Current diabetes reviews最新文献

{"title":"Advances in Wound Healing Strategies for Diabetic Foot Ulcers: From Conventional to Regenerative Therapies.","authors":"Abdullah Alwahbi","doi":"10.2174/0115733998407601251010114114","DOIUrl":"10.2174/0115733998407601251010114114","url":null,"abstract":"<p><p>Diabetic Foot Ulcer (DFU) is a serious and chronic complication of uncontrolled diabetes, significantly increasing the risk of amputation and mortality in diabetic patients. Conventional wound healing techniques often fail to manage chronic wounds in DFU due to several limitations, which eventually raises the need for advanced, innovative, and efficient treatment strategies for the better management of DFU. Many novel interventions, such as growth factor therapy, stem cell therapy, gene therapy, nanotechnology, bioengineered skin substitutes, 3D-bioprinting, and regenerative medicine, have shown promising roles in wound healing and tissue regeneration, suggesting their potential implications in the treatment and control of DFU. An integrated and multidisciplinary approach was proven to be a promising option for rapid and effective DFU management, eventually reducing the financial burden on the patients and healthcare system. Besides, AI-- driven medical technologies were found to support the healthcare system for the prevention, prediction, diagnosis, and personalized treatment of DFU. The present review article provides a brief overview of DFU and its pathophysiology. It highlights traditional DFU treatment strategies, their limitations, and focuses on emerging innovative strategies, emphasizing their potential for addressing DFU. Moreover, it sheds light on challenges and future research areas of these emerging interventions.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":"e15733998407601"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145602876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Low-carbohydrate Diets and 10-year Atherosclerosis Cardiovascular Disease Risk: Data from the National Health and Nutrition Examination Survey.","authors":"Yipeng Du, Hong Ouyang, Huiyong Wang, Jian Shi, Yuanqing Li, Huidong Long, Xiudi Pan","doi":"10.2174/0115733998411207251130184836","DOIUrl":"10.2174/0115733998411207251130184836","url":null,"abstract":"<p><strong>Introduction: </strong>To evaluate the association between low-carbohydrate diet (LCD) score and atherosclerotic cardiovascular disease (ASCVD) among individuals with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>A total of 3685 participants from the National Health and Nutrition Examination Survey database 2007-2020 were included in this cross-sectional study. The primary outcome of this study was the 10-year ASCVD risk. We used the weighted logistic regression models to assess the association between LCD score and 10-year ASCVD risk. Stratified analysis based on age, body mass index (BMI), hypertension, dyslipidemia, and chronic kidney disease (CKD) was conducted. Odds ratio (OR) and 95% confidence interval (CI) were calculated.</p><p><strong>Results: </strong>After adjusting for all confounding factors, when LCD was treated as a continuous variable, the findings revealed an inverse association between LCD and 10-year ASCVD risk among individuals with T2DM (OR=0.97, 95% CI: 0.94-0.99, p=0.045). When LCD was stratified into tertiles, individuals in the highest tertiles of LCD exhibited a negative association with 10-year ASCVD risk compared to those in the first tertile (OR=0.66, 95% CI: 0.46-0.95, p=0.025). Subgroup analysis indicated an negative association between high tertiles of LCD and 10-years ASCVD risk in individuals with T2DM who had a BMI≥25kg/m2 (OR=0.66, 95% CI: 0.45-0.97, p<0.05), hypertension (OR=0.61, 95% CI: 0.40-0.91, p<0.05) and dyslipidemia (OR=0.64, 95% CI: 0.43-0.95, p<0.05), and BMI<25kg/m2 with history of CKD (OR=0.64, 95% CI: 0.42-0.96, p<0.05).</p><p><strong>Discussion: </strong>The inverse association observed between LCD score and ASCVD risk in individuals with T2DM may be partly explained by improved glycemic control, reduced insulin resistance, and favorable lipid profile changes often associated with lower carbohydrate intake. Notably, the protective effect was more pronounced in individuals with additional metabolic comorbidities, such as obesity, hypertension, and dyslipidemia, suggesting that these subgroups may derive greater cardiovascular benefit from LCD-style eating patterns. However, the cross-sectional nature of our study precludes causal inference. Additionally, dietary intake was self-reported and subject to recall bias, and residual confounding cannot be fully ruled out. Despite these limitations, our findings contribute to the growing body of evidence supporting dietary carbohydrate modification as a potential strategy in cardiovascular risk management among patients with T2DM.</p><p><strong>Conclusion: </strong>Our study found an inverse association between LCD score and 10-year ASCVD risk in individuals with T2DM. These findings may provide a reference for future research and inform dietary recommendations, though causal relationships cannot be established due to the cross-sectional design.