Ali Tajik, Vahid Mahdavizadeh, Farzin Hadizadeh, Neda Shakour
{"title":"Circulating Biomarkers as a Window into the Relationship between Sarcopenia and Diabetes: Implications for Effective Management.","authors":"Ali Tajik, Vahid Mahdavizadeh, Farzin Hadizadeh, Neda Shakour","doi":"10.2174/0115733998349193250207045239","DOIUrl":"https://doi.org/10.2174/0115733998349193250207045239","url":null,"abstract":"<p><strong>Aims: </strong>This study aims to investigate the relationship between sarcopenia and circulating biomarkers in diabetes, with a focus on early detection and effective management strategies.</p><p><strong>Methods: </strong>A literature review was conducted using the ScienceDirect, Scopus, PubMed, and Web of Science databases up to December 2024. Key search terms included \"diabetes,\" \"sarcopenia,\" \"HbA1c\", \"glucose,\" \"insulin,\" and specific biomarkers such as inflammatory markers, adipokines, and myokines.</p><p><strong>Results: </strong>Aging is associated with a decline in organ and bodily system functionality, with sarcopenia being particularly prominent due to its progressive loss of muscle mass and function. This condition increases health risks and mortality in the elderly. Muscles, as the primary consumers of glucose, play a crucial role in glucose uptake; reduced mass can exacerbate insulin resistance. Sarcopenia and diabetes share common pathophysiological mechanisms, including insulin resistance, inflammation, and vascular complications. Circulating biomarkers, crucial for diabetes management, may offer insights into the early stages of sarcopenia.</p><p><strong>Conclusion: </strong>The complex relationship between sarcopenia and diabetes, influenced by shared pathophysiological pathways, presents challenges in geriatric healthcare. Circulating biomarkers hold promise for early detection and monitoring of sarcopenia, potentially enhancing patient outcomes and quality of life. Further research is necessary to validate these connections and develop targeted treatments for individuals affected by these conditions.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdullah Y Otayf, Gaurav Agarwal, Muzaynah Al Khairat, Elham Ahmed Khormi, Hamzah Hassan Alnemi, Ahmad Ali Alhazmi, Khalid Abutawil, Shilpi Agarwal
{"title":"Review: Fructose, the Sweet Culprit behind Nonalcoholic Fatty Liver Disease and Type 2 Diabetes.","authors":"Abdullah Y Otayf, Gaurav Agarwal, Muzaynah Al Khairat, Elham Ahmed Khormi, Hamzah Hassan Alnemi, Ahmad Ali Alhazmi, Khalid Abutawil, Shilpi Agarwal","doi":"10.2174/0115733998336827250114071627","DOIUrl":"10.2174/0115733998336827250114071627","url":null,"abstract":"<p><p>The composition of the diet has altered over the past few decades, with a significant increase in the consumption of dietary sugars, particularly fructose, which has risen more than tenfold. This elevated consumption of fructose and sugars is considered to be one of the major risk aspects for the emergence of obesity and other metabolic disorders. In this review, we discuss the correlation between insulin resistance and NAFLD (nonalcoholic fatty liver disease) due to dietary fructose intake. Type 2 Diabetes Mellitus (T2DM) is spreading quickly over the world and has epidemic proportions. The risk of both hepatic and metabolic abnormalities is increased by their connection, founded on shared metabolic risk factors such as obesity, (IR) Insulin Resistance, and an unhealthy standard of living. This review highlights the prevalence of coexisting T2DM (Type 2 diabetes) and NAFLD (Non-Alcoholic Fatty Liver Disease) in the community. In summary, the key pathophysiological pathways and risk stratification algorithms for the onset of nonalcoholic fatty liver disease and type 2 diabetes have been covered.