prevalent inflammatory disease and a critical complication in individuals with Diabetes Mellitus (DM). The bidirectional relationship between periodontitis and DM exacerbates systemic inflammation and complicates disease management. Ozone therapy (OT), with its antimicrobial and immunomodulatory properties, has emerged as a promising adjunctive treatment for periodontitis in individuals with DM, though it remains underexplored. This scoping review evaluates the effects of OT on biomarkers associated with DM, which may indirectly suggest its potential as a complementary therapy for periodontitis management in DM.</p><p><strong>Methods: </strong>A comprehensive search of PubMed, Cochrane, Embase, LIVIVO, Scopus, Web of Science, and LILACS (up to March 2024) identified 38 studies: 19 involving individuals with DM and 19 using DM animal models.</p><p><strong>Results: </strong>OT positively influenced biomarkers such as Malondialdehyde (MDA), Superoxide Dismutase (SOD), reduced Glutathione (GSH), Catalase (CAT), Total Antioxidant Status (TAS), and Total Oxidant Status (TOS). OT also modulated inflammatory markers (TNF-α, IL-1β, IL-6, IL-8, IL-10, and CRP) and regenerative biomarkers (bFGF, BMP-2, CD34, VEGF, PDGF) while improving glycated hemoglobin (HbA1c). This study represents the first review to explore the effects of OT on DM biomarkers and infer possible implications of these effects if used as an adjunct in the treatment of periodontitis associated with DM.</p><p><strong>Conclusion: </strong>OT may complement conventional periodontal treatments in individuals with DM by modulating biomarkers linked to periodontal health. These insights may guide future clinical studies to validate OT's role in the treatment and establish standardized protocols for its application in periodontal management in DM.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Anthelmintic and Antidiabetic Effects of Rosarin in Preclinical Studies Using Zebrafish and Earthworm Models (<i>Pheretima posthuma</i>).","authors":"Akula Sowjanya, Sunil Kumar Kadiri, Deepak S Khobragade, Mallika Shaik, Prashant Tiwari","doi":"10.2174/0115733998343818250306082712","DOIUrl":"https://doi.org/10.2174/0115733998343818250306082712","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;i&gt;Rhodiola rosea&lt;/i&gt; is a traditional medicinal plant that has been found to possess several beneficial properties, including the ability to mitigate cardiac ischemia-reperfusion damage, reduce blood lipid levels, prevent thrombosis, and exhibit antiarrhythmic effects.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study aims to evaluate the potential of rosarin, a key compound derived from the root of &lt;i&gt;Rhodiola rosea&lt;/i&gt;, in treating diabetes mellitus using a zebrafish model and in exhibiting anthelmintic (worm-expelling) activity using the Indian earthworm (&lt;i&gt;Pheretima posthuma&lt;/i&gt;).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The study design utilizes an experimental approach, incorporating both zebrafish (&lt;i&gt;Danio rerio&lt;/i&gt;) and earthworms (&lt;i&gt;Pheretima posthuma&lt;/i&gt;) as subjects for testing. The zebrafish were randomly assigned to different experimental groups, including control and treatment groups (e.g., hyperglycemia induction and comparison with Metformin). The zebrafish were studied for a duration of 4 days, during which the glucose concentration was gradually increased. Zebrafish were housed in controlled aquatic environments with daily water changes and hyperglycemia in zebrafish was induced by gradually increasing the glucose concentration, starting with 50 mM for four days while closely monitoring their health and survival. The body weights, blood glucose levels and histopathological studies were noted and compared with the standard drug Metformin. Liver enzymes such as alkaline phosphatase (ALP), Aspartate aminotransferase (AST), and Alanine aminotransferase (ALT) derived from homogenate supernatants of fish viscera were determined using an autoanalyzer. Earthworms were collected from moist soil and randomly assigned to receive varying doses of test Rosarin or the standard drug albendazole in Petri dishes. Observations included changes in color, thickness, diameter, paralysis, and time to death. Dunnett's test was used to evaluate the statistical significance, followed by one-way ANOVA.