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":"e15733998411207"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Alpha-Lipoic Acid and B Vitamins on Quality of Life and Metabolic Parameters among Diabetic Patients with Symptomatic Distal Symmetric Polyneuropathy: A Randomized Controlled Trial.","authors":"Nani Draman, Che Nur Ain Che Abdullah, Noraini Mohamad, Zainab Mat Yudin, Wan Muhamad Amir W Ahmad, Ritzzaleena Rosli Mohd Rosli, Chee Yong Chuan","doi":"10.2174/0115733998451787260317083008","DOIUrl":"10.2174/0115733998451787260317083008","url":null,"abstract":"<p><strong>Introduction: </strong>Distal symmetric polyneuropathy (DSPN) is a debilitating diabetic complication that impairs Quality of Life (QoL). This study evaluated the effects of Alpha Lipoic Acid (ALA) plus B vitamins on QoL and metabolic parameters in diabetic patients with symptomatic DSPN.</p><p><strong>Methods: </strong>In this randomized, double-blind, placebo-controlled trial, 80 patients were allocated to receive either oral ALA plus B vitamins, i.e., Bionerv® (n =40) (intervention group) or placebo (n = 40) for 12 weeks. QoL, Body Mass Index (BMI), and Blood Pressure (BP) were assessed at baseline, 6 weeks, and 12 weeks. QoL was measured using the Revised Diabetes Quality of Life Questionnaire (Rv-DQoL), where higher scores indicate poorer QoL. Metabolic parameters (glycated haemoglobin (HbA1c), fasting blood sugar (FBS), fasting lipid profile (FLP) were assessed at baseline and 12 weeks.</p><p><strong>Results: </strong>In the intervention group, the mean Rv-DQoL score decreased significantly in withingroup analysis from 29.50 ± 5.25 at baseline to 24.37 ± 3.43 at week 12 [F(2,156)=55.16; p-value <0.001]. However, between-group differences were not significant (p-value =0.151). Blood pressure also declined significantly within the intervention group (p-value <0.05), but no significant differences were observed between the placebo and intervention groups (p-value >0.05). Metabolic parameters (HbA1c, FBS, FLP, BMI) showed no significant changes between intervention and control groups (p-value >0.05).</p><p><strong>Discussion: </strong>Twelve-week treatment with ALA plus B vitamins resulted in improvements in QoL and BP among DSPN patients. However, these changes did not reach statistical significance compared with placebo, and no alterations in metabolic parameters were observed. The short duration and small sample size may have limited the detectability of effects.</p><p><strong>Conclusion: </strong>Twelve weeks of treatment with ALA and B vitamins resulted in an improvement in QoL and BP among DSPN patients. However, these changes did not reach statistical significance compared with placebo, and no alterations in metabolic parameters were observed.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":"e15733998451787"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chain Mediating Role of Illness Perception and Fear of Hypoglycemia in Impaired Hypoglycemic Awareness and Mild Cognitive Impairment in Patients with Type 2 Diabetes Mellitus.","authors":"Mengyao Han, Xiangning Li, Yuying He, Yinshi Kan, Xiaojuan Wan, Lin Liu, Yue Su, Jing Chen, Li Fang, Jinping Wang, Yu Zhang","doi":"10.2174/0115733998418191251127053922","DOIUrl":"10.2174/0115733998418191251127053922","url":null,"abstract":"<p><strong>Introduction: </strong>Impaired hypoglycemic awareness (IAH) in type 2 diabetes mellitus (T2DM) is linked to mild cognitive impairment (MCI), but the underlying mechanisms are unclear. This study aimed to explore the chain mediating role of two psychological factors, illness perception (IP) and fear of hypoglycemia (FOH), in the relationship between IAH and MCI.</p><p><strong>Methods: </strong>A cross-sectional survey of 251 T2DM patients was conducted using convenience sampling at two tertiary hospitals. Data on IAH, IP, FOH, and MCI were collected using standardized questionnaires. Data were analyzed and compared using SPSS 27.0 and AMOS 27.0.</p><p><strong>Results: </strong>There were significant correlations among IAH, IP, FOH, and MCI. Higher IAH was associated with increased FOH and more negative IP, which were both linked to worse cognitive function. Mediation analysis showed that IAH indirectly affects MCI through three pathways: independently via FOH, independently via IP, and via a chained effect of FOH and IP.</p><p><strong>Discussion: </strong>The findings underscored that the link between IAH and cognitive decline is not solely physiological, but is substantially mediated by psychological responses. Negative illness perceptions and heightened fear, triggered by the unpredictability of IAH, drive maladaptive behaviors and emotional distress that contribute to worse cognitive outcomes.</p><p><strong>Conclusion: </strong>The findings highlighted the role of psychological factors in cognitive decline among T2DM patients with IAH. We recommend that future interventions consider the associations between these variables. Diverse interventions aimed at improving IP and FOH levels could help slow cognitive decline in patients with IAH.