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unraveling the Mystery: COVID-19 and Diabetic Complications - A Journey from Pathophysiology to Treatment.","authors":"Muhammed Amanat, Sapna Tandon, Randhir Singh","doi":"10.2174/0115733998341202241202103725","DOIUrl":"https://doi.org/10.2174/0115733998341202241202103725","url":null,"abstract":"<p><p>The connection between COVID-19 and DM unveils a multifaceted interplay that significantly impacts disease severity and management strategies. Initial studies reveal that people with DM had higher severity rates of COVID-19 due to the infection by SARS-CoV-2. The virus solely induces hyperglycemia and, at the same time, profoundly influences the immune and inflammatory reactions, increasing the rate of severe complications and death among diabetes patients. Therefore, understanding the underlying mechanisms behind this interplay is critical for effective treatment. Furthermore, COVID-19 also brings new factors to the equation of managing diabetes. Although the virus thoroughly relies on the ACE2 receptor for viral entry, DPP4 is a substitute receptor. However, glucose-lowering DPP4 inhibitors provide only a minor association with COVID-19 vulnerability. Also, the SGLT2 inhibitors are contraindicated in certain conditions with COVID-19, and hence, insulin is generally recommended as a first-line treatment for acute glycemic control in hospitalized or critically ill COVID-19 patients, particularly those with severe hyperglycemia or diabetic ketoacidosis. COVID-19-associated aggravating factors, such as cardiovascular disease, chronic kidney disease, and neuropathy, predispose people with diabetes to severe conditions. Thus, it is important to explore this speculation, and the present review aims to understand this complex interaction during patient care models and specify the therapeutic approaches to address this problematic convergence of two substantial health concerns.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ritesh Kumar Tiwari, Lalit Singh, Mukesh Kr Tiwari, Rajat Yadav
{"title":"WITHDRAWN: Histological and In Vivo Study on Novel Polyelectrolyte Complex Vildagliptin Loaded Microbeads in Streptozotocin-induced Rat Model","authors":"Ritesh Kumar Tiwari, Lalit Singh, Mukesh Kr Tiwari, Rajat Yadav","doi":"10.2174/1573399819666230419091309","DOIUrl":"10.2174/1573399819666230419091309","url":null,"abstract":"<p><p>Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn from the journal \" Current Diabetes Review \".</p><p><p>Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.</p><p><p>The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php</p><p><strong>Bentham science disclaimer: </strong>It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9349837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haithem Rauf Mohammed, Rym Ben Othman, Zahraa Saad Hatef, Mohamed Kacem Ben Fradj, Haifa Abdesselem
{"title":"Association of ABO Gene rs2073823 Polymorphism with Microvascular Complications, sP-Selectin Levels and Lipid Profile in Type 2 Diabetes.","authors":"Haithem Rauf Mohammed, Rym Ben Othman, Zahraa Saad Hatef, Mohamed Kacem Ben Fradj, Haifa Abdesselem","doi":"10.2174/0115733998341750241208055924","DOIUrl":"https://doi.org/10.2174/0115733998341750241208055924","url":null,"abstract":"<p><strong>Introduction: </strong>Type 2 diabetes (T2D) is a prevalent metabolic disorder linked to chronic inflammation and endothelial dysfunction, which contributes to the development of microvascular complications (MVCs) such as diabetic retinopathy (DR) and diabetic neuropathy (DN). Genetic factors, including variations in the ABO gene, may influence these complications. This study aimed to investigate the association between the ABO rs2073823 polymorphism and the risk of MVCs in patients with T2D, as well as its impact on inflammatory biomarkers, endothelial markers, and lipid profiles.</p><p><strong>Materials and methods: </strong>We conducted an exploratory study involving 96 T2D Iraqi patients (Asian Arabic), examining the distribution of the ABO rs2073823 polymorphism and its correlation with MVCs. We assessed levels of inflammatory markers (TNF-α, IL-6, sE-selectin, sP-selectin), glycemic markers, renal function biomarkers, and lipid profiles. Adjustment was made for confounding factors including age, gender, body mass index, duration of diabetes, and hypertension.