SARS CoV-2 患者罹患 1 型糖尿病的风险。

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM
Shweta Chahal, Rojin G Raj, Ranjeet Kumar
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引用次数: 0

摘要

最近的研究发现,1 型糖尿病(T1DM)患者因感染 COVID-19 而发病和死亡的风险较高,这表明有必要接种疫苗。T1DM 似乎会损害先天性免疫和适应性免疫。COVID-19 病症严重并可能致命时,会产生过量的促炎细胞因子,这就是所谓的 "细胞因子风暴"。大量队列研究表明,慢性炎症是导致 COVID-19 不幸结局的关键风险因素。在 T1DM 患者中,TNF-α、白细胞介素 (IL)-1a、IL-1、IL-2、IL-6 和其他细胞因子的浓度较高。更重要的是,氧化应激对 COVID-19 疾病的严重程度和病程起着重要作用。严重的血糖偏高是 1 型糖尿病的一个显著特征,其作为氧化应激介质的强大作用已得到广泛认可,氧化应激可通过多种途径产生,如增加高级糖化终产物(AGEs)的产生和激活蛋白激酶 C(PKC)。此外,T1DM 中持续存在的内皮功能障碍和高凝状态可能会损害微循环和内皮,从而导致各种器官衰竭和急性呼吸综合征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Risk of Type 1 Diabetes Mellitus in SARS CoV-2 Patients.

Recent studies have found that a link between people with type 1 diabetes mellitus (T1DM) are at higher risk of morbidity as well as mortality from COVID-19 infection, indicating a need for vaccination. T1DM appears to impair innate and adaptive immunity. The overabundance of pro-inflammatory cytokines produced in COVID-19 illness that is severe and potentially fatal is known as a "cytokine storm." Numerous cohorts have revealed chronic inflammation as a key risk factor for unfavorable COVID-19 outcomes. TNF-α, interleukin (IL)-1a, IL-1, IL-2, IL-6, and other cytokines were found in higher concentrations in patients with T1DM. Even more importantly, oxidative stress contributes significantly to the severity and course of COVID- 19's significant role in the progression and severity of COVID-19 diseases. Severe glucose excursions, a defining characteristic of type 1 diabetes, are widely recognized for their potent role as mediating agents of oxidative stress via several routes, such as heightened production of advanced glycation end products (AGEs) and activation of protein kinase C (PKC). Furthermore, persistent endothelial dysfunction and hypercoagulation found in T1DM may impair microcirculation and endothelium, which could result in the development of various organ failure and acute breathing syndrome.

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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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