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":"e15733998418191"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146028650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-efficacy, Knowledge and Outcomes Expectations Foot Self-care among Diabetic Patients with High-Risk Feet in Jordan.","authors":"Yahya Najjar, Kathleen Finlayson, Qusai Aljarrah, Sameh Moosa, Mohammed ALBashtawy, Osama Alkouri, Anas Ababneh","doi":"10.2174/0115733998328984240923115409","DOIUrl":"10.2174/0115733998328984240923115409","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with high-risk feet and diabetes are prone to develop diabetes-related foot ulcers (DFUs). To prevent DFUs and their costs and impacts on diabetes mellitus (DM) patients' productivity and quality of life, patients' foot self-care (FSC) practices are essential to screen for DFUs. Our study aimed to assess the self-efficacy and outcome expectations about FSC and evaluate the knowledge about DFUs among patients with DM in Jordan.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with DM patients who attended two diabetes clinical centers in Jordan in the period from October 2022 to April 2023 in which data were collected through a self-administered questionnaire developed to assess patients' understanding of DFUs, foot care outcomes expectations (FCOE), and self-efficacy about FSC.</p><p><strong>Results and discussion: </strong>The final sample included data from 107 patients. Patient awareness of DFUs and FCOE was good, and the level of self-efficacy for FSC was moderate to high. Multiple linear regression revealed that age was negatively associated with lower self-efficacy for FSC (β = -0.22, p = 0.03) and both confidence (self-efficacy) in FSC and living arrangements (i.e., living with family) were positively associated with higher FCOE (β = 0.19, p = 0.04 and β = 0.39, p <0.001, respectively). Diagnosis of renal failure, diagnosis of retinopathy, elevated levels of glycated hemoglobin, and the settings in which the patient is receiving care for DM were positively associated with an understanding of DFUs. Both age and history of heart attacks and coronary artery disease were negatively associated with realizing DFUs (β = -0.26, p = 0.007, and β = -0.18, p = 0.045, respectively).</p><p><strong>Conclusion: </strong>Patients with diabetes mellitus in Jordan have good FCOE, good awareness of DFUs, and a moderate degree of self-efficacy to execute FSC. Health education and self-efficacy programs should focus on older adults with a history of heart attacks to boost their understanding of DFUs and raise their sense of self-efficacy around FSC.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":"e15733998328984"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical Evaluation of Fisetin in the Management of Diabetic Foot Ulcer in Wistar Rats.","authors":"Aniket Gupta, Rishabh Chalotra, Randhir Singh","doi":"10.2174/0115733998367395250515130758","DOIUrl":"10.2174/0115733998367395250515130758","url":null,"abstract":"<p><strong>Aim: </strong>Preclinical Evaluation of Fisetin in the Management of Diabetic Foot Ulcer in Wistar Rats.</p><p><strong>Introduction: </strong>Diabetic foot ulcer (DFU) is a complication of diabetes mellitus, often leading to non-traumatic amputations and significantly impacting patient morbidity. Globally, the prevalence of DFU ranges from 9.1 to 26.1 million annually. A 2022 meta-analysis revealed that 6.3% of diabetic adults (33 million) are affected by DFUs. The current treatments primarily focus on topical treatments, neglecting the underlying metabolic conditions.</p><p><strong>Objective: </strong>To investigate the wound healing efficacy of the phytoconstituent fisetin, administered orally, in managing DFU in diabetic neuropathic Wistar rats.</p><p><strong>Method: </strong>This study investigates the therapeutic potential of a phytoconstituent fisetin, in the management of wound healing in STZ-NAD induced diabetic animal model with surgically induced wounds after indication of neuropathy. Fisetin was administered orally at doses of 5, 10, and 15 mg/kg for 30 days following the induction of foot ulcers, Various parameters were measured, including blood glucose levels, HbA1c, lipid profile, pro-inflammatory cytokines, antioxidant activity, MDA, and histopathological analysis of wound healing.</p><p><strong>Results and discussion: </strong>Fisetin, particularly at 15 mg/kg, significantly modulates blood glucose level, HbA1c, lipid profile, and pro-inflammatory cytokines, further enhancing antioxidant activity, while reducing MDA, indicating a reduction in oxidative stress. Histopathological analysis demonstrated enhanced wound healing by increased fibroblast proliferation and collagen formation, as well as restoration of the epithelial layer. Fisetin also exhibited potential in enhancing re-epithelization, enhancing pro-angiogenic markers, diminishing inflammation, and reducing wound size.