</p><p><strong>Results: </strong>Among the participants, 75% had MVCs, including DR (42%) and DN (65%). The ABO rs2073823 \"A/A\" genotype was associated with a reduced risk of MVCs under co-dominant (OR=0.16, p=0.045) and recessive models (OR=0.14, p=0.031). This protective effect remained significant after adjusting for confounding factors (OR=0.11, p=0.022). The \"A/A\" genotype was also linked to lower levels of total cholesterol, LDL-cholesterol, triglycerides, and sP-selectin. Patients with MVCs exhibited significantly higher levels of TNF-α, IL-6, and sP-selectin.</p><p><strong>Conclusion: </strong>The ABO rs2073823 polymorphism, particularly the \"A/A\" genotype, is associated with a decreased risk of MVCs in T2D patients and influences lipid metabolism and inflammatory markers. These findings suggest a genetic basis for the susceptibility to MVCs and highlight the role of the ABO gene in modulating inflammation and endothelial function in T2D. Further research is needed to validate these associations and explore potential therapeutic implications.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luis Angel Cendejas Medina, Maria Girlane Sousa Albuquerque Brandão, Glaubervania Alves Lima, Maria Lucia Zanetti, Ana Emília Pace, Maria Del Pilar Serrano Gallardo, Juana Mercedes Gutierrez Valverde, Brena Shellem Bessa de Oliveira, Francisca Elisangela Teixeira Lima, Carla Regina de Souza Teixeira
{"title":"Health Literacy and Numeracy in Self-monitoring of Capillary Glycemia: A Systematic Review of Mixed Methods.","authors":"Luis Angel Cendejas Medina, Maria Girlane Sousa Albuquerque Brandão, Glaubervania Alves Lima, Maria Lucia Zanetti, Ana Emília Pace, Maria Del Pilar Serrano Gallardo, Juana Mercedes Gutierrez Valverde, Brena Shellem Bessa de Oliveira, Francisca Elisangela Teixeira Lima, Carla Regina de Souza Teixeira","doi":"10.2174/0115733998344984241203070203","DOIUrl":"https://doi.org/10.2174/0115733998344984241203070203","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to synthesize scientific evidence on the influence of health literacy and numerical knowledge on self-monitoring of capillary blood glucose.</p><p><strong>Methods: </strong>Adhering to the PRISMA guidelines and the principles of the Joanna Briggs Institute, a comprehensive search was conducted across multiple databases, including CINAHL, Cochrane, Embase, LILACS, PubMed, Scopus, Web of Science, Google Scholar, OPENGREY, and NDLTD. The review included studies published in any language that examined the relationship between HL, numeracy, and SMBG.</p><p><strong>Results: </strong>A total of 12 studies met the inclusion criteria. These studies utilized various assessment tools, such as the Brief Test of Functional Health Literacy in Adults (B-TOFHLA) and the Diabetes Numeracy Test (DNT-15), to evaluate health literacy and numeracy levels. The findings revealed a significant association between adequate HL and numeracy and improved SMBG practices. Specifically, individuals with sufficient health literacy were more likely to monitor their blood glucose levels regularly and make appropriate treatment adjustments based on their readings.</p><p><strong>Conclusion: </strong>The results indicated that numeracy skills and health literacy are critical determinants of effective SMBG, influencing the frequency and accuracy of self-care practices in diabetes management. These findings highlight the urgent need for educational interventions tailored to enhance these skills, which could lead to improved health outcomes for individuals with diabetes.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Remah Salih Al-Salman, Mohammad M Al-Ahmad, Hiba Alameri
