解读糖尿病伤口愈合中的铁代谢和铁下垂。

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM
Yashi Feng, Yunchang Cao, Yun Ou-Yang, Wuxiang Wang, Shaolong Feng
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引用次数: 0

摘要

糖尿病相关并发症,如伤口愈合延迟和不完全,是公共卫生领域日益关注的问题。铁下垂是细胞死亡的一种创新变体。目前认为,铁下垂是糖尿病伤口恢复过程中的一个重要因素。因此,本文探讨了铁下垂在糖尿病伤口修复中的新功能和机制。糖尿病性高血糖可诱导愈合过程,破坏细胞的功能和活性,从而阻碍糖尿病性伤口的修复。根据现有证据,由于血糖升高引起的长期低水平炎症和氧化应激,糖尿病病变中的铁下垂可能会加速。结果,铁下垂的积累阻碍了细胞迁移和增殖,放大了氧化应激和炎症反应,并最终干扰了伤口愈合过程。通过调节与铁死亡率相关的因子表达,这种物质加速了糖尿病啮齿动物的伤口愈合和促进血管生成。此外,在糖尿病伤口愈合的背景下,提供了与铁下垂相关的困难和前景的新观点,从而有助于了解这一领域的进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Deciphering the Iron Metabolism and Ferroptosis in Diabetic Wound Healing.

Diabetic-related complications, such as delayed and incomplete wound healing, are an increasing concern in the realm of public health. Ferroptosis represents an innovative variant of cellular demise. Ferroptosis is currently thought to be an essential factor in the process of diabetic wound recovery. This article, therefore, examines the novel function and mechanism of ferroptosis in the repair of diabetic wounds. Diabetic hyperglycemia can induce a healing process that disrupts the function and activity of cells, thereby impeding the repair of diabetic wounds. Ferroptosis may be accelerated in diabetic lesions due to protracted low-level inflammation and oxidative stress induced by elevated glucose, according to the available evidence. As a result, the buildup of ferroptosis impedes cellular migration and proliferation, amplifies oxidative stress and the inflammatory response, and ultimately interferes with the wound-healing process. By regulating the expression of factors linked to iron mortality, this substance expedites wound healing and fosters angiogenesis in diabetic rodents. Moreover, new perspectives on the difficulties and outlooks related to ferroptosis in the context of diabetic wound healing are provided, thereby contributing to the progression of understanding in this field.

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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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