</p><p><strong>Conclusion: </strong>Fisetin demonstrates promising potential in managing DFU by modulating metabolic conditions, reducing blood glucose, oxidative stress, and inflammation, and promoting wound healing. Future studies should focus on unraveling the detailed molecular pathways involved in fisetin's action, along with clinical trials to validate its efficacy in DFU patients.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":"e15733998367395"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the Landscape of Epigenetic Research in Diabetes Mellitus: A Decade-Long Bibliometric Analysis (2014-2024).","authors":"Yu'e Tang, Huan Zhu, Lele Liu, Xiuying Guo, Qianbo Zhang, Yuhe Dai, Junqi Yang, Rifang Gu, Jidong Rong, Xuqiang Nie","doi":"10.2174/0115733998389913250807044815","DOIUrl":"10.2174/0115733998389913250807044815","url":null,"abstract":"<p><strong>Introduction: </strong>Epigenetic regulation constitutes critical molecular mechanisms underlying the pathogenesis of diabetes and disease progression. While substantial mechanistic investigations exist, the field lacks systematic mapping of research trends, collaborative networks, and emerging frontiers.</p><p><strong>Objectives: </strong>To conduct the first comprehensive bibliometric evaluation of epigenetic studies in diabetes mellitus and its complications (2014-2024), identifying key research domains, international collaboration patterns, and innovative investigative directions to inform strategic research planning and highlight opportunities for innovative therapeutic approaches.</p><p><strong>Methods: </strong>We interrogated the Web of Science Core Collection using stringent inclusion criteria, analyzing 1,451 publications through advanced multi-dimensional metrics in CiteSpace (6.2.R4), VOSviewer (1.6.20), and Bibliometrix (4.1.3).</p><p><strong>Results and discussion: </strong>A total of 1,451 original and review articles were retrieved, involving 83 countries/regions, 576 journals, and 7,645 authors. The United States produced the highest number of publications (n = 464), followed by China (n = 283) and Italy (n = 121). The International Journal of Molecular Sciences was the leading journal (66 publications), dominated by review articles (n = 53). Author collaboration networks were extensive, with Charlotte Ling emerging as the most prolific and influential author in publications, citations, and H-index. Keyword co-occurrence analyses emphasized type 2 DM, gestational DM, and diabetic nephropathy as primary research focuses, while new frontiers highlighted potential links to Alzheimer's disease and fibroblast biology.</p><p><strong>Conclusion: </strong>This multi-dimensional analysis provides quantitative visualization of research evolution, delineates current investigative priorities, and highlights underexplored therapeutic targets. Our findings establish a strategic framework for transdisciplinary collaboration in precision diabetology.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":"e15733998389913"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Diabulimia: Exploring the Intersection of Disordered Eating, Eating Disorders, Insulin Dose Manipulation, and Type 1 Diabetes.","authors":"Velimir Altabas, Jelena Marinković Radosevic, Nika Grubijesic","doi":"10.2174/0115733998347278250309180707","DOIUrl":"10.2174/0115733998347278250309180707","url":null,"abstract":"<p><strong>Introduction: </strong>Although insulin is essential for managing type 1 diabetes and is life-saving for patients with this condition, some individuals may intentionally reduce or omit insulin due to a fear of weight gain or a desire to lose weight. This behavior is commonly referred to as diabulimia.</p><p><strong>Methods: </strong>Since diabulimia is not formally defined, a systematic review of the limited literature was conducted on November 8th, 2024, using PubMed, Scopus, and Web of Science databases. The search terms included \"diabulimia\", \"insulin omission\", \"insulin restriction\", \"eating disorders\", \"disordered eating\", and \"type 1 diabetes\". Out of 288 manuscripts, 19 were selected after excluding non-English articles and screening the titles and abstracts.</p><p><strong>Results and discussion: </strong>Eating disorders and disordered eating are common in patients with type 1 diabetes, often driven by concerns regarding body image and weight. These behaviors can complicate diabetes management, worsen glucose control, and increase the risk of complications. Diabulimia may develop as a coping mechanism, especially in adolescents with higher body mass index and a history of eating disorders. Diagnosis is challenging due to the lack of established guidelines, but poor glucose control can raise suspicion and prompt further psychological evaluation. A multidisciplinary approach, combining medical care, nutrition, mental health support, and therapy, is recommended, despite limited evidence.</p><p><strong>Conclusion: </strong>While diabulimia is not formally recognized, understanding its impact can help healthcare professionals diagnose and manage it more effectively, improving patients' health and well-being.