The Role of Dietary Anthocyanins for Managing Diabetes Mellitus-Associated Complications.

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM
Priya S Mistry, Mehul R Chorawala, Bhagavathi Sundaram Sivamaruthi, Bhupendra G Prajapati, Akash Kumar, Chaiyavat Chaiyasut
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引用次数: 0

Abstract

Diabetes mellitus (DM) is an intricate metabolic disorder marked by persistent hyperglycemia, arising from disruptions in glucose metabolism, with two main forms, type 1 and type 2, involving distinct etiologies affecting β-cell destruction or insulin levels and sensitivity. The islets of Langerhans, particularly β-cells and α-cells, play a pivotal role in glucose regulation, and both DM types lead to severe complications, including retinopathy, nephropathy, and neuropathy. Plant-derived anthocyanins, rich in anti-inflammatory and antioxidant properties, show promise in mitigating DM-related complications, providing a potential avenue for prevention and treatment. Medicinal herbs, fruits, and vegetables, abundant in bioactive compounds like phenolics, offer diverse benefits, including glucose regulation and anti-inflammatory, antioxidant, anticancer, anti-mutagenic, and neuroprotective properties. Anthocyanins, a subgroup of polyphenols, exhibit diverse isoforms and biosynthesis involving glycosylation, making them potential natural replacements for synthetic food colorants. Clinical trials demonstrate the efficacy and safety of anthocyanins in controlling glucose, reducing oxidative stress, and enhancing insulin sensitivity in diabetic patients, emphasizing their therapeutic potential. Preclinical studies revealed their multifaceted mechanisms, positioning anthocyanins as promising bioactive compounds for managing diabetes and its associated complications, including retinopathy, nephropathy, and neuropathy.

膳食花青素在控制糖尿病相关并发症中的作用。
糖尿病(DM)是一种复杂的代谢紊乱疾病,其特征是葡萄糖代谢紊乱引起的持续性高血糖,主要有两种形式,即 1 型和 2 型,涉及不同的病因,影响到 β 细胞破坏或胰岛素水平和敏感性。朗格汉斯胰岛,尤其是β细胞和α细胞,在葡萄糖调节中起着关键作用,这两种类型的糖尿病都会导致严重的并发症,包括视网膜病变、肾病和神经病变。植物提取的花青素富含抗炎和抗氧化特性,有望减轻与糖尿病相关的并发症,为预防和治疗提供了潜在的途径。药用草本植物、水果和蔬菜富含酚类等生物活性化合物,具有多种益处,包括葡萄糖调节、抗炎、抗氧化、抗癌、抗突变和神经保护特性。花青素是多酚类物质的一个亚类,具有多种异构体和涉及糖基化的生物合成,因此有可能成为合成食品着色剂的天然替代品。临床试验证明,花青素在控制糖尿病患者血糖、减少氧化应激和提高胰岛素敏感性方面具有疗效和安全性,强调了花青素的治疗潜力。临床前研究揭示了花青素的多方面机理,使花青素成为治疗糖尿病及其相关并发症(包括视网膜病变、肾病和神经病变)的有前途的生物活性化合物。
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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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