臭氧治疗作为糖尿病牙周治疗辅助手段的潜力:生物标志物范围综述。

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM
Elisa Grillo Araújo, Domitilla Marchiori Sant'Anna Leal de Oliveira, Sérgio Bruzadelli Macedo, Cristine Miron Stefani, Loise Pedrosa Salles
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引用次数: 0

摘要

背景:牙周炎是一种常见的炎症性疾病,也是糖尿病(DM)患者的重要并发症。牙周炎和糖尿病之间的双向关系加剧了全身性炎症并使疾病管理复杂化。臭氧治疗(OT)具有抗菌和免疫调节特性,已成为糖尿病患者牙周炎的一种有希望的辅助治疗方法,尽管它仍未得到充分的探索。本综述评估了OT对糖尿病相关生物标志物的影响,这可能间接表明其作为糖尿病牙周炎治疗补充疗法的潜力。方法:综合检索PubMed、Cochrane、Embase、LIVIVO、Scopus、Web of Science和LILACS(截至2024年3月),确定了38项研究:19项涉及糖尿病患者,19项使用糖尿病动物模型。结果:OT对丙二醛(MDA)、超氧化物歧化酶(SOD)、还原型谷胱甘肽(GSH)、过氧化氢酶(CAT)、总抗氧化状态(TAS)和总氧化状态(TOS)等生物标志物有积极影响。OT还可以调节炎症标志物(TNF-α、IL-1β、IL-6、IL-8、IL-10和CRP)和再生生物标志物(bFGF、BMP-2、CD34、VEGF、PDGF),同时改善糖化血红蛋白(HbA1c)。这项研究首次探讨了OT对糖尿病生物标志物的影响,并推断了如果将OT作为治疗与糖尿病相关的牙周炎的辅助手段,这些影响可能会产生的影响。结论:OT可以通过调节与牙周健康相关的生物标志物来补充糖尿病患者的传统牙周治疗。这些见解可能会指导未来的临床研究,以验证OT在治疗中的作用,并为其在糖尿病牙周管理中的应用建立标准化的协议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Potential of Ozone Therapy as an Adjunct to Periodontal Treatment in Diabetes Mellitus: A Biomarker Scoping Review.

Background: Periodontitis is a prevalent inflammatory disease and a critical complication in individuals with Diabetes Mellitus (DM). The bidirectional relationship between periodontitis and DM exacerbates systemic inflammation and complicates disease management. Ozone therapy (OT), with its antimicrobial and immunomodulatory properties, has emerged as a promising adjunctive treatment for periodontitis in individuals with DM, though it remains underexplored. This scoping review evaluates the effects of OT on biomarkers associated with DM, which may indirectly suggest its potential as a complementary therapy for periodontitis management in DM.

Methods: A comprehensive search of PubMed, Cochrane, Embase, LIVIVO, Scopus, Web of Science, and LILACS (up to March 2024) identified 38 studies: 19 involving individuals with DM and 19 using DM animal models.

Results: OT positively influenced biomarkers such as Malondialdehyde (MDA), Superoxide Dismutase (SOD), reduced Glutathione (GSH), Catalase (CAT), Total Antioxidant Status (TAS), and Total Oxidant Status (TOS). OT also modulated inflammatory markers (TNF-α, IL-1β, IL-6, IL-8, IL-10, and CRP) and regenerative biomarkers (bFGF, BMP-2, CD34, VEGF, PDGF) while improving glycated hemoglobin (HbA1c). This study represents the first review to explore the effects of OT on DM biomarkers and infer possible implications of these effects if used as an adjunct in the treatment of periodontitis associated with DM.

Conclusion: OT may complement conventional periodontal treatments in individuals with DM by modulating biomarkers linked to periodontal health. These insights may guide future clinical studies to validate OT's role in the treatment and establish standardized protocols for its application in periodontal management in DM.

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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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