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":"e15733998347278"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the Mystery: COVID-19 and Diabetic Complications - A Journey from Pathophysiology to Treatment.","authors":"Muhammed Amanat, Sapna Tandon, Randhir Singh","doi":"10.2174/0115733998341202241202103725","DOIUrl":"10.2174/0115733998341202241202103725","url":null,"abstract":"<p><p>The connection between COVID-19 and DM unveils a multifaceted interplay that significantly impacts disease severity and management strategies. Initial studies reveal that people with DM had higher severity rates of COVID-19 due to the infection by SARS-CoV-2. The virus solely induces hyperglycemia and, at the same time, profoundly influences the immune and inflammatory reactions, increasing the rate of severe complications and death among diabetes patients. Therefore, understanding the underlying mechanisms behind this interplay is critical for effective treatment. Furthermore, COVID-19 also brings new factors to the equation of managing diabetes. Although the virus thoroughly relies on the ACE2 receptor for viral entry, DPP4 is a substitute receptor. However, glucose-lowering DPP4 inhibitors provide only a minor association with COVID-19 vulnerability. Also, the SGLT2 inhibitors are contraindicated in certain conditions with COVID-19, and hence, insulin is generally recommended as a first-line treatment for acute glycemic control in hospitalized or critically ill COVID-19 patients, particularly those with severe hyperglycemia or diabetic ketoacidosis. COVID-19-associated aggravating factors, such as cardiovascular disease, chronic kidney disease, and neuropathy, predispose people with diabetes to severe conditions. Thus, it is important to explore this speculation, and the present review aims to understand this complex interaction during patient care models and specify the therapeutic approaches to address this problematic convergence of two substantial health concerns.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":"e15733998341202"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of RAGE Inhibitors from <i>Curcuma caesia</i> Roxb: Implications in Treatment against Diabetic Complications.","authors":"Priyakshi Nath, Anil K Pasupulati, Rupshikha Nath, Rajat Nath, Mriganka Das, Deepa Nath, Jagajjit Sahu, Sibashish Kityania, Anupam Das Talukdar","doi":"10.2174/0115733998416568251122070701","DOIUrl":"10.2174/0115733998416568251122070701","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetic nephropathy (DN) is a progressive renal complication that significantly contributes to end-stage renal disease. Hyperglycaemia contributes to the formation of advanced glycation end-products (AGEs). The interaction between AGEs and their receptor (RAGE) plays a key role in the progression of DN. RAGE activation increases oxidative stress and promotes inflammation, thereby evoking cellular and molecular damage. Together, these events result in kidney injury and varying degrees of proteinuria. This study aims to evaluate the drug-like properties of potential natural compounds derived from Curcuma caesia and their potential effectiveness against DN.</p><p><strong>Methods: </strong>This study investigates the antioxidant properties of Curcuma caesia (CC) rhizome extracts, alongside in silico methodologies including molecular docking, QSAR, and ADMET analysis to identify potential metabolites.</p><p><strong>Results: </strong>In this study, we examined the potential of phytochemicals identified from the rhizome extracts of Curcuma caesia (CC) that may mimic AGEs and inhibit RAGE activation. We assessed whether these phytochemicals could prevent ROS accumulation and inflammation, thereby providing renoprotection in a diabetic milieu. Using molecular docking and ADMET analysis, we identified two compounds, Lappaol A and Piperaduncin B, in the methanolic extract of CC, which demonstrated a stronger affinity for interacting with RAGE than the AGE compound MODIC and the RAGE inhibitor Azeliragon.</p><p><strong>Discussion: </strong>Since the interaction between AGEs and RAGE contributes to major pathological events in the development of DN, inhibiting this interaction could be a valuable therapeutic strategy against DN and other AGE-mediated pathologies such as retinopathy and neuropathy. Virtual screening of the identified compounds revealed that Lappaol A and Piperaduncin B effectively bind to RAGE and may interrupt RAGE activation, thereby potentially slowing the progression of DN.</p><p><strong>Conclusion: </strong>These natural compounds exhibited promising drug-like characteristics against the target protein RAGE and may serve as lead compounds for the development of RAGE inhibitors. The study recommends further <i>in vitro</i> and <i>in vivo</i> investigations to assess the therapeutic potential of these identified compounds in the treatment of diabetic nephropathy.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":"e15733998416568"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}