{"title":"Trends in Total Antioxidant Status and Other Biochemical Parameters in Type 2 Diabetes Mellitus: A Case-control Study.","authors":"Remah Salih Al-Salman, Mohammad M Al-Ahmad, Hiba Alameri","doi":"10.2174/0115733998336940241219182916","DOIUrl":"https://doi.org/10.2174/0115733998336940241219182916","url":null,"abstract":"<p><strong>Objectives: </strong>Owing to the existing evidence of the implication of oxidative stress in the pathophysiology of type 2 diabetes mellitus (T2DM), the present study aims to investigate the correlation of serum total antioxidant status (TAS) with comorbidities, various biochemical parameters, and duration of T2DM. Various factors contributing to disease prevalence and trends in other biochemical parameters are assessed.</p><p><strong>Methods: </strong>A retrospective observational study of 246 patients with T2DM whose data were retrieved from the Proficiency Health Diagnostic Lab System in Al Ain. Data were analyzed using the Statistical Package for the Social Sciences (SPSS) program.</p><p><strong>Results: </strong>The prevalence of T2DM was found to be higher in gender (male), age (≥45 years), ethnicity (Middle Eastern), BMI (≥25), family history, and metabolic syndrome (hypertension and dyslipidemia). TAS was found to be significantly higher in patients with comorbidities, than in those without, particularly dyslipidemia and micro-albuminuria (p<0.05). TAS was weakly positively correlated with various T2DM biochemical parameters (p<0.05), except for Fasting blood glucose (FBG) (p=0.061). TAS was weakly negatively correlated with BMI (≥25) (p=0.042). Albumin- to-creatinine ratio (ACR) was statistically higher in hypertensives than normotensives (p=0.049). Duration of disease was only significantly correlated with ACR (r=0.325, p=0.001). Uric acid levels were statistically higher in patients with microalbuminuria than in patients without microalbuminuria (p=0.001).</p><p><strong>Conclusion: </strong>TAS was higher in patients with dyslipidemia and microalbuminuria, suggesting the influence of other factors such as uric acid and lipid-lowering agents. TAS could be an important factor in the management of T2DM cases. This needs to be further investigated in future studies to fill the gap found in the literature.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigating the Risk Factors Associated with Type 1 Diabetes (T1D) in the South of Iran: A Casecontrol Study.","authors":"Fatemeh Sadat Mirrashidi, Amin Kiani, Kiavash Hushmandi, Rasoul Raesi, Salman Daneshi","doi":"10.2174/0115733998336000241120104439","DOIUrl":"https://doi.org/10.2174/0115733998336000241120104439","url":null,"abstract":"<p><strong>Background: </strong>Type 1 diabetes (T1D) is an autoimmune disorder characterized by a complex interplay of genetic and environmental factors.</p><p><strong>Aim: </strong>The objective of this study was to identify the risk factors associated with T1D in the southern region of Iran during the year 2022.</p><p><strong>Methods: </strong>This research employed a case-control design involving two groups (79 individuals in each group) of healthy children and adolescents diagnosed with T1D. The study assessed and compared the groups regarding various potential risk factors that may influence the development of T1D. Data analysis was performed using SPSS-22 software.</p><p><strong>Results: </strong>Significant differences were observed between the two groups concerning several factors, including the age at which children began kindergarten, their weight at one year and 18 months, maternal weight gain during pregnancy, delivery method, age of introduction to complementary feeding, duration of breastfeeding, use of cow's milk and vitamin D supplements before one year of age, as well as family history of T1D and other autoimmune diseases among fathers and siblings.</p><p><strong>Conclusion: </strong>The findings indicate that, in addition to genetic predispositions, numerous environmental factors contribute to the risk of developing T1D. Consequently, it is recommended that health managers and policymakers investigate these risk factors more broadly across various regions to implement effective strategies aimed at reducing the incidence of T1D nationwide.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Geu Mendoza-Catalan, Jose Alfredo Pimentel-Jaimes, Erika Nallely Orendain-Jaime, Claudia Jennifer Dominguez-Chavez, Jose Luis Higuera-Sainz, Alma Angelica Villa-Rueda, Ulises Rieke-Campoy, Adriana Camargo-Bravo