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results and discussion: &lt;/strong&gt;&lt;i&gt;Zebrafish (Danio rerio)&lt;/i&gt;, three-month-old (500-1000 mg) and &lt;i&gt;Pheretima posthuma&lt;/i&gt; (14 cm) were used for this research. The results confirm that the rosarin glycoside at 50 mg/ml showed significant anti-diabetic activity by decreasing blood glucose levels (82.1 ± 0.5 mg/dl) with p&lt;0.001, 95% CI (81.628- 82.572) limits and body weights (2.0 ± 0.047 g) when equated with diabetic control (Blood glucose levels= 135 ± 3.14 mg/dl and body weights =13.4 ± 0.11 g). ALT, AST and ALP levels significantly decreased in the rosarin group when equated to diabetic control. The anti-diabetic effect of rosarin is comparable with standard Metformin (50 mg/ml). In anthelmintic activity, rosarin (75 mg/ml) significantly decreased the length of the worm (9.5 ± 0.36 cm), time of paralysis (22 ± 0.76 minutes) and time of death (40 ±0.76 minutes). Albendazole (50 mg/ml) is used as a standard drug. The s","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Insight on Flavonoids and Flavonoidsincorporated Nano-formulations in the Management of Diabetes Mellitus.","authors":"Madhavi Patel, Priya Shah, Sudarshan Singh, Bhupendra G Prajapati","doi":"10.2174/0115733998354264250402054755","DOIUrl":"https://doi.org/10.2174/0115733998354264250402054755","url":null,"abstract":"<p><p>Diabetes mellitus is a worldwide health challenge and imposes a considerable strain on healthcare systems. By 2035, it is anticipated that around 592 million adults will be impacted by diabetes as a result of causes like aging, rapid population expansion, urbanization, obesity, lifestyle modifications, and heightened intake of calorie-dense, fatty, and fast meals. Despite the availability of several pharmaceutical therapies, they often come with higher expenses and adverse side effects, making them inaccessible to a large portion of the population. Bioactive compounds, especially flavonoids, are emerging as potential alternatives for diabetes management. Flavonoids, a category of polyphenolic chemicals included in fruits, vegetables, and various plant- derived foods, provide numerous therapeutic advantages. In addition to their glucose-lowering benefits, they increase antioxidant defence, improve insulin efficacy, and diminish the risk of cardiovascular problems. The clinical application of flavonoids is hindered by issues like poor solubility, low bioavailability, and complicated metabolism. This review explores the integration of nanotechnology- based delivery technologies to address these limitations. Advanced nano-formulations, such as polymeric nanoparticles, liposomes, micelles, and solid lipid nanoparticles, improve the solubility, stability, and absorption of flavonoids while facilitating targeted delivery and prolonged therapeutic benefits. The review highlights the efficacy of flavonoid-based nano-formulations in efficiently managing diabetes mellitus and its related problems. Moreover, it highlights the need for ongoing research to enhance these formulations and explore the molecular pathways that underlie their antidiabetic efficacy. This approach demonstrates the significance of nanotechnology in transforming diabetes care and enhancing patient outcomes.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FTO Gene rs 9939609 is Potentially Associated with Diabetes Related Complications in T2DM Patients.","authors":"Mazhar Hussain, Akbar Waheed, Asim Elahi, Javed Iqbal","doi":"10.2174/0115733998343753250226081545","DOIUrl":"https://doi.org/10.2174/0115733998343753250226081545","url":null,"abstract":"<p><strong>Background & objective: </strong>FTO gene rs9939609, an obesity susceptible gene, has strong with type 2 diabetes mellitus (T2DM). Studies have also established an association between the FTO gene rs9939609 and cardiovascular disease (CVD). This research investigated the association of this genetic variant with microvascular and macrovascular complications related to diabetes.