紫花苜蓿(豆科)对糖尿病大鼠切除和切口损伤模型的保护作用。

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM
Phool Chandra, Mohammad Kaleem, Neetu Sachan, Anurag Verma, Atul Kabra
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引用次数: 0

摘要

简介:紫花苜蓿(m.s ativa),俗称苜蓿,是一种来自豆科的草药,长期以来被用于治疗消化系统疾病,糖尿病和血液疾病,以及支持肝脏健康。目的是评价红花乙醇提取物(EEMS)对正常大鼠和四氧嘧啶水合诱导的糖尿病大鼠创伤的影响。方法:采用切除创面(n=30)和切开创面(n=30)两种方法。II-V组为糖尿病大鼠,分别给予单纯BP软膏、10%体重型聚维酮碘(10% PI)、5% w/w EEMS软膏(5% w/w OEEMS)和10% w/w EEMS软膏(10% w/w OEEMS)。第1组为对照组,给予单纯BP软膏治疗。糖尿病对照组创面面积为292.33±0.8 mm sq。在第18天。结果:10% PI、5% OEEMS和10% OEEMS组大鼠创面面积显著减少,分别为68.33±1.29、248.33±1.30、61±1.91 mm sq。分别于第18天与对照组相比。与糖尿病大鼠相比,10% PI、5% w/w OEEMS和10% w/w OEEMS分别在切口创面模型第10天显著增加创面断裂强度。结论:黄芪多糖对糖尿病大鼠具有较强的创面愈合作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Protective Effect of Medicago Sativa L. (Fabaceae) against Excision and Incision Wound Models in Diabetic Rats.

Introduction: Medicago sativa (M. sativa), commonly known as Alfalfa, is a herb from the Fabaceae family that has a long history of being used to treat digestive, diabetic, and blood disorders, as well as to support liver health. The objective was to evaluate the effects of ethanolic extract of M. sativa (EEMS) on wounds in normal rats or alloxan hydrate-induced diabetic rats.

Method: The wounds were created by excision (n=30) and incision (n=30) in rats. The Group II-V were diabetic rats treated with simple ointment BP, 10% weight-based povidone-iodine (10% PI), ointment of 5% w/w EEMS (5% w/w OEEMS), and 10% w/w EEMS (10% w/w OEEMS). Group 1 acted as a control and was treated with simple ointment BP. The wound area in the diabetic control groups was 292.33±0.8 mm sq. on the 18th day.

Results: Rats treated with 10% PI, 5% OEEMS, and 10% OEEMS showed a significant reduction in wound area of 68.33±1.29, 248.33±1.30, and 61±1.91 mm sq., respectively, on the 18th day as compared to the control group. Rats treated with 10% PI, 5% w/w OEEMS, and 10% w/w OEEMS showed a significant increment in wound-breaking strength, respectively, as compared to diabetic rats on day 10 in the incision wound model.

Conclusion: The results demonstrated that the OEEMS has potent wound-healing properties in diabetic rats.

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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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