{"title":"Dating Violence, Lifestyle and Risk of Type 2 Diabetes in Mexican Women University Students.","authors":"Geu Mendoza-Catalan, Jose Alfredo Pimentel-Jaimes, Erika Nallely Orendain-Jaime, Claudia Jennifer Dominguez-Chavez, Jose Luis Higuera-Sainz, Alma Angelica Villa-Rueda, Ulises Rieke-Campoy, Adriana Camargo-Bravo","doi":"10.2174/0115733998283227240117060452","DOIUrl":"10.2174/0115733998283227240117060452","url":null,"abstract":"<p><strong>Background: </strong>Dating violence is a prevalent issue among Mexican women, as is the incidence and prevalence of Type 2 diabetes mellitus (T2DM). The effects of dating violence can negatively impact lifestyle and, consequently, increase the risk of T2DM.</p><p><strong>Objective: </strong>This study aimed to explore the influence of dating violence on lifestyle and the risk of T2DM in women university students from Mexico.</p><p><strong>Methods: </strong>The study employed a cross-sectional and correlational design. The study population consisted of women university students. The sample size included 255 participants. Women aged 18 to 39 with current dating relationships and residency in Mexicali, Baja California, Mexico, were included. Data collection was conducted from February to May 2023. Correlations and multiple linear regression models were conducted.</p><p><strong>Results: </strong>A total of 255 women participated, with an average age of 21.6 years (SD = 3.2), and 32.2% had a history of intrafamily violence during childhood. 58.8% of the participants exhibited some level of risk of T2DM, and 56.7% of the lifestyle was mostly categorized as poor/fair. Detachment was the most prevalent type of dating violence, followed by coercion. Dating violence was correlated with lifestyle (r = -.430) and the risk of T2DM (r = .321). In the multiple linear regression model, dating violence influenced the risk of T2DM.</p><p><strong>Conclusion: </strong>Women who reported higher levels of dating violence have a less healthy lifestyle and a greater risk of T2DM. It is important to consider dating violence to improve lifestyle and prevent T2DM in Mexican women university students.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":"e300124226536"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139650456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impaired Fibroblast Growth Factor 21 (FGF21) Associated with Visceral Adiposity Leads to Insulin Resistance: The Core Defect in Diabetes Mellitus.","authors":"Unnati Jain, Priyanka Srivastava, Ashwani Sharma, Subrata Sinha, Surabhi Johari","doi":"10.2174/0115733998265915231116043813","DOIUrl":"10.2174/0115733998265915231116043813","url":null,"abstract":"<p><p>The Central nervous system (CNS) is the prime regulator of signaling pathways whose function includes regulation of food intake (consumption), energy expenditure, and other metabolic responses like glycolysis, gluconeogenesis, fatty acid oxidation, and thermogenesis that have been implicated in chronic inflammatory disorders. Type 2 diabetes mellitus (T2DM) and obesity are two metabolic disorders that are linked together and have become an epidemic worldwide, thus raising significant public health concerns. Fibroblast growth factor 21 (FGF21) is an endocrine hormone with pleiotropic metabolic effects that increase insulin sensitivity and energy expenditure by elevating thermogenesis in brown or beige adipocytes, thus reducing body weight and sugar intake. In contrast, during starvation conditions, FGF21 induces its expression in the liver to initiate glucose homeostasis. Insulin resistance is one of the main anomalies caused by impaired FGF21 signaling, which also causes abnormal regulation of other signaling pathways. Tumor necrosis factor alpha (TNF-α), the cytokine released by adipocytes and inflammatory cells in response to chronic inflammation, is regarded major factor that reduces the expression of FGF21 and modulates underlying insulin resistance that causes imbalanced glucose homeostasis. This review aims to shed light on the mechanisms underlying the development of insulin resistance in obese individuals as well as the fundamental flaw in type 2 diabetes, which is malfunctioning obese adipose tissue.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":"e260424229342"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}