</p><p><strong>Materials and methods: </strong>We performed a cross-sectional analysis involving 140 participants with T2DM and 70 healthy control subjects. The DNA samples were analyzed for the FTO gene variant rs9939609 using ARMS-PCR. FTO gene association with diabetes-related microvascular and macrovascular complications was assessed through multivariate logistic regression, with unadjusted odds ratios (OR) and 95% confidence intervals. A p- value below 0.05 was considered statistically significant.</p><p><strong>Results: </strong>The genotypic distribution of the FTO gene variant adhered to Hardy-Weinberg equilibrium in the study participants (p>0.05).The AA genotype exhibited a robust association with elevated BMI, HbA1C, SBP, DBP, TGs and decreased HDL-C levels relative to the AT and TT genotypes with p=0.002. FTO genotype frequency increased from AA to AT to TT in both macrovascular (CVD) and microvascular complications (retinopathy, nephropathy, and neuropathy). Moreover, risk allele(A) was also significantly contributed to CVD (p=0.001), retinopathy (p=0.004), nephropathy (p=0.001) and neuropathy (p=0.002). AA genotype of the FTO gene rs 9939609 showed the tendency to increase the risk of CVD (OR,1.21; 95% CI,1.07-1.70; p=0.04) and retinopathy (OR,1.18; 95%CI,1.02-1.87;; p=0.001) while no significant changes were recorded in diabetic nephropathy (OR,1.56; 95%CI,1.2-2.43; p=0.67) and neuropathy (OR,2.49; 95%,1.52-4.1; p=0.06).</p><p><strong>Conclusion: </strong>Our data indicate that the FTO gene variant rs 9939609 is linked to an elevated risk of both microvascular & macrovascular complications in individuals with T2DM.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progresses in Wound Healing: Integrating Nutrition, Physical Therapy, Traditional and Alternative Medicine, and Novel Technologies.","authors":"Phool Chandra, Shahjad, Mayur Porwal, Vaibhav Rastogi, Piyush Mittal, Anurag Verma, Neetu Sachan, Elphine A Prabahar, Manish Kumar Gautam","doi":"10.2174/0115733998350164250228174809","DOIUrl":"https://doi.org/10.2174/0115733998350164250228174809","url":null,"abstract":"<p><p>Wound healing is a complex, tightly regulated biological process essential for restoring the integrity and functionality of damaged skin. Chronic wounds, affecting approximately 6.5 million individuals globally and 1.5% of the Indian population, pose significant healthcare challenges due to their prolonged and intricate healing processes. This review highlights the mechanisms and stages of wound healing-hemostasis, inflammation, proliferation, and maturation-emphasizing the bidirectional influence of internal and external factors on wound progression. Despite advancements in wound management, current therapeutic options, including skin grafts, growth factors, and cell-based therapies, often remain inadequate for diverse wound types. Emerging technologies, such as nanofibers, stem cell therapy, 3D bioprinting, fluorescence imaging, and bacteria- killing laser therapy, offer promising solutions by enhancing therapeutic outcomes and minimizing side effects. This review also explores the roles of nutrition, physical therapy, and traditional medicine in promoting effective wound care. By integrating novel technologies with established therapeutic strategies, this work provides a comprehensive overview of advanced wound healing modalities, their mechanisms, advantages, and limitations. The review concludes with a perspective on future research directions aimed at overcoming current challenges in chronic wound management and optimizing patient outcomes.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Predictors of Albuminuria in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study from the United Arab Emirates","authors":"Moza Saleh Hassan Almukhattin, Suhaj Abdulsalim, Suhaila Mohammed Shareef Alawadhi, Mirza R Biag, Sonal Sekhar Miraj, Noufal Abdulkader","doi":"10.2174/1573399819666221014093352","DOIUrl":"10.2174/1573399819666221014093352","url":null,"abstract":"<p><strong>Background and aim: </strong>Albuminuria in Diabetes mellitus (DM) patients may lead to nephropathy and end-stage renal disease. Our study aimed to assess the prevalence of albuminuria and its associated predictors among type 2 DM patients in the United Arab Emirates.</p><p><strong>Methods: </strong>A retrospective cross-sectional study was conducted among type 2 DM patients in the diabetic clinic at Fujairah Hospital from 1st January 2016 to 30th January 2020 after getting the ethical clearance. Data were collected electronically from the health information system and analyzed using SPSS version 26. Regression analysis and ANOVA were used for inferential analysis. A P-value of ≤0.05 was considered significant.</p><p><strong>Results: </strong>Among the 200 patients included in the study, the mean age of the study population was 56 years, and the majority of them were females (71%). The prevalence of albuminuria was found to be 44%. By using regression analysis, glycated hemoglobin (HbA1c; P=0.038) and systolic blood pressure (SBP; P=0.003) were found to be predictors of albuminuria. One way ANOVA revealed that there were significant associations between the albumin levels and HbA1c (P=0.004), SBP (P= 0.002), diastolic blood pressure (DBP; P=0.028), serum creatinine (Scr) (P=0.039), and glomerular filtration rate (GFR; P=0.013).</p><p><strong>Conclusion: </strong>To the best of our knowledge, this is the first study from Fujairah emirate that explored the prevalence and predictors of albuminuria in type 2 DM patients. We found a high prevalence of albuminuria among type 2 DM patients. HbA1c and SBP directly contributed to albuminuria. To improve glycemic control, patients need to improve physical activity, reduce overweight and, adherence to medications that improve overall therapeutic outcomes.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33538800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effect of Medicago Sativa L. (Fabaceae) against Excision and Incision Wound Models in Diabetic Rats.","authors":"Phool Chandra, Mohammad Kaleem, Neetu Sachan, Anurag Verma, Atul Kabra","doi":"10.2174/0115733998345972250117103918","DOIUrl":"https://doi.org/10.2174/0115733998345972250117103918","url":null,"abstract":"<p><strong>Introduction: </strong>Medicago sativa (M. sativa), commonly known as Alfalfa, is a herb from the Fabaceae family that has a long history of being used to treat digestive, diabetic, and blood disorders, as well as to support liver health. The objective was to evaluate the effects of ethanolic extract of M. sativa (EEMS) on wounds in normal rats or alloxan hydrate-induced diabetic rats.</p><p><strong>Method: </strong>The wounds were created by excision (n=30) and incision (n=30) in rats. The Group II-V were diabetic rats treated with simple ointment BP, 10% weight-based povidone-iodine (10% PI), ointment of 5% w/w EEMS (5% w/w OEEMS), and 10% w/w EEMS (10% w/w OEEMS). Group 1 acted as a control and was treated with simple ointment BP. The wound area in the diabetic control groups was 292.33±0.8 mm sq. on the 18th day.</p><p><strong>Results: </strong>Rats treated with 10% PI, 5% OEEMS, and 10% OEEMS showed a significant reduction in wound area of 68.33±1.29, 248.33±1.30, and 61±1.91 mm sq., respectively, on the 18th day as compared to the control group. Rats treated with 10% PI, 5% w/w OEEMS, and 10% w/w OEEMS showed a significant increment in wound-breaking strength, respectively, as compared to diabetic rats on day 10 in the incision wound model.</p><p><strong>Conclusion: </strong>The results demonstrated that the OEEMS has potent wound-healing properties in diabetic rats.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the Iron Metabolism and Ferroptosis in Diabetic Wound Healing.","authors":"Yashi Feng, Yunchang Cao, Yun Ou-Yang, Wuxiang Wang, Shaolong Feng","doi":"10.2174/0115733998352547250107065356","DOIUrl":"https://doi.org/10.2174/0115733998352547250107065356","url":null,"abstract":"<p><p>Diabetic-related complications, such as delayed and incomplete wound healing, are an increasing concern in the realm of public health. Ferroptosis represents an innovative variant of cellular demise. Ferroptosis is currently thought to be an essential factor in the process of diabetic wound recovery. This article, therefore, examines the novel function and mechanism of ferroptosis in the repair of diabetic wounds. Diabetic hyperglycemia can induce a healing process that disrupts the function and activity of cells, thereby impeding the repair of diabetic wounds. Ferroptosis may be accelerated in diabetic lesions due to protracted low-level inflammation and oxidative stress induced by elevated glucose, according to the available evidence. As a result, the buildup of ferroptosis impedes cellular migration and proliferation, amplifies oxidative stress and the inflammatory response, and ultimately interferes with the wound-healing process. By regulating the expression of factors linked to iron mortality, this substance expedites wound healing and fosters angiogenesis in diabetic rodents. Moreover, new perspectives on the difficulties and outlooks related to ferroptosis in the context of diabetic wound healing are provided, thereby contributing to the progression of understanding in this field.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Biomarkers as a Window into the Relationship between Sarcopenia and Diabetes: Implications for Effective Management.","authors":"Ali Tajik, Vahid Mahdavizadeh, Farzin Hadizadeh, Neda Shakour","doi":"10.2174/0115733998349193250207045239","DOIUrl":"https://doi.org/10.2174/0115733998349193250207045239","url":null,"abstract":"<p><strong>Aims: </strong>This study aims to investigate the relationship between sarcopenia and circulating biomarkers in diabetes, with a focus on early detection and effective management strategies.</p><p><strong>Methods: </strong>A literature review was conducted using the ScienceDirect, Scopus, PubMed, and Web of Science databases up to December 2024. Key search terms included \"diabetes,\" \"sarcopenia,\" \"HbA1c\", \"glucose,\" \"insulin,\" and specific biomarkers such as inflammatory markers, adipokines, and myokines.</p><p><strong>Results: </strong>Aging is associated with a decline in organ and bodily system functionality, with sarcopenia being particularly prominent due to its progressive loss of muscle mass and function. This condition increases health risks and mortality in the elderly. Muscles, as the primary consumers of glucose, play a crucial role in glucose uptake; reduced mass can exacerbate insulin resistance. Sarcopenia and diabetes share common pathophysiological mechanisms, including insulin resistance, inflammation, and vascular complications. Circulating biomarkers, crucial for diabetes management, may offer insights into the early stages of sarcopenia.</p><p><strong>Conclusion: </strong>The complex relationship between sarcopenia and diabetes, influenced by shared pathophysiological pathways, presents challenges in geriatric healthcare. Circulating biomarkers hold promise for early detection and monitoring of sarcopenia, potentially enhancing patient outcomes and quality of life. Further research is necessary to validate these connections and develop targeted treatments for individuals affected by these conditions.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review: Fructose, the Sweet Culprit behind Nonalcoholic Fatty Liver Disease and Type 2 Diabetes.","authors":"Abdullah Y Otayf, Gaurav Agarwal, Muzaynah Al Khairat, Elham Ahmed Khormi, Hamzah Hassan Alnemi, Ahmad Ali Alhazmi, Khalid Abutawil, Shilpi Agarwal","doi":"10.2174/0115733998336827250114071627","DOIUrl":"10.2174/0115733998336827250114071627","url":null,"abstract":"<p><p>The composition of the diet has altered over the past few decades, with a significant increase in the consumption of dietary sugars, particularly fructose, which has risen more than tenfold. This elevated consumption of fructose and sugars is considered to be one of the major risk aspects for the emergence of obesity and other metabolic disorders. In this review, we discuss the correlation between insulin resistance and NAFLD (nonalcoholic fatty liver disease) due to dietary fructose intake. Type 2 Diabetes Mellitus (T2DM) is spreading quickly over the world and has epidemic proportions. The risk of both hepatic and metabolic abnormalities is increased by their connection, founded on shared metabolic risk factors such as obesity, (IR) Insulin Resistance, and an unhealthy standard of living. This review highlights the prevalence of coexisting T2DM (Type 2 diabetes) and NAFLD (Non-Alcoholic Fatty Liver Disease) in the community. In summary, the key pathophysiological pathways and risk stratification algorithms for the onset of nonalcoholic fatty liver disease and type 2 diabetes have been covered.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}